> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/cholestyramine-02403ab6-2c23-416a-ba64-dd03a00539a1 > Record changed: 2026-10-13 # Cholestyramine Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201625) Drug type Unknown First approval year 1973 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201625) ## Development status **First approval year** 1973 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201625) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201625) ## Names and chemistry **Drug type** Unknown **Drug name** Cholestyramine Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201625) ### Brand names (18) - cholestyramine - Cholestyramine - cholestyramine light - Cholestyramine light - cholybar - Cholybar - duolite ap143 resin - Duolite ap143 resin - locholest - Locholest - locholest light - Locholest light - prevalite - Prevalite - questran - Questran - questran light - Questran light ### Other names (45) - a 3384 - A-3384 - a3384 - A3384 - cholestyramine - Cholestyramine - CHOLESTYRAMINE - CHOLESTYRAMINE \[MI\] - CHOLESTYRAMINE \[ORANGE BOOK\] - CHOLESTYRAMINE \[VANDF\] - Cholestyramine 8 g - cholestyramine mi - cholestyramine orange book - Cholestyramine Powder - Cholestyramine Powder 4g - cholestyramine resin - Cholestyramine Resin - CHOLESTYRAMINE RESIN - CHOLESTYRAMINE RESIN \[HSDB\] - CHOLESTYRAMINE RESIN \[USP MONOGRAPH\] - CHOLESTYRAMINE RESIN \[USP-RS\] - cholestyramine resin hsdb - cholestyramine resin usp monograph - cholestyramine resin usp rs - cholestyramine vandf And 20 more, listed on the interactive page. ## Identifiers **ATC classification codes** - C10AC01 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201625) **CAS registry numbers** - 11041-12-6 **ChEMBL ID** CHEMBL1201625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201625) **PubChem compound IDs** - 70695641 **RxNorm IDs (RxCUI)** - 2447 **FDA ingredient codes (UNII)** - 4B33BGI082 ## Regulatory information ### United States **Applicant** BRISTOL MYERS **Approval date** 3 Aug 1973 **Application number** NDA016640 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Pharmacology ### Drug classification #### Administration routes - Oral ### Mechanisms of action - **Mechanism** Bile acids sequestering agent **Action type** SEQUESTERING\_AGENT **Target** Bile acids ### Investigated indications (15) - **Condition** Cardiovascular Diseases **Highest recorded phase** 4 **Condition identifier** EFO:0000319 **Subject identifier** D002318 - **Condition** Myocardial Infarction **Highest recorded phase** 3 **Condition identifier** EFO:0000612 **Subject identifier** D009203 - **Condition** Coronary Disease **Highest recorded phase** 3 **Condition identifier** EFO:0001645 **Subject identifier** D003327 - **Condition** Smoldering Multiple Myeloma **Highest recorded phase** 2 **Condition identifier** EFO:0003073 **Subject identifier** D000075122 - **Condition** Kidney Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0003086 **Subject identifier** D007674 - **Condition** Heart Diseases **Highest recorded phase** 3 **Condition identifier** EFO:0003777 **Subject identifier** D006331 - **Condition** Graves Disease **Highest recorded phase** 3 **Condition identifier** EFO:0004237 **Subject identifier** D006111 - **Condition** Nephrotic Syndrome **Highest recorded phase** 4 **Condition identifier** EFO:0004255 **Subject identifier** D009404 - **Condition** Hypothyroidism **Highest recorded phase** 4 **Condition identifier** EFO:0004705 **Subject identifier** D007037 - **Condition** Hyperlipoproteinemia Type II **Highest recorded phase** 3 **Condition identifier** EFO:0004911 **Subject identifier** D006938 - **Condition** Hyperthyroidism **Highest recorded phase** 3 **Condition identifier** EFO:0009189 **Subject identifier** D006980 - **Condition** Myocardial Ischemia **Highest recorded phase** 3 **Condition identifier** EFO:1001375 **Subject identifier** D017202 - **Condition** Hypercholesterolemia **Highest recorded phase** 4 **Condition identifier** HP:0003124 **Subject identifier** D006937 - **Condition** Multiple Sclerosis **Highest recorded phase** 3 **Condition identifier** MONDO:0005301 **Subject identifier** D009103 - **Condition** Lipid