> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/bexotegrast-d4047472-71e4-4f22-a886-b2e409588e1d > Record changed: 2026-10-13 # Bexotegrast Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095257) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095257) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095257) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095257) **Drug name** Bexotegrast Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095257) **Molecular weight** 492.62 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095257) **Structure (SMILES)** COCCN(CCCCC1=CC=C2CCCN=C2N1)CC\[C@H\](Nc1ncnc2ccccc12)C(=O)O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095257) ### Other names (11) - bexotegrast - Bexotegrast - bexotegrast \[INN\] - BEXOTEGRAST \[USAN\] - bexotegrast inn - bexotegrast usan - pln 74809 - Pln 74809 - PLN 74809 \[WHO-DD\] - pln 74809 who dd - PLN-74809 ## Identifiers **CAS registry numbers** - 2376257-44-0 **ChEMBL ID** CHEMBL5095257 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095257) **InChIKey** CWOFQJBATWQSHL-DEOSSOPVSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095257) **PubChem compound IDs** - 135390719 **FDA ingredient codes (UNII)** - QCV154PFT4 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** bexotegrast **Type** Synthetic organic **Drug name stem** \-ast ### Mechanisms of action - **Action** Antagonist **Action type** Antagonist **Target** integrin, alpha V subunit **Gene symbol** ITGAV **Protein identifier** P06756 **Median affinity** 5.47 **Affinity units** pIC50 ### Investigated indications (4) - **Condition** Idiopathic Pulmonary Fibrosis **Highest recorded phase** 2 **Condition identifier** EFO:0000768 **Subject identifier** D054990 - **Condition** Cholangitis, Sclerosing **Highest recorded phase** 2 **Condition identifier** EFO:0004268 **Subject identifier** D015209 - **Condition** Pulmonary Fibrosis **Highest recorded phase** 1 **Condition identifier** EFO:0009448 **Subject identifier** D011658 - **Condition** Inflammation **Highest recorded phase** 2 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (9) - **Condition identifier** EFO\_0000768 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004268 **Highest recorded phase** 2 - **Condition identifier** EFO\_0009448 - **Condition identifier** HP\_0001395 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002771 - **Condition identifier** MONDO\_0006502 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0018646 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0100096 **Highest recorded phase** 2 - **Condition identifier** MP\_0001845 ### Trial references (5) - NCT04072315 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04072315) - NCT04396756 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04396756) - NCT05621252 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05621252) - NCT06097260 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06097260) - NCT04480840 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04480840) ## Chemical properties **Hydrogen bond acceptors** 8 **Hydrogen bond donors** 3 **Polar surface area** 111.97 **Calculated partition coefficient (ALogP)** 3.61 **Calculated partition coefficient (XLogP)** 1.8 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 14 **Heavy atoms** 36 **Molecular formula** C27H36N6O3 **Monoisotopic mass** 492.28488903 **Natural product** No ## Evidence counts **Recorded assays** 14 **Active assays** 14 ### Active assay types - Confirmatory ## Related records ### Trials (6) - Evaluation of Efficacy and Safety of PLN-74809 in Patients With Idiopathic Pulmonary Fibrosis - Evaluation of the Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Participants With Acute Respiratory Distress Syndrome (ARDS) Associated With at Least Severe COVID-19 - Imaging Evaluation of PLN-74809 in Participants With IPF (PLN-74809) - Phase 2a Evaluation of PLN-74809 on αvβ6 Receptor Occupancy Using PET Imaging in Participants With IPF/ - Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC) - [Randomized, Double-blind Study of Efficacy and Safety of Bexotegrast (PLN-74809) for Idiopathic Pulmonary Fibrosis](https://trialight.com/data/trial/randomized-double-blind-study-of-efficacy-and-safety-of-3c269ab2-3b3b-4eae-9c9d-d18455ab3140.md) ### In development for (3) - [Idiopathic pulmonary fibrosis](https://trialight.com/data/condition/idiopathic-pulmonary-fibrosis-9d400b0a-ada5-55c8-96c1-87bddcdf6913.md) Phase 2 - [Pulmonary fibrosis](https://trialight.com/data/condition/pulmonary-fibrosis-bc07081b-8a87-523b-80ff-c58435a000f3.md) Phase 1 - Sclerosing cholangitis Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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