> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/calcium-05275e83-0f4f-4303-8107-21a57d8d7fb9
> Record changed: 2026-11-04

# Calcium

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200496)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200496)

First approval year

1982

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200496)

## Development status

**First approval year**

1982

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200496)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200496)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200496)

**Drug name**

Calcium

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200496)

**Molecular weight**

40.08

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200496)

**Structure (SMILES)**

These details could not be displayed.

### Other names (16)

- calcium
- Calcium
- CALCIUM \[HSDB\]
- CALCIUM \[II\]
- CALCIUM \[MI\]
- CALCIUM \[ORANGE BOOK\]
- CALCIUM \[USP-RS\]
- CALCIUM \[VANDF\]
- Calcium \[WHO-DD\]
- calcium hsdb
- calcium ii
- calcium mi
- calcium orange book
- calcium usp rs
- calcium vandf
- calcium who dd

## Identifiers

**CAS registry numbers**

- 7440-70-2

**ChEMBL ID**

CHEMBL1200496

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200496)

**InChIKey**

OYPRJOBELJOOCE-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200496)

**PubChem compound IDs**

- 5460341

**RxNorm IDs (RxCUI)**

- 1895

**FDA ingredient codes (UNII)**

- SY7Q814VUP

## Regulatory information

### United States

**Applicant**

GE HEALTHCARE

**Approval date**

30 Apr 1974

**Application number**

NDA017506

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

discontinued

## Approval status

**United States (FDA)**

Approved

## Pharmacology

### Drug classification

**Pharmacology name**

fenoprofen

**Type**

Synthetic organic

#### Administration routes

- Parenteral

### Mechanisms of action

- **Action type**  
Inhibitor

**Target**  
SMCT1

**Gene symbol**  
SMCT1

### Investigated indications (49)

- **Condition**  
Cardiovascular Diseases

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000319

**Subject identifier**  
D002318
- **Condition**  
Hypertension

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000537

**Subject identifier**  
D006973
- **Condition**  
Wounds and Injuries

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0000546

**Subject identifier**  
D014947
- **Condition**  
Leukemia

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000565

**Subject identifier**  
D007938
- **Condition**  
Lymphoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Polycystic Ovary Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000660

**Subject identifier**  
D011085
- **Condition**  
Pre-Eclampsia

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000668

**Subject identifier**  
D011225
- **Condition**  
HIV Infections

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0000764

**Subject identifier**  
D015658
- **Condition**  
Obesity

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001073

**Subject identifier**  
D009765
- **Condition**  
Coronary Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001645

**Subject identifier**  
D003327
- **Condition**  
Arthritis, Juvenile

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0002609

**Subject identifier**  
D001171
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Heart Failure

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003144

**Subject identifier**  
D006333
- **Condition**  
Vitamin D Deficiency

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003762

**Subject identifier**  
D014808
- **Condition**  
Heart Diseases

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003777

**Subject identifier**  
D006331
- **Condition**  
Dental Caries

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003819

**Subject identifier**  
D003731
- **Condition**  
Pain

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003843

**Subject identifier**  
D010146
- **Condition**  
Osteoporosis, Postmenopausal

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003854

**Subject identifier**  
D015663
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003869

**Subject identifier**  
D001943
- **Condition**  
Osteoporosis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003882

**Subject identifier**  
D010024
- **Condition**  
Renal Insufficiency, Chronic

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003884

**Subject identifier**  
D051436
- **Condition**  
Fractures, Bone

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003931

**Subject identifier**  
D050723
- **Condition**  
Motor Activity

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003940

**Subject identifier**  
D009043
- **Condition**  
Hip Fractures

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003964

**Subject identifier**  
D006620
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004142

**Subject identifier**  
D015179

And 24 more, listed on the interactive page.

