> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/bepirovirsen-bbb630ed-e964-4c5c-b95d-826944bbca87 > Record changed: 2026-11-04 # Bepirovirsen Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650468) Drug type Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650468) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650468) ## Names and chemistry **Drug type** Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650468) **Drug name** Bepirovirsen Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650468) ### Other names (26) - bepirovirsen - Bepirovirsen - bepirovirsen \[INN\] - BEPIROVIRSEN \[USAN\] - Bepirovirsen \[WHO-DD\] - bepirovirsen inn - bepirovirsen usan - bepirovirsen who dd - dna d p thio 2 o 2 methoxyethyl rg 2 o 2 methoxyethyl m5rc 2 o 2 methoxyethyl ra 2 o 2 methoxyethyl rg 2 o 2 methoxyethyl ra g g t g a a g m5c g a 2 o 2 methoxyethyl ra 2 o 2 methoxyethyl rg 2 o 2 methoxyethyl m5ru 2 o 2 methoxyethyl rg 2 o 2 methoxyethyl m5rc - DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-G-G-T-G-A-A-G-M5C-G-A-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC) - gsk 3228836 - gsk 3228836b - GSK-3228836 - GSK-3228836B - gsk3228836 - Gsk3228836 - GSK3228836 - gsk3228836b - GSK3228836B - ionis hbvrx - IONIS HBVRX - isis 505358 - ISIS 505358 - isis gsk3rx - ISIS-505358 And 1 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 1403787-62-1 **ChEMBL ID** CHEMBL4650468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650468) **FDA ingredient codes (UNII)** - Z87O6SM01N ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** bepirovirsen **Type** Nucleic acid **Drug name stem** \-rsen; -vir- **Approval recorded by Guide to Pharmacology** Yes ### Mechanisms of action (2) - **Mechanism** mRNA antisense inhibitor **Action type** ANTISENSE\_INHIBITOR **Target** mRNA - **Mechanism** mRNA antisense inhibitor **Action type** Inhibitor **Target** mRNA ### Investigated indications (3) - **Condition** Hepatitis B **Highest recorded phase** 1 **Condition identifier** EFO:0004197 **Subject identifier** D006509 - **Condition** Hepatitis B, Chronic **Highest recorded phase** 3 **Condition identifier** EFO:0004197 **Subject identifier** D019694 - **Condition** Hepatitis B, Chronic **Highest recorded phase** 3 **Condition identifier** EFO:0004239 **Subject identifier** D019694 ### Open Targets indications (5) - **Condition identifier** EFO\_0004197 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004239 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005109 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005344 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005366 **Highest recorded phase** 2 ### Trial references (11) - NCT04449029 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04449029) - NCT04544956 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04544956) - NCT04676724 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04676724) - NCT04954859 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04954859) - NCT04971928 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04971928) - NCT05330455 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05330455) - NCT06058390 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06058390) - NCT06422767 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06422767) - NCT05276297 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276297) - NCT05630807 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05630807) - NCT05630820 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05630820) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (17) - A Mechanistic Study of GSK3228836 With Fine Needle Aspiration (FNA) in Participants With Chronic Hepatitis B - A Study of GSK3228836 in Participants With Chronic Hepatitis B (CHB) - [A Study of Sequential Therapy With Daplusiran/Tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis B (CHB)](https://trialight.com/data/trial/a-study-of-sequential-therapy-with-daplusiran-tomligisiran-6f1a6c38-8de5-4c2b-9983-df4ad6090831.md) - A Study on the Safety, Efficacy and Immune Response Following Sequential Treatment With an Anti-sense Oligonucleotide Against Chronic Hepatitis B (CHB) and Chronic Hepatitis B Targeted Immunotherapy (CHB-TI) in CHB Patients Receiving Nucleos(t)Ide Analogue (NA) Therapy - A Study to Compare Blood Levels of Bepirovirsen and Safety Using Different Methods of Injecting in Healthy Adult Participants - A Study to Evaluate Blood Levels of Bepirovirsen in Adult Participants With Severe or Moderate Kidney Disease - [A Study to Evaluate the Relative Bioavailability of Subcutaneous Bepirovirsen When Delivered From a Vial or Prefilled Syringe Fitted With a Safety Syringe Device in Healthy Adult Participants](https://trialight.com/data/trial/a-study-to-evaluate-the-relative-bioavailability-of-b4a11eb6-f487-4026-bb9b-b936a7748df2.md) - Bepirovirsen Liver Biopsy Study - [Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)](https://trialight.com/data/trial/long-term-follow-up-study-to-evaluate-durability-of-9f9f89f7-30c1-471a-b2b6-19c9787eb0d1.md) - Phase 1 Study of GSK3228836 Pharmacokinetics in Participants With Hepatic Impairment - Safety, Tolerability, Pharmacokinetics and Antiviral Activity of IONIS-HBVRx in Treatment-Naïve Patients With Chronic HBV Infection - [Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 1)](https://trialight.com/data/trial/study-of-bepirovirsen-in-nucleos-t-ide-analogue-treated-5b9232fa-fb53-4c18-9d9a-097dc7fe7aa2.md) - Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 2) - Study of Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection (B-Focus) - Study of GSK3965193 in Healthy Participants and Participants Living With Chronic Hepatitis B Infection - Study of Sequential GSK3228836 and Peginterferon Treatment in Participants With Chronic Hepatitis B (CHB) - Study to Evaluate the Effect of Bepirovirsen on Cardiac Conduction as Assessed by 12-lead Electrocardiogram in Healthy Volunteers ### In development for (3) - [Chronic hepatitis B virus infection](https://trialight.com/data/condition/chronic-hepatitis-b-virus-infection-f0c75c88-745f-5098-8240-0ee9c839439b.md) Phase 3 - [Hepatitis B virus infection](https://trialight.com/data/condition/hepatitis-b-virus-infection-63cb6d13-50c4-5e97-86fd-ce5481d9d1c6.md) Phase 3 - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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