> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/choriogonadotropin-alfa-363525eb-927a-43ad-bd66-8aa43bafffa9 > Record changed: 2026-11-04 # Choriogonadotropin alfa Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201464) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201464) First approval year 2000 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201464) ## Development status **First approval year** 2000 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201464) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201464) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201464) **Drug name** Choriogonadotropin alfa Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201464) ### Brand names (4) - ovidrel - Ovidrel - ovitrelle - Ovitrelle ### Other names (58) - atc code g03 ga gonadotropins - ATC CODE G03 GA GONADOTROPINS - choriogonadotropin alfa - Choriogonadotropin alfa - CHORIOGONADOTROPIN ALFA \[EMA EPAR\] - choriogonadotropin alfa \[INN\] - CHORIOGONADOTROPIN ALFA \[JAN\] - CHORIOGONADOTROPIN ALFA \[MART.\] - CHORIOGONADOTROPIN ALFA \[MI\] - CHORIOGONADOTROPIN ALFA \[ORANGE BOOK\] - CHORIOGONADOTROPIN ALFA \[USAN\] - CHORIOGONADOTROPIN ALFA \[VANDF\] - Choriogonadotropin alfa \[WHO-DD\] - choriogonadotropin alfa ema epar - choriogonadotropin alfa inn - choriogonadotropin alfa jan - choriogonadotropin alfa mart - choriogonadotropin alfa mi - choriogonadotropin alfa orange book - choriogonadotropin alfa usan - choriogonadotropin alfa vandf - choriogonadotropin alfa who dd - choriogonadotropin alpha - Choriogonadotropin alpha - Choriogonadotropin Alpha And 33 more, listed on the interactive page. ## Identifiers **ATC classification codes** - G03GA08 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201464) **CAS registry numbers** - 177073-44-8 **ChEMBL ID** CHEMBL1201464 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201464) **RxNorm IDs (RxCUI)** - 283550 **FDA ingredient codes (UNII)** - 6413W06WR3 ## Regulatory information ### United States **Applicant** EMD SERONO **Approval date** 20 Sept 2000 **Application number** BLA021149 ### European Union **Status** Authorised **Status date** 2 Feb 2001 **Authorisation date** 2 Feb 2001 **Approved indications** Ovitrelle is indicated in the treatment of: women undergoing superovulation prior to assisted reproductive techniques such as in vitro fertilisation (IVF): Ovitrelle is administered to trigger final follicular maturation and luteinisation after stimulation of follicular growth; anovulatory or oligo-ovulatory women: Ovitrelle is administered to trigger ovulation and luteinisation in anovulatory or oligo-ovulatory patients after stimulation of follicular growth. **Product number** EMEA/H/C/000320 **Authorisation holder** Merck Europe B.V. **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Anovulation - Infertility, Female - Reproductive Techniques, Assisted European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/ovitrelle) ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Approval status **United States (FDA)** Approved **European Union (EMA)** Authorised ## Pharmacology ### Drug classification **Drug name stem** \-pin; -trop- #### Administration routes - Parenteral ### Mechanisms of action - **Mechanism** Luteinizing hormone/Choriogonadotropin receptor agonist **Action type** Agonist **Target** Lutropin-choriogonadotropic hormone receptor **Protein identifier** P22888 ### Open Targets mechanisms - **Mechanism** Luteinizing hormone/Choriogonadotropin receptor agonist **Action type** Agonist **Target** Lutropin-choriogonadotropic hormone receptor ### Investigated indications (9) - **Condition** Reproductive Techniques, Assisted **Highest recorded phase** 4 **Subject identifier** D027724 - **Condition** Infertility **Highest recorded phase** 4 **Condition identifier** EFO:0000545 **Subject identifier** D007246 - **Condition** Polycystic Ovary Syndrome **Highest recorded phase** 2 **Condition identifier** EFO:0000660 **Subject identifier** D011085 - **Condition** Obesity **Highest recorded phase** 4 **Condition identifier** EFO:0001073 **Subject identifier** D009765 - **Condition** Primary Ovarian Insufficiency **Highest recorded phase** 4 **Condition identifier** EFO:0004266 **Subject identifier** D016649 - **Condition** Infertility, Female **Highest recorded phase** 4 **Condition identifier** EFO:0008560 **Subject identifier** D007247 - **Condition** Hypogonadism **Highest recorded phase** 4 **Condition identifier** MONDO:0002146 **Subject identifier** D007006 - **Condition** Anovulation **Highest recorded phase** 4 **Condition identifier** MONDO:0002775 **Subject identifier** D000858 - **Condition** Ovarian Hyperstimulation Syndrome **Highest recorded phase** 3 **Condition identifier** MONDO:0011972 **Subject identifier** D016471 ### Open Targets indications (34) - **Condition identifier** EFO\_0000544 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000545 - **Condition identifier** EFO\_0001073 - **Condition identifier** EFO\_0002950 - **Condition identifier** EFO\_0004266 - **Condition identifier** EFO\_0004995 **Highest recorded phase** 1 - **Condition identifier** EFO\_0008560 - **Condition identifier** HP\_0000027 **Highest recorded phase** 3 - **Condition identifier** HP\_0000789 **Highest recorded phase** 4 - **Condition identifier** HP\_0005268 **Highest recorded phase** 3 - **Condition identifier** HP\_0008209 **Highest recorded phase** 1 - **Condition identifier** HP\_0011961 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0001119 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0001572 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0001913 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002146 - **Condition identifier** MONDO\_0002146 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0002775 - **Condition identifier** MONDO\_0002775 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0004995 - **Condition identifier** MONDO\_0005047 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005133 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005267 - **Condition identifier** MONDO\_0005387 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0006823 **Highest recorded phase** 3 And 9 more, listed on the interactive page. ### Reported adverse events (63) - **Event** abdominal distension **Reports** 82 **Reporting signal score** 131.997 - **Event** abdominal pain **Reports** 95 **Reporting signal score** 64.9907 - **Event** abdominal pain lower **Reports** 31 **Reporting signal score** 51.7012 - **Event** abortion induced **Reports** 13 **Reporting signal score** 17.0373 - **Event** abortion spontaneous **Reports** 55 **Reporting signal score** 79.2375 - **Event** adnexal torsion **Reports** 26 **Reporting signal score** 146.425 - **Event** anovulatory cycle **Reports** 4 **Reporting signal score** 17.6208 - **Event** arthralgia **Reports** 3 **Reporting signal score** 21.5491 - **Event** ascites **Reports** 237 **Reporting signal score** 812.896 - **Event** benign hydatidiform mole **Reports** 4 **Reporting signal score** 14.0934 - **Event** body temperature fluctuation **Reports** 19 **Reporting signal score** 68.2123 - **Event** caesarean section **Reports** 15 **Reporting signal score** 19.7281 - **Event** cephalo-pelvic disproportion **Reports** 4 **Reporting signal score** 15.9626 - **Event** cyst rupture **Reports** 5 **Reporting signal score** 18.723 - **Event** diarrhoea **Reports** 10 **Reporting signal score** 28.3598 - **Event** diverticulitis **Reports** 19 **Reporting signal score** 20.5111 - **Event** dyspnoea **Reports** 100 **Reporting signal score** 21.4201 - **Event** ectopic pregnancy **Reports** 25 **Reporting signal score** 80.3815 - **Event** effusion **Reports** 21 **Reporting signal score** 82.1842 - **Event** fall **Reports** 1 **Reporting signal score** 25.2636 - **Event** fatigue **Reports** 10 **Reporting signal score** 32.0676 - **Event** feeling hot **Reports** 19 **Reporting signal score** 15.1147 - **Event** haematocrit increased **Reports** 14 **Reporting signal score** 44.501 - **Event** haemoconcentration **Reports** 6 **Reporting signal score** 28.27 - **Event** haemorrhagic ovarian cyst **Reports** 9 **Reporting signal score** 33.883 And 38 more, listed on the interactive page. ### Trial references (6) - NCT00948805 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00948805) - NCT02118051 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02118051) - NCT04643925 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04643925) - NCT05571111 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05571111) - NCT03071172 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03071172) - NCT03440359 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03440359) ## Dosing **Dose** 4000 USP units; 500 USP units; 5000 USP units; 2000 USP units; 5000 to 10,000 USP units; 10,000 USP units **Route** Intramuscular **How often** Three times weekly for 3 weeks; every second day for 4 injections; 15 injections over 6 weeks; three times weekly for 4 to 6 weeks; once after gonadotropins; three