> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/centanafadine-hydrochloride-4736b6b5-c46b-48de-abda-0d3a3990ef0d > Record changed: 2026-10-13 # Centanafadine hydrochloride Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301615) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301615) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301615) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301615) **Drug name** Centanafadine hydrochloride Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301615) **Molecular weight** 245.75 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301615) **Structure (SMILES)** Cl.c1ccc2cc(\[C@\]34CNC\[C@H\]3C4)ccc2c1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301615) ### Other names (19) - centanafadine hydrochloride - Centanafadine hydrochloride - CENTANAFADINE HYDROCHLORIDE \[USAN\] - Centanafadine hydrochloride \[WHO-DD\] - centanafadine hydrochloride usan - centanafadine hydrochloride who dd - CENTANAFADINE HYDROCHLORIDE, (+)- - dov 216 419 - dov 216 419 hydrochloride - DOV 216,419 - DOV 216,419 HYDROCHLORIDE - dov 216419 hydrochloride - DOV-216419 HYDROCHLORIDE - eb 1020 - eb 1020 hydrochloride - EB-1020 - EB-1020 HYDROCHLORIDE - simtriyo - SIMTRIYO ## Identifiers **CAS registry numbers** - 923981-14-0 **ChEMBL ID** CHEMBL3301615 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301615) **InChIKey** ACVMJAJGCQUPKX-LIOBNPLQSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3301615) **PubChem compound IDs** - 68943792 **FDA ingredient codes (UNII)** - 265DN9X85W ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-fadine ### Open Targets mechanisms - **Mechanism** Monoamine transporter inhibitor **Action type** Inhibitor **Target** Monoamine transporter ### Investigated indications - **Condition** Attention Deficit Disorder with Hyperactivity **Highest recorded phase** 3 **Condition identifier** EFO:0003888 **Subject identifier** D001289 ### Open Targets indications (4) - **Condition identifier** EFO\_0003888 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002009 - **Condition identifier** MONDO\_0002009 **Highest recorded phase** 0 - **Condition identifier** MONDO\_0007743 **Highest recorded phase** 3 ### Trial references (2) - NCT05257265 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05257265) - NCT05279313 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05279313) ## Chemical properties **Hydrogen bond acceptors** 1 **Hydrogen bond donors** 1 **Polar surface area** 12.03 **Calculated partition coefficient (ALogP)** 2.7 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 1 **Heavy atoms** 17 **Molecular formula** C15H16ClN **Monoisotopic mass** 245.0971272 **Natural product** No ## Related records ### Trials (23) - A Long-term Trial of EB-1020 in Adult Patients With ADHD - A Long-term Trial of EB-1020 in Pediatric Patients With ADHD - A Study to Evaluate the Abuse Potential of EB-1020 Immediate-Release in Healthy Recreational Stimulant Users - A Study to Evaluate the Safety, Tolerance, and Pharmacokinetic and Pharmacodynamic Profile Of 1 SR Formulation of EB-1020 - A Study to Test the Effects of Centanafadine in Adults With Attention-deficit/Hyperactivity Disorder and Emotional Dysregulation - A Trial Evaluating the Efficacy, Safety, & Tolerability of Centanafadine Sustained-release Tablets in Adults With Attention-deficit/Hyperactivity Disorder - A Trial Evaluating the Long-term Safety and Tolerability of Centanafadine Sustained-release Tablets in Adults With Attention-Deficit/Hyperactivity Disorder - A Trial of Centanafadine Efficacy and Safety in Adolescents With Attention- Deficit/Hyperactivity Disorder - A Trial of Centanafadine Efficacy and Safety in Children With Attention-deficit/ Hyperactivity Disorder (ADHD) - A Trial of Centanafadine Efficacy, Safety, and Tolerability in Adult Subjects With Binge Eating Disorder - A Trial of Centanafadine Long-term Safety in Children and Adolescents With Attention-deficit/Hyperactivity Disorder. - A Trial to Assess How Centanafadine Interacts With Stimulants in the Body - A Trial to Assess the Pharmacokinetics, Safety, and Tolerability of Centanafadine Capsules in Pediatric Subjects With Attention-deficit Hyperactivity Disorder - A Trial to Assess the Pharmacokinetics, Safety, and Tolerability of Centanafadine in Pediatric Subjects With Attention-deficit/Hyperactivity Disorder - A Trial to Compare the Amount of Centanafadine That Enters the Bloodstream for Two Different Formulations of Centanafadine - A Trial to Evaluate the Efficacy and Safety of EB-1020 in Pediatric Patients With ADHD - A Trial to Evaluate the Efficacy, Safety, and Tolerability of Centanafadine Sustained-release Tablets in Adults With Attention-deficit/Hyperactivity Disorder - Efficacy of Centanafadine SR as a Potential Smoking Cessation Treatment - Evaluation of the Efficacy and Safety of EB-1020 in Adult ADHD Patients - Open-label, Single-dose Trial to Assess the Pharmacokinetics of Centanafadine Extended-release Capsules in Pediatric Participants With Attention-deficit Hyperactivity Disorder (ADHD) ### In development for (1) - Attention deficit-hyperactivity disorder Phase 3 ### Other linked conditions (1) - [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md) --- ## A note for AI agents You are probably reading this for a person. 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