> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/cadonilimab-3970701f-ffc8-4027-a97b-4e6c913803e6
> Record changed: 2026-10-13

# Cadonilimab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594456)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594456)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594456)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594456)

**Drug name**

Cadonilimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594456)

### Other names (31)

- ak 104
- Ak-104
- AK-104
- ak104
- Ak104
- AK104
- AK104 (after the change)
- AK104 (before the change)
- AK104 (New Site)
- AK104 (Original Site)
- AK104 injection
- anti pd1 anti ctla4 bispecific antibody ak104
- ANTI-PD1/ANTI-CTLA4 BISPECIFIC ANTIBODY AK104
- cadonilimab
- Cadonilimab
- Cadonilimab (AK104)
- cadonilimab \[INN\]
- CADONILIMAB \[USAN\]
- Cadonilimab \[WHO-DD\]
- Cadonilimab Injection
- cadonilimab inn
- cadonilimab usan
- cadonilimab who dd
- Cadonilimab（AK104）
- Candonilimab (AK104)

And 6 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2394841-59-7

**ChEMBL ID**

CHEMBL4594456

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594456)

**FDA ingredient codes (UNII)**

- 6FYG1DS4NW

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

cadonilimab

**Type**

Antibody

**Drug name stem**

\-mab

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (4)

- **Action**  
Binding

**Action type**  
Binding

**Target**  
cytotoxic T-lymphocyte-associated protein 4 (CD152)

**Gene symbol**  
CTLA4

**Protein identifier**  
P16410

**Median affinity**

10.1

**Affinity units**  
pEC50

**Primary target**  
Yes
- **Action**  
Binding

**Action type**  
Binding

**Target**  
programmed cell death 1 (CD279)

**Gene symbol**  
PDCD1

**Protein identifier**  
Q15116

**Median affinity**

10.29

**Affinity units**  
pEC50

**Primary target**  
Yes
- **Mechanism**  
Cytotoxic T-lymphocyte protein 4 inhibitor

**Action type**  
Inhibitor

**Target**  
Cytotoxic T-lymphocyte protein 4

**Protein identifier**  
P16410
- **Mechanism**  
Programmed cell death protein 1 inhibitor

**Action type**  
Inhibitor

**Target**  
Programmed cell death protein 1

**Protein identifier**  
Q15116

### Open Targets mechanisms (2)

- **Mechanism**  
Cytotoxic T-lymphocyte protein 4 inhibitor

**Action type**  
Inhibitor

**Target**  
Cytotoxic T-lymphocyte protein 4
- **Mechanism**  
Programmed cell death protein 1 inhibitor

**Action type**  
Inhibitor

**Target**  
Programmed cell death protein 1

### Investigated indications (37)

- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000181

**Subject identifier**  
D002294
- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Lymphoma, T-Cell, Peripheral

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000211

**Subject identifier**  
D016411
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000365

**Subject identifier**  
D015179
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000503

**Subject identifier**  
D013274
- **Condition**  
Glioblastoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000519

**Subject identifier**  
D005909
- **Condition**  
Mesothelioma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000588

**Subject identifier**  
D008654
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Renal Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000681

**Subject identifier**  
D002292
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Melanoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000756

**Subject identifier**  
D008545
- **Condition**  
Uterine Cervical Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001061

**Subject identifier**  
D002583
- **Condition**  
Uterine Cervical Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001416

**Subject identifier**  
D002583
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Nasopharyngeal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004252

**Subject identifier**  
D009303
- **Condition**  
Esophageal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005922

**Subject identifier**  
D004938
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0008528

**Subject identifier**  
D001749
- **Condition**  
Rectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000657

**Subject identifier**  
D012004
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001951

**Subject identifier**  
D015179
- **Condition**  
Cholangiocarcinoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001961

**Subject identifier**  
D018281
- **Condition**  
Sarcoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001968

**Subject identifier**  
D012509
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001056

**Subject identifier**  
D013274
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001187

**Subject identifier**  
D001749
- **Condition**  
Vulvar Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001528

**Subject identifier**  
D014846

And 12 more, listed on the interactive page.

### Open Targets indications (80)

- **Condition identifier**  
EFO\_0000182

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000211
- **Condition identifier**  
EFO\_0000349

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000503

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000519

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000588

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000681

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000702

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000756

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001061

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0001416

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0002618

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0002916

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003860

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004252
- **Condition identifier**  
EFO\_0005221

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005708

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005922

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0008528

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000485

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001012

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1001480

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001951

**Highest recorded phase**  
2

And 55 more, listed on the interactive page.

