> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/carfilzomib-42f49602-1f34-4e14-b345-79d6fd69324f > Record changed: 2026-10-13 # Carfilzomib Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) First approval year 2009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) ## Development status **First approval year** 2009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) **Drug name** Carfilzomib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) **Molecular weight** 719.92 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) **Structure (SMILES)** CC(C)C\[C@H\](NC(=O)\[C@H\](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N\[C@@H\](Cc1ccccc1)C(=O)N\[C@@H\](CC(C)C)C(=O)\[C@@\]1(C)CO1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) ### Brand names (2) - kyprolis - Kyprolis ### Other names (30) - (2S)-N-\[(1S)-1-Benzyl-2-\[\[(1S)-3-methyl-1-\[\[(2R)-2-methyloxiran-2-yl\]carbonyl\]butyl\]amino\]-2-oxoethyl\]-4-methyl-2-\[\[(2S)-2-\[(morpholin-4-ylacetyl)amino\]-4-phenylbutanoyl\]amino\]pentanamide - 2s n 1s 1 benzyl 2 1s 3 methyl 1 2r 2 methyloxiran 2 yl carbonyl butyl amino 2 oxoethyl 4 methyl 2 2s 2 morpholin 4 ylacetyl amino 4 phenylbutanoyl amino pentanamide - carfilzomib - Carfilzomib - carfilzomib (infusion) - carfilzomib \[INN\] - CARFILZOMIB \[JAN\] - CARFILZOMIB \[MI\] - CARFILZOMIB \[ORANGE BOOK\] - CARFILZOMIB \[USAN\] - CARFILZOMIB \[VANDF\] - Carfilzomib \[WHO-DD\] - Carfilzomib Injection - carfilzomib inn - carfilzomib jan - carfilzomib mi - carfilzomib orange book - carfilzomib usan - carfilzomib vandf - carfilzomib who dd - Drug: Carfilzomib - kitprozy - KITPROZY - Kyprolis - l phenylalaninamide alpha s alpha 4 morpholinylacetyl amino benzenebutanoyl l leucyl n 1s 3 methyl 1 2r 2 methyloxiranyl carbonyl butyl And 5 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 868540-17-4 **ChEMBL ID** CHEMBL451887 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) **InChIKey** BLMPQMFVWMYDKT-NZTKNTHTSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) **PubChem compound IDs** - 11556711 **RxNorm IDs (RxCUI)** - 1302966 **FDA ingredient codes (UNII)** - 72X6E3J5AR ### ATC classification codes (2) - L01XG02 - L01XX45 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL451887) ## Regulatory information ### United States **Applicant** ONYX PHARMS AMGEN **Approval date** 20 Jul 2012 **Application number** NDA202714 ### European Union **Status** Authorised **Status date** 19 Nov 2015 **Authorisation date** 19 Nov 2015 **Approved indications** Kyprolis in combination with daratumumab and dexamethasone, with lenalidomide and dexamethasone, or with dexamethasone alone is indicated for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. **Product number** EMEA/H/C/003790 **Authorisation holder** Amgen Europe B.V. **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** Yes **Exceptional circumstances** No #### Therapeutic areas - Multiple Myeloma European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/kyprolis) ### Other regulatory facts **Patents** 8 **Designations** 3 **Earliest recorded loss of exclusivity** 27 Aug 2033 **First in class** No **Fast track** Yes **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** Yes **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** carfilzomib **Type** Synthetic organic **Drug name stem** \-zomib **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral ### Mechanisms of action (39) - **Action** Inhibition **Action type** Inhibitor **Target** proteasome 20S subunit beta 5 **Gene symbol** PSMB5 **Protein identifier** P28074 **Median affinity** 8.24 **Affinity units** pIC50 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** A5LHX3 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** O00231 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** O00232 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** O00487 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** O14818 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** O43242 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P17980 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P20618 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P25786 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P25787 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P25788 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P25789 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P28062 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P28065 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P28066 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P28070 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P28072 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P28074 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P35998 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P40306 