> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e
> Record changed: 2026-10-13

# Carboplatin

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1351)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1351)

First approval year

1989

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1351)

## Development status

**First approval year**

1989

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1351)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1351)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1351)

**Drug name**

Carboplatin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1351)

**Molecular weight**

371.25

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1351)

**Structure (SMILES)**

C1CC(C1)(C(=O)\[O-\])C(=O)\[O-\].N.\[Pt+2\].N

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/BG3F62OND5)

### Brand names (4)

- carboplatin
- Carboplatin
- paraplatin
- Paraplatin

### Other names (76)

- 5fu paraplatin
- carboplatin
- Carboplatin
- CARBOPLATIN
- Carboplatin (area under the concentration curve \[AUC\] 6)
- Carboplatin (AUC 5)
- Carboplatin (Carboplatin Kabi)
- carboplatin (Cb)
- Carboplatin (dose level 1)
- Carboplatin (dose level 2)
- Carboplatin (Induction)
- Carboplatin (Investigator discretion)
- Carboplatin (not mandatory)
- Carboplatin (or cisplatin if carboplatin is not tolerated)
- carboplatin (palaplatin)
- Carboplatin (standard of care)
- CARBOPLATIN \[EP IMPURITY\]
- CARBOPLATIN \[EP MONOGRAPH\]
- CARBOPLATIN \[HSDB\]
- carboplatin \[INN\]
- CARBOPLATIN \[JAN\]
- CARBOPLATIN \[MART.\]
- CARBOPLATIN \[MI\]
- CARBOPLATIN \[ORANGE BOOK\]
- CARBOPLATIN \[USAN\]

And 51 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- L01XA02

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1351)

**CAS registry numbers**

- 41575-94-4

**ChEMBL ID**

CHEMBL1351

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1351)

**InChIKey**

OLESAACUTLOWQZ-UHFFFAOYSA-L

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/BG3F62OND5)

**PubChem compound IDs**

- 10339178

**RxNorm IDs (RxCUI)**

- 40048

**FDA ingredient codes (UNII)**

- BG3F62OND5

## Regulatory information

### United States

**Applicant**

AVYXA HOLDINGS

**Approval date**

8 Aug 2025

**Application number**

NDA219921

### Other regulatory facts

**Patents**

1

**Designations**

2

**Earliest recorded loss of exclusivity**

1 Apr 2045

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

Yes

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

**Boxed warning**

Yes

## Pharmacology

### Drug classification

**Pharmacology name**

carboplatin

**Type**

Inorganic

**Drug name stem**

\-platin

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Parenteral

### Mechanisms of action

- **Mechanism**  
DNA inhibitor

**Action type**  
Inhibitor

**Target**  
DNA

### Investigated indications (197)

- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000096

**Subject identifier**  
D008224
- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000181

**Subject identifier**  
D002294
- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Hodgkin Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000183

**Subject identifier**  
D006689
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000196

**Subject identifier**  
D011471
- **Condition**  
Myelodysplastic Syndromes

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000198

**Subject identifier**  
D009190
- **Condition**  
Squamous Cell Carcinoma of Head and Neck

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000199

**Subject identifier**  
D000077195
- **Condition**  
Neoplasms, Plasma Cell

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000200

**Subject identifier**  
D054219
- **Condition**  
Leukemia, Myeloid, Acute

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000222

**Subject identifier**  
D015470
- **Condition**  
Adenocarcinoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000228

**Subject identifier**  
D000230
- **Condition**  
Astrocytoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000272

**Subject identifier**  
D001254
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000305

**Subject identifier**  
D001943
- **Condition**  
Adenocarcinoma, Bronchiolo-Alveolar

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000308

**Subject identifier**  
D002282
- **Condition**  
Burkitt Lymphoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000309

**Subject identifier**  
D002051
- **Condition**  
Carcinoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000313

**Subject identifier**  
D002277
- **Condition**  
Melanoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000389

**Subject identifier**  
D008545
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Carcinoma, Intraductal, Noninfiltrating

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000432

**Subject identifier**  
D002285
- **Condition**  
Carcinoma, Endometrioid

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000466

**Subject identifier**  
D018269
- **Condition**  
Adenocarcinoma, Follicular

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000501

**Subject identifier**  
D018263
- **Condition**  
Ganglioneuroblastoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000502

**Subject identifier**  
D018305
- **Condition**  
Neoplasms, Germ Cell and Embryonal

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000514

**Subject identifier**  
D009373
- **Condition**  
Glioblastoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000519

**Subject identifier**  
D005909
- **Condition**  
Insulinoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000549

**Subject identifier**  
D007340
- **Condition**  
Leiomyosarcoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000564

**Subject identifier**  
D007890

And 172 more, listed on the interactive page.

