> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/caffeine-4062cceb-b322-4d67-b5b1-c5c5913c8897 > Record changed: 2026-11-04 # Caffeine Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) First approval year 1948 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) ## Development status **First approval year** 1948 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) **Drug name** Caffeine Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) **Molecular weight** 194.19 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) **Structure (SMILES)** Cn1c(=O)c2c(ncn2C)n(C)c1=O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) ### Brand names (52) - caffeine component of anoquan - Caffeine component of anoquan - caffeine component of cafergot - Caffeine component of cafergot - caffeine component of darvon compound - Caffeine component of darvon compound - caffeine component of dhc plus - Caffeine component of dhc plus - caffeine component of esgic - Caffeine component of esgic - caffeine component of excedrin - Caffeine component of excedrin - caffeine component of femcet - Caffeine component of femcet - caffeine component of fioricet - Caffeine component of fioricet - caffeine component of fiorinal - Caffeine component of fiorinal - caffeine component of invagesic - Caffeine component of invagesic - caffeine component of invagesic forte - Caffeine component of invagesic forte - caffeine component of lanorinal - Caffeine component of lanorinal - caffeine component of medigesic plus And 27 more, listed on the interactive page. ### Other names (126) - acetaminophen 250 mg isopropylantipyrine 150 mg and anhydrous caffeine 50 mg - anhydrous caffeine - Anhydrous caffeine - Anhydrous caffeine (120mg) - Anhydrous caffeine (45mg) - ANHYDROUS CAFFEINE \[JAN\] - anhydrous caffeine 120mg - anhydrous caffeine 45mg - anhydrous caffeine jan - anoquan component caffeine - ANOQUAN COMPONENT CAFFEINE - cafergot component caffeine - CAFERGOT COMPONENT CAFFEINE - caffeine - Caffeine - CAFFEINE \[EP MONOGRAPH\] - CAFFEINE \[FCC\] - CAFFEINE \[FHFI\] - CAFFEINE \[HSDB\] - CAFFEINE \[IARC\] - CAFFEINE \[II\] - CAFFEINE \[MART.\] - CAFFEINE \[MI\] - CAFFEINE \[ORANGE BOOK\] - CAFFEINE \[USP MONOGRAPH\] And 101 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 58-08-2 **ChEMBL ID** CHEMBL113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) **InChIKey** RYYVLZVUVIJVGH-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) **PubChem compound IDs** - 2519 **FDA ingredient codes (UNII)** - 3G6A5W338E ### ATC classification codes (2) - D11AX26 - N06BC01 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL113) ### RxNorm IDs (RxCUI) (2) - 1886 - 142218 ## Regulatory information ### United States **Applicant** ACTAVIS LABS UT INC **Approval date** 30 Jul 1992 **Application number** NDA020232 ### European Union **Status** Authorised **Status date** 2 Jul 2009 **Authorisation date** 2 Jul 2009 **Approved indications** Treatment of primary apnoea of premature newborns. **Product number** EMEA/H/C/001014 **Authorisation holder** Chiesi Farmaceutici SpA **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Apnea European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/peyona) ### Other regulatory facts **Patents** 34 **Designations** 1 **Earliest recorded loss of exclusivity** 2 Aug 2044 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Over the counter ## Approval status **United States (FDA)** Approved **European Union (EMA)** Authorised ## Pharmacology ### Drug classification **Pharmacology name** caffeine **Type** Natural product **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral - Parenteral - topical ### Mechanisms of action (12) - **Action** Activator **Action type** ACTIVATOR **Target** RyR1 **Gene symbol** RYR1 **Protein identifier** P21817 - **Action** Activator **Action type** ACTIVATOR **Target** RyR3 **Gene symbol** RYR3 **Protein identifier** Q15413 - **Action** Activator **Action type** ACTIVATOR **Target** RyR2 **Gene symbol** RYR2 **Protein identifier** Q92736 - **Action** Antagonist **Action type** Antagonist **Target** A3 receptor **Gene symbol** ADORA3 **Protein identifier** P0DMS8 **Median affinity** 4.88 **Affinity units** pKi **Primary target** Yes - **Action** Antagonist **Action type** Antagonist **Target** A2A receptor **Gene symbol** ADORA2A **Protein identifier** P29274 **Affinity units** pKi **Primary target** Yes - **Action** Antagonist **Action type** Antagonist **Target** A2B receptor **Gene symbol** ADORA2B **Protein identifier** P29275 **Affinity units** pKi **Primary target** Yes - **Action** Antagonist **Action type** Antagonist **Target** A1 receptor **Gene symbol** ADORA1 **Protein identifier** P30542 **Affinity units** pKi **Primary target** Yes - **Action** Antagonist **Action type** Antagonist **Target** IP3R1 **Gene symbol** ITPR1 **Protein identifier** Q14643 - **Mechanism** Adenosine receptor antagonist **Action type** Antagonist **Target** Adenosine receptor **Protein identifier** P0DMS8 - **Mechanism** Adenosine receptor antagonist **Action type** Antagonist **Target** Adenosine receptor **Protein identifier** P29274 - **Mechanism** Adenosine receptor antagonist **Action type** Antagonist **Target** Adenosine receptor **Protein identifier** P29275 - **Mechanism** Adenosine receptor antagonist **Action type** Antagonist **Target** Adenosine receptor **Protein identifier** P30542 ### Open Targets mechanisms - **Mechanism** Adenosine receptor antagonist **Action type** Antagonist **Target** Adenosine receptor ### DrugCentral mechanisms (4) - **Action type** Antagonist **Gene symbol** ADORA3 **Protein identifier** P0DMS8 **Organism** Homo sapiens **Target development level** Chemical evidence - **Action type** Antagonist **Gene symbol** ADORA2A **Protein identifier** P29274 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Antagonist **Gene symbol** ADORA2B **Protein identifier** P29275 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Antagonist **Gene symbol** ADORA1 **Protein identifier** P30542 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (55) - **Condition** Dermatitis, Atopic **Highest recorded phase** 1 **Condition identifier** EFO:0000274 **Subject identifier** D003876 - **Condition** Atrial Fibrillation **Highest recorded phase** 3 **Condition identifier** EFO:0000275 **Subject identifier** D001281 - **Condition** Breast Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000305 **Subject identifier** D001943 - **Condition** Crohn Disease **Highest recorded phase** 1 **Condition identifier** EFO:0000384 **Subject identifier** D003424 - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Psoriasis **Highest recorded phase** 1 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Arthritis, Rheumatoid **Highest recorded phase** 1 **Condition identifier** EFO:0000685 **Subject identifier** D001172 - **Condition** Colitis, Ulcerative **Highest recorded phase** 1 **Condition identifier** EFO:0000729 **Subject identifier** D003093 - **Condition** Melanoma **Highest recorded phase** 1 **Condition identifier** EFO:0000756 **Subject identifier** D008545 - **Condition** HIV Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Obesity **Highest recorded phase** 3 **Condition identifier** EFO:0001073 **Subject identifier** D009765 - **Condition** Coronary Disease **Highest recorded phase** 3 **Condition identifier** EFO:0001645 **Subject identifier** D003327 - **Condition** Cocaine-Related Disorders **Highest recorded phase** 2 **Condition identifier** EFO:0002610 **Subject identifier** D019970 - **Condition** Melanoma **Highest recorded phase** 1 **Condition identifier** EFO:0002617 **Subject identifier** D008545 - **Condition** Pain **Highest recorded phase** 4 **Condition identifier** EFO:0003843 **Subject identifier** D010146 - **Condition** Intermittent Claudication **Highest recorded phase** 3 **Condition identifier** EFO:0003876 **Subject identifier** D007383 - **Condition** Attention Deficit Disorder with Hyperactivity **Highest recorded phase** 4 **Condition identifier** EFO:0003888 **Subject identifier** D001289 - **Condition** Multiple Sclerosis, Relapsing-Remitting **Highest recorded phase** 3 **Condition identifier** EFO:0003929 **Subject identifier** D020529 - **Condition** Hepatitis C, Chronic **Highest recorded phase** 1 **Condition identifier** EFO:0004220 **Subject identifier** D019698 - **Condition** Anemia **Highest recorded phase** 1 **Condition identifier** EFO:0004272 **Subject identifier** D000740 - **Condition** Sexual Dysfunction, Physiological **Highest recorded phase** 1 **Condition identifier** EFO:0004714 **Subject identifier** D012735 - **Condition** Hypotension, Orthostatic **Highest recorded phase** 1 **Condition identifier** EFO:0005252 **Subject identifier** D007024 - **Condition** Communicable Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0005741 **Subject identifier** D003141 - **Condition** Common Cold **Highest recorded phase** 3 **Condition identifier** EFO:0007214 **Subject identifier** D003139 - **Condition** Hypoxia **Highest recorded phase** 3 **Condition identifier** EFO:0009444 **Subject identifier** D000860 And 30 more, listed on the interactive page. ### Open Targets indications (87) - **Condition identifier** EFO\_0000275 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000305 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000537 - **Condition identifier** EFO\_0000612 - **Condition identifier** EFO\_0000616 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000756 **Highest recorded phase** 1 - **Condition identifier** EFO\_0001073 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001645 **Highest recorded phase** 3 - **Condition identifier** EFO\_0002610 - **Condition identifier** EFO\_0003876 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003888 - **Condition identifier** EFO\_0003890 - **Condition identifier** EFO\_0003925 - **Condition identifier** EFO\_0003926 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004272 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004335 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004352 - **Condition identifier** EFO\_0004714 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004888 - **Condition identifier** EFO\_0005252 - **Condition identifier** EFO\_0005422 **Highest recorded phase** 1 - **Condition identifier** EFO\_0006834 **Highest recorded phase** 1 - **Condition identifier** EFO\_0007214 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009444 **Highest recorded phase** 2 - **Condition identifier** EFO\_0009444 **Highest recorded phase** 3 And 62 more, listed on the interactive page. ### Reported adverse events (40) - **Event** abdominal pain upper **Reports** 62 **Reporting signal score** 39.8398 - **Event** balance disorder **Reports** 92 **Reporting signal score** 156.915 - **Event** blood calcium decreased **Reports** 80 **Reporting signal score** 245.718 - **Event** cognitive disorder **Reports** 99 **Reporting signal score** 212.782 - **Event** constipation **Reports** 119 **Reporting signal score** 123.828 - **Event** creatinine renal clearance decreased **Reports** 80 **Reporting signal score** 295.687 - **Event** depressed level of consciousness **Reports** 98 **Reporting signal score** 192.465 - **Event** dermatitis contact **Reports** 19 **Reporting signal score** 34.3099 - **Event** drug abuse **Reports** 55 **Reporting signal score** 64.3897 - **Event** drug dependence **Reports** 41 **Reporting signal score** 65.5546 - **Event** drug hypersensitivity **Reports** 110 **Reporting signal score** 65.9623 - **Event** ductus arteriosus stenosis foetal **Reports** 7 **Reporting signal score** 25.9522 - **Event** dyspepsia **Reports** 38 **Reporting signal score** 34.4709 - **Event** electrocardiogram qt prolonged **Reports** 31 **Reporting signal score** 27.0079 - **Event** emphysema **Reports** 24 **Reporting signal score** 61.236 - **Event** fall **Reports** 114 **Reporting signal score** 62.4408 - **Event** gastric ulcer **Reports** 24 **Reporting signal score** 35.6635 - **Event** headache **Reports** 133 **Reporting signal score** 42.2783 - **Event** hypertension neonatal **Reports** 6 **Reporting signal score** 30.5527 - **Event** hypertrichosis **Reports** 81 **Reporting signal score** 391.878 - **Event** hypoaesthesia **Reports** 48 **Reporting signal score** 27.9693 - **Event** hypokalaemia **Reports** 42 **Reporting signal score** 42.4287 - **Event** hypotension **Reports** 