> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/cholecalciferol-c9dc6a9a-8bc7-4070-a34e-535013073648
> Record changed: 2026-10-13

# Cholecalciferol

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

First approval year

1999

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

## Development status

**First approval year**

1999

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

**Drug name**

Cholecalciferol

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

**Molecular weight**

384.65

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

**Structure (SMILES)**

C=C1CC\[C@H\](O)C/C1=C/C=C1\\CCC\[C@\]2(C)\[C@@H\](\[C@H\](C)CCCC(C)C)CC\[C@@H\]12

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

### Brand names (100)

- accrete d3
- Accrete d3
- aciferol d3
- Aciferol d3
- adcal d3
- Adcal-d3
- biolife vitamin d3
- Biolife vitamin d3
- cacit d3
- Cacit d3
- calceos
- Calceos
- calci d
- Calci-d
- calcichew d3
- Calcichew d3
- calcichew d3 fte
- Calcichew d3 fte
- calcichew d3 once daily
- Calcichew d3 once daily
- cholecalciferol component of dp r206 vitamin d3
- Cholecalciferol component of dp-r206 vitamin d3
- cholecalciferol component of fosamax plus d
- Cholecalciferol component of fosamax plus d
- colecal d3

And 75 more, listed on the interactive page.

### Other names (184)

- 1000 ne kolekalciferol vitamin d3
- 2400 IU Vitamin D3 (cholecalciferol)
- 2400 iu vitamin d3 cholecalciferol
- 400 IU Vitamin D3 (cholecalciferol)
- 6400 IU Vitamin D3 (cholecalciferol)
- 7 dehydrocholesterol activated
- 7-dehydrocholesterol, activated
- Active Comparator: Vigantol Oil (Vitamin D3)
- Adcal-D3
- aquadetrim
- Aquadetrim
- arachitol
- Arachitol
- Calcichew D3
- calciol
- Calciol
- calcirol
- Calcirol
- capsudar d3 100e
- CapsuDar D3 100E
- cholecalciferol
- Cholecalciferol
- CHOLECALCIFEROL
- Cholecalciferol (2000iu qd)
- Cholecalciferol (inactive vitamin D)

And 159 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- A11CC05

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

**CAS registry numbers**

- 67-97-0

**ChEMBL ID**

CHEMBL1042

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

**InChIKey**

QYSXJUFSXHHAJI-YRZJJWOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1042)

**PubChem compound IDs**

- 5280795

**RxNorm IDs (RxCUI)**

- 2418

**FDA ingredient codes (UNII)**

- 1C6V77QF41

## Regulatory information

### United States

**Applicant**

SANDOZ CANADA INC

**Approval date**

21 Feb 2001

**Application number**

NDA021265

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

**Pharmacology name**

vitamin D3

**Type**

Metabolite

**Drug name stem**

\-calci-

#### Administration routes

- Oral
- Parenteral

### Mechanisms of action

- **Mechanism**  
Vitamin D receptor agonist

**Action type**  
Agonist

**Target**  
Vitamin D3 receptor

**Protein identifier**  
P11473

### Open Targets mechanisms

- **Mechanism**  
Vitamin D receptor agonist

**Action type**  
Agonist

**Target**  
Vitamin D3 receptor

### DrugCentral mechanisms

- **Action type**  
Agonist

**Gene symbol**  
VDR

**Protein identifier**  
P11473

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (102)

- **Condition**  
Leukemia, Lymphocytic, Chronic, B-Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000095

**Subject identifier**  
D015451
- **Condition**  
HIV Infections

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000180

**Subject identifier**  
D015658
- **Condition**  
Metabolic Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000195

**Subject identifier**  
D024821
- **Condition**  
Leukemia, Myeloid, Acute

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000222

**Subject identifier**  
D015470
- **Condition**  
Dermatitis, Atopic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000274

**Subject identifier**  
D003876
- **Condition**  
Barrett Esophagus

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0000280

**Subject identifier**  
D001471
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000305

**Subject identifier**  
D001943
- **Condition**  
Cardiovascular Diseases

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000319

**Subject identifier**  
D002318
- **Condition**  
Pulmonary Disease, Chronic Obstructive

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000341

**Subject identifier**  
D029424
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000365

**Subject identifier**  
D015179
- **Condition**  
Crohn Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000384

**Subject identifier**  
D003424
- **Condition**  
Diabetes Mellitus

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000400

**Subject identifier**  
D003920
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Carcinoma, Intraductal, Noninfiltrating

