> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/buprenorphine-c075c804-b1a4-4839-84d9-79aa0e258585 > Record changed: 2026-10-13 # Buprenorphine Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) First approval year 1981 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) ## Development status **First approval year** 1981 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) **Drug name** Buprenorphine Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) **Molecular weight** 467.65 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) **Structure (SMILES)** CO\[C@@\]12CC\[C@@\]3(C\[C@@H\]1\[C@\](C)(O)C(C)(C)C)\[C@H\]1Cc4ccc(O)c5c4\[C@@\]3(CCN1CC1CC1)\[C@H\]2O5 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) ### Brand names (30) - brixadi - Brixadi - bupeaze - Bupeaze - buplast - Buplast - butec - Butec - butrans - Butrans - buvidal - Buvidal - hapoctasin - Hapoctasin - panitaz - Panitaz - prenotrix - Prenotrix - reletrans - Reletrans - sevodyne - Sevodyne - sublocade - Sublocade - temgesic And 5 more, listed on the interactive page. ### Other names (49) - (αS,5α,7α)-17-(Cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanol - 6 14 ethenomorphinan 7 methanol 17 cyclopropylmethyl α 1 1 dimethylethyl 4 5 epoxy 18 19 dihydro 3 hydroxy 6 methoxy α methyl 5α 7α s - 6 14 ethenomorphinan 7 methanol 17 cyclopropylmethyl α 1 1 dimethylethyl 4 5 epoxy 18 19 dihydro 3 hydroxy 6 methoxy α methyl αs 5α 7α - 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-, (αS,5α,7α)- - 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-, \[5α,7α(S)\]- - alks 5461 component buprenorphine - ALKS-5461 COMPONENT BUPRENORPHINE - brixadi - Brixadi - Brixadi (Injectable Buprenorphine) - buprenorfina - Buprenorfina - buprenorphin - Buprenorphin - buprenorphine - Buprenorphine - BUPRENORPHINE \[EMA EPAR\] - BUPRENORPHINE \[EP IMPURITY\] - BUPRENORPHINE \[EP MONOGRAPH\] - buprenorphine \[INN\] - BUPRENORPHINE \[JAN\] - BUPRENORPHINE \[MART.\] - BUPRENORPHINE \[MI\] - BUPRENORPHINE \[ORANGE BOOK\] - BUPRENORPHINE \[VANDF\] And 24 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 52485-79-7 **ChEMBL ID** CHEMBL511142 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) **InChIKey** RMRJXGBAOAMLHD-CTAPUXPBSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) **RxNorm IDs (RxCUI)** - 1819 **FDA ingredient codes (UNII)** - 40D3SCR4GZ ### ATC classification codes (3) - N02AE01 - N07BC01 - N07BC51 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL511142) ### PubChem compound IDs (2) - 644073 - 9848990 ## Regulatory information ### United States **Applicant** KNOA PHARMA **Approval date** 30 Jun 2010 **Application number** NDA021306 ### European Union **Status** Authorised **Status date** 20 Nov 2018 **Authorisation date** 20 Nov 2018 **Approved indications** Treatment of opioid dependence within a framework of medical, social and psychological treatment. Treatment is intended for use in adults and adolescents aged 16 years or over. **Product number** EMEA/H/C/004651 **Authorisation holder** Camurus AB **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Opioid-Related Disorders European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/buvidal) ### Other regulatory facts **Patents** 20 **Designations** 1 **Earliest recorded loss of exclusivity** 22 Jun 2038 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Pharmacology name** buprenorphine **Type** Synthetic organic **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral - topical ### Mechanisms of action (4) - **Mechanism** Kappa opioid receptor agonist **Action type** Agonist **Target** Kappa-type opioid receptor **Protein identifier** P41145 - **Mechanism** Mu opioid receptor agonist **Action type** Agonist **Target** Mu-type opioid receptor **Protein identifier** P35372 - **Action** Antagonist **Action type** Antagonist **Target** κ receptor **Gene symbol** OPRK1 **Protein identifier** P41145 **Affinity units** pKi **Primary target** Yes - **Action** Partial agonist **Action type** PARTIAL\_AGONIST **Target** μ receptor **Gene symbol** OPRM1 **Protein identifier** P35372 **Median affinity** 8.8 **Affinity units** pKi **Primary target** Yes ### Open Targets mechanisms (2) - **Mechanism** Kappa opioid receptor agonist **Action type** Agonist **Target** Kappa-type opioid receptor - **Mechanism** Mu opioid receptor agonist **Action type** Agonist **Target** Mu-type opioid receptor ### DrugCentral mechanisms (3) - **Action type** Antagonist **Gene symbol** OPRD1 **Protein identifier** P41143 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Antagonist **Gene symbol** OPRK1 **Protein identifier** P41145 **Organism** Homo sapiens **Target development level** Clinical - **Action type** PARTIAL AGONIST **Gene symbol** OPRM1 **Protein identifier** P35372 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (29) - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000181 **Subject identifier** D002294 - **Condition** HIV Infections **Highest recorded phase** 