> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/clivatuzumab-tetraxetan-7c497012-b7b3-4d22-91fc-5e7f1f28682a
> Record changed: 2026-10-13

# Clivatuzumab tetraxetan

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301586)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301586)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301586)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301586)

**Drug name**

Clivatuzumab tetraxetan

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301586)

### Brand names (2)

- clivatucyn
- Clivatucyn

### Other names (16)

- clivatuzumab tetraxetan
- Clivatuzumab tetraxetan
- clivatuzumab tetraxetan \[INN\]
- CLIVATUZUMAB TETRAXETAN \[USAN\]
- clivatuzumab tetraxetan inn
- clivatuzumab tetraxetan usan
- hpam 4
- HPAM-4
- hpam4
- hPAM4
- igg dota
- IgG-DOTA
- immu 107
- IMMU-107
- immunoglobulin g1 anti mucin human mus musculus monoclonal hpam4 heavy chain disulfide with human mus musculus monoclonal hpam4 kappa chain dimer 1 4 7 10 tetraazacyclododecane 1 4 7 10 tetraacetic acid conjugate
- IMMUNOGLOBULIN G1, ANTI-(MUCIN) (HUMAN-MUS MUSCULUS MONOCLONAL HPAM4 HEAVY CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL HPAM4 .KAPPA.-CHAIN, DIMER, 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID CONJUGATE

## Identifiers

**CAS registry numbers**

- 1462876-11-4

**ChEMBL ID**

CHEMBL3301586

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301586)

**FDA ingredient codes (UNII)**

- 1D1F7UG35J

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

yttrium (90Y) clivatuzumab tetraxetan

**Type**

Antibody

**Drug name stem**

\-mab; -mab; -xetan

### Mechanisms of action

- **Mechanism**  
Mucin-5AC binding agent

**Action type**  
BINDING\_AGENT

**Target**  
Mucin-5AC

**Protein identifier**  
P98088

### Open Targets mechanisms

- **Mechanism**  
Mucin-5AC binding agent

**Action type**  
BINDING AGENT

**Target**  
Mucin-5AC

### Investigated indications

- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190

### Open Targets indications (3)

- **Condition identifier**  
EFO\_0002618
- **Condition identifier**  
MONDO\_0005192

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0006047

**Highest recorded phase**  
3

### Trial references (3)

- NCT00597129  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00597129)
- NCT00603863  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00603863)
- NCT01510561  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01510561)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (2)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QVQLQQSGAEVKKPGASVKVSCEASGYTFPSYVLHWVKQAPGQGLEWIGYINPYNDGTQYNEKFKGKATLTRDTSINTAYMELSRLRSDDTAVYYCARGFGGSYGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIQLTQSPSSLSASVGDRVTMTCSASSSVSSSYLYWYQQKPGKAPKLWIYSTSNLASGVPARFSGSGSGTDFTLTISSLQPEDSASYFCHQWNRYPYTFGGGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

## Related records

### Trials (4)

- [A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.](https://trialight.com/data/trial/a-study-of-muc16-directed-antibody-drug-conjugate-hwk-016-in-548b132b-ea69-4673-b544-093f6e3556e5.md)
- Multi-Targeted Recombinant Ad5 (CEA/MUC1/Brachyury) Based Immunotherapy Vaccine Regimen in People With Advanced Cancer
- Phase 3 Trial of 90Y-Clivatuzumab Tetraxetan & Gemcitabine vs Placebo & Gemcitabine in Metastatic Pancreatic Cancer
- Safety and Efficacy Study of Different Doses of 90Y-hPAM4 Combined With Gemcitabine in Pancreatic Cancer

### In development for (1)

- Exocrine pancreatic carcinoma Phase 1

### Targets (1)

- [MUC5AC](https://trialight.com/data/target/muc5ac-40d03189-f4c7-571e-8749-d54dac38aff1.md) Mucin-5AC binding agent

---

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