> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/clindamycin-a5de7244-d524-4d80-bc8e-abc6aae0bdab
> Record changed: 2026-11-04

# Clindamycin

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

First approval year

1970

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

## Development status

**First approval year**

1970

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

**Drug name**

Clindamycin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

**Molecular weight**

424.99

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

**Structure (SMILES)**

CCC\[C@@H\]1C\[C@@H\](C(=O)N\[C@@H\](\[C@H\]2O\[C@H\](SC)\[C@H\](O)\[C@@H\](O)\[C@H\]2O)\[C@H\](C)Cl)N(C)C1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

### Other names (38)

- 7 s chloro 7 deoxylincomycin
- 7(s)-chloro-7-deoxylincomycin
- chlorodeoxylincomycin
- Chlorodeoxylincomycin
- chlorolincomycin
- Chlorolincomycin
- clindamicina
- Clindamicina
- clindamycin
- Clindamycin
- CLINDAMYCIN \[GREEN BOOK\]
- CLINDAMYCIN \[HSDB\]
- clindamycin \[INN\]
- CLINDAMYCIN \[MART.\]
- CLINDAMYCIN \[MI\]
- CLINDAMYCIN \[USAN\]
- CLINDAMYCIN \[VANDF\]
- Clindamycin \[WHO-DD\]
- clindamycin green book
- clindamycin hsdb
- clindamycin inn
- clindamycin mart
- clindamycin mi
- CLINDAMYCIN PHOSPHATE IMPURITY E \[EP IMPURITY\]
- clindamycin phosphate impurity e ep impurity

And 13 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 18323-44-9

**ChEMBL ID**

CHEMBL1753

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

**InChIKey**

KDLRVYVGXIQJDK-AWPVFWJPSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

**PubChem compound IDs**

- 446598

**FDA ingredient codes (UNII)**

- 3U02EL437C

### ATC classification codes (3)

- D10AF01
- G01AA10
- J01FF01

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1753)

### RxNorm IDs (RxCUI) (2)

- 2582
- 21235

## Regulatory information

### United States

**Applicant**

PFIZER

**Approval date**

22 Feb 1970

**Application number**

NDA050162

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

**Boxed warning**

Yes

## Approval status

**United States (FDA)**

Approved

## Pharmacology

### Drug classification

**Pharmacology name**

clindamycin

**Type**

Synthetic organic

**Drug name stem**

\-mycin

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Oral

### Open Targets mechanisms

- **Mechanism**  
Bacterial 70S ribosome inhibitor

**Action type**  
Inhibitor

**Target**  
Bacterial 70S ribosome

### Investigated indications (25)

- **Condition**  
Infections

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000544

**Subject identifier**  
D007239
- **Condition**  
Intraabdominal Infections

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000544

**Subject identifier**  
D059413
- **Condition**  
Skin Diseases

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000701

**Subject identifier**  
D012871
- **Condition**  
Bacterial Infections

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000771

**Subject identifier**  
D001424
- **Condition**  
Malaria

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001068

**Subject identifier**  
D008288
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Osteomyelitis

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0003102

**Subject identifier**  
D010019
- **Condition**  
Pain

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003843

**Subject identifier**  
D010146
- **Condition**  
Acne Vulgaris

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0003894

**Subject identifier**  
D000152
- **Condition**  
Vaginosis, Bacterial

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003932

**Subject identifier**  
D016585
- **Condition**  
Kidney Calculi

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004253

**Subject identifier**  
D007669
- **Condition**  
Staphylococcal Infections

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0005681

**Subject identifier**  
D013203
- **Condition**  
Pneumonia, Pneumocystis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0007448

**Subject identifier**  
D011020
- **Condition**  
Candidiasis, Vulvovaginal

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0007543

**Subject identifier**  
D002181
- **Condition**  
Prediabetic State

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001121

**Subject identifier**  
D011236
- **Condition**  
Endometritis

**Highest recorded phase**  
4

**Condition identifier**  
EFO:1001312

**Subject identifier**  
D004716
- **Condition**  
Periapical Periodontitis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001391