### Open Targets indications (66)

- **Condition identifier**  
EFO\_0000275
- **Condition identifier**  
EFO\_0000537

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000546

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000668
- **Condition identifier**  
EFO\_0001073

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003762

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003854

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003882
- **Condition identifier**  
EFO\_0003884
- **Condition identifier**  
EFO\_0003907
- **Condition identifier**  
EFO\_0003940

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004142
- **Condition identifier**  
EFO\_0004723
- **Condition identifier**  
EFO\_0009444
- **Condition identifier**  
EFO\_0009579
- **Condition identifier**  
EFO\_0009869

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0000083

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000739

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000789

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0000855
- **Condition identifier**  
HP\_0000938
- **Condition identifier**  
HP\_0002647
- **Condition identifier**  
HP\_0002901

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0003419
- **Condition identifier**  
HP\_0004349

**Highest recorded phase**  
2

And 41 more, listed on the interactive page.

### Reported adverse events (94)

- **Event**  
abdominal discomfort

**Reports**  
2,535

**Reporting signal score**  
7,321.06
- **Event**  
alopecia

**Reports**  
2,566

**Reporting signal score**  
7,398.1
- **Event**  
anti-cyclic citrullinated peptide antibody positive

**Reports**  
990

**Reporting signal score**  
4,863.9
- **Event**  
arthralgia

**Reports**  
970

**Reporting signal score**

849.813
- **Event**  
arthropathy

**Reports**  
1,486

**Reporting signal score**  
4,468.76
- **Event**  
asthma

**Reports**  
205

**Reporting signal score**

158.642
- **Event**  
blister

**Reports**  
466

**Reporting signal score**

910.715
- **Event**  
blood cholesterol increased

**Reports**  
222

**Reporting signal score**

342.887
- **Event**  
c-reactive protein abnormal

**Reports**  
70

**Reporting signal score**

142.339
- **Event**  
calciphylaxis

**Reports**  
74

**Reporting signal score**

217.281
- **Event**  
chronic gastrointestinal bleeding

**Reports**  
10

**Reporting signal score**

53.2676
- **Event**  
coma

**Reports**  
179

**Reporting signal score**

173.213
- **Event**  
condition aggravated

**Reports**  
1,161

**Reporting signal score**  
1,424.39
- **Event**  
confusional state

**Reports**  
451

**Reporting signal score**

379.204
- **Event**  
contusion

**Reports**  
333

**Reporting signal score**

407.523
- **Event**  
disability

**Reports**  
72

**Reporting signal score**

139.693
- **Event**  
discomfort

**Reports**  
1,273

**Reporting signal score**  
4,106.5
- **Event**  
drug hypersensitivity

**Reports**  
76

**Reporting signal score**

46.6992
- **Event**  
drug intolerance

**Reports**  
1,420

**Reporting signal score**  
3,125.34
- **Event**  
duodenal ulcer perforation

**Reports**  
615

**Reporting signal score**  
2,837.94
- **Event**  
dyspnoea

**Reports**  
671

**Reporting signal score**

189.183
- **Event**  
fatigue

**Reports**  
2,384

**Reporting signal score**  
2,777.94
- **Event**  
fibromyalgia

**Reports**  
118

**Reporting signal score**

195.093
- **Event**  
folliculitis

**Reports**  
330

**Reporting signal score**  
1,106.18
- **Event**  
gastrointestinal disorder

**Reports**  
355

**Reporting signal score**

502.681

And 69 more, listed on the interactive page.

### Trial references (73)

- NCT00000402  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000402)
- NCT00000426  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000426)
- NCT00000611  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000611)
- NCT00043719  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00043719)
- NCT00048061  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00048061)
- NCT00172172  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00172172)
- NCT00329797  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00329797)
- NCT00357643  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00357643)
- NCT00404820  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00404820)
- NCT00668941  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00668941)
- NCT00729183  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00729183)
- NCT00752557  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00752557)
- NCT00757393  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00757393)
- NCT00885170  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00885170)
- NCT01656512  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01656512)
- NCT03293108  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03293108)
- NCT00000415  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000415)
- NCT00000543  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000543)
- NCT00001304  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001304)
- NCT00030238  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00030238)
- NCT05933499  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05933499)
- NCT00463268  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00463268)
- NCT00051636  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00051636)
- NCT00103740  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00103740)
- NCT00079001  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00079001)

And 48 more, listed on the interactive page.