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000432

**Subject identifier**  
D002285
- **Condition**  
Epilepsy

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000474

**Subject identifier**  
D004827
- **Condition**  
Glioblastoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000519

**Subject identifier**  
D005909
- **Condition**  
Infections

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000544

**Subject identifier**  
D007239
- **Condition**  
Irritable Bowel Syndrome

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000555

**Subject identifier**  
D043183
- **Condition**  
Polycystic Ovary Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000660

**Subject identifier**  
D011085
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000673

**Subject identifier**  
D011471
- **Condition**  
Psoriasis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000676

**Subject identifier**  
D011565
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000694

**Subject identifier**  
D045169
- **Condition**  
Skin Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000701

**Subject identifier**  
D012871
- **Condition**  
Colitis, Ulcerative

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000729

**Subject identifier**  
D003093
- **Condition**  
Melanoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000756

**Subject identifier**  
D008545

And 77 more, listed on the interactive page.

### Open Targets indications (229)

- **Condition identifier**  
EFO\_0000095

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000195

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000274

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000341

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000384

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000389
- **Condition identifier**  
EFO\_0000400

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000403

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000474

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000495

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000519
- **Condition identifier**  
EFO\_0000544

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000660

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000694
- **Condition identifier**  
EFO\_0000701
- **Condition identifier**  
EFO\_0000729

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000756

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000764

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001073

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0002496

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0002503

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0002546
- **Condition identifier**  
EFO\_0002950

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003047

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003095

**Highest recorded phase**  
3

And 204 more, listed on the interactive page.

### Reported adverse events (111)

- **Event**  
abdominal discomfort

**Reports**  
2,565

**Reporting signal score**  
6,885.98
- **Event**  
alopecia

**Reports**  
2,627

**Reporting signal score**  
7,084.39
- **Event**  
anaemia postoperative

**Reports**  
114

**Reporting signal score**

380.812
- **Event**  
anti-cyclic citrullinated peptide antibody positive

**Reports**  
990

**Reporting signal score**  
4,668.33
- **Event**  
arthralgia

**Reports**  
1,345

**Reporting signal score**  
1,341.82
- **Event**  
arthritis

**Reports**  
284

**Reporting signal score**

318.599
- **Event**  
arthropathy

**Reports**  
1,579

**Reporting signal score**  
4,532.05
- **Event**  
asthma

**Reports**  
382

**Reporting signal score**

434.206
- **Event**  
blister

**Reports**  
492

**Reporting signal score**

900.087
- **Event**  
blood cholesterol increased

**Reports**  
365

**Reporting signal score**

666.653
- **Event**  
bone disorder

**Reports**  
121

**Reporting signal score**

163.795
- **Event**  
bursitis

**Reports**  
162

**Reporting signal score**

359.63
- **Event**  
calciphylaxis

**Reports**  
65

**Reporting signal score**

170.594
- **Event**  
coma

**Reports**  
196

**Reporting signal score**

173.044
- **Event**  
condition aggravated

**Reports**  
1,161

**Reporting signal score**  
1,220.22
- **Event**  
confusional state

**Reports**  
574

**Reporting signal score**

506.447
- **Event**  
contusion

**Reports**  
437

**Reporting signal score**

566.841
- **Event**  
dental caries

**Reports**  
109

**Reporting signal score**

192.267
- **Event**  
discomfort

**Reports**  
1,307

**Reporting signal score**  
3,991.25
- **Event**  
drug hypersensitivity

**Reports**  
505

**Reporting signal score**

183.469
- **Event**  
drug intolerance

**Reports**  
1,521

**Reporting signal score**  
3,160.02
- **Event**  
duodenal ulcer perforation

**Reports**  
615

**Reporting signal score**  
2,719.9
- **Event**  
dyspnoea

**Reports**  
913

**Reporting signal score**

331.678
- **Event**  
exostosis

**Reports**  
88

**Reporting signal score**

168.207
- **Event**  
fall

**Reports**  
802

**Reporting signal score**

494.366

And 86 more, listed on the interactive page.

### Trial references (251)

- NCT00022087  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00022087)
- NCT00043069  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00043069)
- NCT00058188  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00058188)
- NCT00092066  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00092066)
- NCT00092079  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00092079)
- NCT00112437  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00112437)
- NCT00421343  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00421343)
- NCT00641771  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00641771)
- NCT00668941  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00668941)
- NCT00692913  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00692913)
- NCT00729183  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00729183)
- NCT00806416  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00806416)
- NCT00885170  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00885170)
- NCT00960934  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00960934)
- NCT00996801  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00996801)
- NCT01120600  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01120600)
- NCT01675297  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01675297)
- NCT01765010  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01765010)
- NCT01904110  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01904110)
- NCT02518763  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02518763)
- NCT03234244  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03234244)
- NCT03382314  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03382314)
- NCT03824171  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03824171)
- NCT03994172  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03994172)
- NCT00292591  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00292591)

And 226 more, listed on the interactive page.

