> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/bepirovirsen-sodium-9ff2f7ec-3a97-4823-836f-d1f3c02f85e0 > Record changed: 2026-10-13 # Bepirovirsen sodium Highest phase reached Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095442) Drug type Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095442) ## Development status **Listing at source** Listed **Highest phase reached** Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095442) ## Names and chemistry **Drug type** Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095442) **Drug name** Bepirovirsen sodium Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095442) ### Other names (13) - bepirovirsen sodium - Bepirovirsen sodium - BEPIROVIRSEN SODIUM \[USAN\] - bepirovirsen sodium usan - dna d p thio 2 o 2 methoxyethyl rg 2 o 2 methoxyethyl m5rc 2 o 2 methoxyethyl ra 2 o 2 methoxyethyl rg 2 o 2 methoxyethyl ra g g t g a a g m5c g a 2 o 2 methoxyethyl ra 2 o 2 methoxyethyl rg 2 o 2 methoxyethyl m5ru 2 o 2 methoxyethyl rg 2 o 2 methoxyethyl m5rc sodium salt 1 19 - DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-G-G-T-G-A-A-G-M5C-G-A-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC), SODIUM SALT (1:19) - gsk 3228836a - GSK-3228836A - gsk3228836a - GSK3228836A - isis 505358 sodium - ISIS 505358 SODIUM - ISIS-505358 SODIUM ## Identifiers **CAS registry numbers** - 2563929-84-8 **ChEMBL ID** CHEMBL5095442 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095442) **FDA ingredient codes (UNII)** - XCC829VFT7 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-rsen; -vir- ### Investigated indications - **Condition** Hepatitis B **Highest recorded phase** 1 **Condition identifier** EFO:0004197 **Subject identifier** D006509 ### Open Targets indications (2) - **Condition identifier** EFO\_0004197 - **Condition identifier** MONDO\_0005344 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (10) - [A Study of Sequential Therapy With Daplusiran/Tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis B (CHB)](https://trialight.com/data/trial/a-study-of-sequential-therapy-with-daplusiran-tomligisiran-6f1a6c38-8de5-4c2b-9983-df4ad6090831.md) - A Study to Evaluate Blood Levels of Bepirovirsen in Adult Participants With Severe or Moderate Kidney Disease - [A Study to Evaluate the Relative Bioavailability of Subcutaneous Bepirovirsen When Delivered From a Vial or Prefilled Syringe Fitted With a Safety Syringe Device in Healthy Adult Participants](https://trialight.com/data/trial/a-study-to-evaluate-the-relative-bioavailability-of-b4a11eb6-f487-4026-bb9b-b936a7748df2.md) - Bepirovirsen Liver Biopsy Study - [Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)](https://trialight.com/data/trial/long-term-follow-up-study-to-evaluate-durability-of-9f9f89f7-30c1-471a-b2b6-19c9787eb0d1.md) - Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 1) - Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 2) - Study of Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection (B-Focus) - Study of GSK3965193 in Healthy Participants and Participants Living With Chronic Hepatitis B Infection - Study to Evaluate the Effect of Bepirovirsen on Cardiac Conduction as Assessed by 12-lead Electrocardiogram in Healthy Volunteers ### In development for (1) - [Hepatitis B virus infection](https://trialight.com/data/condition/hepatitis-b-virus-infection-63cb6d13-50c4-5e97-86fd-ce5481d9d1c6.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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