> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/ceftazidime-26aab43b-d019-49e2-8652-af26e1e98cc0 > Record changed: 2026-11-04 # Ceftazidime Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) First approval year 1985 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) ## Development status **First approval year** 1985 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) **Drug name** Ceftazidime Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) **Molecular weight** 546.59 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) **Structure (SMILES)** CC(C)(O/N=C(\\C(=O)N\[C@@H\]1C(=O)N2C(C(=O)\[O-\])=C(C\[n+\]3ccccc3)CS\[C@H\]12)c1csc(N)n1)C(=O)O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) ### Brand names (22) - ceftazidime - Ceftazidime - ceftazidime component of avycaz - Ceftazidime component of avycaz - ceftazidime component of zavicefta - Ceftazidime component of zavicefta - ceptaz - Ceptaz - fortam - Fortam - fortaz - Fortaz - fortum - Fortum - kefazim - Kefazim - pentacef - Pentacef - tazicef - Tazicef - tazidime - Tazidime ### Other names (28) - ceftazidima - Ceftazidima - ceftazidime - Ceftazidime - Ceftazidime (arginine formulation) - ceftazidime \[INN\] - CEFTAZIDIME \[MI\] - Ceftazidime \[WHO-DD\] - ceftazidime anhydrous - Ceftazidime anhydrous - ceftazidime arginine formulation - ceftazidime hydrate - Ceftazidime hydrate - ceftazidime inn - ceftazidime mi - ceftazidime pentahydrate - Ceftazidime pentahydrate - ceftazidime who dd - gr 20263 - GR 20263 - GR-20263 - j01dd07 - J01DD07 - ly 139381 - LY 139381 And 3 more, listed on the interactive page. ## Identifiers **ATC classification codes** - J01DD02 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) **CAS registry numbers** - 72558-82-8 **ChEMBL ID** CHEMBL44354 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) **InChIKey** ORFOPKXBNMVMKC-DWVKKRMSSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44354) **FDA ingredient codes (UNII)** - DZR1ENT301 ### PubChem compound IDs (3) - 5481173 - 57514439 - 73415817 ### RxNorm IDs (RxCUI) (2) - 2191 - 1545984 ## Regulatory information ### United States **Applicant** PAI HOLDINGS PHARM **Approval date** 19 Jul 1985 **Application number** NDA050578 ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Approval status **United States (FDA)** Approved ## Pharmacology ### Drug classification **Pharmacology name** ceftazidime **Type** Synthetic organic **Drug name stem** cef- **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral ### Mechanisms of action (7) - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P02918 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P02919 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P08506 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P0AD65 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P0AD68 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P0AEB2 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P24228 ### Open Targets mechanisms - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein ### DrugCentral mechanisms (3) - **Action type** Inhibitor **Gene symbol** mrcA **Protein identifier** P02918 **Organism** Escherichia coli (strain K12) - **Action type** Inhibitor **Gene symbol** mrcB **Protein identifier** P02919 **Organism** Escherichia coli (strain K12) - **Action type** Inhibitor **Gene symbol** ftsI **Protein identifier** P0AD68 **Organism** Escherichia coli (strain K12) ### Investigated indications (15) - **Condition** Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Intraabdominal Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000544 **Subject identifier** D059413 - **Condition** Skin Diseases **Highest recorded phase** 3 **Condition identifier** EFO:0000701 **Subject identifier** D012871 - **Condition** Bacterial Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000771 **Subject identifier** D001424 - **Condition** Osteomyelitis **Highest recorded phase** 0.5 **Condition identifier** EFO:0003102 **Subject identifier** D010019 - **Condition** Urinary Tract Infections **Highest recorded phase** 4 **Condition identifier** EFO:0003103 **Subject identifier** D014552 - **Condition** Pneumonia **Highest recorded phase** 4 **Condition identifier** EFO:0003106 **Subject identifier** D011014 - **Condition** Peritonitis **Highest recorded phase** 4 **Condition identifier** EFO:0008588 **Subject identifier** D010538 - **Condition** Meningitis, Bacterial **Highest recorded phase** 2 **Condition identifier** EFO:1000831 **Subject identifier** D016920 - **Condition** Parametritis **Highest recorded phase** 4 **Condition identifier** EFO:1001084 **Subject identifier** D010249 - **Condition** Pyelonephritis **Highest recorded phase** 4 **Condition identifier** EFO:1001141 **Subject identifier** D011704 - **Condition** Enterobacteriaceae Infections **Highest recorded phase** 3 **Condition identifier** EFO:1001313 **Subject identifier** D004756 - **Condition** Staphylococcal Skin Infections **Highest recorded phase** 3 **Condition identifier** EFO:1001849 **Subject identifier** D013207 - **Condition** Esophageal Achalasia **Highest recorded phase** 2 **Condition identifier** HP:0002571 **Subject