> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/chlorhexidine-hydrochloride-783a114e-4af9-441f-8e5f-b41ab1930f71
> Record changed: 2026-10-13

# Chlorhexidine hydrochloride

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1484251)

## Development status

**Listing at source**

Listed

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1484251)

**Drug name**

Chlorhexidine hydrochloride

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1484251)

**Molecular weight**

578.38

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1484251)

**Structure (SMILES)**

Cl.Cl.N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1484251)

### Brand names (2)

- chlorhex hcl
- Chlorhex hcl

### Other names (36)

- 1 1 hexamethylenebis 5 p chlorophenyl biguanide dihydrochloride
- 1,1'-HEXAMETHYLENEBIS(5-(P-CHLOROPHENYL)BIGUANIDE)DIHYDROCHLORIDE
- 2 4 11 13 tetraazatetradecanediimidamide n n bis 4 chlorophenyl 3 12 diimino dihydrochloride
- 2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE, N,N''-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-, DIHYDROCHLORIDE
- ay 5312
- AY-5312
- chlorhexidine dihydrochloride
- Chlorhexidine dihydrochloride
- CHLORHEXIDINE DIHYDROCHLORIDE \[EP MONOGRAPH\]
- CHLORHEXIDINE DIHYDROCHLORIDE \[MI\]
- CHLORHEXIDINE DIHYDROCHLORIDE \[WHO-IP\]
- chlorhexidine dihydrochloride ep monograph
- chlorhexidine dihydrochloride mi
- chlorhexidine dihydrochloride who ip
- chlorhexidine hcl
- Chlorhexidine hcl
- chlorhexidine hydrochloride
- Chlorhexidine hydrochloride
- CHLORHEXIDINE HYDROCHLORIDE \[GREEN BOOK\]
- CHLORHEXIDINE HYDROCHLORIDE \[JAN\]
- CHLORHEXIDINE HYDROCHLORIDE \[MART.\]
- CHLORHEXIDINE HYDROCHLORIDE \[USAN\]
- CHLORHEXIDINE HYDROCHLORIDE \[USP IMPURITY\]
- CHLORHEXIDINE HYDROCHLORIDE \[USP MONOGRAPH\]
- Chlorhexidine hydrochloride \[WHO-DD\]

And 11 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 3697-42-5

**ChEMBL ID**

CHEMBL1484251

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1484251)

**InChIKey**

WJLVQTJZDCGNJN-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1484251)

**RxNorm IDs (RxCUI)**

- 2361

**FDA ingredient codes (UNII)**

- E64XL9U38K

### PubChem compound IDs (4)

- 62517
- 9571016
- 66810670
- 124081984

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Open Targets indications (20)

- **Condition identifier**  
EFO\_0000544

**Highest recorded phase**  
4
- **Condition identifier**  
EFO\_1001390

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1001888

**Highest recorded phase**  
4
- **Condition identifier**  
HP\_0000225
- **Condition identifier**  
HP\_0000822
- **Condition identifier**  
HP\_0011947

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0100806

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0000984
- **Condition identifier**  
MONDO\_0002258

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0002508

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0002635

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004508
- **Condition identifier**  
MONDO\_0005002

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005076

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005113

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005121
- **Condition identifier**  
MONDO\_0005276