## Dosing

**Dose**

1 softgel

**Route**

Oral

**How often**

Once daily

## Chemical properties

**Hydrogen bond acceptors**

1

**Hydrogen bond donors**

1

**Polar surface area**

20.23

**Calculated partition coefficient (ALogP)**

7.62

**Calculated partition coefficient (XLogP)**

7.9

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

6

**Heavy atoms**

28

**Molecular formula**

C27H44O

**Monoisotopic mass**

384.339216023

**Natural product**

Yes

## National Drug Codes

- 0642-0093
- 0642-0207
- 0642-7473
- 10542-009
- 13925-116
- 13925-117
- 15370-103
- 15370-104
- 15370-105
- 15370-250
- 39328-106
- 42192-320
- 42192-321
- 42192-323
- 42192-332
- 50967-219
- 50967-410
- 52796-172
- 52796-173
- 52796-174
- 52796-177
- 58657-325
- 58657-326
- 58657-327
- 59088-005

And 70 more, listed on the interactive page.

## Evidence counts

**Recorded assays**

1,275

**Active assays**

201

### Active assay types (3)

- Confirmatory
- Other
- Screening

## Pharmacologic actions

- Calcium-Regulating Hormones and Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000077264.html)
- Vitamins  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D014815.html)
- Bone Density Conservation Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D050071.html)

## Related records

### Trials (1,574)

- 'Palliative-D' Vitamin D to Palliative Cancer Patients
- "HBV unIversal vs Point-Of-Care-based Antiviral treatMent to Prevent Mother-to-child Transmission"
- "Information Technology Methodology for Patient Motivation in Diabetes Management."
- "The Effect of Comprehensive Non-pharmacological Treatment on Metabolic Disorders in Type 2 Diabetic Patients"
- \[18 Fluorine(F)\]DOPA Determinants and Predictors of Treatment Response in Psychosis
- 18F-Fluoride Positron Emission Tomography (PET) in Paget's Disease of Bone
- 24-hr Intraocular Pressure Control With Dorzolamide/Timolol vs the Brimonidine/Timolol Fixed Combination
- 24-hr IOP With Travoprost/Timolol Compared With Latanoprost/Timolol in XFG
- 2D/3D Imaging to Analyze the Regeneration Rate of Autologous Bone
- 2DR Versus 3DR in a Prospective Randomized Controlled Switch Trial
- 3-year Follow-up Study in Patients Previously Treated With TMC435-Containing Regimen for the Treatment of Hepatitis C Virus Infection
- 3-year Follow-up Study to Assess the Viral Activity in Hepatitis C Patients Who Failed Feeder DEB025/Alisporivir Study
- 30000 IU Per Week Vitamin D Treatment in PCOS Patients
- 4 Consecutive Days on Treatment Followed by 3 Days Off Treatment, in HIV Patients
- 4-Week Study to Assess the Effect of Alendronate and Vitamin D3 Once Weekly on Fractional Calcium Absorption in Postmenopausal Osteoporotic Women (0217A-230)
- A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator
- A 2 Year Trial of Patients With Type 2 Diabetes Focusing on Cardiovascular Diagnostics and Metabolic Control
- A 28-day Clinical Study on Facial Skin Rejuvenation
- A 56-day Clinical Study on Facial Skin Rejuvenation
- A Clinical Intervention Study of Tangningtongluo on Diabetic Foot Ulcer

### Approved for (3)

- Anemia
- Iron deficiency anemia
- Osteoporosis

### In development for (96)

- Actinic keratosis Phase 2
- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 2
- Adrenoleukodystrophy Phase 1
- AIDS Phase 2
- Allergic disease Phase 2
- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 3
- Atopic conjunctivitis Phase 2
- [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2
- Autism Phase 2
- [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 3
- Barrett esophagus Early phase 1
- Bone fracture Phase 3
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3
- Breast carcinoma Phase 3
- Bronchiolitis Phase 2
- Burn Phase 1
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 3
- [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) Phase 3
- [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 2

### Other linked conditions (5)

- [Cutaneous melanoma](https://trialight.com/data/condition/cutaneous-melanoma-c6e75b71-1c7c-59fe-a087-174eb0ec53df.md)
- Diabetic neuropathy
- Enuresis
- Rickets
- Urolithiasis

### Targets (1)

- [VDR](https://trialight.com/data/target/vdr-eaef72d7-61b6-52d0-b626-ff3aa6b0de1e.md) Vitamin D receptor agonist

---

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