> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/camlipixant-f78027db-71c2-49ec-b8aa-5efe920c5532
> Record changed: 2026-10-13

# Camlipixant

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095035)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095035)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095035)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095035)

**Drug name**

Camlipixant

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095035)

**Molecular weight**

458.47

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095035)

**Structure (SMILES)**

CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2C\[C@H\]2CN(C(=O)OC)CCO2)c(F)c1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095035)

### Other names (23)

- az 13410937
- AZ-13410937
- az13410937
- AZ13410937
- blu 5937
- Blu-5937
- BLU-5937
- BLU-5937 ER
- BLU-5937 IR
- blu5937
- BLU5937
- camlipixant
- Camlipixant
- Camlipixant \[INN\]
- CAMLIPIXANT \[USAN\]
- Camlipixant \[WHO-DD\]
- camlipixant inn
- camlipixant usan
- camlipixant who dd
- neo 5937
- NEO-5937
- neo5937
- NEO5937

## Identifiers

**CAS registry numbers**

- 1621164-74-6

**ChEMBL ID**

CHEMBL5095035

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095035)

**InChIKey**

SEHLMRJSQFAPCJ-HNNXBMFYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095035)

**PubChem compound IDs**

- 76955630

**FDA ingredient codes (UNII)**

- TB7D2H7MZZ

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

camlipixant

**Type**

Synthetic organic

### Mechanisms of action (3)

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
P2X3

**Gene symbol**  
P2RX3

**Protein identifier**  
P56373

**Median affinity**

7.6

**Affinity units**  
pIC50
- **Mechanism**  
P2X purinoceptor 3 antagonist

**Action type**  
Antagonist

**Target**  
P2X purinoceptor 3

**Protein identifier**  
P56373
- **Action**  
Non-competitive

**Action type**  
NON\_COMPETITIVE

**Target**  
P2X3

**Gene symbol**  
P2RX3

**Protein identifier**  
P56373

**Median affinity**

7.6

**Affinity units**  
pIC50

### Open Targets mechanisms

- **Mechanism**  
P2X purinoceptor 3 antagonist

**Action type**  
Antagonist

**Target**  
P2X purinoceptor 3

### Investigated indications (3)

- **Condition**  
Pruritus

**Highest recorded phase**  
1

**Condition identifier**  
HP:0000989

**Subject identifier**  
D011537
- **Condition**  
Chronic Cough

**Highest recorded phase**  
1

**Condition identifier**  
HP:0012735

**Subject identifier**  
D000096822
- **Condition**  
Cough

**Highest recorded phase**  
2

**Condition identifier**  
HP:0012735

**Subject identifier**  
D003371

### Open Targets indications (5)

- **Condition identifier**  
HP\_0000989
- **Condition identifier**  
HP\_0000989

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0012735
- **Condition identifier**  
HP\_0012735

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004980

**Highest recorded phase**  
2

### Trial references (4)

- NCT03638180  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03638180)
- NCT03979638  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03979638)
- NCT05570539  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05570539)
- NCT06222892  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06222892)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

1

**Polar surface area**

85.17

**Calculated partition coefficient (ALogP)**

2.96

**Calculated partition coefficient (XLogP)**

3.2

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

4

**Heavy atoms**

33

**Molecular formula**

C23H24F2N4O4

**Monoisotopic mass**

458.17656158

**Natural product**

No

## Evidence counts

**Recorded assays**

1

**Active assays**

1

### Active assay types

- Confirmatory

## Related records

### Trials (16)

- A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
- A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - China Extension
- A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
- A Dose Escalation Study of BLU-5937 in Unexplained or Refractory Chronic Cough
- A Multiple-Dose Study of BLU-5937 in Chronic Pruritus Associated With Atopic Dermatitis
- A Study of Camlipixant in Male and Female Healthy Participants and Participants With Hepatic Impairment Aged 18-75 Years of Age
- [A Study to Investigate Abdominal Symptoms With Camlipixant Compared With Placebo in Adults With Irritable Bowel Syndrome - Diarrhea (IBS-D) and Irritable Bowel Syndrome - Mixed (IBS-M)](https://trialight.com/data/trial/a-study-to-investigate-abdominal-symptoms-with-camlipixant-dcd8f600-128a-4e4c-8b7e-ce5db5b2f12e.md)
- A Study to Investigate the Difference In Blood Levels of Camlipixant Between Different Camlipixant Formulation Prototypes
- A Study to Investigate the Effect of Food on Camlipixant Concentrations in Healthy Participants
- Assessment of the Pharmacokinetics of BLU-5937 Extended Release Prototypes and a BLU-5937 Immediate Release Reference Formulation
- BLU-5937: First-in-Human, Single and Multiple Doses Escalation, Safety, Tolerability, Pharmacokinetics and Food Effect
- Evaluation of the Effect of Rifampin and Rabeprazole on the Pharmacokinetics of Camlipixant
- Evaluation of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
- Evaluation of the Pharmacokinetics and Safety of BLU-5937 in Healthy Adult Japanese and Caucasian Subjects
- Evaluation of the Potential Drug-drug Interactions Between Gemfibrozil or Dabigatran Etexilate and Camlipixant
- Mass Balance Recovery, Absorption, Metabolism and Excretion of \[14C\]-BLU-5937

### Targets (1)

- [P2RX3](https://trialight.com/data/target/p2rx3-70fac3c3-c063-59a6-b147-721c76173df9.md) P2X purinoceptor 3 antagonist

---

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