> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/brensocatib-717d305e-e3c4-4e9b-aad2-a4c12dc5a7dd
> Record changed: 2026-10-13

# Brensocatib

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3900409)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3900409)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3900409)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3900409)

**Drug name**

Brensocatib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3900409)

**Molecular weight**

420.47

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3900409)

**Structure (SMILES)**

Cn1c(=O)oc2ccc(-c3ccc(C\[C@@H\](C#N)NC(=O)\[C@@H\]4CNCCCO4)cc3)cc21

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3900409)

### Other names (23)

- azd 7986
- AZD 7986
- Azd-7986
- AZD-7986
- azd7986
- Azd7986
- AZD7986
- brensocatib
- Brensocatib
- brensocatib \[INN\]
- BRENSOCATIB \[USAN\]
- Brensocatib \[WHO-DD\]
- Brensocatib 10 mg
- Brensocatib 25 mg
- brensocatib inn
- Brensocatib Oral Solution
- Brensocatib Oral Tablet
- brensocatib usan
- brensocatib who dd
- ins 1007
- INS-1007
- ins1007
- INS1007

## Identifiers

**ATC classification codes**

- R03

**CAS registry numbers**

- 1802148-05-5

**ChEMBL ID**

CHEMBL3900409

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3900409)

**InChIKey**

AEXFXNFMSAAELR-RXVVDRJESA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3900409)

**PubChem compound IDs**

- 118253852

**RxNorm IDs (RxCUI)**

- 2721880

**FDA ingredient codes (UNII)**

- 25CG88L0BB

## Regulatory information

### European Union

**Status**

Authorised

**Status date**

18 Nov 2025

**Authorisation date**

18 Nov 2025

**Approved indications**

Brinsupri is indicated for the treatment of non-cystic fibrosis bronchiectasis (NCFB) in patients 12 years of age and older with two or more exacerbations in the prior 12 months.

**Product number**

EMEA/H/C/005820

**Authorisation holder**

Insmed Netherlands B.V.

**Priority medicines scheme**

Yes

**Generic**

No

**Biosimilar**

No

**Generic medicines**

0

**Biosimilar medicines**

0

**Advanced therapy**

No

**Conditional approval**

No

**Additional monitoring**

Yes

**Accelerated assessment**

No

**Exceptional circumstances**

No

#### Therapeutic areas

- Bronchiectasis
- Lung Diseases

European medicines record

Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/brinsupri)

### Other regulatory facts

**Patents**

14

**Designations**

5

**Earliest recorded loss of exclusivity**

21 Feb 2040

**First in class**

No

**Fast track**

No

**Breakthrough designation**

Yes

**Orphan designation**

No

**Priority review**

Yes

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

brensocatib

**Type**

Synthetic organic

**Drug name stem**

\-catib

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (2)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
cathepsin C

**Gene symbol**  
CTSC

**Protein identifier**  
P53634

**Median affinity**

8.4

**Affinity units**  
pIC50

**Primary target**  
Yes
- **Mechanism**  
Dipeptidyl peptidase I inhibitor

**Action type**  
Inhibitor

**Target**  
Dipeptidyl peptidase 1

**Protein identifier**  
P53634

### Open Targets mechanisms

- **Mechanism**  
Dipeptidyl peptidase I inhibitor

**Action type**  
Inhibitor

**Target**  
Dipeptidyl peptidase 1

### Investigated indications (6)

- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Kidney Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003086

**Subject identifier**  
D007674
- **Condition**  
Bronchiectasis

**Highest recorded phase**  
3

**Condition identifier**  
HP:0002110

**Subject identifier**  
D001987
- **Condition**  
Bronchiectasis

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0004822

**Subject identifier**  
D001987
- **Condition**  
Cystic Fibrosis

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0009061

**Subject identifier**  
D003550
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (12)

- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003086

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003818
- **Condition identifier**  
EFO\_1000710

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1002030

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004822
- **Condition identifier**  
MONDO\_0004822

