> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/citric-acid-25b001b8-fd7a-438c-85e8-81f14a72a65a > Record changed: 2026-10-13 # Citric acid Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) First approval year 1982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) ## Development status **First approval year** 1982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) **Drug name** Citric acid Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) **Molecular weight** 192.12 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) **Structure (SMILES)** O=C(O)CC(O)(CC(=O)O)C(=O)O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) ### Brand names (10) - citric acid component of clenpiq - Citric acid component of clenpiq - citric acid component of phexxi - Citric acid component of phexxi - citric acid component of prepopik - Citric acid component of prepopik - citric acid component of renacidin - Citric acid component of renacidin - urologic g - Urologic g ### Other names (84) - 1 2 3 propanetricarboxylic acid 2 hydroxy - 1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY- - acidum citricum - Acidum citricum - ACIDUM CITRICUM \[WHO-IP LATIN\] - acidum citricum monohydrate - Acidum citricum monohydrate - acidum citricum who ip latin - aciletten - Aciletten - anhydrous citric acid - Anhydrous citric acid - ANHYDROUS CITRIC ACID \[II\] - ANHYDROUS CITRIC ACID \[JAN\] - ANHYDROUS CITRIC ACID \[MART.\] - ANHYDROUS CITRIC ACID \[USP MONOGRAPH\] - anhydrous citric acid 1197 0 mg potassium bicarbonate 967 5 mg sodium citrate anhydrous 835 5 mg - anhydrous citric acid ii - anhydrous citric acid jan - anhydrous citric acid mart - anhydrous citric acid usp monograph - b1650 - B1650 - citrate - Citrate And 59 more, listed on the interactive page. ## Identifiers **ATC classification codes** - A09AB04 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) **CAS registry numbers** - 77-92-9 **ChEMBL ID** CHEMBL1261 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) **InChIKey** KRKNYBCHXYNGOX-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1261) **FDA ingredient codes (UNII)** - XF417D3PSL ### PubChem compound IDs (3) - 311 - 19782904 - 88113319 ### RxNorm IDs (RxCUI) (3) - 21183 - 221946 - 1312366 ## Regulatory information ### United States **Applicant** UNITED GUARDIAN **Approval date** 2 Oct 1990 **Application number** NDA019481 ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** citric acid **Type** Metabolite #### Administration routes - Oral - topical ### Mechanisms of action - **Action** Agonist **Action type** Agonist **Target** TRPP2 **Gene symbol** PKD2L1 **Protein identifier** Q9P0L9 **Median affinity** 1.7 **Affinity units** pEC50 ### Investigated indications (6) - **Condition** Kidney Calculi **Highest recorded phase** 2 **Condition identifier** EFO:0004253 **Subject identifier** D007669 - **Condition** Renal Insufficiency **Highest recorded phase** 3 **Condition identifier** HP:0000083 **Subject identifier** D051437 - **Condition** Nephrocalcinosis **Highest recorded phase** 3 **Condition identifier** HP:0000121 **Subject identifier** D009397 - **Condition** Tension-Type Headache **Highest recorded phase** 2 **Condition identifier** HP:0012228 **Subject identifier** D018781 - **Condition** Cataract **Highest recorded phase** 2 **Condition identifier** MONDO:0005129 **Subject identifier** D002386 - **Condition** Osteoarthritis **Highest recorded phase** 1 **Condition identifier** MONDO:0005178 **Subject identifier** D010003 ### Open Targets indications (17) - **Condition identifier** EFO\_0000384 - **Condition identifier** EFO\_0006859 - **Condition identifier** EFO\_0009518 - **Condition identifier** EFO\_0009909 **Highest recorded phase** 2 - **Condition identifier** HP\_0000083 - **Condition identifier** HP\_0002901 - **Condition identifier** HP\_0012228 - **Condition identifier** MONDO\_0001106 - **Condition identifier** MONDO\_0001567 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002492 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005011 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005178 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005372 - **Condition identifier** MONDO\_0005647 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0024647 - **Condition identifier** MONDO\_0100192 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0850098 ### Reported adverse events (25) - **Event** analgesic asthma syndrome **Reports** 1 **Reporting signal score** 5.93494 - **Event** anorectal discomfort **Reports** 2 **Reporting signal score** 7.0949 - **Event** b precursor type acute leukaemia **Reports** 2 **Reporting signal score** 11.4885 - **Event** blood calcium decreased **Reports** 3 **Reporting signal score** 7.38152 - **Event** colitis **Reports** 6 **Reporting signal score** 12.3586 - **Event** dermatitis **Reports** 3 **Reporting signal score** 6.66792 - **Event** device temperature issue **Reports** 1 **Reporting signal score** 7.83919 - **Event** drug hypersensitivity **Reports** 13 **Reporting signal score** 13.5491 - **Event** graft versus host disease in skin **Reports** 2 **Reporting signal score** 7.03147 - **Event** haemorrhage **Reports** 7 **Reporting signal score** 10.377 - **Event** hyponatraemic coma **Reports** 1 **Reporting signal score** 6.74087 - **Event** imaging procedure artifact **Reports** 3 **Reporting signal score** 28.0541 - **Event** intestinal congestion **Reports** 1 **Reporting signal score** 6.11171 - **Event** medical