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P43686 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P48556 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P49720 - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome **Protein identifier** P49721 And 14 more, listed on the interactive page. ### Open Targets mechanisms - **Mechanism** 26S proteasome inhibitor **Action type** Inhibitor **Target** 26S proteasome ### DrugCentral mechanisms - **Action type** Inhibitor **Gene symbol** PSMB5 **Protein identifier** P28074 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (31) - **Condition** Leukemia, Lymphocytic, Chronic, B-Cell **Highest recorded phase** 1 **Condition identifier** EFO:0000095 **Subject identifier** D015451 - **Condition** Lymphoma, Follicular **Highest recorded phase** 2 **Condition identifier** EFO:0000096 **Subject identifier** D008224 - **Condition** Hodgkin Disease **Highest recorded phase** 1 **Condition identifier** EFO:0000183 **Subject identifier** D006689 - **Condition** Lymphoma, T-Cell, Peripheral **Highest recorded phase** 1 **Condition identifier** EFO:0000211 **Subject identifier** D016411 - **Condition** Precursor Cell Lymphoblastic Leukemia-Lymphoma **Highest recorded phase** 1 **Condition identifier** EFO:0000220 **Subject identifier** D054198 - **Condition** Leukemia, Myeloid, Acute **Highest recorded phase** 1 **Condition identifier** EFO:0000222 **Subject identifier** D015470 - **Condition** Lymphoma, Large B-Cell, Diffuse **Highest recorded phase** 1 **Condition identifier** EFO:0000403 **Subject identifier** D016403 - **Condition** Leukemia **Highest recorded phase** 1 **Condition identifier** EFO:0000565 **Subject identifier** D007938 - **Condition** Lymphoma **Highest recorded phase** 2 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Small Cell Lung Carcinoma **Highest recorded phase** 1 **Condition identifier** EFO:0000702 **Subject identifier** D055752 - **Condition** Multiple Myeloma **Highest recorded phase** 4 **Condition identifier** EFO:0001378 **Subject identifier** D009101 - **Condition** Lymphoma, T-Cell, Cutaneous **Highest recorded phase** 1 **Condition identifier** EFO:0002913 **Subject identifier** D016410 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 1 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Smoldering Multiple Myeloma **Highest recorded phase** 2 **Condition identifier** EFO:0003073 **Subject identifier** D000075122 - **Condition** Lymphoma, Non-Hodgkin **Highest recorded phase** 1 **Condition identifier** EFO:0005952 **Subject identifier** D008228 - **Condition** Leukemia, Plasma Cell **Highest recorded phase** 1 **Condition identifier** EFO:0006475 **Subject identifier** D007952 - **Condition** Plasmacytoma **Highest recorded phase** 1 **Condition identifier** EFO:0006738 **Subject identifier** D010954 - **Condition** Waldenstrom Macroglobulinemia **Highest recorded phase** 2 **Condition identifier** EFO:0009441 **Subject identifier** D008258 - **Condition** Sezary Syndrome **Highest recorded phase** 1 **Condition identifier** EFO:1000785 **Subject identifier** D012751 - **Condition** Mycosis Fungoides **Highest recorded phase** 1 **Condition identifier** EFO:1001051 **Subject identifier** D009182 - **Condition** Lymphoma, Mantle-Cell **Highest recorded phase** 2 **Condition identifier** EFO:1001469 **Subject identifier** D020522 - **Condition** Amyloidosis **Highest recorded phase** 1 **Condition identifier** EFO:1001875 **Subject identifier** D000686 - **Condition** Leukemia, Prolymphocytic **Highest recorded phase** 1 **Condition identifier** MONDO:0001023 **Subject identifier** D015463 - **Condition** Carcinoma, Neuroendocrine **Highest recorded phase** 2 **Condition identifier** MONDO:0002120 **Subject identifier** D018278 And 6 more, listed on the interactive page. ### Open Targets indications (54) - **Condition identifier** EFO\_0000095 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000211 - **Condition identifier** EFO\_0000565 - **Condition identifier** EFO\_0000574 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0000702 - **Condition identifier** EFO\_0001378 - **Condition identifier** EFO\_0003060 - **Condition identifier** EFO\_0009441 **Highest recorded phase** 2 - **Condition identifier** EFO\_0009909 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0000430 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0000607 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0001023 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0002120 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002367 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004948 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004949 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004952 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004964 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004967 