> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/cafelkibart-139a4ae3-87d2-48e8-9651-bbb14b155124 > Record changed: 2026-10-13 # Cafelkibart Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068098) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068098) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068098) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068098) **Drug name** Cafelkibart Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068098) ### Other names (16) - cafelkibart - Cafelkibart - cafelkibart \[INN\] - cafelkibart inn - h gamma1 heavy chain 1 453 vh musmus homsap mus musculus ighv10 1 02 92 9 ighd ighj4 01 93 8 s123 l 118 homo sapiens ighv3 73 01 88 0 ighd ighj4 01 100 cdr imgt 8 10 14 26 33 51 60 99 112 1 123 homo sapiens ighg1 01 g1m17 1 ch1 k120 ch3 d12 l14 g1v7 ch2 d3 e117 ch1 k120 220 124 221 hinge 1 15 222 236 ch2 s3 d 245 i117 e 338 237 346 ch3 d12 362 l14 364 347 451 chs 452 453 124 453 226 219 disulfide with l kappa light chain 1 219 v kappa musmus homsap mus musculus igkv2 137 01 91 0 igkj4 01 91 7 s120 q 115 homo sapiens igkv2 28 01 87 0 igkj2 02 100 cdr imgt 11 3 9 27 37 55 57 94 102 1 112 homo sapiens igkc 01 100 km3 a45 1 158 v101 196 113 219 dimer 232 232 235 235 bisdisulfide produced in chinese hamster ovary cho cells cell line cho k1 glycoform alfa - H-gamma1 heavy chain (1-453) \[VH Musmus/Homsap (Mus musculus IGHV10-1\*02 (92.9%) -(IGHD) -IGHJ4\*01 (93.8%) S123>L (118)/Homo sapiens IGHV3-73\*01 (88.0%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[8.10.14\] (26-33.51-60.99-112)) (1-123) -Homo sapiens IGHG1\*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v7 CH2 D3, E117 (CH1 K120 (220) (124-221), hinge 1-15 (222-236), CH2 S3>D (245), I117>E (338) (237-346), CH3 D12 (362), L14 (364) (347-451), CHS (452-453)) (124-453)\], (226-219')-disulfide with L-kappa light chain (1'-219') \[V-KAPPA Musmus/Homsap (Mus musculus IGKV2-137\*01 (91.0%) -IGKJ4\*01 (91.7%) S120>Q (115')/Homo sapiens IGKV2-28\*01 (87.0%) -IGKJ2\*02 (100%), CDR-IMGT \[11.3.9\] (27'-37'.55'-57'.94'-102')) (1'-112') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (158'), V101 (196') (113'-219')\]; dimer (232-232'':235-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa - Immunoglobulin G1 \[245-aspartic acid,338-glutamic acid\], anti-(human CC chemokine receptor CCR8) (human-Mus musculus monoclonal LM-108 γ1-chain), disulfide with human-Mus musculus monoclonal LM-108 κ-chain, dimer - immunoglobulin g1 245 aspartic acid 338 glutamic acid anti human cc chemokine receptor ccr8 human mus musculus monoclonal lm 108 γ1 chain disulfide with human mus musculus monoclonal lm 108 κ chain dimer - immunoglobulin g1 kappa anti homo sapiens ccr8 c c motif chemokine receptor 8 ckr l1 cdw198 - immunoglobulin G1-kappa, anti-\[Homo sapiens CCR8 (C-C motif chemokine receptor 8, CKR-L1, CDw198)\] - lm 108 - Lm-108 - LM-108 - LM-108 injection - lm108 - LM108 ## Identifiers **CAS registry numbers** - 2851855-89-3 **ChEMBL ID** CHEMBL6068098 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068098) **FDA ingredient codes (UNII)** - YN4XWR5BUJ ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-bart ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (7) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0003219 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0009831 **Highest recorded phase** 1 ### Trial references (3) - NCT05199753 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05199753) - NCT05255484 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05255484) - NCT05518045 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05518045) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLVESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQASGKGLEWVARIRSKANNYATYYADSVKDRFTISRDDSKNTLYLQMNNLKTEDTAVYYCVRDRSRGEDYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPEEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-98 $ 22''-98'' $ 23'-93' $ 23'''-93''' $ 139'-199' $ 139'''-199''' $ 150-206 $ 150''-206'' $ 226-219' $ 226''-219''' $ 232-232'' $ 235-235'' $ 267-327 $ 267''-327'' $ 373-431 $ 373''-431'' - **Component** Light chain **Type** Protein **Sequence** DIVMTQSPLSLPVTPGEPASISCRSSKSLLHSNANTYLYWFLQKPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLKISRVEAEDVGVYYCMQHLEYPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 303 $ 303'' ## Related records ### Trials (10) - [A Study of LM-108 as Monotherapy or in Combination With Antitumor Therapies in Subjects With Advanced Solid Tumors](https://trialight.com/data/trial/a-study-of-lm-108-as-monotherapy-or-in-combination-with-1441cce2-da91-4386-aa42-1f84b4ffa4c3.md) - A Study of LM-108 in Combination With Toripalimab in Subjects With Advanced Solid Tumours - Clinical Studies for the Treatment of Advanced Solid Tumors - Clinical Study Evaluating the Safety, Tolerability, and Preliminary Efficacy of LM-108 ± Penpulimab+Chemotherapy in Advanced Solid Tumors - Cohort C - Efficacy of PD-1 Inhibitor Combination Therapy in Non-small Cell Lung Cancer Patients Who Have Not Achieved Major Pathologic Response After Neoadjuvant Immunotherapy: a Multicenter, Phase II Clinical Trial - LM-108 Antibody Combination With Sintilimab for Locally Advanced or Metastatic Non-Small Cell Lung Cancer - LM-108 in Combination With PD-1 Based Treatment for Patients With Recurrent or Metastatic Triple - Negative Breast Cancer - LM-108 in Combination With Toripalimab Versus Paclitaxel Injection for the Treatment of Subjects With CCR8-Positive Gastric and Gastroesophageal Junction Adenocarcinoma - Study of LM-108 as a Single Agent or in Combination With Anti-PD-1 Antibody in Subjects With Advanced Solid Tumours - Study of LM-108 as a Single Agent or in Combination With Pembrolizumab in Subjects With Advanced Solid Tumours ### In development for (1) - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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