> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/calcium-carbonate-37e10d9b-34b0-4b9a-ad7f-b08adfd15b03
> Record changed: 2026-10-13

# Calcium carbonate

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

First approval year

2000

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

## Development status

**First approval year**

2000

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

**Drug name**

Calcium carbonate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

**Molecular weight**

100.09

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

**Structure (SMILES)**

O=C(\[O-\])\[O-\].\[Ca+2\]

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

### Brand names (38)

- adcal
- Adcal
- albacar
- Albacar
- cacit
- Cacit
- calc 500
- Calc 500
- calcette
- Calcette
- calcichew
- Calcichew
- calcichew fte
- Calcichew fte
- calcidrink
- Calcidrink
- calcium carbonate component of pepcid complete
- Calcium carbonate component of pepcid complete
- citrical
- Citrical
- os cal
- Os-cal
- purecal
- Purecal
- remegel

And 13 more, listed on the interactive page.

### Other names (91)

- amlodipine freeze dried powder for oral solution 5 mg
- Amlodipine Freeze-Dried Powder for Oral Solution 5 mg
- calcii carbonas
- Calcii carbonas
- CALCII CARBONAS \[WHO-IP LATIN\]
- calcii carbonas who ip latin
- calcite
- Calcite
- Calcite (ca(co3))
- calcite ca co3
- calcitum
- Calcitum
- Calcium (as calcium carbonate)
- CALCIUM (AS CALCIUM CARBONATE) \[VANDF\]
- Calcium (as carbonate)
- CALCIUM (AS CARBONATE) \[VANDF\]
- calcium as calcium carbonate
- calcium as calcium carbonate vandf
- calcium as carbonate
- calcium as carbonate vandf
- calcium carbonate
- Calcium carbonate
- CALCIUM CARBONATE \[EP MONOGRAPH\]
- CALCIUM CARBONATE \[FCC\]
- CALCIUM CARBONATE \[HSDB\]

And 66 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 471-34-1

**ChEMBL ID**

CHEMBL1200539

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

**InChIKey**

VTYYLEPIZMXCLO-UHFFFAOYSA-L

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

**RxNorm IDs (RxCUI)**

- 1897

**FDA ingredient codes (UNII)**

- H0G9379FGK

### ATC classification codes (2)

- A02AC01
- A12AA04

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200539)

### PubChem compound IDs (2)

- 10112
- 516889

## Regulatory information

### United States

**Applicant**

KENVUE BRANDS

**Approval date**

16 Oct 2000

**Application number**

NDA020958

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Over the counter

## Pharmacology

### Drug classification

#### Administration routes

- Oral

### Investigated indications (31)

- **Condition**  
HIV Infections

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000180

**Subject identifier**  
D015658
- **Condition**  
Atrial Fibrillation

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0000275

**Subject identifier**  
D001281
- **Condition**  
Diabetic Nephropathies

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000401

**Subject identifier**  
D003928
- **Condition**  
Lymphoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
HIV Infections

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000764

**Subject identifier**  
D015658
- **Condition**  
Obesity

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001073

**Subject identifier**  
D009765
- **Condition**  
Liver Cirrhosis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001422

**Subject identifier**  
D008103
- **Condition**  
Arthritis, Juvenile

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002609

**Subject identifier**  
D001171
- **Condition**  
Pregnancy

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0002950

**Subject identifier**  
D011247
- **Condition**  
Vitamin D Deficiency

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003762

**Subject identifier**  
D014808
- **Condition**  
Dental Caries

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0003819

**Subject identifier**  
D003731
- **Condition**  
Osteoporosis, Postmenopausal

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003854

**Subject identifier**  
D015663
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003869

**Subject identifier**  
D001943
- **Condition**  
Osteoporosis

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0003882

**Subject identifier**  
D010024
- **Condition**  
Renal Insufficiency, Chronic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003884

**Subject identifier**  
D051436
- **Condition**  
Gastroesophageal Reflux

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003948

**Subject identifier**  
D005764
- **Condition**  
Radius Fractures

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003957

**Subject identifier**  
D011885
- **Condition**  
Anemia

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0004272

**Subject identifier**  
D000740
- **Condition**  
Colonic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0004288

**Subject identifier**  
D003110
- **Condition**  
Lymphoma, Non-Hodgkin

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0005952

**Subject identifier**  
D008228
- **Condition**  
Hypoparathyroidism

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0009451

**Subject identifier**  
D007011
- **Condition**  
Aging

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0022597

**Subject identifier**  
D000375
- **Condition**  
Chronic Kidney Disease-Mineral and Bone Disorder

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001152

**Subject identifier**  
D012080
- **Condition**  
Hyperparathyroidism, Secondary

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001173

**Subject identifier**  
D006962
- **Condition**  
Bone Diseases, Metabolic

**Highest recorded phase**  
3

**Condition identifier**  
HP:0000938

**Subject identifier**  
D001851

And 6 more, listed on the interactive page.

