Camizestrant
Highest phase reached
Phase 3
Drug type
Small molecule
- Listing at source
- Listed
- Highest phase reached
- Phase 3
- Drug type
- Small molecule
- Drug name
- Camizestrant
- Molecular weight
- 476.52
- Structure (SMILES)
- C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2ccc(NC3CN(CCCF)C3)cn2)N1CC(F)(F)F
- az 14066724
- AZ-14066724
- az14066724
- AZ14066724
- azd 9833
- AZD-9833
- azd9833
- Azd9833
- AZD9833
- AZD9833 Oral Solution
- camizestrant
- Camizestrant
- CAMIZESTRANT
- CAMIZESTRANT (AZD9833)
- camizestrant [INN]
- CAMIZESTRANT [USAN]
- Camizestrant [WHO-DD]
- camizestrant azd9833
- camizestrant inn
- camizestrant usan
- camizestrant who dd
- cpd 28
- CPD 28
- estrogen receptor antagonist 2
- ESTROGEN RECEPTOR ANTAGONIST 2
- ATC classification codes
- L02BA05
- CAS registry numbers
- 2222844-89-3
- ChEMBL ID
- CHEMBL4650365
- InChIKey
- WDHOIABIERMLGY-CMJOXMDJSA-N
- PubChem compound IDs
- 134453496
- FDA ingredient codes (UNII)
- JUP57A8EPZ
- Status
- Authorised
- Status date
- 20 Jul 2026
- Authorisation date
- 20 Jul 2026
- Approved indications
- Etcamah in combination with a CDK4/6 inhibitor (palbociclib, ribociclib, or abemaciclib) is indicated for the treatment of adult patients with ER-positive, HER2-negative, locally advanced or metastatic breast cancer upon detection of ESR1‑mutation and without disease progression during first-line endocrine therapy in combination with a CDK4/6 inhibitor (for biomarker based patient-selection, see section 4.2 and 5.1).
- Product number
- EMEA/H/C/006494
- Authorisation holder
- AstraZeneca AB
- Priority medicines scheme
- No
- Generic
- No
- Biosimilar
- No
- Generic medicines
- 0
- Biosimilar medicines
- 0
- Advanced therapy
- No
- Conditional approval
- No
- Additional monitoring
- Yes
- Accelerated assessment
- No
- Exceptional circumstances
- No
Therapeutic areas
- Breast Neoplasms
European medicines record
- First in class
- No
- Orphan designation
- No
- Pharmacology name
- camizestrant
- Type
- Synthetic organic
- Drug name stem
- -estr-; -estrant
- Action
- Antagonist
- Action type
- Antagonist
- Target
- Estrogen receptor-α
- Gene symbol
- ESR1
- Protein identifier
- P03372
- Median affinity
- 9.8
- Affinity units
- pIC50
- Mechanism
- Estrogen receptor alpha degrader
- Action type
- DEGRADER
- Target
- Estrogen receptor
- Protein identifier
- P03372
Open Targets mechanisms
- Mechanism
- Estrogen receptor alpha degrader
- Action type
- DEGRADER
- Target
- Estrogen receptor
- Condition
- Liver Diseases
- Highest recorded phase
- 1
- Condition identifier
- EFO:0001421
- Subject identifier
- D008107
- Condition
- Breast Neoplasms
- Highest recorded phase
- 3
- Condition identifier
- EFO:0003869
- Subject identifier
- D001943
- Condition
- Breast Neoplasms
- Highest recorded phase
- 3
- Condition identifier
- MONDO:0007254
- Subject identifier
- D001943
- Condition identifier
- EFO_0001421
- Highest recorded phase
- 1
- Condition identifier
- EFO_0003869
- Condition identifier
- MONDO_0007254
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0008170
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0021100
- Highest recorded phase
- 3
- NCT04214288
- NCT04588298
- NCT04711252
- NCT04818632
- NCT04964934
- NCT05364255
- NCT05774951
- NCT05952557
- NCT06380751
- NCT05790304
- Hydrogen bond acceptors
- 5
- Hydrogen bond donors
- 2
- Polar surface area
- 60.08
- Calculated partition coefficient (ALogP)
- 4.31
- Calculated partition coefficient (XLogP)
- 4.2
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Rule-of-five violations
- 0
- Rotatable bonds
- 7
- Heavy atoms
- 34
- Molecular formula
- C24H28F4N6
- Monoisotopic mass
- 476.23115757
- Natural product
- No
- Recorded assays
- 209
- Active assays
- 20
Active assay types
- Confirmatory
These details could not be displayed.
Related records
Trials (21)
- A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
- A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors
- A Phase 1 Study of AZD9833 in Japanese Women With ER Positive, HER2 Negative Advanced Breast Cancer
- A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer
- A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
- A Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]AZD9833
- A Study to Assess the Pharmacokinetics of Camizestrant (AZD9833) When Administered Alone and in Combination With Itraconazole
- A Study to Assess the Rel Bioavailability, Food Effect and Absolute Bioavailability on the Pharmacokinetics of AZD9833
- A Study to Investigate Efficacy and Safety With Oral AZD9833 Compared With Intramuscular Fulvestrant in Post-menopausal Women at Least 18 Years of Age With Advanced ER-positive HER2 Negative Breast Cancer
- A Study to Investigate the Biological Effects of AZD9833 in Women With ER-positive, HER2 Negative Primary Breast Cancer
- A Study to Investigate the Pharmacokinetics of Midazolam After Repeated Doses of Camizestrant (AZD9833) and to Investigate the Pharmacokinetics of Camizestrant When Administered Alone and in Combination With Carbamazepine in Healthy Post-Menopausal Female Participants
- An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
- AZD9833 China PK Study
- Efficacy and Safety of Camizestrant Plus Ribociclib in Patients With Breast Cancer
- Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)
- Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
- Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
- Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer.
- Study to Assess the Effect of Co-Administration of AZD9833 on the Pharmacokinetics of Midazolam, of Omeprazole, of Celecoxib and of Dabigatran Etexilate in Healthy Postmenopausal Female Volunteers
- Study to Evaluate the Safety and Tolerability of Camizestrant in Combination With Atirmociclib in Women With Advanced Breast Cancer
In development for (3)
- Breast cancer Phase 3
- Breast neoplasm Phase 3
- Liver disorder Phase 1
Targets (1)
- ESR1 Estrogen receptor alpha degrader