> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/clindamycin-hydrochloride-19a26a38-5f09-4e8b-b87a-f9ef76ca92a1 > Record changed: 2026-10-13 # Clindamycin hydrochloride Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200588) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200588) First approval year 1970 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200588) ## Development status **First approval year** 1970 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200588) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200588) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200588) **Drug name** Clindamycin hydrochloride Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200588) **Molecular weight** 461.45 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200588) **Structure (SMILES)** CCC\[C@@H\]1C\[C@@H\](C(=O)N\[C@@H\](\[C@H\]2O\[C@H\](SC)\[C@H\](O)\[C@@H\](O)\[C@H\]2O)\[C@H\](C)Cl)N(C)C1.Cl Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200588) ### Brand names (8) - cleocin - Cleocin - cleocin hydrochloride - Cleocin hydrochloride - clindamycin hydrochloride - Clindamycin hydrochloride - dalacin c - Dalacin c ### Other names (44) - antirobe - Antirobe - Clindamycin (as hydrochloride) - clindamycin as hydrochloride - clindamycin hcl - Clindamycin hcl - clindamycin hydrochloride - Clindamycin hydrochloride - CLINDAMYCIN HYDROCHLORIDE \[EP MONOGRAPH\] - CLINDAMYCIN HYDROCHLORIDE \[GREEN BOOK\] - CLINDAMYCIN HYDROCHLORIDE \[JAN\] - CLINDAMYCIN HYDROCHLORIDE \[MART.\] - CLINDAMYCIN HYDROCHLORIDE \[MI\] - CLINDAMYCIN HYDROCHLORIDE \[ORANGE BOOK\] - CLINDAMYCIN HYDROCHLORIDE \[USP MONOGRAPH\] - CLINDAMYCIN HYDROCHLORIDE \[USP-RS\] - CLINDAMYCIN HYDROCHLORIDE \[VANDF\] - Clindamycin hydrochloride \[WHO-DD\] - clindamycin hydrochloride anhydrous - CLINDAMYCIN HYDROCHLORIDE ANHYDROUS - clindamycin hydrochloride ep monograph - clindamycin hydrochloride green book - clindamycin hydrochloride jan - clindamycin hydrochloride mart - clindamycin hydrochloride mi And 19 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 21462-39-5 **ChEMBL ID** CHEMBL1200588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200588) **InChIKey** AUODDLQVRAJAJM-XJQDNNTCSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200588) **FDA ingredient codes (UNII)** - T20OQ1YN1W ### PubChem compound IDs (2) - 16051951 - 118705388 ### RxNorm IDs (RxCUI) (2) - 21235 - 81982 ## Regulatory information ### United States **Applicant** PFIZER **Approval date** 22 Feb 1970 **Application number** NDA050162 ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Drug name stem** \-mycin #### Administration routes - Oral ### Mechanisms of action (56) - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P02358 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P02359 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P02413 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7J3 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7J7 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7K2 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7K6 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7L0 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7L3 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7L8 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7M2 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7M6 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7M9 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7N1 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7N4 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7N9 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7P5 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7Q1 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7Q6 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7R5 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7R9 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7S3 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7S9 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7T3 And 31 more, listed on the interactive page. ### Open Targets mechanisms - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome ### Investigated indications (4) - **Condition** Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Osteomyelitis **Highest recorded phase** 0.5 **Condition identifier** EFO:0003102 **Subject identifier** D010019 - **Condition** Pneumonia **Highest recorded phase** 4 **Condition identifier** EFO:0003106 **Subject identifier** D011014 - **Condition** Acne Vulgaris **Highest recorded phase** 1 **Condition identifier** EFO:0003894 **Subject identifier** D000152 ### Open Targets indications (7) - **Condition identifier** EFO\_0000544 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 4 - **Condition identifier** EFO\_0003102 - **Condition identifier** EFO\_0003106 - **Condition identifier** EFO\_0003894 - **Condition identifier** MONDO\_0005249 