> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/bleximenib-8410a7c7-cf52-49bb-8cde-af708defc08b
> Record changed: 2026-10-13

# Bleximenib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314509)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314509)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314509)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314509)

**Drug name**

Bleximenib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314509)

**Molecular weight**

599.8

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314509)

**Structure (SMILES)**

CCN(C(=O)c1cc(F)ccc1Oc1nncnc1N1CCC2(C1)CN(\[C@H\](CCCN(C)CCOC)C(C)C)C2)C(C)C

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314509)

### Other names (10)

- bleximenib
- Bleximenib
- bleximenib \[INN\]
- BLEXIMENIB \[USAN\]
- Bleximenib \[WHO-DD\]
- bleximenib inn
- bleximenib usan
- bleximenib who dd
- jnj 75276617
- JNJ-75276617

## Identifiers

**CAS registry numbers**

- 2654081-35-1

**ChEMBL ID**

CHEMBL5314509

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314509)

**InChIKey**

PDUGAXSIWNMIBQ-HHHXNRCGSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314509)

**PubChem compound IDs**

- 156498110

**FDA ingredient codes (UNII)**

- DCN5WEN78T

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

bleximenib

**Type**

Synthetic organic

**Drug name stem**

\-menib

### Open Targets indications (3)

- **Condition identifier**  
MONDO\_0004967

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0010643

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018874

**Highest recorded phase**  
3

## Chemical properties

**Hydrogen bond acceptors**

9

**Hydrogen bond donors**

0

**Polar surface area**

87.16

**Calculated partition coefficient (ALogP)**

4.57

**Calculated partition coefficient (XLogP)**

4.3

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

15

**Heavy atoms**

43

**Molecular formula**

C32H50FN7O3

**Monoisotopic mass**

599.39591664

**Natural product**

No

## Evidence counts

**Recorded assays**

8

**Active assays**

8

### Active assay types

- Confirmatory

## Related records

### Trials (7)

- A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)
- A Study of 14C-Bleximenib (Radiolabeled) in Participants With Acute Leukemia
- [A Study of Bleximenib in Combination With Acute Myeloid Leukemia (AML) Directed Therapies](https://trialight.com/data/trial/a-study-of-bleximenib-in-combination-with-acute-myeloid-b7aa7af0-58a1-483b-9c8c-b5f315df79f3.md)
- A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)
- A Study of JNJ-75276617 in Combination With Conventional Chemotherapy for Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias
- Bleximenib in Combination With Standard Induction and Consolidation Therapy Followed by Maintenance for Treatment of Patients With Acute Myeloid Leukemia (AML)
- Efficacy and Safety of G001 in Patients With Osteoarthritis (OA) of the Knee

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