3 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Stress Disorders, Post-Traumatic **Highest recorded phase** 2 **Condition identifier** EFO:0001358 **Subject identifier** D013313 - **Condition** Cocaine-Related Disorders **Highest recorded phase** 3 **Condition identifier** EFO:0002610 **Subject identifier** D019970 - **Condition** Hepatitis C **Highest recorded phase** 1 **Condition identifier** EFO:0003047 **Subject identifier** D006526 - **Condition** Pain **Highest recorded phase** 4 **Condition identifier** EFO:0003843 **Subject identifier** D010146 - **Condition** Acute Pain **Highest recorded phase** 4 **Condition identifier** EFO:0003843 **Subject identifier** D059787 - **Condition** Substance-Related Disorders **Highest recorded phase** 4 **Condition identifier** EFO:0003890 **Subject identifier** D019966 - **Condition** Heroin Dependence **Highest recorded phase** 3 **Condition identifier** EFO:0004240 **Subject identifier** D006556 - **Condition** Amphetamine-Related Disorders **Highest recorded phase** 2 **Condition identifier** EFO:0004701 **Subject identifier** D019969 - **Condition** Opioid-Related Disorders **Highest recorded phase** 4 **Condition identifier** EFO:0005611 **Subject identifier** D009293 - **Condition** Morphine Dependence **Highest recorded phase** 3 **Condition identifier** EFO:0005612 **Subject identifier** D009021 - **Condition** Neuralgia **Highest recorded phase** 3 **Condition identifier** EFO:0005762 **Subject identifier** D009437 - **Condition** Neonatal Abstinence Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0005799 **Subject identifier** D009357 - **Condition** Substance Withdrawal Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0005800 **Subject identifier** D013375 - **Condition** Toothache **Highest recorded phase** 2 **Condition identifier** EFO:0010072 **Subject identifier** D014098 - **Condition** Opioid-Related Disorders **Highest recorded phase** 4 **Condition identifier** EFO:0010702 **Subject identifier** D009293 - **Condition** Drug Overdose **Highest recorded phase** 4 **Condition identifier** EFO:0020911 **Subject identifier** D062787 - **Condition** Rotator Cuff Injuries **Highest recorded phase** 2 **Condition identifier** EFO:1001250 **Subject identifier** D000070636 - **Condition** Back Pain **Highest recorded phase** 3 **Condition identifier** HP:0003418 **Subject identifier** D001416 - **Condition** Low Back Pain **Highest recorded phase** 3 **Condition identifier** HP:0003419 **Subject identifier** D017116 - **Condition** Intervertebral Disc Degeneration **Highest recorded phase** 3 **Condition identifier** HP:0008419 **Subject identifier** D055959 - **Condition** Chronic Pain **Highest recorded phase** 4 **Condition identifier** HP:0012532 **Subject identifier** D059350 - **Condition** Depressive Disorder, Major **Highest recorded phase** 3 **Condition identifier** MONDO:0002009 **Subject identifier** D003865 - **Condition** Depressive Disorder **Highest recorded phase** 3 **Condition identifier** MONDO:0002050 **Subject identifier** D003866 And 4 more, listed on the interactive page. ### Open Targets indications (60) - **Condition identifier** EFO\_0000181 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000342 - **Condition identifier** EFO\_0000764 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001074 - **Condition identifier** EFO\_0001358 **Highest recorded phase** 2 - **Condition identifier** EFO\_0002610 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003890 - **Condition identifier** EFO\_0004240 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004320 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004616 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004701 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004888 - **Condition identifier** EFO\_0005611 - **Condition identifier** EFO\_0005799 **Highest recorded phase** 3 - **Condition identifier** EFO\_0005800 - **Condition identifier** EFO\_0007624 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009842 **Highest recorded phase** 1 - **Condition identifier** EFO\_0010445 **Highest recorded phase** 2 - **Condition identifier** EFO\_0010702 **Highest recorded phase** 3 - **Condition identifier** EFO\_0020911 - **Condition identifier** EFO\_0020911 **Highest recorded phase** 4 - **Condition identifier** EFO\_0022195 **Highest recorded phase** 1 - **Condition identifier** EFO\_0022861 **Highest recorded phase** 3 - **Condition identifier** EFO\_0801084 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001250 And 35 more, listed on the interactive page. ### Warnings (2) - **Warning** Black Box Warning **Effect** misuse - **Warning** Black Box Warning **Effect** respiratory toxicity ### Open Targets warnings (3) - **Warning** Black Box Warning **Country** United States - **Warning** Black Box Warning **Effect** misuse **Country** United States - **Warning** Black Box Warning **Effect** respiratory toxicity **Country** United States ### Reported