times weekly for 3 weeks, then twice weekly for 3 weeks; three times weekly for 6 to 9 months, then three times weekly for 3 months ### Conditions of use (3) - Reconstitute with solvent, do not shake - Refrigerate if stored, discard after 60 days if unused - Use one vial per patient ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (2) - **Component** Beta Chain **Type** Protein **Sequence** SKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ - **Component** Alpha Chain **Type** Protein **Sequence** APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS ## National Drug Codes - 44087-1150 ## Related records ### Trials (57) - A Phase II Study to Assess the Efficacy and Safety of Luveris® (Lutropin Alfa) in Mid Follicular Phase for Controlled Ovarian Stimulation (COS) in Advanced Reproductive Age - A Randomized Controlled Study of Different Trigger Modes of Antagonist Regimen in Patients With Low Ovarian Reserve - A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA) - A Study to Compare the Safety and Efficacy of Cetrotide® 3 Milligram (mg) Versus Antagon™ in Women Undergoing Ovarian Stimulation - A Trial to Investigate the Efficacy and Safety of FE 999302 as add-on Treatment to Follitropin Delta (REKOVELLE) in Women Undergoing Controlled Ovarian Stimulation. - An Efficacy and Safety Study of Corifollitropin Alfa (MK-8962) in Contrast to Recombinant FSH for Use in Controlled Ovarian Stimulation of Indian Women (P07056, Also Known as MK-8962-029) - An Exploratory Study to Investigate the Effect of FE 999302 When Given Together With Follitropin Delta at Different Time Intervals During Controlled Ovarian Stimulation. - [An Exploratory Study to Investigate the Effect of FE 999302 When Given Together With Follitropin Delta During Controlled Ovarian Stimulation](https://trialight.com/data/trial/an-exploratory-study-to-investigate-the-effect-of-fe-999302-95b41d5f-487a-4553-a2bd-9498703d0e1f.md) - An Open Label, Canadian Phase IIIb Study With Ovidrel in Ovulation Induction (OI) and Assisted Reproductive Technique (ART) - An Open Labeled RCT on the Effect of Additional hCG Injection for LPS on Pregnancy Outcomes in IHH Patients - Analysis of Two Therapeutic With Cetrotide® in Polycystic Ovarian (PCO) Women in Assisted Reproductive Technology (ART) - Can Biotin Supplementation be Used to Mask hCG Abuse? - Clinical Research Study to Learn About the Effect and Safety of Different Doses of FE 999302 When Given as a Single Dose for Final Development of the Eggs After Ovarian Stimulation - Clinical Study of Recombinant Human Follitropin for Injection Assisted in COH Assisted IVF-ET - Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility - Comparing the Efficacy of Urinary and Recombinant Human Chorionic Gonadotropin (hCG) on Oocyte Maturity - Comparison of Micro-dose Human Chorionic Gonadotropin (hCG) With Human Menopausal Gonadotropin (HMG) in Polycystic Ovary Syndrome - Comparison of Triggers in Double Ovarian Stimulation (DuoStim). - Corpus Luteum Function and Cardiovascular Adaptation in a Natural MOCK Cycle. - Double Trigger in Patients With Low Number of Oocytes Retrieved Per Number of Preovulatory Follicles ### Approved for (6) - Anovulation - Female infertility - Hypogonadism - Infertility disorder - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) - Primary ovarian failure ### In development for (11) - Acute graft versus host disease Phase 1 - [Endometriosis](https://trialight.com/data/condition/endometriosis-3a5471b6-6d24-50b8-b1e6-8803dd78b0db.md) Phase 3 - Graft versus host disease Phase 2 - Hypogonadotropic hypogonadism Phase 3 - [Ischemic stroke](https://trialight.com/data/condition/ischemic-stroke-22957443-39c1-55ea-8c6d-d5be07d42dc0.md) Phase 2 - Klinefelter syndrome Phase 3 - [Leiomyoma](https://trialight.com/data/condition/leiomyoma-f84b9cb4-e902-5ed0-bb93-4d36211170f3.md) Phase 1 - Oligospermia Phase 2 - Ovarian hyperstimulation syndrome Phase 3 - [Polycystic ovary syndrome](https://trialight.com/data/condition/polycystic-ovary-syndrome-441e4a14-977c-536f-a5ad-0c5be955054b.md) Phase 2 - Premature menopause Phase 1 ### Other linked conditions (2) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - [Heart disorder](https://trialight.com/data/condition/heart-disorder-76f9236b-5b5b-52a4-b1c8-771e427815e6.md) ### Targets (1) - [LHCGR](https://trialight.com/data/target/lhcgr-b05eb9a7-81b7-55ff-9199-87b67bebb470.md) Luteinizing hormone/Choriogonadotropin receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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