### Open Targets indications (350)

- **Condition identifier**  
EFO\_0000181

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000183

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000196

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000305

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000313

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000389

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000403

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000432

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000519

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000565

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000571

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000574

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000588

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000621

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000637

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000673

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000691

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000702

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000707

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000708

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000756

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000770

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001061

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0001075

And 325 more, listed on the interactive page.

### Warnings (5)

- **Warning**  
Black Box Warning

**Effect**  
cardiotoxicity
- **Warning**  
Black Box Warning

**Effect**  
gastrointestinal toxicity
- **Warning**  
Black Box Warning

**Effect**  
hematological toxicity
- **Warning**  
Black Box Warning

**Effect**  
immune system toxicity
- **Warning**  
Black Box Warning

**Effect**  
nephrotoxicity

### Open Targets warnings (5)

- **Warning**  
Black Box Warning

**Effect**  
cardiotoxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
gastrointestinal toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
hematological toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
immune system toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
nephrotoxicity

**Country**  
United States

### Reported adverse events (21)

- **Event**  
acute myeloid leukaemia

**Reports**  
331

**Reporting signal score**

507.106
- **Event**  
anaemia

**Reports**  
3,624

**Reporting signal score**  
2,305.83
- **Event**  
bone marrow failure

**Reports**  
1,004

**Reporting signal score**  
1,203.88
- **Event**  
dehydration

**Reports**  
2,224

**Reporting signal score**  
1,521.78
- **Event**  
disease progression

**Reports**  
2,004

**Reporting signal score**  
1,625.01
- **Event**  
febrile neutropenia

**Reports**  
4,014

**Reporting signal score**  
6,553.87
- **Event**  
haematotoxicity

**Reports**  
698

**Reporting signal score**  
1,209.13
- **Event**  
hypokalaemia

**Reports**  
1,201

**Reporting signal score**

994.497
- **Event**  
hypomagnesaemia

**Reports**  
632

**Reporting signal score**

785.586
- **Event**  
injection site pain

**Reports**  
9

**Reporting signal score**

782.398
- **Event**  
leukopenia

**Reports**  
1,493

**Reporting signal score**  
1,298.38
- **Event**  
malignant neoplasm progression

**Reports**  
1,847

**Reporting signal score**  
1,955.69
- **Event**  
mucosal inflammation

**Reports**  
1,582

**Reporting signal score**  
2,365.86
- **Event**  
myelosuppression

**Reports**  
760

**Reporting signal score**  
1,266.3
- **Event**  
nausea

**Reports**  
4,962

**Reporting signal score**

828.225
- **Event**  
neutropenia

**Reports**  
4,293

**Reporting signal score**  
4,326.68
- **Event**  
neutropenic sepsis

**Reports**  
541

**Reporting signal score**  
1,007.89
- **Event**  
neutrophil count decreased

**Reports**  
1,380

**Reporting signal score**  
1,531.79
- **Event**  
pancytopenia

**Reports**  
1,735

**Reporting signal score**  
1,789.88
- **Event**  
thrombocytopenia

**Reports**  
3,208

**Reporting signal score**  
2,730.95
- **Event**  
vomiting

**Reports**  
3,986

**Reporting signal score**  
1,097.84

### Trial references (1,833)

- NCT00001502  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001502)
- NCT00002944  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002944)
- NCT00003141  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003141)
- NCT00003203  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003203)
- NCT00027846  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00027846)
- NCT00078988  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00078988)
- NCT00085098  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00085098)
- NCT00528437  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00528437)
- NCT02253212  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02253212)
- NCT00180791  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00180791)
- NCT00336024  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00336024)
- NCT00392327  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00392327)
- NCT00749723  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00749723)
- NCT01857453  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01857453)
- NCT02025881  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02025881)
- NCT05535166  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05535166)
- NCT01445119  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01445119)
- NCT03149575  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03149575)
- NCT00002474  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002474)
- NCT00002477  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002477)
- NCT00002600  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002600)
- NCT00002819  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002819)
- NCT00002894  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002894)
- NCT00003064  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003064)
- NCT00003136  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003136)

And 1,808 more, listed on the interactive page.

## Dosing

**Dose**

360 mg/m2

**Route**

Intravenous

**How often**

Every 4 weeks

## Chemical properties

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Heavy atoms**

13

**Molecular formula**

C6H12N2O4Pt

**Monoisotopic mass**

371.044501

**Natural product**

No

## National Drug Codes

- 0703-4239
- 0703-4244
- 0703-4246
- 0703-4248
- 16729-295
- 54288-164
- 54288-165
- 54288-166
- 54288-167
- 55150-333
- 55150-334
- 55150-335
- 55150-386
- 61703-150
- 61703-262
- 61703-339
- 61703-360
- 61703-600
- 63323-172
- 68083-190
- 68083-191
- 68083-192
- 68083-193
- 69339-364
- 69339-365

And 9 more, listed on the interactive page.

