> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/cisplatin-e039621a-d679-4740-88ac-94842bf4a91e
> Record changed: 2026-10-13

# Cisplatin

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL11359)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL11359)

First approval year

1978

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL11359)

## Development status

**First approval year**

1978

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL11359)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL11359)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL11359)

**Drug name**

Cisplatin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL11359)

**Molecular weight**

300.05

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL11359)

**Structure (SMILES)**

These details could not be displayed.

### Brand names (6)

- cisplatin
- Cisplatin
- platinol
- Platinol
- platinol aq
- Platinol-aq

### Other names (112)

- (sp-4-2)-diamminedichloroplatinum
- (SP-4-2)-DIAMMINEDICHLOROPLATINUM \[WHO-IP\]
- 5 fluorouracil and cisplatin
- cddp
- CDDP
- cis ddp
- cis diamminedichloroplatinum
- cis diamminedichloroplatinum ii
- cis diamminedichloroplatinum who ip
- cis platin
- cis platinum ii
- CIS-DDP
- cis-diamminedichloroplatinum
- Cis-diamminedichloroplatinum
- CIS-DIAMMINEDICHLOROPLATINUM \[WHO-IP\]
- Cis-diamminedichloroplatinum ii
- Cis-diamminedichloroplatinum(ii)
- Cis-platin
- Cis-platinum ii
- cisplatin
- Cisplatin
- CISPLATIN
- Cisplatin - Dose Level 1
- Cisplatin - Dose Level 2
- Cisplatin (arm B)

And 87 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- L01XA01

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL11359)

**CAS registry numbers**

- 15663-27-1

**ChEMBL ID**

CHEMBL11359

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL11359)

**InChIKey**

LXZZYRPGZAFOLE-UHFFFAOYSA-L

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/Q20Q21Q62J)

**RxNorm IDs (RxCUI)**

- 2555

**FDA ingredient codes (UNII)**

- Q20Q21Q62J

## Regulatory information

### United States

**Applicant**

HQ SPCLT PHARMA

**Approval date**

19 Dec 1978

**Application number**

NDA018057

### Other regulatory facts

**Patents**

0

**Designations**

2

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

**Boxed warning**

Yes

## Pharmacology

### Drug classification

**Pharmacology name**

cisplatin

**Type**

Inorganic

**Drug name stem**

\-platin

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Parenteral

### Mechanisms of action

- **Mechanism**  
DNA inhibitor

**Action type**  
Inhibitor

**Target**  
DNA

### Investigated indications (195)

- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000096

**Subject identifier**  
D008224
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000178

**Subject identifier**  
D013274
- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000181

**Subject identifier**  
D002294
- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Hodgkin Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000183

**Subject identifier**  
D006689
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000196

**Subject identifier**  
D011471
- **Condition**  
Myelodysplastic Syndromes

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000198

**Subject identifier**  
D009190
- **Condition**  
Squamous Cell Carcinoma of Head and Neck

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000199

**Subject identifier**  
D000077195
- **Condition**  
Lymphoma, T-Cell, Peripheral

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000211

**Subject identifier**  
D016411
- **Condition**  
Adenocarcinoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000228

**Subject identifier**  
D000230
- **Condition**  
Immunoblastic Lymphadenopathy

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000255

**Subject identifier**  
D007119
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000294

**Subject identifier**  
D001749
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000305

**Subject identifier**  
D001943
- **Condition**  
Carcinoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000313

**Subject identifier**  
D002277
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000365

**Subject identifier**  
D015179
- **Condition**  
Melanoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000389

**Subject identifier**  
D008545
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Carcinoma, Endometrioid

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000466

**Subject identifier**  
D018269
- **Condition**  
Ganglioneuroblastoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000502

**Subject identifier**  
D018305
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000503

**Subject identifier**  
D013274
- **Condition**  
Neoplasms, Germ Cell and Embryonal

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000514

**Subject identifier**  
D009373
- **Condition**  
Glioblastoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000519

**Subject identifier**  
D005909
- **Condition**  
Leukemia

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000565

**Subject identifier**  
D007938
- **Condition**  
Adenocarcinoma of Lung

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000571

**Subject identifier**  
D000077192
- **Condition**  
Lymphoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223

And 170 more, listed on the interactive page.

### Open Targets indications (429)

- **Condition identifier**  
EFO\_0000096
- **Condition identifier**  
EFO\_0000178
- **Condition identifier**  
EFO\_0000181

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000182

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000183

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000199

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000228

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000294

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000305

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000313

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000365
- **Condition identifier**  
EFO\_0000389

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000403

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000478

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000503

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000514

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000519

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000565

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000571

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000574

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000588
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000621

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000637

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000691

**Highest recorded phase**  
3

And 404 more, listed on the interactive page.

