> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/clindamycin-phosphate-419e01e3-b65c-4586-a4bd-e2ef6ecfc03b > Record changed: 2026-10-13 # Clindamycin phosphate Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3184512) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3184512) First approval year 1972 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3184512) ## Development status **First approval year** 1972 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3184512) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3184512) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3184512) **Drug name** Clindamycin phosphate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3184512) **Molecular weight** 504.97 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3184512) **Structure (SMILES)** CCC\[C@@H\]1C\[C@@H\](C(=O)N\[C@@H\](\[C@H\]2O\[C@H\](SC)\[C@H\](OP(=O)(O)O)\[C@@H\](O)\[C@H\]2O)\[C@H\](C)Cl)N(C)C1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3184512) ### Brand names (50) - cleocin - Cleocin - cleocin phosphate - Cleocin phosphate - cleocin t - Cleocin t - clinadac - Clinadac - clinda derm - Clinda-derm - clindac - Clindac - clindagel - Clindagel - clindamycin phosphate - Clindamycin phosphate - clindamycin phosphate component of acanya - Clindamycin phosphate component of acanya - clindamycin phosphate component of benzaclin - Clindamycin phosphate component of benzaclin - clindamycin phosphate component of cabtreo - Clindamycin phosphate component of cabtreo - clindamycin phosphate component of duac - Clindamycin phosphate component of duac - clindamycin phosphate component of idp 126 And 25 more, listed on the interactive page. ### Other names (68) - 7 s chloro 7 deoxylincomycin 2 phosphate - 7(S)-CHLORO-7-DEOXYLINCOMYCIN 2-PHOSPHATE - acanya component clindamycin phosphate - ACANYA COMPONENT CLINDAMYCIN PHOSPHATE - benzaclin component clindamycin phosphate - BENZACLIN COMPONENT CLINDAMYCIN PHOSPHATE - cabtreo component clindamycin phosphate - CABTREO COMPONENT CLINDAMYCIN PHOSPHATE - CLINDAMYCIN (AS PHOSPHATE) - clindamycin 2 dihydrogen phosphate - clindamycin 2 dihydrogen phosphate mi - clindamycin 2 phosphate - Clindamycin 2-dihydrogen phosphate - CLINDAMYCIN 2-DIHYDROGEN PHOSPHATE \[MI\] - CLINDAMYCIN 2-PHOSPHATE - clindamycin as phosphate - clindamycin phosphate - Clindamycin phosphate - CLINDAMYCIN PHOSPHATE \[EP MONOGRAPH\] - CLINDAMYCIN PHOSPHATE \[JAN\] - CLINDAMYCIN PHOSPHATE \[MART.\] - CLINDAMYCIN PHOSPHATE \[ORANGE BOOK\] - CLINDAMYCIN PHOSPHATE \[USAN\] - CLINDAMYCIN PHOSPHATE \[USP MONOGRAPH\] - CLINDAMYCIN PHOSPHATE \[USP-RS\] And 43 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 24729-96-2 **ChEMBL ID** CHEMBL3184512 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3184512) **InChIKey** UFUVLHLTWXBHGZ-MGZQPHGTSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3184512) **PubChem compound IDs** - 443385 **FDA ingredient codes (UNII)** - EH6D7113I8 ### RxNorm IDs (RxCUI) (2) - 21235 - 797272 ## Regulatory information ### United States **Applicant** PFIZER **Approval date** 2 Oct 1972 **Application number** NDA050441 ### Other regulatory facts **Patents** 3 **Designations** 0 **Earliest recorded loss of exclusivity** 22 Sept 2036 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Drug name stem** \-mycin #### Administration routes - Parenteral - topical ### Mechanisms of action (56) - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P02358 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P02359 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P02413 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7J3 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7J7 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7K2 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7K6 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7L0 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7L3 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7L8 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7M2 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7M6 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7M9 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7N1 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7N4 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7N9 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7P5 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7Q1 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7Q6 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7R5 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7R9 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7S3 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7S9 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7T3 And 31 more, listed on the interactive page. ### Open Targets mechanisms - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome ### Investigated indications (22) - **Condition** Soft Tissue Infections **Highest recorded phase** 4 **Subject identifier** D018461 - **Condition** Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Intraabdominal Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000544 **Subject identifier** D059413 - **Condition** Irritable Bowel Syndrome **Highest recorded phase** 4 **Condition identifier** EFO:0000555 **Subject identifier** D043183 - **Condition** Abscess **Highest recorded phase** 4 **Condition identifier** EFO:0003030 **Subject identifier** D000038 - **Condition** Empyema **Highest recorded phase** 4 **Condition identifier** EFO:0003097 **Subject identifier** D004653 - **Condition** Osteomyelitis **Highest recorded phase** 4 **Condition identifier** EFO:0003102 **Subject identifier** D010019 - **Condition** Pneumonia **Highest recorded phase** 4 **Condition identifier** EFO:0003106 **Subject identifier** D011014 - **Condition** Acne Vulgaris **Highest recorded phase** 4 **Condition identifier** EFO:0003894 **Subject identifier** D000152 - **Condition** Vaginosis, Bacterial **Highest recorded phase** 4 **Condition identifier** EFO:0003932 **Subject identifier** D016585 - **Condition** Peritonitis **Highest recorded phase** 4 **Condition identifier** EFO:0008588 **Subject identifier** D010538 - **Condition** Genital Diseases, Female **Highest recorded phase** 4 **Condition identifier** EFO:0009549 **Subject identifier** D005831 - **Condition** Rosacea **Highest recorded phase** 2 **Condition identifier** EFO:1000760 **Subject identifier** D012393 - **Condition** Parametritis **Highest recorded phase** 4 **Condition identifier** EFO:1001084 **Subject identifier** D010249 - **Condition** Vulvovaginitis **Highest recorded phase** 3 **Condition identifier** EFO:1001240 **Subject identifier** D014848 - **Condition** Endometritis **Highest recorded phase** 4 **Condition identifier** EFO:1001312 **Subject identifier** D004716 - **Condition** Enterocolitis, Pseudomembranous **Highest recorded phase** 4 **Condition identifier** EFO:1001314 **Subject identifier** D004761 - **Condition** Lung Abscess **Highest recorded phase** 4 **Condition identifier** EFO:1001362 **Subject identifier** D008169 - **Condition** Abdominal Abscess **Highest recorded phase** 4 **Condition identifier** EFO:1001753 **Subject identifier** D018784 - **Condition** Sepsis **Highest recorded phase** 4 **Condition identifier** HP:0100806 **Subject identifier** D018805 - **Condition** Vaginitis **Highest recorded phase** 3 **Condition identifier** MONDO:0002234 **Subject identifier** D014627 - **Condition** Respiratory Tract Infections **Highest recorded phase** 4 **Condition identifier** MONDO:0024355 **Subject identifier** D012141 ### Open Targets indications (39) - **Condition identifier** EFO\_0000544 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 4 - **Condition identifier** EFO\_0000555 - **Condition identifier** EFO\_0003030 - **Condition identifier** EFO\_0003097 - **Condition identifier** EFO\_0003102 - **Condition identifier** EFO\_0003106 - **Condition identifier** EFO\_0003894 - **Condition identifier** EFO\_0003932 - **Condition identifier** EFO\_0008588 - **Condition identifier** EFO\_0009549 - **Condition identifier** EFO\_1000760 - **Condition identifier** EFO\_1001084 - **Condition identifier** EFO\_1001240 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001312 - **Condition identifier** EFO\_1001314 - **Condition identifier** EFO\_1001314 **Highest recorded phase** 4 - **Condition identifier** EFO\_1001362 - **Condition identifier** EFO\_1001753 - **Condition identifier** EFO\_1001753 **Highest recorded phase** 4 - **Condition identifier** HP\_0100806 - **Condition identifier** HP\_0100806 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0000744 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0000918 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0002234 **Highest recorded phase** 3 And 14 more, listed on the interactive page. ### Warnings (2) - **Warning** Black Box Warning **Effect** gastrointestinal toxicity - **Warning** Black Box Warning **Effect** infectious disease ### Open Targets warnings (2) - **Warning** Black Box Warning **Effect** gastrointestinal toxicity **Country** United States - **Warning** Black Box Warning **Effect** infectious disease **Country** United States ### Reported adverse events (15) - **Event** acute generalised exanthematous pustulosis **Reports** 199 **Reporting signal score** 519.205 - **Event** acute kidney injury **Reports** 201 **Reporting signal score** 84.8801 - **Event** clostridium difficile colitis **Reports** 101 **Reporting signal score** 201.491 - **Event** clostridium difficile infection **Reports** 129 **Reporting signal score** 235.355 - **Event** dermatitis allergic **Reports** 104 **Reporting signal score** 200.904 - **Event** drug hypersensitivity **Reports** 1,769 **Reporting signal score** 3,466.52 - **Event** drug reaction with eosinophilia and systemic symptoms **Reports** 145 **Reporting signal score** 188.853 - **Event** graft infection **Reports** 33 **Reporting signal score** 138.071 - **Event** oesophageal ulcer **Reports** 44 **Reporting signal score** 90.7761 - **Event** pseudomembranous colitis **Reports** 42 **Reporting signal score** 107.061 - **Event** rash **Reports** 461 **Reporting signal score** 177.567 - **Event** rash maculo-papular **Reports** 226 **Reporting signal score** 417.496 - **Event** toxic skin eruption **Reports** 82 **Reporting signal score** 130.721 - **Event** type iv hypersensitivity reaction **Reports** 99 **Reporting signal score** 298.382 - **Event** urticaria **Reports** 213 **Reporting signal score** 97.7151 ### Trial references (23) - NCT00361322 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00361322) - NCT00757523 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00757523) - NCT00807014 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00807014) - NCT00841776 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00841776) - NCT01015638 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01015638) - NCT01016977 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01016977) - NCT01047189 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01047189) - NCT01111994 