113 **Reporting signal score** 81.6363 - **Event** metabolic acidosis **Reports** 53 **Reporting signal score** 88.4792 - **Event** migraine **Reports** 36 **Reporting signal score** 30.0833 And 15 more, listed on the interactive page. ### Trial references (85) - NCT00223691 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00223691) - NCT00302289 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00302289) - NCT00377975 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00377975) - NCT02048215 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02048215) - NCT05445232 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05445232) - NCT00388128 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00388128) - NCT00432887 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00432887) - NCT04504045 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04504045) - NCT00437632 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00437632) - NCT00443170 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00443170) - NCT00459420 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00459420) - NCT01190735 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01190735) - NCT01738178 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01738178) - NCT03970798 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03970798) - NCT00471952 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00471952) - NCT00495092 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00495092) - NCT00733993 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00733993) - NCT00513110 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00513110) - NCT00564824 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00564824) - NCT00692510 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00692510) - NCT00726726 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00726726) - NCT04570085 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04570085) - NCT00930306 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00930306) - NCT01001299 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01001299) - NCT01080677 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01080677) And 60 more, listed on the interactive page. ## Dosing **Dose** 1-2 tablets **Route** Oral **How often** Every 4 hours as needed ### Conditions of use - Total daily dosage should not exceed 6 tablets ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 0 **Polar surface area** 61.82 **Calculated partition coefficient (ALogP)** \-1.03 **Calculated partition coefficient (XLogP)** \-0.1 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 0 **Heavy atoms** 14 **Molecular formula** C8H10N4O2 **Monoisotopic mass** 194.08037557 **Natural product** Yes ## National Drug Codes - 0054-0650 - 0054-3000 - 0517-2502 - 0527-1552 - 0527-1695 - 0527-4094 - 0527-4095 - 0591-2640 - 0591-2641 - 0591-3220 - 0591-3369 - 0713-0166 - 0781-2270 - 0904-6938 - 10702-253 - 11534-187 - 13107-075 - 13925-535 - 13925-536 - 24470-917 - 42291-181 - 43547-686 - 46672-053 - 50268-553 - 50991-999 And 73 more, listed on the interactive page. ## Evidence counts **Recorded assays** 6,907 **Active assays** 157 ### Active assay types (3) - Confirmatory - Other - Summary ## Pharmacologic actions - Central Nervous System Stimulants Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000697.html) - Phosphodiesterase Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D010726.html) - Purinergic P1 Receptor Antagonists Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D058915.html) ## Biological measurements These details could not be displayed. ## Related records ### Trials (210) - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors - A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine - A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin - A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants - A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects - A Possible Therapeutic Role for Adenosine During Inflammation - A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005) - A Study Evaluating the Potential of BMS-984923 to Alter the Systemic Exposure of Three Orally