Metabolism Disorders **Highest recorded phase** 3 **Condition identifier** Orphanet:309005 **Subject identifier** D052439 ### Open Targets indications (24) - **Condition identifier** EFO\_0000319 - **Condition identifier** EFO\_0003073 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003086 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004237 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004255 - **Condition identifier** EFO\_0004705 - **Condition identifier** EFO\_0009189 **Highest recorded phase** 3 - **Condition identifier** HP\_0001513 - **Condition identifier** HP\_0002014 - **Condition identifier** HP\_0002014 **Highest recorded phase** 4 - **Condition identifier** HP\_0003124 - **Condition identifier** HP\_0003124 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0004425 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004995 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005010 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005301 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005311 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005364 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005377 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005420 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0007027 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0013209 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0015183 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0021661 **Highest recorded phase** 2 ### Reported adverse events (47) - **Event** abdominal discomfort **Reports** 15 **Reporting signal score** 10.052 - **Event** abdominal pain **Reports** 24 **Reporting signal score** 10.6185 - **Event** acidosis hyperchloraemic **Reports** 3 **Reporting signal score** 11.4907 - **Event** alanine aminotransferase increased **Reports** 21 **Reporting signal score** 22.0123 - **Event** anencephaly **Reports** 3 **Reporting signal score** 11.9075 - **Event** aspartate aminotransferase increased **Reports** 20 **Reporting signal score** 22.136 - **Event** bile acid malabsorption **Reports** 4 **Reporting signal score** 21.7501 - **Event** blood alkaline phosphatase increased **Reports** 17 **Reporting signal score** 28.711 - **Event** blood lactate dehydrogenase increased **Reports** 7 **Reporting signal score** 9.53983 - **Event** choking **Reports** 12 **Reporting signal score** 31.8768 - **Event** cholangitis sclerosing **Reports** 4 **Reporting signal score** 11.8919 - **Event** cholecystitis infective **Reports** 7 **Reporting signal score** 25.2726 - **Event** cholelithiasis **Reports** 15 **Reporting signal score** 27.2396 - **Event** cholestasis **Reports** 9 **Reporting signal score** 11.6085 - **Event** colitis **Reports** 11 **Reporting signal score** 13.4342 - **Event** crohn's disease **Reports** 11 **Reporting signal score** 10.5406 - **Event** dehydration **Reports** 19 **Reporting signal score** 12.553 - **Event** dermatomyositis **Reports** 5 **Reporting signal score** 14.406 - **Event** diarrhoea **Reports** 62 **Reporting signal score** 31.53 - **Event** drug hypersensitivity **Reports** 26 **Reporting signal score** 10.4047 - **Event** eye disorder **Reports** 7 **Reporting signal score** 9.98956 - **Event** flatulence **Reports** 9 **Reporting signal score** 11.6774 - **Event** foetal heart rate abnormal **Reports** 3 **Reporting signal score** 10.1987 - **Event** foreign body in throat **Reports** 3 **Reporting signal score** 12.8016 - **Event** gamma-glutamyltransferase increased **Reports** 12 **Reporting signal score** 16.5455 And 22 more, listed on the interactive page. ### Trial references (13) - NCT00000461 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000461) - NCT00000463 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000463) - NCT00000488 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000488) - NCT00000594 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000594) - NCT01239459 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01239459) - NCT01863888 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01863888) - NCT02046629 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02046629) - NCT06141473 