> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/citicoline-f5938bef-5da4-4d58-8885-c4ba9dd1cf3c > Record changed: 2026-10-13 # Citicoline Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1231700) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1231700) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1231700) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1231700) **Drug name** Citicoline Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1231700) **Molecular weight** 488.33 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1231700) **Structure (SMILES)** C\[N+\](C)(C)CCOP(=O)(O)OP(=O)(\[O-\])OC\[C@H\]1O\[C@@H\](n2ccc(N)nc2=O)\[C@H\](O)\[C@@H\]1O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1231700) ### Other names (35) - cdp choline - Cdp-choline - CDP-choline - CDP-Choline - citicolina - Citicolina - citicoline - Citicoline - citicoline \[INN\] - CITICOLINE \[JAN\] - CITICOLINE \[MART.\] - CITICOLINE \[MI\] - CITICOLINE \[USP-RS\] - CITICOLINE \[VANDF\] - Citicoline \[WHO-DD\] - citicoline inn - citicoline jan - citicoline mart - citicoline mi - citicoline usp rs - citicoline vandf - citicoline who dd - cytidine 5 diphosphate choline - cytidine 5 diphosphocholine - cytidine 5 trihydrogen diphosphate p 2 trimethylammonio ethyl ester inner salt And 10 more, listed on the interactive page. ## Identifiers **ATC classification codes** - N06BX06 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1231700) **CAS registry numbers** - 987-78-0 **ChEMBL ID** CHEMBL1231700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1231700) **InChIKey** RZZPDXZPRHQOCG-OJAKKHQRSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1231700) **RxNorm IDs (RxCUI)** - 997602 **FDA ingredient codes (UNII)** - 536BQ2JVC7 ### PubChem compound IDs (3) - 13804 - 11583971 - 76963096 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (11) - **Condition** Stroke **Highest recorded phase** 3 **Condition identifier** EFO:0000712 **Subject identifier** D020521 - **Condition** Attention Deficit Disorder with Hyperactivity **Highest recorded phase** 3 **Condition identifier** EFO:0003888 **Subject identifier** D001289 - **Condition** Glaucoma, Open-Angle **Highest recorded phase** 3 **Condition identifier** EFO:0004190 **Subject identifier** D005902 - **Condition** Amphetamine-Related Disorders **Highest recorded phase** 3 **Condition identifier** EFO:0004701 **Subject identifier** D019969 - **Condition** Marijuana Abuse **Highest recorded phase** 2 **Condition identifier** EFO:0007191 **Subject identifier** D002189 - **Condition** Ischemic Stroke **Highest recorded phase** 3 **Condition identifier** HP:0002140 **Subject identifier** D000083242 - **Condition** Cerebral Infarction **Highest recorded phase** 3 **Condition identifier** MONDO:0002679 **Subject identifier** D002544 - **Condition** Brain Ischemia **Highest recorded phase** 3 **Condition identifier** MONDO:0005299 **Subject identifier** D002545 - **Condition** Alcoholism **Highest recorded phase** 2 **Condition identifier** MONDO:0007079 **Subject identifier** D000437 - **Condition** Brain Injuries **Highest recorded phase** 3 **Condition identifier** MONDO:0043510 **Subject identifier** D001930 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 1 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (28) - **Condition identifier** EFO\_0000712 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001072 - **Condition identifier** EFO\_0003888 - **Condition identifier** EFO\_0004190 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004701 **Highest recorded phase** 3 - **Condition identifier** EFO\_0005772 - **Condition identifier** EFO\_0007191 **Highest recorded phase** 2 - **Condition identifier** EFO\_0009444 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009965 **Highest recorded phase** 3 - **Condition identifier** HP\_0002140 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002009 - **Condition identifier** MONDO\_0002679 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004456 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004985 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005041 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005090 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005186 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005299 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005338 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005419 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005689 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0006663 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0007079 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007743 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0010382 **Highest recorded phase** 2 And 3 more, listed on the interactive