> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/chloroquine-60719e05-c0d4-438d-9681-2c553d6d6e4d
> Record changed: 2026-11-04

# Chloroquine

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

First approval year

1949

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

## Development status

**First approval year**

1949

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

**Drug name**

Chloroquine

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

**Molecular weight**

319.88

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

**Structure (SMILES)**

CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

### Other names (24)

- 1 4 pentanediamine n sup 4 7 chloro 4 quinolinyl n sup 1 n sup 1 diethyl
- 1,4-PENTANEDIAMINE, N(SUP 4)-(7-CHLORO-4-QUINOLINYL)-N(SUP 1),N (SUP 1)-DIETHYL-
- chloroquine
- Chloroquine
- CHLOROQUINE \[HSDB\]
- chloroquine \[INN\]
- CHLOROQUINE \[MART.\]
- CHLOROQUINE \[MI\]
- CHLOROQUINE \[USP IMPURITY\]
- CHLOROQUINE \[USP MONOGRAPH\]
- CHLOROQUINE \[VANDF\]
- Chloroquine \[WHO-DD\]
- chloroquine hsdb
- chloroquine inn
- chloroquine mart
- chloroquine mi
- chloroquine usp impurity
- chloroquine usp monograph
- chloroquine vandf
- chloroquine who dd
- cloroquina
- Cloroquina
- nsc 187208
- NSC-187208

## Identifiers

**ATC classification codes**

- P01BA01

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

**CAS registry numbers**

- 54-05-7

**ChEMBL ID**

CHEMBL76

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

**InChIKey**

WHTVZRBIWZFKQO-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL76)

**PubChem compound IDs**

- 2719

**FDA ingredient codes (UNII)**

- 886U3H6UFF

### RxNorm IDs (RxCUI) (2)

- 2393
- 203119

## Regulatory information

### United States

**Applicant**

SANOFI AVENTIS US

**Approval date**

31 Oct 1949

**Application number**

NDA006002

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

## Approval status

**United States (FDA)**

Approved

## Pharmacology

### Drug classification

**Pharmacology name**

chloroquine

**Type**

Synthetic organic

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Oral
- Parenteral

### Mechanisms of action (2)

- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
MRGPRX1

**Gene symbol**  
MRGPRX1

**Protein identifier**  
Q96LB2

**Median affinity**

3.53

**Affinity units**  
pEC50
- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
TAS2R3

**Gene symbol**  
TAS2R3

**Protein identifier**  
Q9NYW6

### Investigated indications (21)

- **Condition**  
Carcinoma, Intraductal, Noninfiltrating

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000432

**Subject identifier**  
D002285
- **Condition**  
Glioblastoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000519

**Subject identifier**  
D005909
- **Condition**  
Arthritis, Rheumatoid

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000685

**Subject identifier**  
D001172
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
HIV Infections

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000764

**Subject identifier**  
D015658
- **Condition**  
Acquired Immunodeficiency Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000765

**Subject identifier**  
D000163
- **Condition**  
Malaria

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0001068

**Subject identifier**  
D008288
- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Pregnancy

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0002950

**Subject identifier**  
D011247
- **Condition**  
Severe Dengue

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0004227

**Subject identifier**  
D019595
- **Condition**  
Brain Diseases

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005774

**Subject identifier**  
D001927
- **Condition**  
Influenza, Human

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0007328

**Subject identifier**  
D007251
- **Condition**  
Malaria, Falciparum

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0007444

**Subject identifier**  
D016778
- **Condition**  
Malaria, Vivax

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0007445

**Subject identifier**  
D016780
- **Condition**  
Gliosarcoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001465

**Subject identifier**  
D018316
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Lupus Erythematosus, Systemic

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007915

**Subject identifier**  
D008180
- **Condition**  
Anemia, Sickle Cell

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0011382

**Subject identifier**  
D000755
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (46)

- **Condition identifier**  
EFO\_0000195

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000432
- **Condition identifier**  
EFO\_0000519

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000685

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000702

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000764

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000765

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000771

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0001068
- **Condition identifier**  
EFO\_0001378

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0002950

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0004227
- **Condition identifier**  
EFO\_0005774

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0007328

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0007444
- **Condition identifier**  
EFO\_0007445

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0001945
- **Condition identifier**  
HP\_0006767
- **Condition identifier**  
MONDO\_0003210

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004981

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005023

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005109

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005113

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005136

**Highest recorded phase**  
4

And 21 more, listed on the interactive page.