adverse events (28) - **Event** alcohol abuse **Reports** 81 **Reporting signal score** 190.505 - **Event** application site burn **Reports** 157 **Reporting signal score** 523.025 - **Event** application site erythema **Reports** 369 **Reporting signal score** 1,001.81 - **Event** application site irritation **Reports** 118 **Reporting signal score** 290.019 - **Event** application site pain **Reports** 217 **Reporting signal score** 447.647 - **Event** application site pruritus **Reports** 500 **Reporting signal score** 1,674.25 - **Event** application site rash **Reports** 281 **Reporting signal score** 856.629 - **Event** application site vesicles **Reports** 198 **Reporting signal score** 647.215 - **Event** drug abuse **Reports** 797 **Reporting signal score** 1,320.97 - **Event** drug delivery system removal **Reports** 42 **Reporting signal score** 196.876 - **Event** drug dependence **Reports** 694 **Reporting signal score** 1,563.1 - **Event** drug detoxification **Reports** 68 **Reporting signal score** 251.605 - **Event** drug screen negative **Reports** 135 **Reporting signal score** 529.095 - **Event** drug screen positive **Reports** 124 **Reporting signal score** 254.724 - **Event** drug withdrawal syndrome **Reports** 1,368 **Reporting signal score** 3,448.03 - **Event** drug withdrawal syndrome neonatal **Reports** 333 **Reporting signal score** 875.297 - **Event** euphoric mood **Reports** 137 **Reporting signal score** 279.178 - **Event** hyperhidrosis **Reports** 369 **Reporting signal score** 207.744 - **Event** inadequate analgesia **Reports** 277 **Reporting signal score** 850.497 - **Event** injection site extravasation **Reports** 129 **Reporting signal score** 187.137 - **Event** injection site infection **Reports** 89 **Reporting signal score** 218.046 - **Event** injection site pain **Reports** 518 **Reporting signal score** 180.248 - **Event** miosis **Reports** 168 **Reporting signal score** 293.724 - **Event** oral administration complication **Reports** 52 **Reporting signal score** 184.814 - **Event** respiratory depression **Reports** 142 **Reporting signal score** 211.037 And 3 more, listed on the interactive page. ### Trial references (239) - NCT00000202 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000202) - NCT00000203 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000203) - NCT00000204 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000204) - NCT00000205 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000205) - NCT00000206 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000206) - NCT00000207 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000207) - NCT00000208 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000208) - NCT00000209 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000209) - NCT00000216 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000216) - NCT00000219 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000219) - NCT00000220 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000220) - NCT00000221 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000221) - NCT00000222 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000222) - NCT00000223 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000223) - NCT00000224 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000224) - NCT00000225 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000225) - NCT00000226 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000226) - NCT00000227 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000227) - NCT00000228 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000228) - NCT00000229 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000229) - NCT00000230 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000230) - NCT00000231 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000231) - NCT00000232 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000232) - NCT00000233 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000233) - NCT00000234 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000234) And 214 more, listed on the interactive page. ## Dosing **Dose** Up to 8 mg/2 mg on Day 1; up to 16 mg/4 mg on Day 2; generally 4 mg/1 mg to 24 mg/6 mg per day for maintenance **Route** Sublingual or buccal **How often** Once daily ### Conditions of use (2) - Do not cut, chew, or swallow - Take whole ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 2 **Polar surface area** 62.16 **Calculated partition coefficient (ALogP)** 4.41 **Calculated partition coefficient (XLogP)** 5 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 4 **Heavy atoms** 34 **Molecular formula** C29H41NO4 **Monoisotopic mass** 467.30355879 **Natural product** Yes ## National Drug Codes - 0093-3239 - 0093-3656 - 0093-3657 - 0093-3658 - 0093-3659 - 3215-1521 - 3215-1522 - 3215-1523 - 3215-1524 - 3215-1525 - 42858-353 - 42858-493 - 42858-586 - 42858-750 - 42858-839 - 47781-406 - 47781-407 - 47781-408 - 47781-419 - 50742-372 - 50742-373 - 50742-374 - 50742-375 - 50742-376 - 58284-208 And 22 more, listed on the interactive page. ## Evidence counts **Recorded assays** 3 **Active assays** 3 ### Active assay types (2) - Confirmatory - Other ## Pharmacologic actions - Analgesics, Opioid Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000701.html) - Narcotic Antagonists Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D009292.html) - Narcotics Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D009294.html) ## Biological measurements ### Observed measurements #### Distribution coefficient (LogD) **Median** 3.585 **Mean** 3.15 **Minimum** 0.45 **Maximum** 4.98 **Unit** unitless **Assays** 4 **Standard deviation** 1.93696 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - LogD #### Cardiac potassium channel inhibition **Median** 7,764.53 **Mean** 7,764.53 **Minimum** 7,585.78 **Maximum** 7,943.28 **Unit** nM **Assays** 2 **Standard deviation** 252.791 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - IC50 ## Related records ### Trials (402) - 4-drug Nerve Block Versus Plain Local Anesthetic for Knee and Hip Arthroplasty Analgesia in Veterans - A Bioavailability and Safety Study of Probuphine Versus Sublingual Buprenorphine in Patients With Opioid Dependence - A Bundled Intervention to End Opioid Overdoses - A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use - A Double-Blind Study of Buprenorphine Treatment of Acute Suicidality - A Pragmatic Randomized Control Trial Comparing Models of Care in the Management of Prescription Opioid Misuse - A Randomized Acceptability and Safety Study of Suboxone Induction in Heroin Users (P05042)(COMPLETED) - A Randomized Acceptability and Safety Study of the Transfer From Subutex to Suboxone in Opioid- Dependent Subjects (Study P04843)(COMPLETED) - A Single-Dose Study of an Investigational Capsule Formulation of 2 mg/0.5 mg Buprenorphine/Naloxone - A Six-Month Randomized Controlled Trial (RCT) of Probuphine Safety and Efficacy in Opioid Addiction - A Stepwise Strategy Utilizing Buprenorphine and Methadone - A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders - A Study Comparing Norspan Patch and Oral Tramadol - A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder - A Study of Adult Outpatients With Opioid Dependence Transitioned From a Daily SL Buprenorphine to Probuphine® Subdermal Implants - [A Study of Brenipatide in Participants With Opioid Use Disorder](https://trialight.com/data/trial/a-study-of-brenipatide-in-participants-with-opioid-use-ee48f66b-f6b4-48b4-a862-a257cd647cf8.md) - A Study of the Abuse Liability Potential of ALKS 5461 in Healthy, Non-Dependent, Recreational Opioid Users - A Study to Assess the Drug-drug Interaction of BMS 663068 With Methadone and Also With Buprenorphine/Naloxone - A Study to Assess the Effect of a Single Dose of ASP8062 on the Multiple Dose Safety, Tolerability and Pharmacokinetics of Buprenorphine/Naloxone in Participants With Opioid Use Disorder - A Study to Assess the Safety and Efficacy of ASP8062 as an Add-on Therapy to Buprenorphine/Naloxone in Participants With Opioid Use Disorder ### Approved for (4) - Drug dependence - Opiate dependence - Opioid abuse - Substance abuse ### In development for (21) - Cocaine dependence Phase 3 - [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) Phase 3 - [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 2 - Hepatitis C virus infection Phase 1 - Heroin dependence Phase 3 - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 3 - Intervertebral disk degenerative disorder Phase 3 - [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md) Phase 3 - [Methamphetamine dependence](https://trialight.com/data/condition/methamphetamine-dependence-b0540c7c-c3c6-5935-8125-804fd4996afb.md) Phase 2 - [Migraine disorder](https://trialight.com/data/condition/migraine-disorder-0a28e77d-6415-5582-980f-2d0721f95f76.md) Phase 2 - Morphine dependence Phase 3 - Neonatal abstinence syndrome Phase 3 - Neuralgia Phase 3 - [Osteoarthritis](https://trialight.com/data/condition/osteoarthritis-e8c428fb-1597-576d-bcf0-f3b27ebc6a00.md) Phase 3 - [Osteoarthritis, knee](https://trialight.com/data/condition/osteoarthritis-knee-217c801b-d59c-514b-92dd-3abbf23b24d7.md) Phase 3 - Post-traumatic stress disorder Phase 2 - Psychiatric disorder Phase 3 - Rotator cuff syndrome Phase 2 - [Schizophrenia](https://trialight.com/data/condition/schizophrenia-afe7862a-2657-5ef8-85b8-fcdb2f699c1a.md) Phase 2 - Sickle cell disease Phase 2 ### Other linked conditions (4) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Chronic pancreatitis - Complex regional pain syndrome - Morbid obesity ### Targets (2) - [OPRK1](https://trialight.com/data/target/oprk1-7b0a0fa0-a4b4-537b-bd00-d871256424e5.md) Kappa opioid receptor agonist - [OPRM1](https://trialight.com/data/target/oprm1-04284660-78ba-5225-a86d-21f8a7325d8f.md) Mu opioid receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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