## Dosing

**How often**

Twice daily

### Conditions of use (2)

- Dry
- Wash affected area with warm water

## Chemical properties

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

Yes

**Heavy atoms**

1

**Molecular formula**

Ca

**Monoisotopic mass**

39.9625908

**Natural product**

Yes

## National Drug Codes

- 42192-321
- 42192-323
- 58657-170
- 63629-1140
- 70518-3579
- 72162-1658

## Pharmacologic actions

- Calcium-Regulating Hormones and Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000077264.html)

## Related records

### Trials (64)

- A Phase 1b/2 Clinical Trial Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of AUR103 Calcium in Patients With HER2-positive Advanced Gastric/Gastroesophageal Junction Adenocarcinoma
- Alendronate Treatment of Osteoporosis in Rheumatoid Arthritis
- Antiepileptic Drugs and Osteoporotic Prevention Trial
- AUR103 Calcium in Advanced Neuroendocrine Tumours (BHARAT-3 Study)
- Calcium and Bone Mass in Young Females
- Calcium and Vitamin D to Optimize Bone Mass in Boys With Risperidone-induced Hyperprolactinemia
- Calcium Electroporation for Urinary Bladder Tumors: A First-in-Human Feasibility, Safety, and Early Response Trial
- Calcium for Pre-Eclampsia Prevention (CPEP)
- Calcium for Prevention of Ovarian Hyperstimulation Syndrome
- Calcium Supplementation to Prevent Preeclampsia in Sichuan Province of China
- Calcium-41 (41Ca) Chloride Aqueous Solution in Diagnosing Patients With Prostate Cancer and Bone Metastasis
- Comparison of Fluoxetine, Calcium and Placebo for the Treatment of Moderate to Severe Premenstrual Syndrome (PMS)
- Effect of Calcium and Vitamin D on Bone Loss From the Hip
- Effect of Calcium Chloride on Recovery From Neuromuscular Blockade
- Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium
- Effect of Soluble Corn Fiber Supplementation for 1 Year on Bone Metabolism in Adolescents
- Effect of Vitamin D and Calcium on Genes in the Colon
- Effect of Vitamin D Supplement in Induction of Ovulation in Overweight Women With Polycystic Ovary Syndrome
- Effectiveness of Supplemental Calcium in Preventing Postpartum Depression
- Effects of Denosumab on Bone Fusion in Osteoporotic Patients After Lumbar Fusion

### In development for (61)

- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 1
- Allergic disease Phase 3
- Anxiety Phase 2
- [Bipolar disorder](https://trialight.com/data/condition/bipolar-disorder-a61ecd6f-6fb9-5323-bc0d-ebf861411d3c.md) Phase 2
- Bone fracture Phase 3
- Bone giant cell tumor Phase 2
- Bone Paget disease Phase 3
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3
- [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 3
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 3
- Chronic kidney disease Phase 1
- [Colonic neoplasm](https://trialight.com/data/condition/colonic-neoplasm-be61bc3a-c82f-5b84-a20f-3f9931cfcc77.md) Phase 3
- Colorectal adenoma Phase 3
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 3
- [Colorectal carcinoma](https://trialight.com/data/condition/colorectal-carcinoma-51401c02-7884-5c5c-bb91-90106e7d0d4a.md) Phase 3
- [Colorectal neoplasm](https://trialight.com/data/condition/colorectal-neoplasm-31f0a633-3abe-5df4-9d3a-9292c6541f1d.md) Phase 3
- [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) Phase 3
- Dental caries Phase 2
- [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) Phase 2

### Other linked conditions (5)

- Aortic aneurysm
- [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md)
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md)
- [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md)
- [Systemic lupus erythematosus](https://trialight.com/data/condition/systemic-lupus-erythematosus-6c9d074f-cc5f-588b-bf0c-6338d30c6eac.md)

---

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