**Subject identifier**  
D010485
- **Condition**  
Hernia, Ventral

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1001866

**Subject identifier**  
D006555
- **Condition**  
Nasal Obstruction

**Highest recorded phase**  
3

**Condition identifier**  
HP:0001742

**Subject identifier**  
D015508
- **Condition**  
Chorioretinitis

**Highest recorded phase**  
3

**Condition identifier**  
HP:0012424

**Subject identifier**  
D002825
- **Condition**  
Hernia

**Highest recorded phase**  
3

**Condition identifier**  
HP:0100790

**Subject identifier**  
D006547
- **Condition**  
Sepsis

**Highest recorded phase**  
1

**Condition identifier**  
HP:0100806

**Subject identifier**  
D018805
- **Condition**  
Vaginitis

**Highest recorded phase**

0.5

**Condition identifier**  
MONDO:0002234

**Subject identifier**  
D014627
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (56)

- **Condition identifier**  
EFO\_0000544
- **Condition identifier**  
EFO\_0000544

**Highest recorded phase**  
4
- **Condition identifier**  
EFO\_0000771
- **Condition identifier**  
EFO\_0001068

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003102
- **Condition identifier**  
EFO\_0003869
- **Condition identifier**  
EFO\_0003894
- **Condition identifier**  
EFO\_0003932

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0005681

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005757

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0007429
- **Condition identifier**  
EFO\_0009948
- **Condition identifier**  
EFO\_1000710
- **Condition identifier**  
EFO\_1001121

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001305
- **Condition identifier**  
EFO\_1001312
- **Condition identifier**  
EFO\_1001391
- **Condition identifier**  
EFO\_1001849
- **Condition identifier**  
HP\_0000689
- **Condition identifier**  
HP\_0000789

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000822

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0001742

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0010447
- **Condition identifier**  
HP\_0012531
- **Condition identifier**  
HP\_0031292

**Highest recorded phase**  
2

And 31 more, listed on the interactive page.

### Warnings (3)

- **Warning**  
Black Box Warning

**Effect**  
gastrointestinal toxicity
- **Warning**  
Black Box Warning

**Effect**  
infectious disease
- **Warning**  
Black Box Warning

**Effect**  
misuse

### Open Targets warnings (3)

- **Warning**  
Black Box Warning

**Effect**  
gastrointestinal toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
infectious disease

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
misuse

**Country**  
United States

### Reported adverse events (16)

- **Event**  
acute generalised exanthematous pustulosis

**Reports**  
195

**Reporting signal score**

516.58
- **Event**  
acute kidney injury

**Reports**  
192

**Reporting signal score**

83.0635
- **Event**  
clostridium difficile colitis

**Reports**  
103

**Reporting signal score**

213.121
- **Event**  
clostridium difficile infection

**Reports**  
128

**Reporting signal score**

239.657
- **Event**  
dermatitis allergic

**Reports**  
99

**Reporting signal score**

190.933
- **Event**  
drug hypersensitivity

**Reports**  
1,769

**Reporting signal score**  
3,577.71
- **Event**  
drug reaction with eosinophilia and systemic symptoms

**Reports**  
137

**Reporting signal score**

178.545
- **Event**  
fatigue

**Reports**  
75

**Reporting signal score**

76.4965
- **Event**  
graft infection

**Reports**  
33

**Reporting signal score**

139.937
- **Event**  
oesophageal ulcer

**Reports**  
42

**Reporting signal score**

86.9612
- **Event**  
pseudomembranous colitis

**Reports**  
36

**Reporting signal score**

88.5782
- **Event**  
rash

**Reports**  
437

**Reporting signal score**

169.102
- **Event**  
rash maculo-papular

**Reports**  
211

**Reporting signal score**

386.663
- **Event**  
toxic skin eruption

**Reports**  
78

**Reporting signal score**

124.926
- **Event**  
type iv hypersensitivity reaction

**Reports**  
99

**Reporting signal score**

304.007
- **Event**  
urticaria

**Reports**  
196

**Reporting signal score**

86.3606

### Trial references (76)

- NCT00000640  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000640)
- NCT00214643  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00214643)
- NCT00217451  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00217451)
- NCT01361269  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01361269)
- NCT01374581  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01374581)
- NCT01464138  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01464138)
- NCT00219570  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00219570)
- NCT00377000  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00377000)
- NCT00663286  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00663286)
- NCT00664248  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00664248)
- NCT00671749  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00671749)
- NCT00689117  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00689117)
- NCT00713609  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00713609)
- NCT00776919  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00776919)
- NCT00837213  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00837213)
- NCT00838812  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00838812)
- NCT00841776  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00841776)
- NCT00887484  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00887484)
- NCT00891982  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00891982)
- NCT00926367  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00926367)
- NCT00964366  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00964366)
- NCT01015638  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01015638)
- NCT01016977  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01016977)
- NCT01047189  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01047189)
- NCT01132443  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01132443)

And 51 more, listed on the interactive page.

