> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/bimagrumab-0a25ca88-023e-46fb-a721-cf5c435758d7
> Record changed: 2026-10-13

# Bimagrumab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137353)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137353)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137353)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137353)

**Drug name**

Bimagrumab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137353)

### Other names (20)

- bimagrumab
- Bimagrumab
- bimagrumab \[INN\]
- BIMAGRUMAB \[JAN\]
- BIMAGRUMAB \[USAN\]
- Bimagrumab \[WHO-DD\]
- bimagrumab inn
- bimagrumab jan
- bimagrumab usan
- bimagrumab who dd
- bym 338
- BYM-338
- bym338
- BYM338
- human anti actriib monoclonal antibody
- HUMAN ANTI-ACTRIIB MONOCLONAL ANTIBODY
- immunoglobulin g1 lambda2 anti homo sapiens acvr2b activin a receptor type iib actr iib homo sapiens monoclonal antibody
- IMMUNOGLOBULIN G1-LAMBDA2, ANTI-(HOMO SAPIENS ACVR2B (ACTIVIN A RECEPTOR TYPE IIB, ACTR-IIB)), HOMO SAPIENS MONOCLONAL ANTIBODY
- o81t794r34
- O81t794r34

## Identifiers

**CAS registry numbers**

- 1356922-05-8

**ChEMBL ID**

CHEMBL3137353

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137353)

**FDA ingredient codes (UNII)**

- N15SW1DIV8

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

2

**First in class**

No

**Fast track**

No

**Breakthrough designation**

Yes

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

bimagrumab

**Type**

Antibody

**Drug name stem**

\-mab

### Mechanisms of action (3)

- **Mechanism**  
Activin receptor type-2B antagonist

**Action type**  
Antagonist

**Target**  
Activin receptor type-2B

**Protein identifier**  
Q13705
- **Action**  
Binding

**Action type**  
Binding

**Target**  
activin A receptor type 2A

**Gene symbol**  
ACVR2A

**Protein identifier**  
P27037

**Median affinity**

9.36

**Affinity units**  
pKd
- **Action**  
Binding

**Action type**  
Binding

**Target**  
activin A receptor type 2B

**Gene symbol**  
ACVR2B

**Protein identifier**  
Q13705

**Median affinity**

11.76

**Affinity units**  
pKd

**Primary target**  
Yes

### Open Targets mechanisms

- **Mechanism**  
Activin receptor type-2B antagonist

**Action type**  
Antagonist

**Target**  
Activin receptor type-2B

### Investigated indications (6)

- **Condition**  
Pulmonary Disease, Chronic Obstructive

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000341

**Subject identifier**  
D029424
- **Condition**  
Myositis, Inclusion Body

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0007323

**Subject identifier**  
D018979
- **Condition**  
Muscular Atrophy

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0009851

**Subject identifier**  
D009133
- **Condition**  
Sarcopenia

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000653

**Subject identifier**  
D055948
- **Condition**  
Cachexia

**Highest recorded phase**  
2

**Condition identifier**  
HP:0004326

**Subject identifier**  
D002100
- **Condition**  
Diabetes Mellitus, Type 2

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005148

**Subject identifier**  
D003924

### Open Targets indications (13)

- **Condition identifier**  
EFO\_0000341

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0007323

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0009851

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000653

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0001513

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0004326

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0025502

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005002

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007827

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0011122

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0015667
- **Condition identifier**  
MONDO\_0015667

**Highest recorded phase**  
2

### Trial references (11)

- NCT01423110  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01423110)
- NCT01925209  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01925209)
- NCT02250443  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02250443)
- NCT02573467  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02573467)
- NCT01433263  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01433263)
- NCT01601600  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01601600)
- NCT02333331  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02333331)
- NCT02468674  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02468674)
- NCT01669174  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01669174)
- NCT02152761  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02152761)
- NCT03005288  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03005288)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (2)

- **Component**  
Heavy chain

**Type**  
Protein

**Organism**  
Homo sapiens

**Sequence**  
QVQLVQSGAEVKKPGASVKVSCKASGYTFTSSYINWVRQAPGQGLEWMGTINPVSGSTSYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGGWFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
- **Component**  
Light chain

**Type**  
Protein

**Organism**  
Homo sapiens

**Sequence**  
QSALTQPASVSGSPGQSITISCTGTSSDVGSYNYVNWYQQHPGKAPKLMIYGVSKRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCGTFAGGSYYGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

## Related records

### Trials (17)

- A 24-week Off-drug Extension Study in Sarcopenic Elderly Who Completed Treatment in the 6-month Core Study
- A Multi-center Study to Assess the Effects of BYM338 on Skeletal Muscle in Sarcopenic Adults
- A Study of Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Participants With Obesity or Overweight With Type 2 Diabetes
- A Study of Bimagrumab Alone (LY3985863) and Bimagrumab With Tirzepatide (LY900042) in Healthy Participants
- A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight
- An Extension Study of the Efficacy, Safety and Tolerability of BYM338 (Bimagrumab) in Patients With Sporadic Inclusion Body Myositis Who Previously Participated in the Core Study CBYM338B2203
- BYM338 in Chronic Obstructive Pulmonary Disease (COPD) Patients With Cachexia
- Clinical Study of BYM338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or the Pancreas
- Dose Range Finding Study of Bimagrumab in Sarcopenia
- Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity
- Efficacy and Safety of Bimagrumab/BYM338 at 52 Weeks on Physical Function, Muscle Strength, Mobility in sIBM Patients
- Efficacy, Safety and Tolerability of BYM338 in Patients With Sporadic Inclusion Body Myositis
- [Safety and Efficacy of Bimagrumab and Semaglutide in Adults Who Are Overweight or Obese](https://trialight.com/data/trial/safety-and-efficacy-of-bimagrumab-and-semaglutide-in-adults-16cfc7b8-1ff8-4269-8368-303d52efc59c.md)
- Safety, Pharmacokinetics and Efficacy of Bimagrumab in Overweight and Obese Patients With Type 2 Diabetes
- Study of Efficacy and Safety of Bimagrumab in Patients After Hip Fracture Surgery
- Study of Long-term Safety, Efficacy Tolerability of BYM338 in Patients With Sporadic Inclusion Body Myositis
- Study of Muscle Effects of BYM338 in Mechanically Ventilated Patients

### In development for (4)

- [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 2
- Inclusion body myositis Phase 3
- Muscular atrophy Phase 2
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 2

### Other linked conditions (1)

- Acute myeloid leukemia by FAB classification

### Targets (1)

- [ACVR2B](https://trialight.com/data/target/acvr2b-cb4a236d-550a-5b3c-be5a-939d03d0fc1e.md) Activin receptor type-2B antagonist

---

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