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06141473) - NCT02890992 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02890992) - NCT03510884 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03510884) - NCT03303053 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03303053) - NCT03510715 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03510715) - NCT05014646 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05014646) ## Dosing **Dose** 8.78 grams (1 pouch or scoopful) **Route** Oral **How often** Once or twice daily (can be administered 1 to 6 doses per day) ### Conditions of use - Must be mixed with water or other fluids before ingesting ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## National Drug Codes - 0245-0036 - 11788-150 - 24658-266 - 24658-270 - 24658-271 - 27241-134 - 33342-293 - 33342-319 - 42571-508 - 42806-265 - 42806-266 - 42806-267 - 42806-269 - 42806-270 - 42806-271 - 49884-465 - 49884-466 - 49884-936 - 49884-937 - 51224-009 - 51224-011 - 62135-008 - 62135-937 - 67877-298 - 67877-422 And 14 more, listed on the interactive page. ## Related records ### Trials (27) - A Clinical Study to Assess the Effect of Change of Bile Acid on the PD and Safety of Metformin and Microbiome Profiles - A Safety and Pharmakokinetic Study of A4250 Alone or in Combination With A3384 - A Single Research Site Bile Acid Sequestrant Acceptability (BASA) Scale Pilot Validation Study - A Study to Evaluate the Effect of Cholestyramine on LOXO-783 in Healthy Participants - A Study to Evaluate the Pharmacokinetic Profiles of Single 14 mg Teriflunomide Tablet in Healthy Chinese Volunteers - An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia - An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia - An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia - Comparison of Colesevelam Hydrogen Chloride (HCl) Powder For Oral Suspension Versus Generic Cholestyramine Through Use of the Bile Acid Sequestrant Acceptability (BASA) Scale - Double-blind, Randomised Study of A3384 in BAM/BAD - Effect of Lipid Modifying Drugs on HDL Function in Patients With Hyperlipidemia - Effect of Teriflunomide on Immune Cell Subsets in the Blood of Patients With Multiple Sclerosis - Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism - Efficacy and Safety of Cholestyramine in the Management of Hyperphosphatemia in Adult Hemodialysis Patients - Efficacy and Safety of Elobixibat in Combination With Cholestyramine for Nonalcoholic Fatty Liver Disease - [Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis](https://trialight.com/data/trial/efficacy-and-safety-studies-of-frexalimab-sar441344-in-9348ac4f-5759-4557-9e91-20570fc44ceb.md) - Exploratory Evaluation of the Effect of Cholestyramine on Serum Levels of POPs in Obese Female Patients - Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer - Harvard Atherosclerosis Reversibility Project (HARP) - Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients ### Approved for (3) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - [Hypothyroidism](https://trialight.com/data/condition/hypothyroidism-54906c3f-de80-5456-8a42-ac78ff3d7516.md) - Nephrotic syndrome ### In development for (12) - [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) Phase 3 - [Familial hypercholesterolemia](https://trialight.com/data/condition/familial-hypercholesterolemia-ee6bd6b4-71cd-509a-9360-eb8a7c2bd428.md) Phase 3 - Graves disease Phase 3 - Heart disorder Phase 3 - Hyperthyroidism Phase 3 - Inherited lipid metabolism disorder Phase 3 - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1 - [Multiple sclerosis](https://trialight.com/data/condition/multiple-sclerosis-62806c95-fe1b-529e-bd16-95cb92d15375.md) Phase 3 - [Myocardial infarction](https://trialight.com/data/condition/myocardial-infarction-b4e97483-7435-5701-81dc-26d955e420ec.md) Phase 3 - Myocardial ischemia Phase 3 - Short bowel syndrome Phase 2 - Smoldering plasma cell myeloma Phase 2 ### Other linked conditions (1) - [Diarrheal disease](https://trialight.com/data/condition/diarrheal-disease-623389f5-2a35-5350-9dae-f2dc4bc0fc34.md) --- ## A note for AI agents You are probably reading this for a person. 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