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004977 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004992 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005005 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005059 **Highest recorded phase** 1 And 29 more, listed on the interactive page. ### Reported adverse events (11) - **Event** acute kidney injury **Reports** 291 **Reporting signal score** 119.536 - **Event** cardiac failure **Reports** 208 **Reporting signal score** 177.458 - **Event** cytopenia **Reports** 103 **Reporting signal score** 172.984 - **Event** disease progression **Reports** 230 **Reporting signal score** 131.471 - **Event** intercepted product preparation error **Reports** 186 **Reporting signal score** 486.565 - **Event** plasma cell myeloma **Reports** 538 **Reporting signal score** 1,221.57 - **Event** plasma cell myeloma recurrent **Reports** 67 **Reporting signal score** 155.212 - **Event** pneumonia **Reports** 410 **Reporting signal score** 130.487 - **Event** thrombocytopenia **Reports** 401 **Reporting signal score** 269.414 - **Event** thrombotic microangiopathy **Reports** 111 **Reporting signal score** 204.435 - **Event** unevaluable event **Reports** 162 **Reporting signal score** 118.208 ### Trial references (193) - NCT00511238 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00511238) - NCT00530816 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00530816) - NCT00603447 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00603447) - NCT00721734 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00721734) - NCT00884312 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00884312) - NCT01029054 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01029054) - NCT01057225 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01057225) - NCT01080391 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01080391) - NCT01246063 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01246063) - NCT01279694 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01279694) - NCT01297764 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01297764) - NCT01301807 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01301807) - NCT01302392 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01302392) - NCT01346787 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01346787) - NCT01351623 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01351623) - NCT01365559 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01365559) - NCT01372540 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01372540) - NCT01402284 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01402284) - NCT01464034 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01464034) - NCT01496118 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01496118) - NCT01537861 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01537861) - NCT01549431 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01549431) - NCT01554852 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01554852) - NCT01559935 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01559935) - NCT01568866 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01568866) And 168 more, listed on the interactive page. ## Dosing **Dose** 20/70 mg/m2 **Route** Intravenous **How often** Once weekly ### Conditions of use (2) - Administer as a 30-minute infusion - Administer on Days 1, 8, and 15 of each 28-day cycle ## Chemical properties **Hydrogen bond acceptors** 8 **Hydrogen bond donors** 4 **Polar surface area** 158.47 **Calculated partition coefficient (ALogP)** 2.58 **Calculated partition coefficient (XLogP)** 4.7 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 20 **Heavy atoms** 52 **Molecular formula** C40H57N5O7 **Monoisotopic mass** 719.42579917 **Natural product** Yes ## National Drug Codes - 76075-101 - 76075-102 - 76075-103 ## Evidence counts **Recorded assays** 1,511 **Active assays** 770 ### Active assay types (3) - Confirmatory - Screening - Summary ## Biological measurements These details could not be displayed. ## Related records ### Trials (624) - 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy - 3D PET Myocardial Blood Flow and Rb82 Infusion Profiles - 4SCAR-T Therapy Post CD19-targeted Immunotherapy - A Basket Study of CTA313 in Participants With Active Autoimmune Diseases - A Clinical Research About CD70-targeted CAR-NKT Cells Therapy Advanced Malignant Solid Tumors - A Clinical Study Evaluating the Safety and Efficacy of BCMA-GPRC5D CAR-T in Patients With Relapsed/Refractory Multiple Myeloma Who Have Received Three or More Lines of Treatment - A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer - A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer - A Clinical Study of CD19 CAR-T in Active Systemic Lupus Erythematosus - A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors - A Clinical Study of T3011 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer - A Clinical Study on the Safety, Tolerance, and Preliminary Efficacy of γδ-T Cell Injection in the Treatment of Advanced Bladder Cancer - A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma - A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma - A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis - A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion - A Hypoxia-Inducible CAR-T Cell Targeting AXL and CD73 for Advanced Gastric Cancer - A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy - A Multicenter, Open-label, Phase 1b Study of Carfilzomib, Cyclophosphamide and Dexamethasone in Newly Diagnosed Multiple Myeloma Subjects - A Nationwide Phase 2 Trial of Patients With Smoldering and Active Multiple Myeloma (MM) ### Approved for (3) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Neoplasm - [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) ### In development for (28) - Acute lymphoblastic leukemia Phase 1 - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 1 - [Amyloidosis](https://trialight.com/data/condition/amyloidosis-b8b4cb9d-0eae-5851-8654-8d69fd195e67.md) Phase 1 - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 1 - Chronic graft versus host disease Phase 2 - [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 1 - [Follicular lymphoma](https://trialight.com/data/condition/follicular-lymphoma-88de1ce9-ab0e-5d65-85c4-45a681fa2931.md) Phase 2 - Hodgkins lymphoma Phase 1 - Kidney cancer Phase 2 - [Leukemia](https://trialight.com/data/condition/leukemia-519aefcd-8521-5941-851b-5b77ca925ca5.md) Phase 1 - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 2 - [Mantle cell lymphoma](https://trialight.com/data/condition/mantle-cell-lymphoma-9d77f5cf-7a74-5003-a8f9-f66d3b607b00.md) Phase 2 - [Mycosis fungoides](https://trialight.com/data/condition/mycosis-fungoides-dfed1f75-762a-528c-b446-218ae612379e.md) Phase 1 - Neoplasm of mature B-cells Phase 2 - [Neuroendocrine carcinoma](https://trialight.com/data/condition/neuroendocrine-carcinoma-66cf52f3-045d-597f-80d3-d7a422d5ef1c.md) Phase 2 - [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 1 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 1 - Peripheral T-cell lymphoma, not otherwise specified Phase 1 - Plasma cell leukemia Phase 1 - Plasmacytoma Phase 1 ### Targets (38) - [ADRM1](https://trialight.com/data/target/adrm1-21aacba2-e414-54a6-9f55-4bf543c44c62.md) 26S proteasome inhibitor - [PSMA1](https://trialight.com/data/target/psma1-1a956ca8-78e9-55cf-b44b-560f5cfb1ba8.md) 26S proteasome inhibitor - [PSMA2](https://trialight.com/data/target/psma2-b6cdbdc0-82f0-5196-899c-7b9432c6cdda.md) 26S proteasome inhibitor - [PSMA3](https://trialight.com/data/target/psma3-a2764924-6b4d-5acf-9eff-dbea2141aa2f.md) 26S proteasome inhibitor - [PSMA4](https://trialight.com/data/target/psma4-593e4b71-d38d-502d-8b54-c8007dcaa3fd.md) 26S proteasome inhibitor - [PSMA5](https://trialight.com/data/target/psma5-b00fc409-cd81-57ea-a85a-fe4cb526fcb3.md) 26S proteasome inhibitor - [PSMA6](https://trialight.com/data/target/psma6-bad5198f-7678-5327-b1ac-6a30d99e444d.md) 26S proteasome inhibitor - [PSMA7](https://trialight.com/data/target/psma7-b2a4597f-767f-5e0d-9db6-b84884d029a3.md) 26S proteasome inhibitor - [PSMA8](https://trialight.com/data/target/psma8-fe91f265-3b28-517b-a83f-80ecefdabadb.md) 26S proteasome inhibitor - [PSMB1](https://trialight.com/data/target/psmb1-3b057ce7-508d-57c4-a183-4fe8471ad0ef.md) 26S proteasome inhibitor - [PSMB10](https://trialight.com/data/target/psmb10-44bce842-f863-5480-936a-3f039f83fc4d.md) 26S proteasome inhibitor - [PSMB11](https://trialight.com/data/target/psmb11-d76fbce1-5b6a-50fc-88d6-5e31b147d0a3.md) 26S proteasome inhibitor - [PSMB2](https://trialight.com/data/target/psmb2-d67cfad8-2c3c-5c37-ae3e-74f480c7f6d1.md) 26S proteasome inhibitor - [PSMB3](https://trialight.com/data/target/psmb3-062cecb0-b4fa-5d3a-987f-d5525d28dd23.md) 26S proteasome inhibitor - [PSMB4](https://trialight.com/data/target/psmb4-0affe5ee-8158-586b-9014-48077b633172.md) 26S proteasome inhibitor - [PSMB5](https://trialight.com/data/target/psmb5-593cbddb-d269-5860-be8a-c9226d3b3327.md) 26S proteasome inhibitor - [PSMB6](https://trialight.com/data/target/psmb6-f162b589-24bb-5635-b139-99c13a674f11.md) 26S proteasome inhibitor - [PSMB7](https://trialight.com/data/target/psmb7-47ccd5bc-2399-599a-82f0-4a88363bb74f.md) 26S proteasome inhibitor - [PSMB8](https://trialight.com/data/target/psmb8-a231f88c-6972-5fe6-b9a2-1ed268a9085b.md) 26S proteasome inhibitor - [PSMB9](https://trialight.com/data/target/psmb9-360db099-af82-5f0e-b96d-185d2d320a63.md) 26S proteasome inhibitor --- ## A note for AI agents You are probably reading this for a person. 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