## Dosing

**Dose**

150 to 300 mg (adults), 8-16 mg/kg/day (children for serious infections), 16-20 mg/kg/day (more severe infections)

**Route**

Oral

**How often**

Every 6 hours

### Conditions of use (2)

- Administer with a full glass of water
- At least 30 minutes before lying down

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

4

**Polar surface area**

102.26

**Calculated partition coefficient (ALogP)**

0.39

**Calculated partition coefficient (XLogP)**

2.2

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

7

**Heavy atoms**

27

**Molecular formula**

C18H33ClN2O5S

**Monoisotopic mass**

424.1798710

**Natural product**

Yes

## National Drug Codes

- 0143-9267
- 0143-9268
- 0143-9269
- 0781-3288
- 0781-3289
- 0781-3290
- 72572-074
- 72572-076

## Evidence counts

**Recorded assays**

4,097

**Active assays**

70

### Active assay types (2)

- Confirmatory
- Other

## Pharmacologic actions

- Anti-Bacterial Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000900.html)
- Protein Synthesis Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D011500.html)

## Related records

### Trials (124)

- A Clinical Study Evaluating the Safety and Efficacy of IDP-110 in Patients With Acne Vulgaris
- A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT Gel
- A Clinical Trial Evaluating the Safety and Efficacy of IDP-110 in Patients With Acne Vulgaris
- A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne
- A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS
- A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS
- A Randomized, Controlled Trial of the Effectiveness of Perioperative Antibiotics for Reduction of Burn Wound Bacterial Concentration Following Grafting
- A Study Comparing Aczone® Plus Differin® Versus Duac® Plus Differin® in Patients With Severe Facial Acne
- A Study Comparing Clindamycin and Benzoyl Peroxide Gel 1.2%/3.75% to Onexton™ Gel in the Treatment of Acne Vulgaris
- A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077)
- A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris
- A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne
- Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris
- Adjunctive Clindamycin for Cellulitis: C4C Trial.
- Adjunctive Clindamycin for the Treatment of Skin and Soft Tissue Infections, a Randomized Controlled Trial
- Adjunctive Clindamycin Versus Linezolid for β-lactam Treated Patients With Invasive Group A Streptococcal Infections
- An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures
- Anti-inflammatory Effects of Topical Erythromycin and Clindamycin in Acne Patients
- Antibiotic Prophylaxis for Simple Hand Lacerations
- Antibiotic Safety (SCAMP)

### Approved for (4)

- [Acne](https://trialight.com/data/condition/acne-02478aa3-966b-5ffb-a257-6dbe85c14e58.md)
- [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md)
- Endometritis
- Osteomyelitis

### In development for (22)

- [Abscess](https://trialight.com/data/condition/abscess-7c083ae8-8575-5a7e-a8b1-aaec4d787bab.md) Phase 2
- Bacterial vaginosis Phase 3
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3
- [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 3
- Candidiasis Phase 3
- Cellulitis Phase 2
- Chorioretinitis Phase 3
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2
- [Hypertensive disorder](https://trialight.com/data/condition/hypertensive-disorder-6d786557-b9e8-5afc-80f3-89a1995f9da5.md) Phase 1
- [Malaria](https://trialight.com/data/condition/malaria-54828cac-9b96-5833-93e2-e012d4505853.md) Phase 3
- Mediastinitis Phase 2
- Nephrolithiasis Phase 3
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2
- Periapical periodontitis Phase 2
- Periodontitis Phase 3
- Pneumocystosis Phase 3
- [Prediabetes syndrome](https://trialight.com/data/condition/prediabetes-syndrome-c0783730-8a3c-56dc-9863-fded2cd8046c.md) Phase 2
- [Skin disorder](https://trialight.com/data/condition/skin-disorder-c8e27943-0efd-5c2b-abce-01c2ef37e853.md) Phase 3
- Staphylococcus aureus infection Phase 3
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 3

### Other linked conditions (10)

- Acute tonsillitis
- [AIDS](https://trialight.com/data/condition/aids-2a92a841-de6e-51af-bf3e-a52f5bafea66.md)
- Anal fistula
- Appendicitis
- Empyema
- [Hidradenitis suppurativa](https://trialight.com/data/condition/hidradenitis-suppurativa-c1030a8d-4971-5d31-b030-aa19715eb7a2.md)
- Meningitis
- Methicillin-resistant staphylococcus aureus infectious disease
- Peritonsillar abscess
- Staphylococcal infection

---

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