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005316

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005593

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005629

**Highest recorded phase**  
2

### Open Targets warnings (2)

- **Warning**  
Withdrawn

**Effect**  
dermatological toxicity

**Description**  
associated with chemical and thermal burns

**Year**  
1984

**Country**  
United States

**Condition**  
caustic injury
- **Warning**  
Withdrawn

**Effect**  
dermatological toxicity

**Description**  
associated with chemical and thermal burns

**Year**  
1984

**Country**  
United States

**Condition**  
thermal burn

### Reported adverse events (136)

- **Event**  
abdominal discomfort

**Reports**  
173

**Reporting signal score**

416.51
- **Event**  
abdominal pain upper

**Reports**  
128

**Reporting signal score**

232.162
- **Event**  
abdominal wound dehiscence

**Reports**  
5

**Reporting signal score**

22.107
- **Event**  
acanthamoeba keratitis

**Reports**  
4

**Reporting signal score**

24.3886
- **Event**  
allergy to chemicals

**Reports**  
10

**Reporting signal score**

43.8538
- **Event**  
alopecia

**Reports**  
165

**Reporting signal score**

386.658
- **Event**  
anaphylactic reaction

**Reports**  
125

**Reporting signal score**

301.598
- **Event**  
anaphylactic shock

**Reports**  
15

**Reporting signal score**

18.4649
- **Event**  
anti-cyclic citrullinated peptide antibody

**Reports**  
3

**Reporting signal score**

14.3198
- **Event**  
anti-cyclic citrullinated peptide antibody positive

**Reports**  
153

**Reporting signal score**

814.546
- **Event**  
arthralgia

**Reports**  
298

**Reporting signal score**

576.65
- **Event**  
arthropathy

**Reports**  
169

**Reporting signal score**

522.115
- **Event**  
aspartate aminotransferase increased

**Reports**  
19

**Reporting signal score**

11.2199
- **Event**  
asthenia

**Reports**  
125

**Reporting signal score**

134.928
- **Event**  
asthenopia

**Reports**  
18

**Reporting signal score**

67.5198
- **Event**  
back pain

**Reports**  
113

**Reporting signal score**

168.197
- **Event**  
blister

**Reports**  
313

**Reporting signal score**  
1,226.38
- **Event**  
blood alkaline phosphatase increased

**Reports**  
18

**Reporting signal score**

21.7549
- **Event**  
blood cholesterol increased

**Reports**  
15

**Reporting signal score**

17.073
- **Event**  
blood lactate dehydrogenase increased

**Reports**  
19

**Reporting signal score**

33.1836
- **Event**  
blood pressure diastolic abnormal

**Reports**  
8

**Reporting signal score**

26.7551
- **Event**  
blood pressure diastolic increased

**Reports**  
8

**Reporting signal score**

19.7996
- **Event**  
blood pressure systolic abnormal

**Reports**  
8

**Reporting signal score**

26.9173
- **Event**  
blood pressure systolic increased

**Reports**  
10

**Reporting signal score**

13.2696
- **Event**  
body temperature increased

**Reports**  
115

**Reporting signal score**

407.392

And 111 more, listed on the interactive page.

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

10

**Polar surface area**

167.58

**Calculated partition coefficient (ALogP)**

4.18

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

9

**Heavy atoms**

36

**Molecular formula**

C22H32Cl4N10

**Monoisotopic mass**

576.156552

**Natural product**

No

## Evidence counts

**Recorded assays**

1

**Active assays**

0

## Pharmacologic actions

- Anti-Infective Agents, Local  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000891.html)
- Disinfectants  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D004202.html)
- Mouthwashes  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D009067.html)

## Related records

### Trials (216)

- "Clinical Trials to Enhance Elders' Oral Health" ("TEETH")
- 0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia
- 0.2% Chlorhexidine vs MicroRepair ABX in Gingivitis
- 2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament
- A Clinical Study of Connective Tissue Graft and Enamel Matrix Derivative in the Treatment of Intrabony Periodontal Defects
- A Comparative Analysis of 4% Chlorhexidine Versus Methylated Spirit as Prophylaxis of Omphalitis and Sepsis in Newborns
- A Comparison of Mouth Rinse Containing Alcohol-free Chlorhexidine With a Cetylpyridinium Chloride in Periodontal Diseases
- A New Antibiotic Prophylaxis Regimen to Prevent Bacteremia Following Dental Procedures
- A Randomized Clinical Trial to Prevent Recurrent CA-MRSA Infection
- Alcoholic Chlorhexidine Compared to Povidone Iodine to Limit Perineural Catheter Colonisation
- Animal-Assisted Visitation Program Chlorhexidine Trial
- Anti-inflammatory and Anti-plaque Efficacies of Mouth Rinse Containing Hyaluronic Acid and Hydrogen Peroxide
- Antibacterial Effect of Chlorhexidine Added to the Preventive Protocol in Adolescent Special Needs
- Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients
- Anticaries Effect of Xylitol,Probiotic and Chlorhexidine Mouth Rinses Among Individuals at High Risk
- Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash
- Antimicrobial Activity of Two Mouthwashes
- Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash
- Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth.
- Antiplaque, Antigingivitis and Anti-inflammatory Effects of Myrrh Mouthwash

---

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