> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/benzoyl-peroxide-8f48f9ff-6406-480d-bf76-e43e5cea29ee > Record changed: 2026-10-13 # Benzoyl peroxide Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) First approval year 1984 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) ## Development status **First approval year** 1984 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) **Drug name** Benzoyl peroxide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) **Molecular weight** 242.23 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) **Structure (SMILES)** O=C(OOC(=O)c1ccccc1)c1ccccc1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) ### Brand names (106) - acetoxyl 2 5 - Acetoxyl 2.5 - acetoxyl 5 - Acetoxyl 5 - acnecide - Acnecide - acnecide 10 - Acnecide 10 - acnegel - Acnegel - acnegel fte - Acnegel fte - acnidazil - Acnidazil - benoxyl 10 - Benoxyl 10 - benoxyl 20 - Benoxyl 20 - benoxyl 5 - Benoxyl 5 - benzagel 10 - Benzagel 10 - benzagel 5 - Benzagel 5 - benzamycin And 81 more, listed on the interactive page. ### Other names (75) - acanya component benzoyl peroxide - ACANYA COMPONENT BENZOYL PEROXIDE - adapalene and benzoyl peroxide - anhydrous benzoyl peroxide - Anhydrous benzoyl peroxide - benzaclin component benzoyl peroxide - BENZACLIN COMPONENT BENZOYL PEROXIDE - benzamycin component benzoyl peroxide - BENZAMYCIN COMPONENT BENZOYL PEROXIDE - benzoyl peroxide - Benzoyl peroxide - Benzoyl Peroxide - BENZOYL PEROXIDE \[FCC\] - BENZOYL PEROXIDE \[HSDB\] - BENZOYL PEROXIDE \[IARC\] - BENZOYL PEROXIDE \[JAN\] - BENZOYL PEROXIDE \[MART.\] - BENZOYL PEROXIDE \[MI\] - BENZOYL PEROXIDE \[ORANGE BOOK\] - BENZOYL PEROXIDE \[USAN\] - BENZOYL PEROXIDE \[USP IMPURITY\] - BENZOYL PEROXIDE \[VANDF\] - Benzoyl peroxide \[WHO-DD\] - benzoyl peroxide anhydrous - Benzoyl peroxide anhydrous And 50 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 94-36-0 **ChEMBL ID** CHEMBL1200370 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) **InChIKey** OMPJBNCRMGITSC-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) **PubChem compound IDs** - 7187 **RxNorm IDs (RxCUI)** - 1418 **FDA ingredient codes (UNII)** - W9WZN9A0GM ### ATC classification codes (2) - D10AE01 - D10AE51 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200370) ## Regulatory information ### United States **Applicant** BAUSCH **Approval date** 23 Oct 2008 **Application number** NDA050819 ### Other regulatory facts **Patents** 14 **Designations** 0 **Earliest recorded loss of exclusivity** 23 May 2041 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification #### Administration routes - topical ### Investigated indications (5) - **Condition** Infections **Highest recorded phase** 3 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Keratosis, Actinic **Highest recorded phase** 2 **Condition identifier** EFO:0002496 **Subject identifier** D055623 - **Condition** Acne Vulgaris **Highest recorded phase** 4 **Condition identifier** EFO:0003894 **Subject identifier** D000152 - **Condition** Molluscum Contagiosum **Highest recorded phase** 3 **Condition identifier** EFO:0007375 **Subject identifier** D008976 - **Condition** Rosacea **Highest recorded phase** 1 **Condition identifier** EFO:1000760 **Subject identifier** D012393 ### Open Targets indications (9) - **Condition identifier** EFO\_0000544 **Highest recorded phase** 2 - **Condition identifier** EFO\_0002496 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003894 - **Condition identifier** EFO\_0007375 **Highest recorded phase** 3 - **Condition identifier** EFO\_1000760 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005855 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0006559 - **Condition identifier** MONDO\_0006604 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0011438 **Highest recorded phase** 4 ### Reported adverse events (55) - **Event** acne **Reports** 11 **Reporting signal score** 22.8987 - **Event** acne fulminans **Reports** 2 **Reporting signal score** 9.68672 - **Event** angioedema **Reports** 13 **Reporting signal score** 15.9008 - **Event** application site burn **Reports** 8 **Reporting signal score** 32.6088 - **Event** application site discolouration **Reports** 4 **Reporting signal score** 14.692 - **Event** application site dryness **Reports** 3 **Reporting signal score** 12.8011 - **Event** application site erythema **Reports** 17 **Reporting signal score** 57.1103 - **Event** application site exfoliation **Reports** 5 **Reporting signal score** 21.8653 - **Event** application site inflammation **Reports** 2 **Reporting signal score** 7.64493 - **Event** application site irritation **Reports** 4 **Reporting signal score** 11.1534 - **Event** application site pain **Reports** 11 **Reporting signal score** 30.6434 - **Event** application site paraesthesia **Reports** 2 **Reporting signal score** 9.32734 - **Event** application site pruritus **Reports** 10 **Reporting signal score** 31.5908 - **Event** application site rash **Reports** 5 **Reporting signal score** 13.7314 - **Event** application site swelling **Reports** 8 **Reporting signal score** 34.2139 - **Event** application site warmth **Reports** 2 **Reporting signal score** 8.69865 - **Event** broncholithiasis **Reports** 3 **Reporting signal score** 20.9417 - **Event** burning sensation **Reports** 8 **Reporting signal score** 9.00386 - **Event** burns second degree **Reports** 4 **Reporting signal score** 15.8864 - **Event** chemical burn of skin **Reports** 3 **Reporting signal score** 15.0284 - **Event** choroiditis **Reports** 10 **Reporting signal score** 53.6088 - **Event** dermatitis **Reports** 9 **Reporting signal score** 20.099 - **Event** dermatitis allergic **Reports** 10 **Reporting signal score** 24.7533 - **Event** dermatitis contact **Reports** 13 **Reporting signal score** 41.9047 - **Event** diarrhoea **Reports** 1 **Reporting signal score** 9.35499 And 30 more, listed on the interactive page. ### Trial references (85) - NCT00151541 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00151541) - NCT00377000 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00377000) - NCT00421993 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00421993) - NCT00422240 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00422240) - NCT00441415 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00441415) - NCT00446043 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00446043) - NCT00658112 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00658112) - NCT00663286 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00663286) - NCT00664248 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00664248) - NCT00671749 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00671749) - NCT00687908 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00687908) - NCT00713609 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00713609) - NCT00757523 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00757523) - NCT00776919 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00776919) - NCT00807014 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00807014) - NCT00837213 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00837213) - NCT00841776 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00841776) - NCT00869492 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00869492) - NCT00877409 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00877409) - NCT00887484 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00887484) - NCT00891982 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00891982) - NCT00907257 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00907257) - NCT00913185 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00913185) - NCT00919191 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00919191) - NCT00926367 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00926367) And 60 more, listed on the interactive page. ## Dosing **How often** Once daily, then up to three times daily ### Conditions of use (5) - Apply a thin layer to the affected area - Cover the entire affected area - Reduce application if dryness or peeling occurs - Start with once