### Open Targets indications (42)

- **Condition identifier**  
EFO\_0000401

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000764

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001422

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0002609

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003762

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003841
- **Condition identifier**  
EFO\_0003854

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003882
- **Condition identifier**  
EFO\_0003884

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003948

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0004272
- **Condition identifier**  
EFO\_0004272

**Highest recorded phase**  
4
- **Condition identifier**  
EFO\_0004288

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0009451

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0009909
- **Condition identifier**  
EFO\_1001152

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001173

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0001324

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0002014

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0002901
- **Condition identifier**  
HP\_0002901

**Highest recorded phase**  
4
- **Condition identifier**  
HP\_0004349

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0025502

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0000328
- **Condition identifier**  
MONDO\_0000328

**Highest recorded phase**  
3

And 17 more, listed on the interactive page.

### Reported adverse events (81)

- **Event**  
abdominal discomfort

**Reports**  
2,535

**Reporting signal score**  
7,265.69
- **Event**  
alopecia

**Reports**  
2,566

**Reporting signal score**  
7,353.31
- **Event**  
anti-cyclic citrullinated peptide antibody positive

**Reports**  
990

**Reporting signal score**  
4,848.62
- **Event**  
arthralgia

**Reports**  
970

**Reporting signal score**

837.602
- **Event**  
arthropathy

**Reports**  
1,486

**Reporting signal score**  
4,443.3
- **Event**  
asthma

**Reports**  
205

**Reporting signal score**

155.737
- **Event**  
blister

**Reports**  
466

**Reporting signal score**

906.169
- **Event**  
blood cholesterol increased

**Reports**  
222

**Reporting signal score**

338.107
- **Event**  
c-reactive protein abnormal

**Reports**  
70

**Reporting signal score**

141.364
- **Event**  
calciphylaxis

**Reports**  
75

**Reporting signal score**

220.129
- **Event**  
coma

**Reports**  
179

**Reporting signal score**

170.414
- **Event**  
condition aggravated

**Reports**  
1,161

**Reporting signal score**  
1,405.04
- **Event**  
confusional state

**Reports**  
451

**Reporting signal score**

372.676
- **Event**  
contusion

**Reports**  
335

**Reporting signal score**

406.844
- **Event**  
disability

**Reports**  
72

**Reporting signal score**

138.602
- **Event**  
discomfort

**Reports**  
1,273

**Reporting signal score**  
4,084.56
- **Event**  
drug intolerance

**Reports**  
1,420

**Reporting signal score**  
3,103.73
- **Event**  
duodenal ulcer perforation

**Reports**  
615

**Reporting signal score**  
2,829.64
- **Event**  
dyspnoea

**Reports**  
686

**Reporting signal score**

200.689
- **Event**  
fatigue

**Reports**  
2,384

**Reporting signal score**  
2,752.13
- **Event**  
fibromyalgia

**Reports**  
118

**Reporting signal score**

192.53
- **Event**  
folliculitis

**Reports**  
330

**Reporting signal score**  
1,101.33
- **Event**  
gastrointestinal disorder

**Reports**  
355

**Reporting signal score**

496.896
- **Event**  
gastrooesophageal reflux disease

**Reports**  
233

**Reporting signal score**

248.948
- **Event**  
general physical health deterioration

**Reports**  
408

**Reporting signal score**

520.344

And 56 more, listed on the interactive page.

### Trial references (45)

- NCT00000429  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000429)
- NCT00043069  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00043069)
- NCT00054418  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00054418)
- NCT00112437  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00112437)
- NCT00421343  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00421343)
- NCT00960934  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00960934)
- NCT00996801  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00996801)
- NCT01120600  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01120600)
- NCT00061256  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00061256)
- NCT01762995  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01762995)
- NCT02473367  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02473367)
- NCT00073073  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00073073)
- NCT00263185  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00263185)
- NCT00352846  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00352846)
- NCT00486512  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00486512)
- NCT00529373  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00529373)
- NCT00620113  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00620113)
- NCT01552122  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01552122)
- NCT00560300  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00560300)
- NCT00650637  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00650637)
- NCT00967629  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00967629)
- NCT01493050  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01493050)
- NCT01052051  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01052051)
- NCT03057314  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03057314)
- NCT01190683  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01190683)

And 20 more, listed on the interactive page.

## Dosing

**Dose**

2-4 tablets

**Route**

Oral

**How often**

As needed

## Chemical properties

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Heavy atoms**

5

**Molecular formula**

CCaO3

**Monoisotopic mass**

99.9473347

**Natural product**

No

## National Drug Codes

- 13925-116
- 13925-117
- 39328-106
- 42192-320
- 42192-332
- 50967-219
- 59088-005
- 59088-008
- 59088-009
- 59088-078
- 59088-139
- 59088-156
- 59088-164
- 59088-165
- 59088-166
- 59088-167
- 59088-168
- 59088-169
- 59088-171
- 59088-172
- 59088-173
- 59088-176
- 59088-177
- 59088-178
- 59088-180

And 21 more, listed on the interactive page.

