> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/cirmtuzumab-2e8f54d4-5214-4698-8544-18a9d77e438c
> Record changed: 2026-10-13

# Cirmtuzumab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297728)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297728)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297728)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297728)

**Drug name**

Cirmtuzumab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297728)

### Other names (6)

- cirmtuzumab
- Cirmtuzumab
- uc 961
- UC-961
- zilovertamab
- Zilovertamab

## Identifiers

**ChEMBL ID**

CHEMBL4297728

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297728)

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab; -mab

### Mechanisms of action

- **Mechanism**  
Inactive tyrosine-protein kinase transmembrane receptor ROR1 inhibitor

**Action type**  
Inhibitor

**Target**  
Inactive tyrosine-protein kinase transmembrane receptor ROR1

**Protein identifier**  
Q01973

### Open Targets mechanisms

- **Mechanism**  
Inactive tyrosine-protein kinase transmembrane receptor ROR1 inhibitor

**Action type**  
Inhibitor

**Target**  
Inactive tyrosine-protein kinase transmembrane receptor ROR1

### Investigated indications (10)

- **Condition**  
Leukemia, Lymphocytic, Chronic, B-Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000095

**Subject identifier**  
D015451
- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000096

**Subject identifier**  
D008224
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Triple Negative Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005537

**Subject identifier**  
D064726
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0008528

**Subject identifier**  
D001749
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001056

**Subject identifier**  
D013274
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0008170

**Subject identifier**  
D010051
- **Condition**  
Prostatic Neoplasms, Castration-Resistant

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0008315

**Subject identifier**  
D064129

### Open Targets indications (23)

- **Condition identifier**  
EFO\_0000095

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000096

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000403

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0008528
- **Condition identifier**  
EFO\_1001469

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004948

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004967

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005072

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005082

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005192

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005494

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007243

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0012817

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0017604

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018876

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018905

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018906

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0040679

**Highest recorded phase**  
1

### Trial references (9)

- NCT02222688  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02222688)
- NCT02860676  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02860676)
- NCT04501939  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04501939)
- NCT04504916  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04504916)
- NCT05139017  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05139017)
- NCT05406401  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05406401)
- NCT05144841  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05144841)
- NCT05156905  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05156905)
- NCT05562830  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05562830)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

## Related records

### Trials (17)

- [A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)](https://trialight.com/data/trial/a-clinical-study-of-zilovertamab-vedotin-mk-2140-plus-134b8f98-3329-4e9d-af03-b73bfdbc1295.md)
- A Study of Cirmtuzumab and Ibrutinib in Patients With B-Cell Lymphoid Malignancies
- A Study of Zilovertamab and Ibrutinib in Patients With Relapsed or Refractory Mantle Cell Lymphoma
- A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)
- A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
- A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007)
- A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
- A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002)
- [A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)](https://trialight.com/data/trial/a-study-to-evaluate-zilovertamab-vedotin-mk-2140-combination-47c43a74-d190-4960-aac9-afe2cea567bf.md)
- A Study to Evaluate Zilovertamab Vedotin (MK-2140) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-004)
- A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)
- Cirmtuzumab Consolidation for Treatment of Patients With Detectable CLL on Venetoclax
- Extension Study of UC-961 (Cirmtuzumab) for Patients With Chronic Lymphocytic Leukemia Treated Previously With UC-961
- Study of Cirmtuzumab and Paclitaxel for Metastatic or Locally Advanced, Unresectable Breast Cancer
- Study of Docetaxel Combined with Cirmtuzumab in Metastatic Castration Resistant Prostate Cancer
- Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
- UC-961 (Cirmtuzumab) in Relapsed or Refractory Chronic Lymphocytic Leukemia

### In development for (11)

- [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 2
- [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 2
- Exocrine pancreatic carcinoma Phase 2
- [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 2
- [Mantle cell lymphoma](https://trialight.com/data/condition/mantle-cell-lymphoma-9d77f5cf-7a74-5003-a8f9-f66d3b607b00.md) Phase 2
- Neoplasm of mature B-cells Phase 2
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2
- [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md) Phase 2
- [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 1
- [Triple-negative breast carcinoma](https://trialight.com/data/condition/triple-negative-breast-carcinoma-059174a2-9b5f-5234-90b9-4a4fee6eb9bb.md) Phase 2
- [Urothelial carcinoma](https://trialight.com/data/condition/urothelial-carcinoma-b2aa266d-2d5f-5e5d-a0de-62274f2dc094.md) Phase 1

### Targets (1)

- [ROR1](https://trialight.com/data/target/ror1-af4a7f63-4559-5599-9f7d-abf429641139.md) Inactive tyrosine-protein kinase transmembrane receptor ROR1 inhibitor

---

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