> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/cipargamin-a39a1487-b981-492f-a4bd-eef13926cc13
> Record changed: 2026-10-13

# Cipargamin

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1082723)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1082723)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1082723)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1082723)

**Drug name**

Cipargamin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1082723)

**Molecular weight**

390.24

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1082723)

**Structure (SMILES)**

C\[C@H\]1Cc2c(\[nH\]c3cc(Cl)c(F)cc23)\[C@@\]2(N1)C(=O)Nc1ccc(Cl)cc12

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1082723)

### Other names (21)

- cipargamin
- Cipargamin
- cipargamin \[INN\]
- Cipargamin \[WHO-DD\]
- cipargamin inn
- cipargamin who dd
- cipargamina
- Cipargamina
- cipargamine
- Cipargamine
- kae 609
- KAE-609
- kae609
- Kae609
- KAE609
- KAE609 (Cipargamin)
- nitd 609
- NITD-609
- NITD-609, (+)-
- nitd609
- NITD609

## Identifiers

**CAS registry numbers**

- 1193314-23-6

**ChEMBL ID**

CHEMBL1082723

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1082723)

**InChIKey**

CKLPLPZSUQEDRT-WPCRTTGESA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1082723)

**PubChem compound IDs**

- 44469321

**FDA ingredient codes (UNII)**

- Z7Q4FWA04P

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

2

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

cipargamin

**Type**

Synthetic organic

### Mechanisms of action

- **Mechanism**  
P-type ATPase inhibitor

**Action type**  
Inhibitor

**Target**  
P-type ATPase

**Protein identifier**  
Q27724

### Open Targets mechanisms

- **Mechanism**  
P-type ATPase inhibitor

**Action type**  
Inhibitor

**Target**  
P-type ATPase

### Investigated indications (2)

- **Condition**  
Malaria

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001068

**Subject identifier**  
D008288
- **Condition**  
Malaria, Falciparum

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0007444

**Subject identifier**  
D016778

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0001068

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005136

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005920

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005921

**Highest recorded phase**  
2

### Trial references (7)

- NCT01524341  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01524341)
- NCT01836458  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01836458)
- NCT03334747  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03334747)
- NCT04321252  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04321252)
- NCT04675931  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04675931)
- NCT02543086  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02543086)
- NCT05750628  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05750628)

## Chemical properties

**Hydrogen bond acceptors**

2

**Hydrogen bond donors**

3

**Polar surface area**

56.92

**Calculated partition coefficient (ALogP)**

4.34

**Calculated partition coefficient (XLogP)**

3.9

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

0

**Heavy atoms**

26

**Molecular formula**

C19H14Cl2FN3O

**Monoisotopic mass**

389.0497956

**Natural product**

No

## Evidence counts

**Recorded assays**

354

**Active assays**

65

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (9)

- A Study to Assess Efficacy, Safety of KAE609 in Adult Patients With Acute Malaria Mono-infection
- A Study to Find the Minimum Inhibitory Concentration of KAE609 in Adult Male Patients With P. Falciparum Monoinfection
- Effectiveness of KAE609 in Reducing Asexual & Sexual Blood-stage P.Falciparum Infection & Infectivity to Mosquitos
- Efficacy, Safety, Tolerability and Pharmacokinetics of KAE609 in Adult Patients With Acute, Uncomplicated Plasmodium Falciparum or Vivax Malaria Mono-infection
- Platform Study to Evaluate the Efficacy and Safety of Anti-malarial Agents in Participants With Uncomplicated Plasmodium Falciparum Malaria (Cohort B2)
- [Platform Study to Evaluate the Efficacy and Safety of Anti-malarial Agents in Patients With Uncomplicated Plasmodium Falciparum Malaria](https://trialight.com/data/trial/platform-study-to-evaluate-the-efficacy-and-safety-of-anti-b58bfb52-35c2-47d7-abda-97e375b50e61.md)
- Safety of KAE609 in Adults With Uncomplicated Plasmodium Falciparum Malaria.
- Study to Assess Safety, Tolerability and Phamacokinetics of KAE609 Administered Intravenously in Healthy Subjects
- To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum Malaria

### In development for (2)

- [Malaria](https://trialight.com/data/condition/malaria-54828cac-9b96-5833-93e2-e012d4505853.md) Phase 2
- [Plasmodium falciparum malaria](https://trialight.com/data/condition/plasmodium-falciparum-malaria-5e0103dd-4e60-581d-924b-3435883b51f8.md) Phase 2

---

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