> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/buloxibutid-159891e9-bf22-46f4-8684-d6908d9b646b
> Record changed: 2026-10-13

# Buloxibutid

Highest phase reached

Early phase 1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189568)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189568)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Early phase 1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189568)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189568)

**Drug name**

Buloxibutid

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189568)

**Molecular weight**

475.64

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189568)

**Structure (SMILES)**

CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189568)

### Other names (19)

- buloxibutid
- Buloxibutid
- buloxibutid \[INN\]
- BULOXIBUTID \[USAN\]
- buloxibutid inn
- buloxibutid usan
- c 21
- C 21
- C 21 \[WHO-DD\]
- c 21 who dd
- C-21
- c21
- C21
- compound 21
- Compound 21
- m 24
- M-24
- t2 agonist compound 21
- T2 agonist compound 21

## Identifiers

**CAS registry numbers**

- 477775-14-7

**ChEMBL ID**

CHEMBL189568

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189568)

**InChIKey**

XTEOJPUYZWEXFI-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL189568)

**PubChem compound IDs**

- 9804984

**FDA ingredient codes (UNII)**

- RC2V4W0EYC

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

compound 21 \[PMID: 22802221\]

**Type**

Synthetic organic

### Mechanisms of action (2)

- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
AT2 receptor

**Gene symbol**  
AGTR2

**Protein identifier**  
P50052

**Median affinity**

9.4

**Affinity units**  
pKi
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
AT2 receptor

**Gene symbol**  
AGTR2

**Protein identifier**  
P50052

**Median affinity**

4.8

**Affinity units**  
pEC50

### Investigated indications

- **Condition**  
Pre-Eclampsia

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0000668

**Subject identifier**  
D011225

### Open Targets indications (9)

- **Condition identifier**  
EFO\_0000668
- **Condition identifier**  
EFO\_0000768

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001461

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004995

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005044

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005081

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005252

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
3

### Trial references (2)

- NCT05937841  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05937841)
- NCT06157580  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06157580)

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

1

**Polar surface area**

90.29

**Calculated partition coefficient (ALogP)**

5.07

**Calculated partition coefficient (XLogP)**

5.3

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

10

**Heavy atoms**

32

**Molecular formula**

C23H29N3O4S2

**Monoisotopic mass**

475.15994876

**Natural product**

No

## Evidence counts

**Recorded assays**

161

**Active assays**

37

### Active assay types (3)

- Confirmatory
- Other
- Screening

## Pharmacologic actions

- Anti-Inflammatory Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000893.html)

## Related records

### Trials (11)

- [A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis.](https://trialight.com/data/trial/a-trial-to-evaluate-efficacy-and-safety-of-buloxibutid-in-8242d8e6-1eb0-4402-84a0-ed9db8324a63.md)
- A Trial to Evaluate the Effect of C21 on Endothelial Dysfunction in Subjects With Type 2 Diabetes
- A Trial to Investigate Recovery From COVID-19 With C21 in Adult Subjects
- Balance of Angiotensin II Receptors in Vessel Function After Preeclampsia
- Cold Challenge With C21 in RP
- Effect of C21 on Forearm Blood Flow
- Retrospective Evaluation of Lung Pathology in Subjects With COVID-19
- Safety and Efficacy of C21 in Subjects With COVID-19
- Safety, Efficacy and Pharmacokinetics of C21 in Subjects With IPF
- Sensitivity of Angiotensin II Type II Receptors in Women Following Preeclampsia
- Sex Differences in the Dilatory Response of Compound 21

### In development for (2)

- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3
- Preeclampsia Early phase 1

---

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