## Evidence counts

**Recorded assays**

16

**Active assays**

0

## Pharmacologic actions

- Antacids  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000863.html)

## Related records

### Trials (146)

- A Clinical Trial of Freeze-dried Human Rabies Vaccine (MRC-5 Cells)
- A Clinical Trial of Freeze-dried Human Rabies Vaccine (Vero Cells)
- A Clinical Trial of Rabies Vaccine（Human Diploid Cell）for Human Use,Freeze-dried
- A Clinical Trial of Rabies Vaccine（Human Diploid Cell）for Human Use,Freeze-dried in a Population Aged 10 to 60 Years
- A Clinical Trial of Rabies Vaccine（Human Diploid Cell）for Human Use,Freeze-dried in a Population Aged 10-60 Years
- A Dose Finding Study of CycloSam® Combined With External Beam Radiotherapy
- A First-in-Human Study to Learn How Well a Bi-Layer Calcium Carbonate Antacid Tablet Works Compared to a Standard, Non-Layered Calcium Carbonate Tablet in Healthy Male Participants
- A Randomized, Controlled Trial on the Efficacy and Safety of Live-Attenuated Influenza Vaccine (LAIV) Among Children in Bangladesh
- A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors
- [A Single Dose Study to Investigate the Pharmacokinetics (PK) of Telitacicept Pre-filled Injection and Freeze-dried Powder Injection in Chinese Healthy Subjects](https://trialight.com/data/trial/a-single-dose-study-to-investigate-the-pharmacokinetics-pk-328a96aa-9bc8-4c22-a24c-41e79cb3fd64.md)
- A Single-center, Open Trials to Evaluate the Safety of Freeze-dried Group ACYW135 Meningococcal Conjugate Vaccine
- A Study of Freeze-dried Human Protein C Concentrate (TAK-662) in Participants With Congenital Protein C Deficiency
- A Study of Pharmacokinetic Comparison of Two Recombinant Exendin-4 Formulations in Chinese Healthy Male Subjects
- A Study of the Drug Interactions Between Danicopan and Cyclosporine, Tacrolimus, Antacids, and Omeprazole in Healthy Adults
- A Study on the Prevention and Treatment of GIOP With Eldecalcitol
- A Study to Assess the Bioequivalence of Famotidine/Antacid Combination Tablets Compared to Famotidine/Antacid EZ Chew Tablets (0208C-145)(COMPLETED)
- A Study to Assess the Pharmacokinetics of Lanthanum Carbonate, Investigate and Compare the Efficacy, Safety and Tolerability of Lanthanum Carbonate With Calcium Carbonate in Hyperphosphataemic Children and Adolescents With Chronic Kidney Disease on Dialysis
- A Study to Compare PK/PD Characteristics and Safety Profiles Between AD-212-A and AD-2121
- A Study to Determine Effective Prophylaxis and Treatment of Nelfinavir-Associated Diarrhea
- [A Study to Evaluate a PIKA Rabies Vaccine（Vero Cell）for Human Use,Freeze-dried](https://trialight.com/data/trial/a-study-to-evaluate-a-pika-rabies-vaccine-vero-cell-for-d8878797-8a33-4e8c-a655-425939e0fa58.md)

### Approved for (3)

- Anemia
- Dyspepsia
- Osteoporosis

### In development for (25)

- [Alcohol dependence](https://trialight.com/data/condition/alcohol-dependence-d26b3f0d-c0fb-5084-9194-e963df0e9179.md) Phase 3
- [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md) Early phase 1
- [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) Phase 2
- [Cirrhosis of liver](https://trialight.com/data/condition/cirrhosis-of-liver-d90e4a84-9e82-54fc-a553-1e42086e8382.md) Phase 3
- [Classic familial adenomatous polyposis](https://trialight.com/data/condition/classic-familial-adenomatous-polyposis-3e5f34e5-9319-567e-8ab8-cb7bb898a156.md) Phase 3
- [Colonic neoplasm](https://trialight.com/data/condition/colonic-neoplasm-be61bc3a-c82f-5b84-a20f-3f9931cfcc77.md) Phase 1
- Dental caries Early phase 1
- [Diabetic kidney disease](https://trialight.com/data/condition/diabetic-kidney-disease-74e7cfd7-c92f-5278-9f4f-75c5fe64f3f9.md) Phase 2
- [Diarrheal disease](https://trialight.com/data/condition/diarrheal-disease-623389f5-2a35-5350-9dae-f2dc4bc0fc34.md) Phase 3
- Gastroesophageal reflux disease Phase 1
- [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 2
- Hyperphosphatemia Phase 3
- Hypoparathyroidism Phase 1
- Juvenile idiopathic arthritis Phase 2
- [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 3
- Metabolic bone disorder Phase 3
- [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 3
- [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Phase 2

### Other linked conditions (2)

- Acute kidney injury
- [Thyroid tumor](https://trialight.com/data/condition/thyroid-tumor-fc2bab9d-d468-5acb-8a62-e5f68e538979.md)

---

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