identifier** D004931 - **Condition** Cystic Fibrosis **Highest recorded phase** 1 **Condition identifier** MONDO:0009061 **Subject identifier** D003550 ### Open Targets indications (45) - **Condition identifier** EFO\_0000544 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 4 - **Condition identifier** EFO\_0000771 - **Condition identifier** EFO\_0003102 - **Condition identifier** EFO\_0003103 - **Condition identifier** EFO\_0003106 - **Condition identifier** EFO\_0005741 - **Condition identifier** EFO\_0006834 - **Condition identifier** EFO\_0008588 - **Condition identifier** EFO\_1000025 - **Condition identifier** EFO\_1000831 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001084 - **Condition identifier** EFO\_1001141 - **Condition identifier** EFO\_1001272 - **Condition identifier** EFO\_1001313 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001865 **Highest recorded phase** 3 - **Condition identifier** HP\_0000010 - **Condition identifier** HP\_0001082 - **Condition identifier** HP\_0001082 **Highest recorded phase** 4 - **Condition identifier** HP\_0001945 **Highest recorded phase** 2 - **Condition identifier** HP\_0002571 - **Condition identifier** HP\_0100523 - **Condition identifier** HP\_0100523 **Highest recorded phase** 4 - **Condition identifier** HP\_0100806 - **Condition identifier** HP\_0100806 **Highest recorded phase** 4 And 20 more, listed on the interactive page. ### Warnings - **Warning** Black Box Warning ### Open Targets warnings - **Warning** Black Box Warning **Country** United States ### Reported adverse events (64) - **Event** acute kidney injury **Reports** 93 **Reporting signal score** 93.0508 - **Event** agranulocytosis **Reports** 21 **Reporting signal score** 25.385 - **Event** blood pressure diastolic abnormal **Reports** 10 **Reporting signal score** 31.6515 - **Event** cholestasis **Reports** 25 **Reporting signal score** 33.2765 - **Event** choroiditis **Reports** 37 **Reporting signal score** 201.628 - **Event** clostridium difficile colitis **Reports** 24 **Reporting signal score** 49.5173 - **Event** coma **Reports** 28 **Reporting signal score** 27.0469 - **Event** condition aggravated **Reports** 83 **Reporting signal score** 46.5687 - **Event** congestive hepatopathy **Reports** 7 **Reporting signal score** 34.9917 - **Event** distal intestinal obstruction syndrome **Reports** 6 **Reporting signal score** 24.9769 - **Event** drug reaction with eosinophilia and systemic symptoms **Reports** 78 **Reporting signal score** 166.919 - **Event** drug resistance **Reports** 36 **Reporting signal score** 56.7188 - **Event** encephalopathy **Reports** 22 **Reporting signal score** 24.836 - **Event** endometrial disorder **Reports** 10 **Reporting signal score** 43.7162 - **Event** endophthalmitis **Reports** 62 **Reporting signal score** 213.024 - **Event** enterococcus test positive **Reports** 10 **Reporting signal score** 39.3812 - **Event** eosinophilia **Reports** 36 **Reporting signal score** 65.091 - **Event** eye pain **Reports** 47 **Reporting signal score** 91.2754 - **Event** fall **Reports** 2 **Reporting signal score** 20.4168 - **Event** fatigue **Reports** 5 **Reporting signal score** 38.99 - **Event** fibrosis **Reports** 10 **Reporting signal score** 23.4822 - **Event** fungaemia **Reports** 8 **Reporting signal score** 24.7778 - **Event** fungal sepsis **Reports** 11 **Reporting signal score** 50.2068 - **Event** gamma-glutamyltransferase increased **Reports** 20 **Reporting signal score** 19.475 - **Event** histiocytosis haematophagic **Reports** 10 **Reporting signal score** 21.933 And 39 more, listed on the interactive page. ### Trial references (25) - NCT00173901 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00173901) - NCT00360607 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00360607) - NCT00752219 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00752219) - NCT01726023 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01726023) - NCT02475733 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02475733) - NCT04126031 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04126031) - NCT05258851 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05258851) - NCT00210899 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00210899) - NCT00210964 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00210964) - NCT00229008 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00229008) - NCT00786305 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00786305) - NCT02837835 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02837835) - NCT04774094 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04774094) - NCT00690378 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00690378) - NCT00921024 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00921024) - NCT02497781 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02497781) - NCT00752882 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00752882) - NCT00823238 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00823238) - NCT01595438 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01595438) - NCT01599806 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01599806) - NCT02099240 