> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/chlorhexidine-gluconate-3bac4140-cfe7-4d11-9be4-8cdd892e90a4 > Record changed: 2026-10-13 # Chlorhexidine gluconate Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297088) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297088) First approval year 1976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297088) ## Development status **First approval year** 1976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297088) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297088) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297088) **Drug name** Chlorhexidine gluconate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297088) **Molecular weight** 897.77 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297088) **Structure (SMILES)** N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1.O=C(O)\[C@H\](O)\[C@@H\](O)\[C@H\](O)\[C@H\](O)CO.O=C(O)\[C@H\](O)\[C@@H\](O)\[C@H\](O)\[C@H\](O)CO Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297088) ### Brand names (132) - acriflex - Acriflex - aerocide 1 - Aerocide 1 - bacticlens - Bacticlens - bioscrub - Bioscrub - brian care - Brian care - cepton - Cepton - cetriclens - Cetriclens - cetriclens fte - Cetriclens fte - chg scrub - Chg scrub - chloraprep - Chloraprep - chlorhex glucon - Chlorhex glucon - chlorhexidine gluconate - Chlorhexidine gluconate - chlorhexidine gluconate component of avagard And 107 more, listed on the interactive page. ### Other names (51) - 1 1 hexamethylenebis 5 p chlorophenyl biguanide di d gluconate - 1,1'-HEXAMETHYLENEBIS(5-(P-CHLOROPHENYL)BIGUANIDE) DI-D-GLUCONATE - 2 4 11 13 tetraazatetradecanediimidamide n n bis 4 chlorophenyl 3 12 diimino di d gluconate - 2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE, N,N''-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-, DI-D-GLUCONATE - avagard component chlorhexidine gluconate - AVAGARD COMPONENT CHLORHEXIDINE GLUCONATE - cepton - chlohexidine gluconate - Chlohexidine gluconate - chloraprep - Chloraprep - ChloraPrep - chloraprep component chlorhexidine gluconate - CHLORAPREP COMPONENT CHLORHEXIDINE GLUCONATE - chlorhexidine d digluconate - chlorhexidine d digluconate mi - Chlorhexidine d-digluconate - CHLORHEXIDINE D-DIGLUCONATE \[MI\] - chlorhexidine digluconate - Chlorhexidine digluconate - chlorhexidine digluconate solution - CHLORHEXIDINE DIGLUCONATE SOLUTION - CHLORHEXIDINE DIGLUCONATE SOLUTION \[EP MONOGRAPH\] - chlorhexidine digluconate solution ep monograph - chlorhexidine gluconate And 26 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 18472-51-0 **ChEMBL ID** CHEMBL4297088 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297088) **InChIKey** YZIYKJHYYHPJIB-UUPCJSQJSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297088) **FDA ingredient codes (UNII)** - MOR84MUD8E ### PubChem compound IDs (3) - 29089 - 5360565 - 9552081 ### RxNorm IDs (RxCUI) (2) - 20791 - 133054 ## Regulatory information ### United States **Applicant** MOLNLYCKE HLTH **Approval date** 17 Sept 1976 **Application number** NDA017768 ### Other regulatory facts **Patents** 2 **Designations** 0 **Earliest recorded loss of exclusivity** 2 Oct 2027 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Over the counter ## Pharmacology ### Drug classification #### Administration routes - topical ### Mechanisms of action - **Mechanism** Cell membrane inhibitor **Action type** Inhibitor **Target** Cell membrane ### Investigated indications (20) - **Condition** Infections **Highest recorded phase** 3 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Periodontitis **Highest recorded phase** 4 **Condition identifier** EFO:0000649 **Subject identifier** D010518 - **Condition** HIV Infections **Highest recorded phase** 2 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Abscess **Highest recorded phase** 2 **Condition identifier** EFO:0003030 **Subject identifier** D000038 - **Condition** Pneumonia **Highest recorded phase** 3 **Condition identifier** EFO:0003106 **Subject identifier** D011014 - **Condition** Dental Caries **Highest recorded phase** 3 **Condition identifier** EFO:0003819 **Subject identifier** D003731 - **Condition** Head and Neck Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0006859 **Subject identifier** D006258 - **Condition** Acanthamoeba Keratitis **Highest recorded phase** 3 **Condition identifier** EFO:0007126 **Subject identifier** D015823 - **Condition** Candidiasis, Vulvovaginal **Highest recorded phase** 2 **Condition identifier** EFO:0007543 **Subject identifier** D002181 - **Condition** Clostridium Infections **Highest recorded phase** 2 **Condition identifier** EFO:1000874 **Subject identifier** D003015 - **Condition** Peri-Implantitis **Highest recorded phase** 3 **Condition identifier** EFO:1001390 **Subject identifier** D057873 - **Condition** Mucositis **Highest recorded phase** 2 **Condition identifier** EFO:1001898 **Subject identifier** D052016 - **Condition** Stomatitis **Highest recorded phase** 2 **Condition identifier** EFO:1001904 **Subject identifier** D013280 - **Condition** Sepsis **Highest recorded phase** 2 **Condition identifier** HP:0100806 **Subject identifier** D018805 - **Condition** Pharyngitis **Highest recorded phase** 4 **Condition identifier** MONDO:0002258 **Subject identifier** D010612 - **Condition** Gingivitis **Highest recorded phase** 4 **Condition identifier** MONDO:0002508 **Subject identifier** D005891 - **Condition** Cystic Fibrosis **Highest recorded phase** 2 **Condition identifier** MONDO:0009061 **Subject identifier** D003550 - **Condition** Cross Infection **Highest recorded phase** 2 **Condition identifier** MONDO:0043544 **Subject identifier** D003428 - **Condition** Radiodermatitis **Highest recorded phase** 2 **Condition identifier** MONDO:0043771 **Subject identifier** D011855 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 2 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (43) - **Condition identifier** EFO\_0000544 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000649 - **Condition identifier** EFO\_0000764 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003030 - **Condition identifier** EFO\_0003106 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003819 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003938 - **Condition identifier** EFO\_0005681 - **Condition identifier** EFO\_0006859 **Highest recorded phase** 1 - **Condition identifier** EFO\_0007543 **Highest recorded phase** 2 - **Condition identifier** EFO\_0009373 - **Condition identifier** EFO\_1000874 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001390 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001849 - **Condition identifier** EFO\_1001865 - **Condition identifier** EFO\_1001898 - **Condition identifier** EFO\_1001898 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001904 **Highest recorded phase** 2 - **Condition identifier** HP\_0001945 **Highest recorded phase** 1 - **Condition identifier** HP\_0011947 **Highest recorded phase** 2 - **Condition identifier** HP\_0012531 - **Condition identifier** HP\_0100806 - **Condition identifier** MONDO\_0000918 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0002258 - **Condition identifier** MONDO\_0002258 **Highest recorded phase** 4 And 18 more, listed on the interactive page. ### Warnings - **Warning** Withdrawn **Effect** dermatological toxicity **Description** associated with chemical and thermal burns **Year** 1984 ### Open Targets warnings (2) - **Warning** Withdrawn **Effect** dermatological toxicity **Description** associated with chemical and thermal burns **Year** 1984 **Country** United States **Condition** caustic injury - **Warning** Withdrawn **Effect** dermatological toxicity **Description** associated with chemical and thermal burns **Year** 1984 **Country** United States **Condition** thermal burn ### Reported adverse events (145) - **Event** abdominal discomfort **Reports** 274 **Reporting signal score** 632.932 - **Event** abdominal pain upper **Reports** 230 **Reporting signal score** 424.948 - **Event** administration site rash **Reports** 11 **Reporting signal score** 63.0033 - **Event** allergy to chemicals **Reports** 7 **Reporting signal score** 24.3611 - **Event** alopecia **Reports** 274 **Reporting signal score** 629.077 - **Event** anaphylactic reaction **Reports** 101 **Reporting signal score** 166.962 - **Event** anti-cyclic citrullinated peptide antibody **Reports** 4 **Reporting signal score** 18.0366 - **Event** anti-cyclic citrullinated peptide antibody positive **Reports** 262 **Reporting signal score** 1,390.74 - **Event** application site erythema **Reports** 28 **Reporting signal score** 64.8884 - **Event** application site hypersensitivity **Reports** 5 **Reporting signal score** 17.5247 - **Event** application site irritation **Reports** 11 **Reporting signal score** 24.9051 - **Event** application site necrosis **Reports** 4 **Reporting signal score** 18.6648 - **Event** application site papules **Reports** 5 **Reporting signal score** 20.314 - **Event** application site pruritus **Reports** 13 **Reporting signal score** 24.7451 - **Event** application site rash **Reports** 59 **Reporting signal score** 215.942 - **Event** application site reaction **Reports** 25 **Reporting signal score** 87.116 - **Event** application site vesicles **Reports** 17 **Reporting signal score** 50.8184 - **Event** arthralgia **Reports** 556 **Reporting signal score** 1,120.87 - **Event** arthropathy **Reports** 281 **Reporting signal score** 854.864 - **Event** asthenia **Reports** 237 **Reporting signal score** 274.97 - **Event** asthenopia **Reports** 16 **Reporting signal score** 49.3577 - **Event** back pain **Reports** 183 **Reporting signal score** 260.049 - **Event** blister **Reports** 559 **Reporting signal score** 2,208.7 - **Event** blood lactate dehydrogenase increased **Reports** 16 **Reporting signal score** 17.4568 - **Event** body temperature increased **Reports** 213 **Reporting signal score** 768.928 And 120 more, listed on the interactive page. ### Trial references (43) - NCT00006075 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00006075) - NCT00066950 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00066950) - NCT02001311 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02001311) - NCT02598778 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02598778) - NCT03061916 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03061916) - NCT00123123 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00123123) - NCT03442023 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03442023) - NCT00425451 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00425451) - NCT01030666 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01030666) - NCT02215473 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02215473) - NCT04027179 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04027179) - NCT00528008 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00528008) - NCT00549393 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00549393) - NCT01495117 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01495117) - NCT01613365 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01613365) - NCT02160574 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02160574) - NCT02160587 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02160587) - NCT02221232 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02221232) - NCT02296645 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02296645) - NCT02490631 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02490631) - NCT02915289 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02915289) - NCT03423147 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03423147) - NCT04218110 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04218110) - NCT04756804 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04756804) - NCT06126614 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06126614) And 18 more, listed on the interactive page. ## Dosing **Dose** 2 mL **Route** Topical **How often** As needed ### Conditions of use (2) - Allow to dry before donning gloves - Apply to clean, dry hands and nails ## Chemical properties **Hydrogen bond acceptors** 4 **Hydrogen bond donors** 10 **Polar surface area** 167.58 **Calculated partition coefficient (ALogP)** 4.18 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 2 **Rotatable bonds** 9 **Heavy atoms** 60 **Molecular