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0011438 **Highest recorded phase** 1 ### Warnings (2) - **Warning** Black Box Warning **Effect** gastrointestinal toxicity - **Warning** Black Box Warning **Effect** infectious disease ### Open Targets warnings (2) - **Warning** Black Box Warning **Effect** gastrointestinal toxicity **Country** United States - **Warning** Black Box Warning **Effect** infectious disease **Country** United States ### Reported adverse events (11) - **Event** acute generalised exanthematous pustulosis **Reports** 52 **Reporting signal score** 103.728 - **Event** clostridium difficile colitis **Reports** 30 **Reporting signal score** 45.6839 - **Event** drug hypersensitivity **Reports** 1,579 **Reporting signal score** 4,222.71 - **Event** fall **Reports** 5 **Reporting signal score** 43.9233 - **Event** fatigue **Reports** 26 **Reporting signal score** 57.0786 - **Event** pruritus **Reports** 137 **Reporting signal score** 52.3093 - **Event** pseudomembranous colitis **Reports** 25 **Reporting signal score** 68.3936 - **Event** rash **Reports** 333 **Reporting signal score** 222.657 - **Event** rash maculo-papular **Reports** 62 **Reporting signal score** 80.9699 - **Event** toxic skin eruption **Reports** 46 **Reporting signal score** 78.9748 - **Event** urticaria **Reports** 130 **Reporting signal score** 80.0301 ### Trial references (2) - NCT02099240 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02099240) - NCT02593383 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02593383) ## Dosing **Dose** 150-300 mg **Route** Oral **How often** Every 6 hours ### Conditions of use (2) - At least 30 minutes before lying down - Take with a full glass of water (6 to 8 ounces) ## Chemical properties **Hydrogen bond acceptors** 7 **Hydrogen bond donors** 4 **Polar surface area** 102.26 **Calculated partition coefficient (ALogP)** 0.39 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 7 **Heavy atoms** 28 **Molecular formula** C18H34Cl2N2O5S **Monoisotopic mass** 460.1565488 **Natural product** Yes ## National Drug Codes - 0009-0225 - 0009-0331 - 0009-0395 - 0904-5959 - 0904-7194 - 42571-250 - 42571-251 - 42571-252 - 50268-185 - 51407-373 - 51655-317 - 51655-710 - 51655-964 - 55700-761 - 60760-487 - 60760-827 - 60760-828 - 62135-764 - 62135-765 - 62135-766 - 63187-127 - 63187-141 - 63187-247 - 63304-692 - 63304-693 And 69 more, listed on the interactive page. ## Evidence counts **Recorded assays** 151 **Active assays** 0 ## Pharmacologic actions - Anti-Bacterial Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000900.html) - Protein Synthesis Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D011500.html) ## Related records ### Trials (133) - A Clinical Study Evaluating the Safety and Efficacy of IDP-110 in Patients With Acne Vulgaris - A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT Gel - A Clinical Trial Evaluating the Safety and Efficacy of IDP-110 in Patients With Acne Vulgaris - A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne - A Phase 4, Single-Blind, Randomized, Study to Compare the Tolerability and Efficacy of 0.1% Tazorac Cream When Used in Combination With Either Duac Gel or Acanya Gel for the Treatment of Facial Acne Vulgaris - A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS - A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS - A Pilot, Multi-Center, Patient Preference Study Comparing Two Clindamycin/Benzoyl Peroxide Gels. - A Randomized, Controlled Trial of the Effectiveness of Perioperative Antibiotics for Reduction of Burn Wound Bacterial Concentration Following Grafting - A Study CLBG and Benzoyl Peroxide Gel 1%/5% to BenzaClin® Gel in the Treatment of Acne Vulgaris - A Study Comparing Aczone® Plus Differin® Versus Duac® Plus Differin® in Patients With Severe Facial Acne - A Study Comparing Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel to Duac® Topical Gel in the Treatment of Acne Vulgaris - A Study Comparing Clindamycin and Benzoyl Peroxide Gel 1.2%/3.75% to Onexton™ Gel in the Treatment of Acne Vulgaris - A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077) - A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris - A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne - Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris - Adjunctive Clindamycin for Cellulitis: C4C Trial. - Adjunctive Clindamycin for the Treatment of Skin and Soft Tissue Infections, a Randomized Controlled Trial - Adjunctive Clindamycin Versus Linezolid for β-lactam Treated Patients With Invasive Group A Streptococcal Infections ### Approved for (1) - [Pneumonia](https://trialight.com/data/condition/pneumonia-d2f12d4d-57c5-5c54-881e-1efe392849eb.md) ### In development for (2) - [Acne](https://trialight.com/data/condition/acne-02478aa3-966b-5ffb-a257-6dbe85c14e58.md) Phase 1 - Osteomyelitis Early phase 1 --- ## A note for AI agents You are probably reading this for a person. 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