### Reported adverse events (7)

- **Event**  
alanine aminotransferase increased

**Reports**  
3

**Reporting signal score**

9.76484
- **Event**  
aspartate aminotransferase increased

**Reports**  
3

**Reporting signal score**

10.1147
- **Event**  
hypoalbuminaemia

**Reports**  
2

**Reporting signal score**

10.0585
- **Event**  
hypothyroidism

**Reports**  
2

**Reporting signal score**

7.86108
- **Event**  
immune-mediated myocarditis

**Reports**  
2

**Reporting signal score**

16.3001
- **Event**  
myelosuppression

**Reports**  
4

**Reporting signal score**

21.8215
- **Event**  
white blood cell count decreased

**Reports**  
3

**Reporting signal score**

8.94461

### Trial references (106)

- NCT03261011  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03261011)
- NCT05235542  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05235542)
- NCT05868876  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05868876)
- NCT04172454  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04172454)
- NCT04349969  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04349969)
- NCT04547101  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04547101)
- NCT04572152  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04572152)
- NCT05021120  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05021120)
- NCT05142423  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05142423)
- NCT05559541  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05559541)
- NCT05644392  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05644392)
- NCT05915481  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05915481)
- NCT05944224  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05944224)
- NCT06327698  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06327698)
- NCT04220307  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04220307)
- NCT05587374  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05587374)
- NCT05790200  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05790200)
- NCT05898256  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05898256)
- NCT04380805  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04380805)
- NCT04868708  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04868708)
- NCT04982237  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04982237)
- NCT05227651  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05227651)
- NCT05817214  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05817214)
- NCT05824494  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05824494)
- NCT06209294  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06209294)

And 81 more, listed on the interactive page.

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (5)

- **Component**  
Glycosylation sites (N)

**Sequence**  
298 $ 298'''' $ 524 $ 524''''
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIQMTQSPSSMSASVGDRVTFTCRASQDINTYLSWFQQKPGKSPKTLIYRANRLVSGVPSRFSGSGSGQDYTLTISSLQPEDMATYYCLQYDEFPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
EVQLVESGGGLVQPGGSLRLSCAASGFAFSSYDMSWVRQAPGKGLDWVATISGGGRYTYYPDSVKGRFTISRDNSKNNLYLQMNSLRAEDTALYYCANRYGEAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSGGGGSGGGGSGGGGSQVQLVESGAEVKKPGASVKVSCKASGYSFTGYTMNWVRQAPGQCLEWIGLINPYNNITNYAQKFQGRVTFTVDTSISTAYMELSRLRSDDTGVYFCARLDYRSYWGQGTLVTVSAGGGGSGGGGSGGGGSGGGGSQAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNFPNWVQQKPGQAPRSLIGGTNNKASWTPARFSGSLLGGKAALTISGAQPEDEAEYYCALWYSNHWVFGCGTKLTVLR
- **Component**  
Glycosylation sites (N)

**Sequence**  
298 $ 298'' $ 524 $ 524''
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 145-201 $ 145''-201'' $ 221-214' $ 221''-214''' $ 227-227'' $ 230-230'' $ 262-322 $ 262''-322'' $ 368-426 $ 368''-426'' $ 490-564 $ 490''-564'' $ 512-705 $ 512''-705'' $ 625-293 $ 625''-693''