daily, then increase as needed - Stop use and consult a doctor if irritation occurs ## Chemical properties **Hydrogen bond acceptors** 4 **Hydrogen bond donors** 0 **Polar surface area** 52.6 **Calculated partition coefficient (ALogP)** 2.62 **Calculated partition coefficient (XLogP)** 3.5 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 2 **Heavy atoms** 18 **Molecular formula** C14H10O4 **Monoisotopic mass** 242.05790880 **Natural product** Yes ## National Drug Codes - 0187-0006 - 0187-3050 - 0299-5906 - 0299-5945 - 0480-3154 - 13548-132 - 16714-984 - 21922-022 - 21922-052 - 21922-074 - 43538-176 - 45802-383 - 45802-597 - 45802-736 - 45802-846 - 45802-853 - 46708-662 - 51862-771 - 51862-772 - 59651-604 - 62332-662 - 64980-328 - 68308-127 - 68308-662 - 68462-301 And 24 more, listed on the interactive page. ## Evidence counts **Recorded assays** 979 **Active assays** 12 ### Active assay types (3) - Confirmatory - Other - Summary ## Pharmacologic actions - Dermatologic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D003879.html) ## Related records ### Trials (87) - "A Comparative Clinical Evaluation of the Efficacy of Topical Adapalene, Benzoyl Peroxide Gel, Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule, and Their Fixed Combination in Mild to Moderate Acne Vulgaris Patients." - 2940nm Er:YAG Laser Versus Benzoyl Peroxide Gel for the Treatment of Inflammatory Acne - A Bioequivalence Study With Clinical Endpoints Comparing Adapalene and Benzoyl Peroxide Topical Gel 0.1%/2.5% (Actavis Mid-Atlantic LLC) To Epiduo™ (Adapalene and Benzoyl Peroxide) Gel 0.1%/2.5% (Galderma Laboratories, L.P.) in the Treatment of Mild to Severe Acne Vulgaris - A Clinical Study Evaluating the Safety and Efficacy of IDP-110 in Patients With Acne Vulgaris - A Clinical Trial Evaluating the Safety and Efficacy of IDP-110 in Patients With Acne Vulgaris - A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne - A Five Day Clinical Study to Examine the Effects of a Benzoyl Peroxide Treatment on Facial Acne Lesions - A Novel Method to Improve Acne Outcomes - A Phase 3 Study to Compare the Safety and Efficacy of 5% Dapsone Topical Gel, (DTG) Twice Daily in Combination With Once Daily Vehicle Control, Adapalene Gel 0.1% or Benzoyl Peroxide Gel 4% - A Phase 4, Single-Blind, Randomized, Study to Compare the Tolerability and Efficacy of 0.1% Tazorac Cream When Used in Combination With Either Duac Gel or Acanya Gel for the Treatment of Facial Acne Vulgaris - A Pilot, Multi-Center, Patient Preference Study Comparing Two Clindamycin/Benzoyl Peroxide Gels. - A Study CLBG and Benzoyl Peroxide Gel 1%/5% to BenzaClin® Gel in the Treatment of Acne Vulgaris - A Study Comparing Aczone® Plus Differin® Versus Duac® Plus Differin® in Patients With Severe Facial Acne - A Study Comparing Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel to Duac® Topical Gel in the Treatment of Acne Vulgaris - A Study Comparing Clindamycin and Benzoyl Peroxide Gel 1.2%/3.75% to Onexton™ Gel in the Treatment of Acne Vulgaris - [A Study Comparing Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Topical Gel 0.15%;3.1%;1.2% (Taro Pharmaceuticals U.S.A., Inc.) and CABTREO Topical Gel for the Treatment of Acne Vulgaris.](https://trialight.com/data/trial/a-study-comparing-clindamycin-phosphate-adapalene-and-ba9c70f3-fa12-4215-ac68-4e41d58205e0.md) - A Study Comparing Combination Clindamycin Phosphate/Tretinoin Gel Alone Versus With Benzoyl Peroxide Foaming Cloths for Facial Acne - A Study of Different Use Regimens Using Two Acne Treatments - A Study of Efficacy of Benzoyl Peroxide Regimens in Treatment of Unpleasant Foot Odor - A Study to Compare Clindamycin Phosphate and Benzoyl Peroxide Topical Gel 1.2%/2.5% to Acanya® Topical Gel in the Treatment of Acne Vulgaris ### Approved for (1) - [Acne](https://trialight.com/data/condition/acne-02478aa3-966b-5ffb-a257-6dbe85c14e58.md) ### In development for (3) - Actinic keratosis Phase 2 - Molluscum contagiosum Phase 3 - Rosacea Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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