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01111994) - NCT01422785 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01422785) - NCT01448733 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01448733) - NCT01769235 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01769235) - NCT01788384 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01788384) - NCT01796665 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01796665) - NCT01915732 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01915732) - NCT02005666 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02005666) - NCT03717506 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03717506) - NCT04321070 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04321070) - NCT05582434 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05582434) - NCT00616330 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00616330) - NCT00823901 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00823901) - NCT02099240 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02099240) - NCT03476941 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03476941) - NCT04370548 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04370548) ## Dosing **Dose** 1% **Route** Topical **How often** Twice daily ### Conditions of use - Keep container tightly closed ## Chemical properties **Hydrogen bond acceptors** 8 **Hydrogen bond donors** 5 **Polar surface area** 148.79 **Calculated partition coefficient (ALogP)** 0.51 **Calculated partition coefficient (XLogP)** \-1.2 **Prodrug** Yes **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 9 **Heavy atoms** 31 **Molecular formula** C18H34ClN2O8PS **Monoisotopic mass** 504.1462019 **Natural product** Yes ## National Drug Codes - 0009-0775 - 0009-0870 - 0009-0902 - 0009-3051 - 0009-3329 - 0009-3448 - 0009-4073 - 0009-5095 - 0009-7667 - 0168-0201 - 0168-0202 - 0168-0203 - 0168-0277 - 0187-0006 - 0187-3050 - 0338-3410 - 0338-3612 - 0338-3616 - 0338-3814 - 0338-4114 - 0338-9545 - 0338-9549 - 0338-9553 - 0404-9837 - 0404-9838 And 107 more, listed on the interactive page. ## Evidence counts **Recorded assays** 317 **Active assays** 0 ## Pharmacologic actions - Anti-Bacterial Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000900.html) ## Related records ### Trials (27) - A Efficacy and Safety of Duac™Compared With Clindamycin Phosphate Gel in the Treatment of Mild to Moderate Acne Vulgaris - A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control in the Treatment of Bacterial Vaginosis in Non-pregnant Women - A Phase 4, Single-Blind, Randomized, Study to Compare the Tolerability and Efficacy of 0.1% Tazorac Cream When Used in Combination With Either Duac Gel or Acanya Gel for the Treatment of Facial Acne Vulgaris - A Randomized, Multicenter, Open-label, Active-controlled Phase Ib Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Multiple Intravaginal Doses of GenSci142 in Patients With Bacterial Vaginosis (BV) - [A Study Comparing Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Topical Gel 0.15%;3.1%;1.2% (Taro Pharmaceuticals U.S.A., Inc.) and CABTREO Topical Gel for the Treatment of Acne Vulgaris.](https://trialight.com/data/trial/a-study-comparing-clindamycin-phosphate-adapalene-and-ba9c70f3-fa12-4215-ac68-4e41d58205e0.md) - A Study Comparing Combination Clindamycin Phosphate/Tretinoin Gel Alone Versus With Benzoyl Peroxide Foaming Cloths for Facial Acne - A Study to Compare Clindamycin Phosphate and Benzoyl Peroxide Topical Gel 1.2%/2.5% to Acanya® Topical Gel in the Treatment of Acne Vulgaris - Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris - Antibiotic Irrigations for Intra-Abdominal Drains - Bio-equivalence Study With Clinical Endpoints in the Treatment of Acne Vulgaris - Bioequivalence Study of Clindamycin Phosphate Topical Lotion, 1% in Subjects With Acne Vulgaris - Clindamycin and Triamcinolone in People With Glioblastoma to Prevent Skin-Related Side Effects of Tumor Treating Fields - Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Triple Combination Gel in Canadian Patients With Acne Vulgaris - Compare the Tolerance of Clindamycin 1% /Benzoyl Peroxide (BPO) 5% Gel to Clindamycin 1.2%/ BPO 2.5% Topical Medications - Efficacy & Safety of Clindamycin and Tretinoin in Acne - Efficacy and Safety of a Preparation Containing an Antibiotic and Anti-Inflammatory Agent in Acne Vulgaris - Evaluate Therapeutic Equivalence and Safety of Two Clindamycin Phosphate and Benzoyl Peroxide Gels in Acne Vulgaris - Experience With Topical Acne Treatment - Safety and Efficacy Study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to Treat Rosacea - Safety and Tolerability of Acanya Gel in Combination With Atralin Gel for Acne Vulgaris ### Approved for (14) - Abscess - [Acne](https://trialight.com/data/condition/acne-02478aa3-966b-5ffb-a257-6dbe85c14e58.md) - Bacterial vaginosis - Clostridium difficile colitis - Empyema - Endometritis - Female reproductive system disorder - Infectious peritonitis - [Irritable bowel syndrome](https://trialight.com/data/condition/irritable-bowel-syndrome-10830a51-118b-59c5-8ff4-5e11dbe81c01.md) - Lung abscess - Osteomyelitis - Parametritis - [Pneumonia](https://trialight.com/data/condition/pneumonia-d2f12d4d-57c5-5c54-881e-1efe392849eb.md) - [Respiratory tract infectious disorder](https://trialight.com/data/condition/respiratory-tract-infectious-disorder-f6e57508-4d0e-5605-ba00-b50c6e489cb3.md) ### In development for (3) - Rosacea Phase 2 - Vaginitis Phase 3 - Vulvovaginitis Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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