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005275

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0006502

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0006559

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0009061

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
3

### Trial references (6)

- NCT03218917  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03218917)
- NCT04594369  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04594369)
- NCT04817332  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04817332)
- NCT05090904  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05090904)
- NCT05517525  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05517525)
- NCT05673603  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05673603)

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

2

**Polar surface area**

109.29

**Calculated partition coefficient (ALogP)**

1.73

**Calculated partition coefficient (XLogP)**

2

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

5

**Heavy atoms**

31

**Molecular formula**

C23H24N4O4

**Monoisotopic mass**

420.17975526

**Natural product**

No

## National Drug Codes

- 71558-001
- 71558-002

## Evidence counts

**Recorded assays**

108

**Active assays**

37

### Active assay types (2)

- Confirmatory
- Other

## Biological measurements

These details could not be displayed.

## Related records

### Trials (18)

- A Phase I Study to Assess PK of AZD7986 Alone & With Verapamil, Itraconazole or Diltiazem in Healthy Subjects
- A Study of Brensocatib Following a Single Oral Administration in Participants With or Without Renal Impairment
- A Study of the Absorption, Metabolism, and Excretion of \[14C\]-Brensocatib Following a Single Oral Administration in Healthy Male Participants
- A Study of the Efficacy and Safety of Brensocatib in Adults With Moderate to Severe Hidradenitis Suppurativa (HS)
- [A Study of the Efficacy and Safety of Brensocatib in Participants With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)](https://trialight.com/data/trial/a-study-of-the-efficacy-and-safety-of-brensocatib-in-7eebaaf6-87ca-420f-abab-c78d40df1233.md)
- A Study of the Palatability and Acceptability of Different Brensocatib Oral Liquid Formulations in Healthy Participants
- A Study of the Safety, Pharmacokinetics, and Pharmacodynamics of INS1007 in Healthy Japanese and Caucasian Participants
- A Study to Assess Pharmacokinetics (PK) of Brensocatib Alone and With Multiple Doses of Rifampin or Esomeprozole in Healthy Participants
- A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis
- A Study to Assess the Relative Bioavailability of Brensocatib Pediatric Oral Solution to Oral Tablets in Healthy Participants
- A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Brensocatib Tablets in Adults With Cystic Fibrosis
- A Study to Evaluate the Pharmacokinetics (PK) and Safety of a Single Dose of Brensocatib in Participants With Normal Hepatic Function and Participants With Hepatic Impairment
- A Study to Investigate Effect of Clarithromycin, a Strong CYP3A4 Inhibitor, on Brensocatib Pharmacokinetics in Healthy Participants
- A Study to Investigate the Effects of Brensocatib on QT Interval in Healthy Participants
- An Expanded Access Study to Assess Brensocatib for Participants With Non-Cystic Fibrosis Bronchiectasis
- Assessment of INS1007 in Participants With Non-Cystic Fibrosis Bronchiectasis
- Single + Multiple Ascending Dose and Food Effect Study of AZD7986 in Healthy Volunteers, PK, PD and Safety Study
- STOP-COVID19: Superiority Trial Of Protease Inhibition in COVID-19

### In development for (6)

- [Bronchiectasis](https://trialight.com/data/condition/bronchiectasis-8d498aad-545e-518d-b298-07bc2c8370b0.md) Phase 3
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3
- [Cystic fibrosis](https://trialight.com/data/condition/cystic-fibrosis-6f9870eb-6ebc-5bec-a50b-34b0b323a7c3.md) Phase 2
- [Hidradenitis suppurativa](https://trialight.com/data/condition/hidradenitis-suppurativa-c1030a8d-4971-5d31-b030-aa19715eb7a2.md) Phase 2
- [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1

### Other linked conditions (1)

- [Lung disorder](https://trialight.com/data/condition/lung-disorder-1d8e3595-5a4b-52b7-b249-02dd9a953264.md)

### Targets (1)

- [CTSC](https://trialight.com/data/target/ctsc-9460a36c-a83b-5723-bbeb-37392b4baed6.md) Dipeptidyl peptidase I inhibitor

---

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