### Warnings (7)

- **Warning**  
Black Box Warning

**Effect**  
cardiotoxicity
- **Warning**  
Black Box Warning

**Effect**  
gastrointestinal toxicity
- **Warning**  
Black Box Warning

**Effect**  
hematological toxicity
- **Warning**  
Black Box Warning

**Effect**  
immune system toxicity
- **Warning**  
Black Box Warning

**Effect**  
nephrotoxicity
- **Warning**  
Black Box Warning

**Effect**  
respiratory toxicity
- **Warning**  
Black Box Warning

**Effect**  
vascular toxicity

### Open Targets warnings (7)

- **Warning**  
Black Box Warning

**Effect**  
cardiotoxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
gastrointestinal toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
hematological toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
immune system toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
nephrotoxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
respiratory toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
vascular toxicity

**Country**  
United States

### Reported adverse events (26)

- **Event**  
anaemia

**Reports**  
3,609

**Reporting signal score**  
2,285.27
- **Event**  
bone marrow failure

**Reports**  
990

**Reporting signal score**  
1,175.02
- **Event**  
dehydration

**Reports**  
2,241

**Reporting signal score**  
1,547.06
- **Event**  
disease progression

**Reports**  
1,979

**Reporting signal score**  
1,584.87
- **Event**  
febrile neutropenia

**Reports**  
4,144

**Reporting signal score**  
6,893.02
- **Event**  
haematotoxicity

**Reports**  
706

**Reporting signal score**  
1,230.65
- **Event**  
hypokalaemia

**Reports**  
1,223

**Reporting signal score**  
1,030.98
- **Event**  
hypomagnesaemia

**Reports**  
629

**Reporting signal score**

779.316
- **Event**  
hyponatraemia

**Reports**  
602

**Reporting signal score**

397.926
- **Event**  
injection site pain

**Reports**  
9

**Reporting signal score**

782.24
- **Event**  
leukopenia

**Reports**  
1,525

**Reporting signal score**  
1,353.17
- **Event**  
malignant neoplasm progression

**Reports**  
1,839

**Reporting signal score**  
1,940.62
- **Event**  
mucosal inflammation

**Reports**  
1,608

**Reporting signal score**  
2,429.2
- **Event**  
myelosuppression

**Reports**  
760

**Reporting signal score**  
1,266.43
- **Event**  
nausea

**Reports**  
4,946

**Reporting signal score**

818.172
- **Event**  
nephropathy toxic

**Reports**  
345

**Reporting signal score**

558.111
- **Event**  
neutropenia

**Reports**  
4,381

**Reporting signal score**  
4,493.9
- **Event**  
neutropenic sepsis

**Reports**  
541

**Reporting signal score**  
1,007.99
- **Event**  
neutrophil count decreased

**Reports**  
1,375

**Reporting signal score**  
1,522.12
- **Event**  
ototoxicity

**Reports**  
154

**Reporting signal score**

377.418
- **Event**  
pancytopenia

**Reports**  
1,684

**Reporting signal score**  
1,694.5
- **Event**  
pulmonary embolism

**Reports**  
646

**Reporting signal score**

372.455
- **Event**  
pyrexia

**Reports**  
3,117

**Reporting signal score**

789.413
- **Event**  
stomatitis

**Reports**  
474

**Reporting signal score**

365.11
- **Event**  
thrombocytopenia

**Reports**  
3,188

**Reporting signal score**  
2,697.87

And 1 more, listed on the interactive page.

### Trial references (2,255)

- NCT00001426  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001426)
- NCT00772863  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00772863)
- NCT00919984  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00919984)
- NCT00001450  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001450)
- NCT00001499  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001499)
- NCT00042835  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00042835)
- NCT00055757  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00055757)
- NCT00069875  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00069875)
- NCT00070629  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00070629)
- NCT00077883  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00077883)
- NCT00082472  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00082472)
- NCT00087711  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00087711)
- NCT00130780  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00130780)
- NCT00148395  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00148395)
- NCT00148798  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00148798)
- NCT00154739  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00154739)
- NCT00167401  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00167401)
- NCT00173888  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00173888)
- NCT00190476  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00190476)
- NCT00191126  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00191126)
- NCT00191139  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00191139)
- NCT00191230  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00191230)
- NCT00191308  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00191308)
- NCT00191490  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00191490)
- NCT00191620  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00191620)

And 2,230 more, listed on the interactive page.