### Reported adverse events (122)

- **Event**  
abdominal discomfort

**Reports**  
1,234

**Reporting signal score**  
2,052.5
- **Event**  
acquired pigmented retinopathy

**Reports**  
2

**Reporting signal score**

14.9849
- **Event**  
alopecia

**Reports**  
1,161

**Reporting signal score**  
1,842.54
- **Event**  
anti-cyclic citrullinated peptide antibody positive

**Reports**  
492

**Reporting signal score**  
1,834.77
- **Event**  
apparent death

**Reports**  
89

**Reporting signal score**

235.327
- **Event**  
arthralgia

**Reports**  
1,902

**Reporting signal score**  
2,038.58
- **Event**  
arthritis

**Reports**  
412

**Reporting signal score**

502.666
- **Event**  
arthropathy

**Reports**  
1,142

**Reporting signal score**  
2,590.17
- **Event**  
atrioventricular block complete

**Reports**  
10

**Reporting signal score**

42.3374
- **Event**  
bipolar disorder

**Reports**  
3

**Reporting signal score**

9.76516
- **Event**  
blister

**Reports**  
282

**Reporting signal score**

302.796
- **Event**  
blood cholesterol increased

**Reports**  
214

**Reporting signal score**

236.442
- **Event**  
blood iron abnormal

**Reports**  
158

**Reporting signal score**

632.872
- **Event**  
blood parathyroid hormone decreased

**Reports**  
83

**Reporting signal score**

237.591
- **Event**  
body height below normal

**Reports**  
67

**Reporting signal score**

222.657
- **Event**  
bone density decreased

**Reports**  
101

**Reporting signal score**

179.053
- **Event**  
bone erosion

**Reports**  
151

**Reporting signal score**

443.52
- **Event**  
breast cancer stage iii

**Reports**  
63

**Reporting signal score**

213.918
- **Event**  
c-reactive protein abnormal

**Reports**  
508

**Reporting signal score**  
1,796.39
- **Event**  
c-reactive protein increased

**Reports**  
571

**Reporting signal score**

985.661
- **Event**  
cardiomyopathy

**Reports**  
6

**Reporting signal score**

18.4789
- **Event**  
cardiotoxicity

**Reports**  
5

**Reporting signal score**

17.5714
- **Event**  
colour vision tests abnormal red-green

**Reports**  
1

**Reporting signal score**

8.5851
- **Event**  
condition aggravated

**Reports**  
1,605

**Reporting signal score**  
1,777.53
- **Event**  
corneal deposits

**Reports**  
3

**Reporting signal score**

15.844

And 97 more, listed on the interactive page.

### Trial references (84)

- NCT00074841  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00074841)
- NCT00082563  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00082563)
- NCT00082576  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00082576)
- NCT00084227  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00084227)
- NCT00084240  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00084240)
- NCT00158548  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00158548)
- NCT00282919  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00282919)
- NCT00379821  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00379821)
- NCT00677833  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00677833)
- NCT00682578  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00682578)
- NCT00959517  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00959517)
- NCT02773979  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02773979)
- NCT02996695  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02996695)
- NCT00118807  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00118807)
- NCT00131703  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00131703)
- NCT00290420  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00290420)
- NCT00323375  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00323375)
- NCT00367653  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00367653)
- NCT00440999  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00440999)
- NCT00442403  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00442403)
- NCT00844207  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00844207)
- NCT00871156  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00871156)
- NCT01100060  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01100060)
- NCT01205178  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01205178)
- NCT01290601  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01290601)

And 59 more, listed on the interactive page.

## Dosing

**Dose**

300mg

**How often**

Once per week

## Chemical properties

**Hydrogen bond acceptors**

3

**Hydrogen bond donors**

1

**Polar surface area**

28.16

**Calculated partition coefficient (ALogP)**

4.81

**Calculated partition coefficient (XLogP)**

4.6

**Prodrug**

No

**Chirality**

Racemic

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

8

**Heavy atoms**

22

**Molecular formula**

C18H26ClN3

**Monoisotopic mass**

319.1815255

**Natural product**

Yes

## Evidence counts

**Recorded assays**

7,594

**Active assays**

2,256

### Active assay types (3)

- Confirmatory
- Other
- Screening

## Pharmacologic actions

- Amebicides  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000563.html)
- Antimalarials  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000962.html)
- Antirheumatic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018501.html)

## Biological measurements

These details could not be displayed.