formula** C34H54Cl2N10O14 **Monoisotopic mass** 896.3198018 **Natural product** No ## National Drug Codes - 0116-0003 - 0116-0101 - 0116-0175 - 0116-0200 - 0116-0301 - 0116-0407 - 0116-0800 - 0116-2001 - 0116-4075 - 0116-6000 - 0116-6720 - 0121-0893 - 0121-1786 - 0126-0272 - 0126-0282 - 0374-5080 - 0404-4075 - 0904-7035 - 16571-128 - 53329-301 - 53462-003 - 59883-175 - 60687-714 - 61037-469 - 62135-649 And 27 more, listed on the interactive page. ## Evidence counts **Recorded assays** 7 **Active assays** 0 ## Pharmacologic actions - Anti-Infective Agents, Local Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. - Dermatologic Agents Drugs used to treat or prevent skin disorders or for the routine care of skin. - Anti-Infective Agents, Local Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000891.html) - Dermatologic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D003879.html) ## Related records ### Trials (192) - "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients. - 2% Chlorhexidine Gluconate Skin Cloths to Prevent SSI in Spine Surgery Patients - 4% Chlorhexidine Gluconate Daily Bathing for Prevention of Hospital-acquired Infections in Intensive Care Settings - A 96-hour Patch Test Study Using Healthy Human Volunteers to Assess the Skin Irritation Potential of 11 Topically Applied Formulations - A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal - A Clinical Trial for Chlorhexidine as Treatment for Vulvovaginal Candidiasis - A Cluster-randomized Cross-over Trial Evaluating the Comparative Effectiveness of Three Skin Antiseptic Interventions - A Double-blind Randomized Placebo Controlled Clinical Trial Evaluating Effect of Chlorhexidine Gluconate 2% Cloth vs Placebo Cloth Baths on the Incidence of Central Line-Associated Blood Stream Infections in Outpatient Hematopoietic Stem Cell Transplant Patients - A Pilot Study of Microbiota Transplant With Antibiotic Preconditioning and Fiber Supplementation in Pulmonary Arterial Hypertension (GUT RESTORE-PAH) - A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs - A Study of Chlorhexidine in the Prevention of HIV-1 Transmission From Mothers to Their Babies - An Efficacy Study of Chlorhexidine Mouthwashes - An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining - An Evaluation of the Efficacy of HEXI-PREP by Clinell Wipes - Anti-staining Efficacy of Anti-Discoloration System (ADS) Added to Chlorhexidine (CHX) - Antimicrobial Agent for Reducing Bacteria in Aerosols and Oral Cavity - Antimicrobial Efficacy of Biogenic Gold Nano Particle From Pelargonium Graveolens Leaves Extract Mouthwash for Children - Antimicrobial Photodynamic Therapy Applied in Orthodontic. Orthodontic Patients. - Antiviral Efficacy and Acceptability of Mouth Rinses for Inactivation of COVID-19 - Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections ### Approved for (3) - Gingivitis - Periodontitis - [Pharyngitis](https://trialight.com/data/condition/pharyngitis-81ed933e-75b3-5382-aebe-66ffd4ec6446.md) ### In development for (14) - Abscess Phase 2 - Acanthamoeba keratitis Phase 3 - Clostridium infectious disease Phase 2 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2 - [Cystic fibrosis](https://trialight.com/data/condition/cystic-fibrosis-6f9870eb-6ebc-5bec-a50b-34b0b323a7c3.md) Phase 2 - Dental caries Phase 3 - [Head and neck cancer](https://trialight.com/data/condition/head-and-neck-cancer-3a2645b9-a3db-5103-b6f8-5d2ec40c5339.md) Phase 1 - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 2 - Mucositis Phase 2 - [Nosocomial infection](https://trialight.com/data/condition/nosocomial-infection-b3dd6ec1-3bfe-553c-b076-48a800eff89d.md) Phase 2 - [Pneumonia](https://trialight.com/data/condition/pneumonia-d2f12d4d-57c5-5c54-881e-1efe392849eb.md) Phase 3 - Radiodermatitis Phase 2 - Stomatitis Phase 2 - Vulvovaginal candidiasis Phase 2 ### Other linked conditions (3) - Canker sore - [Staphylococcal infection](https://trialight.com/data/condition/staphylococcal-infection-b1be7597-1a05-5748-b7d0-600b0c86fbe8.md) - Staphylococcus aureus infection --- ## A note for AI agents You are probably reading this for a person. 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