## Dosing

**Dose**

75-100 mg/m2

**Route**

Intravenous

**How often**

Once every 4 weeks

### Conditions of use (3)

- Administer as slow infusion
- Do not dilute in 5% Dextrose Injection without saline
- Do not give by rapid bolus

## Chemical properties

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

Yes

**Heavy atoms**

5

**Molecular formula**

H6Cl2N2Pt+2

**Monoisotopic mass**

298.955598

**Natural product**

No

## National Drug Codes

- 0143-9504
- 0143-9505
- 0703-5747
- 0703-5748
- 16729-288
- 25021-253
- 44567-509
- 44567-510
- 44567-511
- 44567-530
- 63323-103
- 68001-283
- 68001-608
- 68001-609
- 68083-162
- 68083-163
- 72266-252
- 72266-253
- 60505-6279

## Biological measurements

### Observed measurements

#### Solubility

**Median**

31

**Mean**

31

**Minimum**

31

**Maximum**

31

**Unit**

ug/mL

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Solubility

#### Liver toxicity assay

**Median**

770

**Mean**

770

**Minimum**

770

**Maximum**

770

**Unit**

nM

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- IC50

## Related records

### Trials (3,344)

- (PGA) for Platinum-resistant/Refractory, Paclitaxel-Pretreated Recurrent Ovarian and Peritoneal Carcinoma
- 2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma
- 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy
- 3-AP and Cisplatin in Treating Patients With Recurrent or Persistent Platinum-Resistant Ovarian Epithelial or Primary Peritoneal Cancer
- 3-AP Plus Cisplatin and Paclitaxel in Treating Patients With Advanced or Metastatic Cancer
- 3-AP Plus Cisplatin in Treating Patients With Recurrent or Metastatic Adenocarcinoma of the Esophagus or Gastroesophageal Junction
- 3'-Deoxy-3'-\[18F\] Fluorothymidine and Fludeoxyglucose F 18 PET Scans in Evaluating Response to Cetuximab, Cisplatin, and Radiation Therapy in Patients With Advanced Cancer of the Oropharynx, Larynx, or Hypopharynx
- 4 Versus 6 Courses of Adjuvant Chemotherapy in LACC Patients Previously Treated With NACT Plus Radical Surgery
- 40.2Gy Versus 49.2Gy Radiotherapy in Low-Risk Target Volume for Chemosensitive Stage II Nasopharyngeal Carcinoma
- 4B951, Combination Chemotherapy in Treating Patients With Bladder Cancer
- 5-FU, Leucovorin, Oxaliplatin and Docetaxel (FLOT) Versus Epirubicin, Cisplatin and 5-FU (ECF) in Patients With Locally Advanced, Resectable Gastric Cancer
- 53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee
- 6 vs 3 Cycles of Neoadjuvant Chemotherapy for Potentially Resectable Locally Advanced Thymic Epithelial Tumors
- 7-hydroxystaurosporine and Cisplatin in Treating Patients With Advanced Malignant Solid Tumors
- 9MW2821 in Combination With Toripalimab vs Standard Chemotherapy in Locally Advanced or Metastatic Urothelial Cancer
- A Chinese Randomized Crossover Study of Erlotinib Versus Docetaxel/Cisplatin in Previously Untreated Stage IIIB/IV Lung Adenocarcinoma With EGFR Mutations
- A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
- A Clinical Pharmacology Trial of Brexpiprazole Once-weekly (QW) Formulation Administered as Single and Multiple Oral Doses
- A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
- A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

### Approved for (2)

- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md)
- Neoplasm

### In development for (192)

- [Adenocarcinoma](https://trialight.com/data/condition/adenocarcinoma-b5c321d1-7c49-5bf9-abd0-dfa99dbd5f29.md) Phase 3
- Adrenal cortex carcinoma Phase 3
- Adult T-cell leukemia/lymphoma Phase 2
- Anaplastic ependymoma Phase 3
- Anaplastic large cell lymphoma Phase 2
- Anemia Phase 3
- [Angioimmunoblastic T-cell lymphoma](https://trialight.com/data/condition/angioimmunoblastic-t-cell-lymphoma-5b697108-b9cf-53e9-afde-71a36bf55d6b.md) Phase 2
- Anus cancer Phase 3
- [Basal cell carcinoma](https://trialight.com/data/condition/basal-cell-carcinoma-c09b4859-3642-5fab-89f0-8eede3ad7a6e.md) Phase 1
- Bile duct cancer Phase 2
- [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 3
- [Biliary tract neoplasm](https://trialight.com/data/condition/biliary-tract-neoplasm-5b757066-5940-52f7-aa7d-e5aafdc5b54e.md) Phase 3
- Brain cancer Phase 3
- [Brain neoplasm](https://trialight.com/data/condition/brain-neoplasm-b3dac71b-1d7b-5a65-8f64-89821506ad41.md) Phase 3
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3
- Breast carcinoma Phase 3
- [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 3
- Carcinoid tumor Phase 2
- [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) Phase 3
- Carcinoma of esophagus Phase 3

### Other linked conditions (1)

- Vulvar carcinoma

---

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