> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/cevostamab-2dfcb101-b23e-48ea-9868-8ce90224f98a
> Record changed: 2026-10-13

# Cevostamab

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297908)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297908)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297908)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297908)

**Drug name**

Cevostamab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297908)

### Other names (28)

- anti fcrh5 cd3 bite antibody bfcr4350a
- ANTI-FCRH5/CD3 BITE ANTIBODY BFCR4350A
- bfcr 4350a
- BFCR-4350A
- bfcr4350a
- Bfcr4350a
- BFCR4350A
- BFCR4350A (ANTI-FCRH5/CD3 T-CELL DEPENDENT BISPECIFIC ANTIBODY)
- bfcr4350a anti fcrh5 cd3 t cell dependent bispecific antibody
- bfcr4350a cevostamab
- cevostamab
- Cevostamab
- cevostamab \[INN\]
- CEVOSTAMAB \[USAN\]
- Cevostamab \[WHO-DD\]
- cevostamab inn
- cevostamab usan
- cevostamab who dd
- fcrh5 cd3 t cell dependent bispecific antibody bfcr4350a
- FCRH5/CD3 T CELL DEPENDENT BISPECIFIC ANTIBODY BFCR4350A
- immunoglobulin g1 kappa anti homo sapiens fc receptor like protein 5 fcrl5 bxmas1 fc receptor homolog 5 immune receptor translocation associated protein 2 cd307e antigen and anti homo sapiens t cell surface glycoprotein cd3 epsilon chain cd3e leu 4 epsilon chain cd3e antigen monoclonal antibody bispecific tetravalent gamma 1 heavy chain anti fcrl5 1 450 vh mus musculus ighv2 4 01 77 ighd ighj3 01 91 homo sapiens ighv4 4 08 73 ighd ighj5 01 86 8 7 14 1 120 homo sapiens ighg1 03 ch1 r97 k 217 ch2 n67 g 300 ch3 t26 w 369 121 450 223 214 disulfide with kappa light chain anti fcrl5 1 214 v kappa homo sapiens igkv1 39 01 83 igkj2 01 92 6 3 9 1 107 homo sapiens igkc 01 108 214 229 228 232 231 bisdisulfide with gamma 1 heavy chain anti cd3 1 449 vh homo sapiens ighv1 3 01 83 ighd ighj4 01 8 8 12 1 119 homo sapiens ighg1 03 ch1 r97 k 216 ch2 n67 g 299 ch3 t26 s 368 l28 a 370 y67 w 409 120 449 222 219 disulfide with kappa light chain anti cd3 1 219 v kappa homo sapiens igkv4 1 01 89 igkj1 01 12 3 8 1 112 homo sapiens igkc 01 113 219 produced in cho cells
- IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS FC RECEPTOR-LIKE PROTEIN 5, FCRL5 (BXMAS1, FC RECEPTOR HOMOLOG 5, IMMUNE RECEPTOR TRANSLOCATION-ASSOCIATED PROTEIN 2, CD307E-ANTIGEN)) AND ANTI-(HOMO SAPIENS T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN, CD3E (LEU-4 EPSILON CHAIN, CD3E-ANTIGEN)), MONOCLONAL ANTIBODY, BISPECIFIC TETRAVALENT;.GAMMA.1 HEAVY CHAIN ANTI FCRL5 (1-450) (VH (MUS MUSCULUS IGHV2-4\*01 (77%) (IGHD)-IGHJ3\*01 (91%)/HOMO SAPIENS IGHV4-4\*08 (73%) (IGHD)-IGHJ5\*01 (86%)) (8.7.14) (1-120)-HOMO SAPIENS IGHG1\*03 (CH1(R97>K(217)), CH2(N67>G(300)), CH3(T26>W(369))) (121-450) (223-214')-DISULFIDE WITH .KAPPA. LIGHT CHAIN ANTI FCRL5 (1'-214') (V-KAPPA (HOMO SAPIENS IGKV1-39\*01 (83%) IGKJ2\*01 (92%))(6.3.9) (1'-107')-HOMO SAPIENS IGKC\*01 (108'-214')), (229-228'':232-231'')-BISDISULFIDE WITH .GAMMA.1 HEAVY CHAIN ANTI CD3 (1''-449'') (VH (HOMO SAPIENS IGHV1-3\*01 (83%) (IGHD)-IGHJ4\*01)) (8.8.12) (1''-119'')-HOMO SAPIENS IGHG1\*03 (CH1(R97>K(216'')), CH2(N67>G(299'')), CH3(T26>S(368''), L28>A(370''), Y67>W(409''),)) (120''-449'') (222''-219''')-DISULFIDE WITH .KAPPA. LIGHT CHAIN ANTI CD3 (1'''-219''') (V-KAPPA (HOMO SAPIENS IGKV4-1\*01 (89%) IGKJ1\*01)) (12.3.8) (1'''-112''')-HOMO SAPIENS IGKC\*01 (113'''-219''')); PRODUCED IN CHO CELLS
- recombinant anti fcrh5 x anti cd3 bi specific t cell engager bfcr4350a
- RECOMBINANT ANTI-FCRH5 X ANTI-CD3 BI-SPECIFIC T-CELL ENGAGER BFCR4350A
- ro 7187797