## Evidence counts

**Recorded assays**

2

**Active assays**

0

## Pharmacologic actions

- Antineoplastic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000970.html)
- Cross-Linking Reagents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D003432.html)

## Biological measurements

### Observed measurements

#### Liver toxicity assay

**Median**

36,100

**Mean**

36,100

**Minimum**

36,100

**Maximum**

36,100

**Unit**

nM

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- IC50

## Related records

### Trials (3,038)

- 'ADVANCE' (A Pilot Trial)
- (Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations
- (HARMONY) Study of BLU-701 in EGFR-mutant NSCLC
- (PGA) for Platinum-resistant/Refractory, Paclitaxel-Pretreated Recurrent Ovarian and Peritoneal Carcinoma
- (VELA) Study of BLU-222 in Advanced Solid Tumors
- 131I-MIBG With Myeloablative Chemotherapy and Autologous Stem Cell Transplantation for the Treatment of High-risk Neuroblastoma
- 4 Courses vs 2 Courses of Pembrolizumab Combined With Carboplatin and Albumin-binding Paclitaxel of Neoadjuvant Therapy in HNSCC
- 6 vs 3 Cycles of Neoadjuvant Chemotherapy for Potentially Resectable Locally Advanced Thymic Epithelial Tumors
- 9-ING-41 in Patients With Advanced Cancers
- 9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland Carcinoma
- 9-ING-41 Plus Carboplatin in Salivary Gland Carcinoma
- 9MW2821 in Combination With Toripalimab vs Standard Chemotherapy in Locally Advanced or Metastatic Urothelial Cancer
- A BRIDGING STUDY OF PF-06439535 (CN) PLUS PACLITAXEL-CARBOPLATIN VERSUS BEVACIZUMAB PLUS PACLITAXEL-CARBOPLATIN IN NSCLC
- A Clinical Research of NK Cell Infusion Combined With Chemotherapy in the Treatment of Non-small Cell Lung Cancer
- A Clinical Study Conducted in Multiple Centers Comparing Veliparib in Combination With Carboplatin and Paclitaxel Versus a Placebo in Combination With Carboplatin and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer
- A Clinical Study in Cancer Patients to Investigate the Potential Impact of Custirsen, on the Blood Levels of the Chemotherapeutic Drug, Paclitaxel, When Given Together as Part of a Treatment Regimen
- A Clinical Study of Bemcentinib With Standard of Care Chemoimmunotherapy in Untreated Advanced/Metastatic Non-small Cell Lung Cancer Patients With a Mutation in the STK11 Gene
- A Clinical Study of Boserolimab (MK-5890) With Pembrolizumab and Chemotherapy in People With Early Triple-Negative Breast Cancer (MK-5890-003)
- A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
- A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)

### Approved for (6)

- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md)
- Malignant epithelial tumor of ovary
- Neoplasm
- [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md)
- Ovarian carcinoma
- [Ovarian neoplasm](https://trialight.com/data/condition/ovarian-neoplasm-1e9924ea-041c-5daa-b6c4-a97ec4fabeda.md)

### In development for (189)

- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 2
- [Adenocarcinoma](https://trialight.com/data/condition/adenocarcinoma-b5c321d1-7c49-5bf9-abd0-dfa99dbd5f29.md) Phase 2
- Adrenal cortex carcinoma Phase 1
- Adult T-cell leukemia/lymphoma Phase 3
- Anaplastic astrocytoma Phase 3
- Anaplastic ependymoma Phase 3
- Anaplastic large cell lymphoma Phase 1
- Anaplastic oligodendroglioma Phase 2
- Anemia Phase 3
- Anus cancer Phase 1
- Appendix carcinoma Phase 1
- [Astrocytoma (excluding glioblastoma)](https://trialight.com/data/condition/astrocytoma-excluding-glioblastoma-dd29b6db-5e3d-590d-b093-7a770a5facb2.md) Phase 3
- [B-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/b-cell-non-hodgkin-lymphoma-8a6ff7f0-9b90-5c25-a39b-741d9bfb5343.md) Phase 2
- Bile duct cancer Phase 2
- [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 3
- Bone cancer Phase 2
- Bone neoplasm Phase 2
- Brain cancer Phase 3
- [Brain neoplasm](https://trialight.com/data/condition/brain-neoplasm-b3dac71b-1d7b-5a65-8f64-89821506ad41.md) Phase 3
- Brainstem neoplasm Phase 2

### Other linked conditions (2)

- Lip and oral cavity carcinoma
- Tongue neoplasm

---

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