> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/camoteskimab-48927821-d0ff-4f39-82a9-4d5e630d220c
> Record changed: 2026-10-13

# Camoteskimab

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109604)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109604)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109604)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109604)

**Drug name**

Camoteskimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109604)

### Other names (25)

- aevi 007
- Aevi-007
- AEVI-007
- aevi007
- AEVI007
- avtx 007
- AVTX-007
- avtx007
- AVTX007
- camoteskimab
- Camoteskimab
- camoteskimab \[INN\]
- Camoteskimab \[WHO-DD\]
- camoteskimab inn
- camoteskimab who dd
- cerc 007
- CERC-007
- cerc007
- CERC007
- IMMUNOGLOBULIN G1 (242-PHENYLALANINE,243-GLUTAMIC ACID,339-SERINE), ANTI-(HUMAN INTERLEUKIN 18) (HUMAN MONOCLONAL CERC-007 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL CERC-007 .KAPPA.-CHAIN, DIMER
- immunoglobulin g1 242 phenylalanine 243 glutamic acid 339 serine anti human interleukin 18 human monoclonal cerc 007 gamma 1 chain disulfide with human monoclonal cerc 007 kappa chain dimer
- medi 2338
- MEDI-2338
- medi2338
- MEDI2338

## Identifiers

**CAS registry numbers**

- 2492472-82-7

**ChEMBL ID**

CHEMBL2109604

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109604)

**FDA ingredient codes (UNII)**

- ONX021SC9O

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

camoteskimab

**Type**

Antibody

**Drug name stem**

\-mab

### Mechanisms of action (2)

- **Action**  
Binding

**Action type**  
Binding

**Target**  
IL-18

**Gene symbol**  
IL-18
- **Mechanism**  
Interleukin-18 cross-linking agent

**Action type**  
CROSS\_LINKING\_AGENT

**Target**  
Interleukin-18

**Protein identifier**  
Q14116

### Open Targets mechanisms

- **Mechanism**  
Interleukin-18 cross-linking agent

**Action type**  
CROSS-LINKING AGENT

**Target**  
Interleukin-18

### Investigated indications (4)

- **Condition**  
Pulmonary Disease, Chronic Obstructive

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000341

**Subject identifier**  
D029424
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Still's Disease, Adult-Onset

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0007135

**Subject identifier**  
D016706

### Open Targets indications (9)

- **Condition identifier**  
EFO\_0000341

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0001378

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0007135

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004980

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005002

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0009693

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0019355

**Highest recorded phase**  
1

### Trial references (3)

- NCT01322594  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01322594)
- NCT04671251  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04671251)
- NCT04752371  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04752371)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (5)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QVQLQESGPGLVKPSETLSLTCTVSGGSISADGYYWSWIRQPPGKGLEWIGSLYYSGSTYYNPSLKGRVTISGDTSKNQFSLKLSSVTAADTAVYYCARTPAYFGQDRTDFFDVWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIQMTQSPSTLSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKVLIYKASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQSHHPPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Glycosylation sites (N)

**Sequence**  
305 $ 305''''
- **Component**  
Disulfide bridges

**Sequence**  
22-97 $ 22''-97'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 152-208 $ 152''-208'' $ 228-214' $ 228''-214''' $ 234-234'' $ 237-237'' $ 269-329 $ 269''-329'' $ 375-433 $ 375''-433''
- **Component**  
Glycosylation sites (N)

**Sequence**  
305 $ 305''

## Related records

### Trials (5)

- [A Phase 2b Study of the Effects of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis](https://trialight.com/data/trial/a-phase-2b-study-of-the-effects-of-camoteskimab-in-adults-79c26739-27cf-4aa9-8fdd-fb99ce4b9b09.md)
- A Study of the Effects of Camoteskimab in Adults With Moderate to Severe Atopic Dermatitis
- A Study to Evaluate Camoteskimab in Participants With Still's Disease
- A Study to Evaluate the Safety of MEDI2338 in Subjects With Chronic Obstructive Pulmonary Disease
- Phase 1b Study of AEVI-007 in Subjects With Relapsed or Refractory Multiple Myeloma

### In development for (4)

- Adult-onset Still disease Phase 1
- [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 1
- Neoplasm Phase 2
- [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 1

### Targets (1)

- [IL18](https://trialight.com/data/target/il18-6856427e-0233-5cbe-ade1-0c708535a973.md) Interleukin-18 cross-linking agent

---

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