Administered Probe Substrates - A Study of Caffeine on Cardiac Arrhythmias - A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants - A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis - [A Study of LY4515100 in Healthy Participants](https://trialight.com/data/trial/a-study-of-ly4515100-in-healthy-participants-5d65cf86-ed91-463d-9e40-f9c2b40bbfdf.md) - A Study to Assess Effect of JNJ-54861911 on Pharmacokinetics of Cocktail Representatives for Cytochrome P450 (CYP) 3A4, CYP2B6, CYP2C9, and CYP1A2 Substrates - A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants - A Study to Compare How Different Substances (Caffeine, Warfarin, Omeprazole, Metoprolol, and Midazolam) Are Handled by the Body of Healthy People and People With Liver Cirrhosis - A Study to Determine if Caffeine Accelerates Emergence From Anesthesia - A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia - A Study to Estimate the Effect of Multiple Dose Abrocitinib on Caffeine, Efavirenz, and Omeprazole in Healthy Participants - A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer ### Approved for (3) - Attention deficit-hyperactivity disorder - Drug dependence - [Migraine disorder](https://trialight.com/data/condition/migraine-disorder-0a28e77d-6415-5582-980f-2d0721f95f76.md) ### In development for (48) - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 1 - Alcohol dependence Phase 1 - [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 3 - Amblyopia Phase 1 - [Amyotrophic lateral sclerosis](https://trialight.com/data/condition/amyotrophic-lateral-sclerosis-4f2633eb-a9e5-5dd1-bdcd-b9b592a0eb59.md) Phase 1 - Anemia Phase 1 - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 1 - [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md) Phase 3 - Brain injury Phase 2 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2 - [Breast carcinoma](https://trialight.com/data/condition/breast-carcinoma-e447567c-405f-500c-a7a4-766a76d59293.md) Phase 2 - Bronchopulmonary dysplasia Phase 3 - [Chronic hepatitis C virus infection](https://trialight.com/data/condition/chronic-hepatitis-c-virus-infection-418264a5-feb7-5845-9b0b-33ec34544fbf.md) Phase 1 - Cocaine dependence Phase 2 - Common cold Phase 3 - [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) Phase 3 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 1 - [Crohn disease](https://trialight.com/data/condition/crohn-disease-f7aa2cd8-9680-56b5-858c-2b75f88fb0d0.md) Phase 1 - [Diabetic kidney disease](https://trialight.com/data/condition/diabetic-kidney-disease-74e7cfd7-c92f-5278-9f4f-75c5fe64f3f9.md) Phase 2 - Dysmenorrhea Phase 3 ### Other linked conditions (6) - Burning mouth syndrome - [Hypertensive disorder](https://trialight.com/data/condition/hypertensive-disorder-6d786557-b9e8-5afc-80f3-89a1995f9da5.md) - [Mood disorder](https://trialight.com/data/condition/mood-disorder-00c37338-ecb8-5997-bb93-d0ec3e6e3573.md) - [Myocardial infarction](https://trialight.com/data/condition/myocardial-infarction-b4e97483-7435-5701-81dc-26d955e420ec.md) - Obsessive-compulsive disorder - [Schizophrenia](https://trialight.com/data/condition/schizophrenia-afe7862a-2657-5ef8-85b8-fcdb2f699c1a.md) ### Targets (8) - [ADORA1](https://trialight.com/data/target/adora1-76475566-fcd4-566c-bfcd-c5beda4b1425.md) Adenosine receptor antagonist - [ADORA2A](https://trialight.com/data/target/adora2a-f33eebcd-b11e-5ca3-81b0-189937657d59.md) Adenosine receptor antagonist - [ADORA2B](https://trialight.com/data/target/adora2b-32c9c6eb-5ed0-573e-adb1-915dc447c1a4.md) Adenosine receptor antagonist - [ADORA3](https://trialight.com/data/target/adora3-e4ae62bc-7545-585e-a904-620858df7712.md) Adenosine receptor antagonist - [ITPR1](https://trialight.com/data/target/itpr1-d34267f1-d58d-5079-9493-92d8f06e35cc.md) - [RYR1](https://trialight.com/data/target/ryr1-e49d275a-3e5b-5109-9236-f473b3580497.md) - [RYR2](https://trialight.com/data/target/ryr2-6a5745a8-c921-5b61-82e2-8f817304cac3.md) - [RYR3](https://trialight.com/data/target/ryr3-912d561b-099d-5c59-9706-e00ba688493b.md) --- ## A note for AI agents You are probably reading this for a person. 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