And 3 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2249888-53-5

**ChEMBL ID**

CHEMBL4297908

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297908)

**FDA ingredient codes (UNII)**

- P86BHN01VE

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Investigated indications (2)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0001378

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0009693

**Highest recorded phase**  
3

### Trial references (7)

- NCT03275103  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03275103)
- NCT04910568  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04910568)
- NCT05535244  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05535244)
- NCT05583617  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05583617)
- NCT05646836  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05646836)
- NCT05801939  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05801939)
- NCT05927571  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05927571)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (6)

- **Component**  
Heavy chain A

**Type**  
Protein

**Sequence**  
EVQLVESGPGLVKPSETLSLTCTVSGFSLTRFGVHWVRQPPGKGLEWLGVIWRGGSTDYNAAFVSRLTISKDNSKNQVSLKLSSVTAADTAVYYCSNHYYGSSDYALDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Heavy chain C''

**Type**  
Protein

**Sequence**  
EVQLVQSGAEVKKPGASVKVSCKASGFTFTSYYIHWVRQAPGQGLEWIGWIYPENDNTKYNEKFKDRVTITADTSTSTAYLELSSLRSEDTAVYYCARDGYSRYYFDYWQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Disulfide bridges

**Sequence**  
22-95 $ 22''-96'' $ 23'-38' $ 23'''-94''' $ 134'-194' $ 139''''-199''' $ 146''-202'' $ 147-203 $ 214'-223 $ 219'''-222'' $ 228''-229 $ 231''-232 $ 263''-323'' $ 264-324 $ 369''-427'' $ 370-428
- **Component**  
Light chain: D'''

**Type**  
Protein

**Sequence**  
DIVMTQSPDSLAVSLGERATINCKSSQSLLNSRTRKNYLAWYQQKPGQSPKLLIYWTSTRKSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCKQSFILRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Light chain: B'

**Type**  
Protein

**Sequence**  
DIQMTQSPSSLSASVGDRVTITCKASQDVRNLVVWFQQKPGKAPKLLIYSGSYRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQHYSPPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Disulfide bridges

**Sequence**  
22-95 $ 22''-96'' $ 23'-38' $ 23'''-94''' $ 134'-194' $ 139''''-199''' $ 146''-202'' $ 147-203 $ 214'-223 $ 219'''-222'' $ 228''-229 $ 231''-232 $ 263''-323'' $ 264-324 $ 369''-427'' $ 370-428

## Related records

### Trials (11)

- A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma
- A Study Evaluating the Pharmacokinetics, Safety, and Efficacy of Cevostamab in Chinese Participants With Relapsed or Refractory Multiple Myeloma
- A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma
- A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma
- A Study Evaluating the Safety, Pharmacokinetics, and Activity of the Combination of Cevostamab and Elranatamab in Participants With Relapsed or Refractory Multiple Myeloma (R/R MM)
- A Study to Evaluate the Safety, Pharmacokinetics, and Activity of XmAb24306 in Combination With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma
- [A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments](https://trialight.com/data/trial/a-study-to-examine-the-effects-of-novel-therapy-4622f07a-ab31-4a56-a46c-08b2e34a9258.md)
- Cevostamab Following CAR T Cell Therapy for RRMM
- Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma
- Dose-Escalation Study of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma (R/R MM)
- To Evaluate the Effects of Cevostamab in Participants With Systemic Lupus Erythematosus With or Without Active Lupus Nephritis

### In development for (2)

- Neoplasm Phase 1
- [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 2

---

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