> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/bordetella-pertussis-toxin-e32dbfd0-a6c2-489f-ab2b-3cee47ba51bc > Record changed: 2026-11-04 # Bordetella pertussis toxin Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068349) Drug type Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068349) First approval year 1999 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068349) ## Development status **First approval year** 1999 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068349) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068349) ## Names and chemistry **Drug type** Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068349) **Drug name** Bordetella pertussis toxin Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068349) ### Brand names (2) - bordetella pertussis toxin component of triacelluvax - Bordetella pertussis toxin component of triacelluvax ### Other names (2) - bordetella pertussis toxin - Bordetella pertussis toxin ## Identifiers **ChEMBL ID** CHEMBL6068349 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068349) ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Mechanisms of action (5) - **Mechanism** Pertussis toxin vaccine antigen **Action type** VACCINE\_ANTIGEN **Target** Pertussis toxin **Protein identifier** P04977 - **Mechanism** Pertussis toxin vaccine antigen **Action type** VACCINE\_ANTIGEN **Target** Pertussis toxin **Protein identifier** P04978 - **Mechanism** Pertussis toxin vaccine antigen **Action type** VACCINE\_ANTIGEN **Target** Pertussis toxin **Protein identifier** P04979 - **Mechanism** Pertussis toxin vaccine antigen **Action type** VACCINE\_ANTIGEN **Target** Pertussis toxin **Protein identifier** P04981 - **Mechanism** Pertussis toxin vaccine antigen **Action type** VACCINE\_ANTIGEN **Target** Pertussis toxin **Protein identifier** P0A3R5 ### Open Targets mechanisms - **Mechanism** Pertussis toxin vaccine antigen **Action type** VACCINE ANTIGEN **Target** Pertussis toxin ### Investigated indications (2) - **Condition** Whooping Cough **Highest recorded phase** 4 **Condition identifier** EFO:0000650 **Subject identifier** D014917 - **Condition** Vaccination **Highest recorded phase** 4 **Condition identifier** EFO:0004292 **Subject identifier** D014611 ### Open Targets indications (2) - **Condition identifier** EFO\_0000650 - **Condition identifier** MONDO\_0005077 **Highest recorded phase** 4 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (45) - 2-year Follow-up After a Single Dose Acellular Pertussis Vaccination - 3 Formulations of Hib-MenCY-TT Vaccine & 1 Formulation of Hib-MenC-TT Vaccine Compared to Licensed Meningococcal Serogroup C Conjugate Vaccine, Each Administered at 2,3,4 Mths of Age - [A Clinical Trials of Adsorbed Cell-free DPT Vaccine (Five-component)](https://trialight.com/data/trial/a-clinical-trials-of-adsorbed-cell-free-dpt-vaccine-five-dca16796-773d-4e86-acf1-c706700c4704.md) - A Phase I Clinical Trial of Absorbed Acellular Pertussis (Two-Component) Diphtheria-Tetanus Combined Vaccine (For Adults and Adolescents) - [A Phase II Clinical Trial of Absorbed Acellular Pertussis (Two-Component) Diphtheria-Tetanus Combined Vaccine (For Adults and Adolescents)](https://trialight.com/data/trial/a-phase-ii-clinical-trial-of-absorbed-acellular-pertussis-73cc426d-48a7-4776-a534-d6eded0b6880.md) - A Study of DTaP//PRP-T Combined Vaccine (ACTACEL) Versus Local DTaP and Act-HIB Monovalent Vaccine in Healthy Infants - A Study of the Immunogenicity and Safety of Whole-Cell Pertussis Containing Vaccine Administered Concomitantly With RotaTeq™ (V260) or Rotarix™ (V260-036)(WITHDRAWN) - A Study on the Immune Response and Safety of a Combined Vaccine Against Diphtheria, Tetanus and Acellular Pertussis (dTpa) in Healthy Japanese Adolescents Aged 11 Years to <13 Years - A Study to Assess the Safety of Adacel® Vaccine - A Study to Evaluate the Safety and Immune Response to an Unadjuvanted RSV Maternal Vaccine in Healthy Non-pregnant Females From 9 to 49 Years of Age - A Study to Investigate Vaccine Responses in Subcutaneous Amlitelimab Treated Atopic Dermatitis Participants Aged 18 Years and Older Compared With Placebo - [Clinical Trial of the Adsorbed Acellular Pertussis (Tricomponent) DTaP-Haemophilus Influenzae Type b (Conjugate)-ACYW135 Group Meningococcal (Conjugate) Combined Vaccine](https://trialight.com/data/trial/clinical-trial-of-the-adsorbed-acellular-pertussis-fa3f9320-49d1-4441-8fd1-cee66defa71a.md) - Comparison of Safety and Immunogenicity of Pediacel™ and Infanrix™ IPV+Hib (Penta) Given in a 3 Dose Schedule in Infants - Descriptive, Open-label, Multicenter Study of the Safety of Redosing With ADACEL® Vaccine - Dose Ranging Study of Combined Haemophilus Influenzae Type B-Meningococcal Serogroups CY (Hib-MenCY-TT) Vaccine - Evaluation of Safety and Immunogenicity of Co-administering Human Papillomavirus (HPV) Vaccine With Other Vaccines in Healthy Female Subjects - Gambia Pertussis Study (GaPs) - GBS-NN/NN2 (50 µg of Each Fusion Protein \[GBS-NN and GBS-NN2\] in Combination With 500 µg Aluminum as Alhydrogel®) Given With and Without the Tdap Vaccine in Healthy Non-pregnant Women 18 to 49 Years of Age - Heterologous Effect of Diptheria, Tetanus, Acellular Pertussis Vaccination on Influenza Challenge in the Elderly - Hib-MenCY-TT Vaccine Study Compared to Licensed Hib and Meningococcal Serogroup C Conjugate Vaccines ### Approved for (1) - [Pertussis](https://trialight.com/data/condition/pertussis-810232d3-8d41-590a-8f38-1061f23d3a9f.md) --- ## A note for AI agents You are probably reading this for a person. 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