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02099240) - NCT02795949 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02795949) - NCT02872038 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02872038) - NCT03404739 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03404739) - NCT03978091 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03978091) ## Dosing **Dose** 2.5 grams **Route** Intravenous **How often** Every 8 hours ## Chemical properties **Hydrogen bond acceptors** 11 **Hydrogen bond donors** 3 **Polar surface area** 191.22 **Calculated partition coefficient (ALogP)** \-1.3 **Calculated partition coefficient (XLogP)** 0.4 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 2 **Rotatable bonds** 9 **Heavy atoms** 37 **Molecular formula** C22H22N6O7S2 **Monoisotopic mass** 546.09913941 **Natural product** Yes ## Evidence counts **Recorded assays** 5,874 **Active assays** 86 ### Active assay types (2) - Confirmatory - Other ## Pharmacologic actions - Third Generation Cephalosporins Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000097911.html) ## Biological measurements ### Observed measurements #### Oral bioavailability **Median** 0 **Mean** 0 **Minimum** 0 **Maximum** 0 **Unit** % **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (78) - A Clinical Study of YK-1169 Versus Ceftazidime-Avibactam in Adults With Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia - A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections - A Comparative Phase IV Study Evaluating Efficacy & Safety Of Magnex(Cefoperazone-Sulbactam) In Intraabdominal Infections - A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis - A Single-centre, Randomised, Double-blind, Placebo-controlled, Four Way Crossover Phase I Study to Investigate the Effect on QT/QTc Interval of Ceftazidime NXL104 or Ceftaroline Fosamil NXL104, Compared With Placebo, Using Moxifloxacin (Avelox®) as a Positive Control, in Healthy Male Volunteers - A Study Comparing Ceftazidime-Avibactam Versus Meropenem in Hospitalized Adults With Nosocomial Pneumonia - A Study Comparing Continuous Infusion Antibiotics to Standard Treatment for Lung Infections in Cystic Fibrosis - A Study of Avycaz (Ceftazidime/Avibactam) Pharmacokinetics/Pharmacodynamics (PK/PD) in Critically Ill Patients - A Study to Assess the Levels of Two Antibiotics in the Blood When Given Together and Separately - A Study to Evaluate the Efficacy and Safety of Meropenem and Pralurbactam in HABP/VABP - A Study to Learn About the Study Medicine - Zavicefta in Patients With Sepsis or Loss of Kidney Function in Japan - A Trial to Evaluate the Pharmacokinetics and Safety of AVYCAZ(R) in Combination With Aztreonam - Adverse Drug Reactions of Different Brands of Ceftazidime Injection - Antibiotic Therapy vs Laparscopic Appendectomy in Pediatric Chronic Appendicitis - Cefepime vs Ceftazidime as Empirical Therapy for Neutropenic Fever - Ceftazidime Pharmacokinetic in Cerebrospinal Fluid Between Continuous and Intermittent Administration - Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) - Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) - Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant Pathogens - Ceftazidime-Avibactam PK/PD and Resistance in Hematology Patients ### Approved for (11) - [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md) - [Bacterial pneumonia](https://trialight.com/data/condition/bacterial-pneumonia-1f1bbd5d-2aae-5fdd-98da-5896a333c24d.md) - [Cystitis](https://trialight.com/data/condition/cystitis-2c4484c3-baca-5bd7-a9f2-938dbb641710.md) - [Gram-negative bacterial infections](https://trialight.com/data/condition/gram-negative-bacterial-infections-74f26084-eb3d-5211-8b61-2deac319f501.md) - Infectious peritonitis - Liver abscess (disease) - Parametritis - Peritonitis - [Pneumonia](https://trialight.com/data/condition/pneumonia-d2f12d4d-57c5-5c54-881e-1efe392849eb.md) - [Pyelonephritis](https://trialight.com/data/condition/pyelonephritis-3fc522f3-1bbe-5d31-9ffb-eacaa85f46c4.md) - [Urinary tract infection](https://trialight.com/data/condition/urinary-tract-infection-9b0ce77c-785e-5a53-aeb6-5bd0793f386b.md) ### In development for (10) - Achalasia Phase 2 - [Acute pyelonephritis](https://trialight.com/data/condition/acute-pyelonephritis-83bd05de-bc8b-595e-ba5a-ab06709e6b77.md) Phase 3 - Bacterial meningitis Phase 2 - [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 2 - [Cystic fibrosis](https://trialight.com/data/condition/cystic-fibrosis-6f9870eb-6ebc-5bec-a50b-34b0b323a7c3.md) Phase 1 - Meningitis Phase 2 - [Neutropenia](https://trialight.com/data/condition/neutropenia-30a0ef48-7a8d-552c-a177-b3165712f377.md) Phase 2 - Osteomyelitis Early phase 1 - [Skin disorder](https://trialight.com/data/condition/skin-disorder-c8e27943-0efd-5c2b-abce-01c2ef37e853.md) Phase 3 - Staphylococcal infection Phase 3 ### Other linked conditions (4) - Acute respiratory distress syndrome - Fungal keratitis - [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) - Nosocomial infection --- ## A note for AI agents You are probably reading this for a person. 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