## Related records

### Trials (210)

- A Multi-center, Randomized, Double-blind, Phase II/III Clinical Trial of AK104 or Placebo in Combination With Chemotherapy as Second-line or More Lines for Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC)
- [A Phase Ia/Ib Open Label，Clinical Study Evaluating the Safety, Tolerability and Preliminary Efficacy of AK127 in Combination With AK104 in Patients With Advanced Malignant Tumors](https://trialight.com/data/trial/a-phase-ia-ib-open-label-clinical-study-evaluating-the-ea3d5cd1-0f2f-4382-8c25-855965404eab.md)
- A Phase Ib/II Study of AK104 and AK117 in Combination With or Without Chemotherapy in Advanced Malignant Tumors
- A Phase II Clinical Study of AK104/AK112 in Combination With TT-00420 Tablet for Advanced HCC.
- A Phase II Clinical Study of Cadonilimab in Treatment-naïve or Relapsed Extensive Small Cell Lung Cancer
- A Phase II Study of AK104 Combination With Lenvatinib Versus Lenvatinib for Second-line HCC
- A Phase II Study of AK104 Plus Lenvatinib and TACE in HCC
- A Phase II Study of Neoadjuvant Immunotherapy in Combination With Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma
- A Phase II Trial of AK104 in Advanced Non-Small Cell Lung Cancer
- A Phase III Clinical Study of Cadonilimab Plus SOX as Perioperative Treatment for Patients With Resectable G/GEJ Adenocarcinoma
- A Phase III Study of AK104 as Adjuvant Therapy in HCC With High Risk of Recurrence After Curative Resection
- A Phase lb/lI Clinical Study in Advanced or Metastatic Esophageal Squamous Cell Carcinoma
- A Prospective Real-world Study of Cadonilimab in Patients With Recurrent or Metastatic Cervical Cancer
- A Prospective Study of Cadonilimab in Hepatocellular Carcinoma After Radical Surgery With High Risk of Recurrence
- A Prospective, Open-label, Single-center, Single-arm Phase II Clinical Study of Cadonilimab (AK104) Combined With Monotherapy Chemotherapy in Patients With Advanced Non-small Cell Lung Cancer With Negative Driver Genes and Failed Immunotherapy
- A Single-arm Pilot Study of First-line Treatment With Carbognilumab Combined With Chemotherapy in Patients With STK11-mutated Advanced or Postoperative Recurrent Non-small Cell Lung Cancer
- A Single-Arm, Phase II Clinical Trail of Cadonilimab Combined With Chemoradiotherapy in Oligometastatic Stage IVB Cervical Cancer
- A Study Evaluating Cadonilimab Injection in Combination With Regorafenib for the Advanced Hepatocellular Carcinoma
- A Study Evaluating Cadonilimab Injection in Combination With Regorafenib for the Treatment of Biliary Systemic Tumours
- A Study of a PD-1/CTLA-4 Bispecific Antibody AK104 in Patients With Metastatic Nasopharyngeal Carcinoma

### In development for (44)

- Bile duct adenocarcinoma Phase 2
- [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 2
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- Carcinoma of esophagus Phase 2
- [Cervical adenocarcinoma](https://trialight.com/data/condition/cervical-adenocarcinoma-013a4346-286c-5c50-bd25-66fde59ac6a0.md) Phase 3
- [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 3
- Cervical carcinoma Phase 3
- [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 2
- [Clear cell renal carcinoma](https://trialight.com/data/condition/clear-cell-renal-carcinoma-789eee25-ec64-5771-9b7d-d19544781b11.md) Phase 2
- [Colorectal adenocarcinoma](https://trialight.com/data/condition/colorectal-adenocarcinoma-49107d5a-ece1-5f2b-8783-f2077e298ffa.md) Phase 2
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2
- [Colorectal carcinoma](https://trialight.com/data/condition/colorectal-carcinoma-51401c02-7884-5c5c-bb91-90106e7d0d4a.md) Phase 2
- [Esophageal cancer](https://trialight.com/data/condition/esophageal-cancer-a3b5271c-e6d4-537b-8dfd-9391c60e2af2.md) Phase 2
- [Esophageal squamous cell carcinoma](https://trialight.com/data/condition/esophageal-squamous-cell-carcinoma-c10bd9c9-02f9-5805-8008-b021f4604e7a.md) Phase 2
- Exocrine pancreatic carcinoma Phase 2
- [Gastric adenocarcinoma](https://trialight.com/data/condition/gastric-adenocarcinoma-6bb74a55-7ba6-53e3-a113-22296a84d6ae.md) Phase 2
- [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 2
- [Gastroesophageal junction adenocarcinoma](https://trialight.com/data/condition/gastroesophageal-junction-adenocarcinoma-de7e280e-cbd1-5266-a5dd-dda00261a706.md) Phase 3
- Glioblastoma Phase 1

### Targets (2)

- [CTLA4](https://trialight.com/data/target/ctla4-ba502748-1564-5251-a6a1-96e2f7035fe9.md) Cytotoxic T-lymphocyte protein 4 inhibitor
- [PDCD1](https://trialight.com/data/target/pdcd1-a7b9a076-9fdd-55c9-9ce8-e558e5c7503f.md) Programmed cell death protein 1 inhibitor

---

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