> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/cetrelimab-3efc0fa4-bffb-4b48-bdc8-d69f58f2bb03
> Record changed: 2026-10-13

# Cetrelimab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298001)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298001)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298001)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298001)

**Drug name**

Cetrelimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298001)

### Other names (16)

- cetrelimab
- Cetrelimab
- cetrelimab \[INN\]
- CETRELIMAB \[USAN\]
- Cetrelimab \[WHO-DD\]
- Cetrelimab 240 mg
- Cetrelimab 480 mg
- cetrelimab inn
- cetrelimab usan
- cetrelimab who dd
- jnj 63723283
- Jnj 63723283
- Jnj-63723283
- JNJ-63723283
- jnj63723283
- JNJ63723283

## Identifiers

**CAS registry numbers**

- 2050478-92-5

**ChEMBL ID**

CHEMBL4298001

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298001)

**FDA ingredient codes (UNII)**

- LYK98WP91F

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Mechanisms of action

- **Mechanism**  
Programmed cell death protein 1 inhibitor

**Action type**  
Inhibitor

**Target**  
Programmed cell death protein 1

**Protein identifier**  
Q15116

### Open Targets mechanisms

- **Mechanism**  
Programmed cell death protein 1 inhibitor

**Action type**  
Inhibitor

**Target**  
Programmed cell death protein 1

### Investigated indications (9)

- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000294

**Subject identifier**  
D001749
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000673

**Subject identifier**  
D011471
- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001663

**Subject identifier**  
D011471
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Hepatitis B, Chronic

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0004239

**Subject identifier**  
D019694
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0008528

**Subject identifier**  
D001749
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0001187

**Subject identifier**  
D001749

### Open Targets indications (25)

- **Condition identifier**  
EFO\_0000294

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000673

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000729

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001378
- **Condition identifier**  
EFO\_0001663

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003060
- **Condition identifier**  
EFO\_0004239

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0008528
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004647

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004986

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005101

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005206

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005344

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0006509

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0007576

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008315
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008433

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0009693

**Highest recorded phase**  
2

### Trial references (15)

- NCT02908906  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02908906)
- NCT03547037  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03547037)
- NCT06311578  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06311578)
- NCT03357952  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03357952)
- NCT03431350  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03431350)
- NCT03551782  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03551782)
- NCT03473743  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03473743)
- NCT04640623  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04640623)
- NCT04658862  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04658862)
- NCT04919512  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04919512)
- NCT05242445  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05242445)
- NCT05714202  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05714202)
- NCT05818683  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05818683)
- NCT05908734  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05908734)
- NCT06116786  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06116786)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (5)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFDTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARPGLAAAYDTGSLDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
EIVLTQSPATLSLSPGERATLSCRASQSVRSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRNYWPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-300 $ Asn-300''''
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 137-214' $ 137''-214''' $ 150-206 $ 150''-206'' $ 229-229'' $ 232-232'' $ 264-324 $ 264''-324'' $ 370-428 $ 370''-428''
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-300 $ Asn-300''

## Related records

### Trials (21)

- A Study of Cetrelimab (JNJ-63723283), a Programmed Cell Death Receptor-1 (PD-1) Inhibitor, Administered in Combination With Apalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer
- A Study of Cetrelimab in Participants With Chronic Hepatitis B Virus Infection
- A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer
- A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer
- A Study of JNJ-1761981 in Participants With Solid Tumors
- A Study of JNJ-63723283, an Anti-programmed Death-1 Monoclonal Antibody, Administered in Combination With Daratumumab, Compared With Daratumumab Alone in Participants With Relapsed or Refractory Multiple Myeloma
- A Study of JNJ-86974680 in Participants With Advanced Non-small Cell Lung Cancer
- A Study of JNJ-87704916, as Monotherapy and in Combination for Advanced Solid Tumors
- A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer
- [A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer](https://trialight.com/data/trial/a-study-of-pasritamig-jnj-78278343-in-combination-with-other-e6590381-7e15-4bbc-982a-d0945f86d1f5.md)
- A Study of TAR-200 in Combination With Cetrelimab and Cetrelimab Alone in Participants With Muscle-Invasive Urothelial Carcinoma of the Bladder
- [A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)](https://trialight.com/data/trial/a-study-of-tar-200-in-combination-with-cetrelimab-or-tar-200-c2d24d0f-7d72-4524-afd5-aba625ff2bc7.md)
- A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder
- A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy
- A Study of Tolododekin Alfa (ANK-101) in Combination With an Anti-PD-1/PD-L1 Antibody in Participants With Advanced Non-Small Cell Lung Cancer
- A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Advanced Cancers
- A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of JNJ-63723283, an Anti-Programmed Cell Death (PD)-1 Monoclonal Antibody, as Monotherapy or in Combination With Erdafitinib in Japanese Participants With Advanced Solid Cancers
- Apalutamide Plus Cetrelimab in Patients With Treatment-Emergent Small Cell Neuroendocrine Prostate Cancer
- Cabazitaxel, Carboplatin, and Cetrelimab Followed by Niraparib With or Without Cetrelimab for the Treatment of Aggressive Variant Metastatic Prostate Cancer
- CD8 PET Imaging in Metastatic Solid Tumours

### In development for (10)

- [Chronic hepatitis B virus infection](https://trialight.com/data/condition/chronic-hepatitis-b-virus-infection-f0c75c88-745f-5098-8240-0ee9c839439b.md) Phase 1
- Neoplasm Phase 1
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 1
- [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 2
- [Prostate adenocarcinoma](https://trialight.com/data/condition/prostate-adenocarcinoma-84e3e3af-1ae1-5760-8157-8d9fc0cff608.md) Phase 1
- [Prostate carcinoma](https://trialight.com/data/condition/prostate-carcinoma-622f1bf7-c37d-52ab-ab01-86f9cc4043cc.md) Phase 1
- [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 2
- Urinary bladder cancer Phase 3
- [Urinary bladder neoplasm](https://trialight.com/data/condition/urinary-bladder-neoplasm-269fb796-5527-5895-bad6-63dc153c3401.md) Phase 3
- [Urothelial carcinoma](https://trialight.com/data/condition/urothelial-carcinoma-b2aa266d-2d5f-5e5d-a0de-62274f2dc094.md) Phase 3

### Other linked conditions (1)

- [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md)

### Targets (1)

- [PDCD1](https://trialight.com/data/target/pdcd1-a7b9a076-9fdd-55c9-9ce8-e558e5c7503f.md) Programmed cell death protein 1 inhibitor

---

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