## Related records

### Trials (132)

- "Pharmacoepidemiological Evaluation of Autophagy Inhibition in Treatment of HCV Patients Resistant to Standard Therapy. Pilot Study"
- A Comparative Study of Artekin With Standard Malarial Treatment Regimes in Afghanistan
- A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) Malaria
- A Phase 1 Study To Estimate The Relative Bioavailability Of Co-Administered Formulations Of Azithromycin Microsphere And Chloroquine Test Formulation Compared With Co-Administered Immediate Release Individual Azithromycin And Chloroquine Tablets In Healthy Adult Subjects
- A Phase 1 Study To Estimate The Relative Bioavailability Of Fixed Combination Tablets Of Azithromycin And Chloroquine Compared To Co-Administered Individual Tablets Of Azithromycin And Chloroquine
- A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer
- A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands
- A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid Arthritis
- A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh
- A Three Day Trial of Azithromycin Plus Chloroquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria
- Acceptability and Cost Effectiveness of Home Based Management of Fever: Different Strategies
- ACT vs CQ With Tafenoquine for P. Vivax Mono-infection
- Adjuvant Effect of Chloroquine on Gemcitabine
- An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older
- Antimalarial Drug Resistance in Mali
- Antimalarial Drug Susceptibility and Molecular Characterization of Plasmodium Vivax Isolates in Vietnam
- Artemether-lumefantrine vs Chloroquine for Uncomplicated P. Vivax Malaria in Malaysia
- Artesunate Plus Sulfadoxine-Pyrimethamine Versus Chloroquine for Vivax Malaria
- Assessing a Risk Model for G6PD Deficiency
- Atheroma Reduction With Chloroquine in Patients With the Metabolic Syndrome (ARCH-MS)

### Approved for (1)

- [Malaria](https://trialight.com/data/condition/malaria-54828cac-9b96-5833-93e2-e012d4505853.md)

### In development for (29)

- [AIDS](https://trialight.com/data/condition/aids-2a92a841-de6e-51af-bf3e-a52f5bafea66.md) Phase 2
- [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md) Phase 2
- [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md) Phase 3
- [Brain disorder](https://trialight.com/data/condition/brain-disorder-4e393319-afcc-52a0-8ac4-4c73ea743874.md) Phase 2
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- Chondrosarcoma Phase 1
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3
- Dengue hemorrhagic fever Phase 1
- Ductal breast carcinoma in situ Phase 1
- Exocrine pancreatic carcinoma Phase 1
- Glioblastoma Phase 3
- [Glioma](https://trialight.com/data/condition/glioma-4ac240c4-7ffb-5f08-b793-0b205a4b5d03.md) Phase 1
- Gliosarcoma Phase 1
- [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 2
- [Influenza](https://trialight.com/data/condition/influenza-ea12369b-7ed6-5f6b-94fe-eb0e56c24def.md) Phase 2
- Intrahepatic cholangiocarcinoma Phase 1
- [Malignant pancreatic neoplasm](https://trialight.com/data/condition/malignant-pancreatic-neoplasm-5dd0b53e-5962-50ea-a2e5-cf2444bd0485.md) Phase 1
- [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 1
- [Pancreatic neoplasm](https://trialight.com/data/condition/pancreatic-neoplasm-de300cc3-339a-5c06-97d8-2d9155fc3a7b.md) Phase 1

### Other linked conditions (3)

- [Atherosclerosis](https://trialight.com/data/condition/atherosclerosis-5dab64e9-1fd4-5dd2-90c2-ce84935652d1.md)
- [Lupus nephritis](https://trialight.com/data/condition/lupus-nephritis-2794deed-1735-531d-b3ca-1e5d38aadc8a.md)
- Prolactin-producing pituitary gland adenoma

### Targets (2)

- [MRGPRX1](https://trialight.com/data/target/mrgprx1-f21d8f55-8de7-5dfc-8a47-04a8293ab150.md)
- [TAS2R3](https://trialight.com/data/target/tas2r3-0510463a-8e15-531b-8b74-613fe404a396.md)

---

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You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them.

- Cite this page with its date. Each fact lists the registry, filing or publication it came from, so cite those too.
- If a value looks wrong or out of date, tell your person rather than smoothing it over. Registries lag, and so can we.
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- More about Trialight, written for you: https://trialight.com/for-ai.md
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