> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/chymotrypsin-c6253bc9-01ac-4c62-b707-0446287d3184 > Record changed: 2026-11-04 # Chymotrypsin Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201465) Drug type Protein Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/BVS505O332) First approval year 1959 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201465) ## Development status **First approval year** 1959 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201465) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201465) ## Names and chemistry **Drug type** Protein Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/BVS505O332) **Drug name** Chymotrypsin Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201465) ### Brand names (16) - alpha chymar - Alpha chymar - catarase - Catarase - chymar - Chymar - chymoral - Chymoral - chymoral fte - Chymoral fte - deanase dc - Deanase dc - zolyse - Zolyse - zonulysin - Zonulysin ### Other names (32) - .alpha.-chymotrypsin - .ALPHA.-CHYMOTRYPSIN \[MI\] - alpha chymotrypsin - alpha chymotrypsin mi - chymotrypsin - Chymotrypsin - CHYMOTRYPSIN \[EP IMPURITY\] - CHYMOTRYPSIN \[EP MONOGRAPH\] - CHYMOTRYPSIN \[GREEN BOOK\] - CHYMOTRYPSIN \[HSDB\] - chymotrypsin \[INN\] - CHYMOTRYPSIN \[JAN\] - CHYMOTRYPSIN \[ORANGE BOOK\] - CHYMOTRYPSIN \[USP MONOGRAPH\] - CHYMOTRYPSIN \[USP-RS\] - CHYMOTRYPSIN \[VANDF\] - Chymotrypsin \[WHO-DD\] - chymotrypsin ep impurity - chymotrypsin ep monograph - chymotrypsin green book - chymotrypsin hsdb - chymotrypsin inn - chymotrypsin jan - chymotrypsin orange book - chymotrypsin usp monograph And 7 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 9004-07-3 **ChEMBL ID** CHEMBL1201465 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201465) **RxNorm IDs (RxCUI)** - 2530 **FDA ingredient codes (UNII)** - BVS505O332 ### ATC classification codes (2) - B06AA04 - S01KX01 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201465) ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** discontinued ## Pharmacology ### Drug classification #### Administration routes - topical ### Mechanisms of action - **Mechanism** Polypeptides proteolytic enzyme **Action type** PROTEOLYTIC\_ENZYME **Target** Polypeptides ### Investigated indications - **Condition** Autistic Disorder **Highest recorded phase** 3 **Condition identifier** EFO:0003758 **Subject identifier** D001321 ### Open Targets indications (5) - **Condition identifier** EFO\_0003758 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004979 - **Condition identifier** MONDO\_0004979 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005258 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005260 **Highest recorded phase** 3 ### Trial references (4) - NCT00881452 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00881452) - NCT00912691 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00912691) - NCT02410902 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02410902) - NCT02649959 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02649959) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (8) - A Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of OsrhCT in Patients With Pleurisy - Comparative Evaluation of Intraligamentary Injection of Dexamethasone, Diclofenac Sodium, and Chymotrypsin for Enhancing the Success of 4% Articaine Buccal Infiltration in Mandibular Molars With Symptomatic Irreversible Pulpitis - Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-endodontic Treatment Pain - Comparison Of Acetaminophen, NSAIDs, And Trypsin-Chymotrypsin Plus Acetaminophen For Post-Endodontic Pain After Single-Visit Root Canal Treatment - Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery - [Efficacy and Safety of OsrhCT and Dimethicone Emulsion Before Upper Endoscopy on Visualization of the Gastric Mucosa.](https://trialight.com/data/trial/efficacy-and-safety-of-osrhct-and-dimethicone-emulsion-814f4920-6465-42aa-8bf7-ead0a0154c45.md) - Efficacy and Safety of OsrhCT Before Upper Endoscopy on Improving Visualization of the Gastric Mucosa. - Phase II Clinical Trial of KJ101in the Treatment of Deep II Degree Burns ### Approved for (1) - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) ### In development for (2) - Autism Phase 3 - Autism spectrum disorder Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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