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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/bosmolisib-d09aa2ba-0b86-4218-8055-251b85a95d66 > Record changed: 2026-10-13 # Bosmolisib Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068044) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068044) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068044) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068044) **Drug name** Bosmolisib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068044) **Molecular weight** 478.34 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068044) **Structure (SMILES)** C\[C@H\](Nc1ncnc2\[nH\]ccc(=O)c12)c1c(Cl)c2cccc(Cl)c2c(=O)n1-c1ccccc1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068044) ### Other names (12) - 4 1s 1 4 8 dichloro 1 oxo 2 phenyl 3 isoquinolyl ethyl amino 8h pyrido 2 3 d pyrimidin 5 one - 4-\[\[(1S)-1-(4, 8-Dichloro-1-oxo-2-phenyl-3-isoquinolyl) ethyl\] amino\]-8H- pyrido\[2,3-d\] pyrimidin-5-one\] - bosmolisib - Bosmolisib - bosmolisib \[INN\] - bosmolisib inn - br 101801 - BR-101801 - br101801 - BR101801 - BR101801 (Phase Ia) - BR101801 (Phase Ib) ## Identifiers **CAS registry numbers** - 2055765-77-8 **ChEMBL ID** CHEMBL6068044 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068044) **InChIKey** HIXUFHUKIOTXLJ-ZDUSSCGKSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068044) **PubChem compound IDs** - 134427646 **FDA ingredient codes (UNII)** - FJ5CTS1VNJ ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** bosmolisib **Type** Synthetic organic **Drug name stem** \-lisib ### Mechanisms of action (2) - **Action** Inhibition **Action type** Inhibitor **Target** phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta **Gene symbol** PIK3CD **Protein identifier** O00329 **Median affinity** 8.7 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma **Gene symbol** PIK3CG **Protein identifier** P48736 **Median affinity** 7.82 **Affinity units** pIC50 ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (5) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0000430 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004948 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0015759 **Highest recorded phase** 1 ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 2 **Polar surface area** 92.67 **Calculated partition coefficient (ALogP)** 5.1 **Calculated partition coefficient (XLogP)** 5.1 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 4 **Heavy atoms** 33 **Molecular formula** C24H17Cl2N5O2 **Monoisotopic mass** 477.0759302 **Natural product** No ## Related records ### Trials (15) - [A Phase I Study of CFT8919 in Patients With Advanced NSCLC](https://trialight.com/data/trial/a-phase-i-study-of-cft8919-in-patients-with-advanced-nsclc-f10a39b9-d38e-4ea2-9400-e94cdd4058c3.md) - A Phase I/II, Open-label Study to Investigate the Safety, Tolerability, PK, and Preliminary Efficacy of FB849 - A Phase Ib/II Study of Recombinant Anti-IL-1β Humanized Monoclonal Antibody Injection in Chinese Participants With Acute Gout - A Study of Bosmolisib (BR101801) in Participants With R/R PTCL. - [A Study of HS-20089 in Patients With Advanced Solid Tumors](https://trialight.com/data/trial/a-study-of-hs-20089-in-patients-with-advanced-solid-tumors-8ab96ade-7f60-4347-8650-bb92f6e58b86.md) - [A Study of HS-20110 in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-study-of-hs-20110-in-participants-with-advanced-solid-6e1c4320-3175-4fd7-b84d-f95a49a5e3d5.md) - [A Study of HS-20124 in Patients with Advanced Solid Tumors](https://trialight.com/data/trial/a-study-of-hs-20124-in-patients-with-advanced-solid-tumors-657c7310-dd47-4c58-b2f6-c23fc92749a2.md) - [ARTEMIS-001: Phase 1 Study of the HS-20093 in Patients With Advanced Solid Tumors](https://trialight.com/data/trial/artemis-001-phase-1-study-of-the-hs-20093-in-patients-with-362c1290-294c-4fc7-8869-fba6fe2e0a8b.md) - BR101801 in Adult Patients With Advanced Hematologic Malignancies(Phase I) - HDM2005 Combination Therapy in Relapsed/Refractory Mantle Cell Lymphoma - IMA401 TCER® in Recurrent and/or Refractory Solid Tumors, Alone or in Combination With a Checkpoint Inhibitor - Pembrolizumab and ADG106 in Advanced Solid Cancers and Triple Negative Breast Cancer - Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab - This Study is a FIH Study Which is Required to Understand the PK Characteristics, MTD, RP2D and Safety Profile. - Yttrium-90 Radioembolization + Nivolumab for Liver + Extra-hepatic Metastases From Colorectal Cancer ### In development for (2) - Mature T-cell and NK-cell non-Hodgkin lymphoma Phase 2 - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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