device site fibrosis **Reports** 1 **Reporting signal score** 6.17835 - **Event** mucosal dryness **Reports** 2 **Reporting signal score** 7.61942 - **Event** nasogastric output high **Reports** 1 **Reporting signal score** 7.23318 - **Event** ochronosis **Reports** 1 **Reporting signal score** 6.21341 - **Event** oropharyngeal discolouration **Reports** 1 **Reporting signal score** 7.4338 - **Event** product barcode issue **Reports** 4 **Reporting signal score** 25.1062 - **Event** product label issue **Reports** 2 **Reporting signal score** 7.33843 - **Event** radiation alopecia **Reports** 2 **Reporting signal score** 17.4374 - **Event** swollen tongue **Reports** 4 **Reporting signal score** 7.08767 - **Event** tongue discomfort **Reports** 2 **Reporting signal score** 7.64279 - **Event** toxic epidermal necrolysis **Reports** 9 **Reporting signal score** 29.7269 - **Event** upper airway obstruction **Reports** 2 **Reporting signal score** 8.87596 ### Trial references (6) - NCT00249951 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00249951) - NCT01012349 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01012349) - NCT01421160 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01421160) - NCT01602068 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01602068) - NCT01754779 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01754779) - NCT01962116 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01962116) ## Dosing **Dose** 1 bottle **Route** Oral **How often** Split-dose regimen ### Conditions of use (6) - Do not drink alcohol - Do not drink anything colored red or purple - Do not eat solid food or dairy on the day before colonoscopy - No solid food or dairy - Stop liquids at least 2 hours before colonoscopy - Take with clear liquids ## Chemical properties **Hydrogen bond acceptors** 4 **Hydrogen bond donors** 4 **Polar surface area** 132.13 **Calculated partition coefficient (ALogP)** \-1.25 **Calculated partition coefficient (XLogP)** \-1.7 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 5 **Heavy atoms** 13 **Molecular formula** C6H8O7 **Monoisotopic mass** 192.02700259 **Natural product** Yes ## National Drug Codes - 0121-0595 - 0121-1190 - 0327-0012 - 0942-0641 - 0942-6305 - 0942-6307 - 0942-6308 - 0942-6312 - 0942-6316 - 0942-6320 - 0942-6322 - 0942-6326 - 0942-9001 - 0942-9201 - 0942-9202 - 0942-9393 - 0942-9394 - 0942-9398 - 50268-182 - 50268-183 - 53877-108 - 53877-109 - 53877-110 - 60687-832 - 60687-834 And 9 more, listed on the interactive page. ## Evidence counts **Recorded assays** 2,354 **Active assays** 41 ### Active assay types (3) - Confirmatory - Other - Screening ## Pharmacologic actions - Anticoagulants Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000925.html) - Calcium Chelating Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D065096.html) ## Related records ### Trials (58) - 68Ga Citrate PET/MRI for Evaluation of Fever of Unknown Origin (FUO) - 68Ga-citrate PET/MR Imaging for Glioma - [A Bioequivalence Study of Citrate Free Mirikizumab (LY3074828) in Healthy Participants](https://trialight.com/data/trial/a-bioequivalence-study-of-citrate-free-mirikizumab-ly3074828-5d425438-f7df-47c3-8054-edc0cdafae5f.md) - A Cross-sectional Study to Measure Cough in Severe Asthma - A Dose-Response Controlled Trial of Bevifibatide for Acute Ischemic Stroke - A Pilot Study of Commercially Available Bowel Preparation Regimens Packaged and Ingested Via Vegan Capsules - A Study Comparing Picoprep With Mannitol and Bisacodyl for Colon Cleansing in Preparation for Colonoscopy - A Study Comparing the Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid Oral Solution With PREPOPIK® for Colon Cleansing in Preparation for Colonoscopy - A Study of the Efficacy and Safety of Bowklean and Klean-Prep With Dulcolax for the Bowel Preparation Prior Colonoscopy - A Study of Two Formulations (Both Refrigerated and Room Temperature) Using an Autoinjector Device in Healthy Participants - Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm Infants - Antibiotic Lock Solutions in the Prevention of Catheter Related Bacteremia - Arterial pH and Total Body Nitrogen Balances in APD - Biological and Clinical Measurements Following Systemic Leakage When a Citrate or Heparin Lock is Used - Bismuth Based Quadruple Therapy 10 Days in Children - Bone in CKD Alkali Response (BICARb Pilot Trial) - Bowel Preparation in Elective Pediatric Colorectal Surgery - Citrate 4% Versus Heparinised Saline in Preventing Peripherally Inserted Central Catheter (PICC) Occlusions - Citrate Anticoagulation in Renal Replacement Therapy: Impact of a High Post-filter Calcium Target on Efficacy - Citrate Versus Heparin Anticoagulation: Effect on Molecules Clearances ### In development for (6) - Acute kidney injury Phase 3 - Cataract Phase 2 - [Kidney failure](https://trialight.com/data/condition/kidney-failure-f26737b4-3a55-50be-b6c3-b76514cb5067.md) Phase 3 - Nephrocalcinosis Phase 3 - Nephrolithiasis Phase 2 - [Osteoarthritis](https://trialight.com/data/condition/osteoarthritis-e8c428fb-1597-576d-bcf0-f3b27ebc6a00.md) Phase 1 ### Other linked conditions (3) - [Crohn disease](https://trialight.com/data/condition/crohn-disease-f7aa2cd8-9680-56b5-858c-2b75f88fb0d0.md) - [Head and neck cancer](https://trialight.com/data/condition/head-and-neck-cancer-3a2645b9-a3db-5103-b6f8-5d2ec40c5339.md) - Urolithiasis --- ## A note for AI agents You are probably reading this for a person. 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