page. ### Reported adverse events (8) - **Event** apraxia **Reports** 4 **Reporting signal score** 25.3635 - **Event** cognitive disorder **Reports** 5 **Reporting signal score** 17.5726 - **Event** disorientation **Reports** 4 **Reporting signal score** 12.9851 - **Event** drug interaction **Reports** 15 **Reporting signal score** 48.926 - **Event** hepatitis **Reports** 3 **Reporting signal score** 9.36954 - **Event** hyperreflexia **Reports** 4 **Reporting signal score** 20.9693 - **Event** myoclonus **Reports** 4 **Reporting signal score** 16.5729 - **Event** neuroleptic malignant syndrome **Reports** 7 **Reporting signal score** 32.7976 ### Trial references (12) - NCT00158249 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00158249) - NCT00331890 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00331890) - NCT00545662 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00545662) - NCT01591759 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01591759) - NCT00950352 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00950352) - NCT02823106 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02823106) - NCT05154903 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05154903) - NCT06210646 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06210646) - NCT03181646 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03181646) - NCT05710198 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05710198) - NCT05870111 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05870111) - NCT05881135 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05881135) ## Chemical properties **Hydrogen bond acceptors** 13 **Hydrogen bond donors** 4 **Polar surface area** 215.72 **Calculated partition coefficient (ALogP)** \-2.23 **Calculated partition coefficient (XLogP)** \-4 **Prodrug** No **Chirality** Racemic **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 10 **Heavy atoms** 31 **Molecular formula** C14H26N4O11P2 **Monoisotopic mass** 488.10733165 **Natural product** Yes ## Evidence counts **Recorded assays** 4 **Active assays** 0 ## Pharmacologic actions - Nootropic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018697.html) ## Related records ### Trials (32) - A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence - A Pilot Trial of Citicoline in Individuals With Mild Traumatic Brain Injury (mTBI) - CDP-Choline and Working Memory After TBI: A Neuroimaging Study - CDP-choline Treatment in ATS Users - Citicoline and Omega-3 Fatty Acid Effects in Veterans With Traumatic Brain Injury (TBI) - Citicoline as Neuroprotector in Neonates Exposed to Hypoxia - Citicoline as Neuroprotector in Preterm - Citicoline Concentration in Human Vitreous - Citicoline for Alcohol Dependence - Citicoline for Bipolar 1 Disorder and Cocaine Dependence - Citicoline in Ischemic Stroke - Citicoline in Ischemic Stroke, a Randomized Trial - Citicoline in Youth Alcohol Use Disorder - Citicoline Treatment of Methamphetamine Dependence - Citicoline, Creatine, and Omega-3 Effects in Middle Age Women - Cognizin Citicoline Dosing in a Healthy Adolescent Male Population - Effect of Citicoline on Neurological Severity Score and Cerebral Doppler Resistive Index in Neonatal Hypoxic Ischemic Encephalopathy - Effect of Fixed Combination Citicoline Homotaurine and Pyrroloquinoline Quinone on Pattern-electroretinogram in Glaucoma - Effects of Citicoline on Brain Function and Behavior in Marijuana-Dependent Individuals - [Efficacy of Citicoline Eye Drops 2% on Visual Field Preservation in Patients With Open Angle Glaucoma](https://trialight.com/data/trial/efficacy-of-citicoline-eye-drops-2-on-visual-field-c408b658-a93a-4e9b-935c-dc31dbff7571.md) ### In development for (11) - [Alcohol dependence](https://trialight.com/data/condition/alcohol-dependence-d26b3f0d-c0fb-5084-9194-e963df0e9179.md) Phase 2 - Attention deficit-hyperactivity disorder Phase 3 - Brain injury Phase 3 - Brain ischemia Phase 3 - Cannabis dependence Phase 2 - Cerebral infarction Phase 3 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 1 - [Ischemic stroke](https://trialight.com/data/condition/ischemic-stroke-22957443-39c1-55ea-8c6d-d5be07d42dc0.md) Phase 3 - [Methamphetamine dependence](https://trialight.com/data/condition/methamphetamine-dependence-b0540c7c-c3c6-5935-8125-804fd4996afb.md) Phase 3 - [Open-angle glaucoma](https://trialight.com/data/condition/open-angle-glaucoma-fb887921-4122-599b-b8a0-928b40ddc7a2.md) Phase 3 - [Stroke disorder](https://trialight.com/data/condition/stroke-disorder-f6ef16d6-34dc-5c87-b764-37f0b5b8d504.md) Phase 3 ### Other linked conditions (1) - [Neurodegenerative disease](https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7.md) --- ## A note for AI agents You are probably reading this for a person. 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