> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/benmelstobart-2bff71aa-d2ac-4a5a-9949-c935954a2314
> Record changed: 2026-10-13

# Benmelstobart

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315042)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315042)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315042)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315042)

**Drug name**

Benmelstobart

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315042)

### Other names (27)

- apl 502
- APL-502
- apl502
- APL502
- benmelstobart
- Benmelstobart
- benmelstobart \[INN\]
- Benmelstobart \[WHO-DD\]
- benmelstobart Injection
- benmelstobart inn
- benmelstobart who dd
- cbt 502
- CBT-502
- cbt502
- CBT502
- gamma1 heavy chain humanized (1-446) \[VH (Homo sapiens IGHV2-5\*01 (78.6%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[8.7.10\] (26-33.51-57.96-105)) (1-116)-Homo sapiens IGHG1\*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v66 CH2 A27 (CH1 K120(213) (117-214), hinge 1-15 (215-229), CH2 D27>A (264) (230-339), CH3 D12 (355),L14 (357) (340-444), CHS (445-446)) (117-446)\], (219-214')-disulfide with kappa light chain humanized (1'-214') \[V-KAPPA (Homo sapiens IGKV1-33\*01 (82.1%) -IGKJ2\*01 (100%), CDR-IMGT \[6.3.9\] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3, A45.1 (153), V101 (191) (108'-214')\]; dimer (225-225'':228-228'')-bisdisulfide
- gamma1 heavy chain humanized 1 446 vh homo sapiens ighv2 5 01 78 6 ighd ighj4 01 100 cdr imgt 8 7 10 26 33 51 57 96 105 1 116 homo sapiens ighg1 01 g1m17 1 ch1 k120 ch3 d12 l14 g1v66 ch2 a27 ch1 k120 213 117 214 hinge 1 15 215 229 ch2 d27 a 264 230 339 ch3 d12 355 l14 357 340 444 chs 445 446 117 446 219 214 disulfide with kappa light chain humanized 1 214 v kappa homo sapiens igkv1 33 01 82 1 igkj2 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 225 225 228 228 bisdisulfide
- Immunoglobulin G1 \[264-alanine\], anti-(human programmed death-ligand 1) (human-Mus musculus monoclonal CBT-502 γ1-chain), disulfide with human-Mus musculus monoclonal CBT-502 κ-chain, dimer
- immunoglobulin g1 264 alanine anti human programmed death ligand 1 human mus musculus monoclonal cbt 502 γ1 chain disulfide with human mus musculus monoclonal cbt 502 κ chain dimer
- tqb 2450
- TQB-2450
- tqb2450
- Tqb2450
- TQB2450
- TQB2450 injection

And 2 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2303884-58-2

**ChEMBL ID**

CHEMBL5315042

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315042)

**FDA ingredient codes (UNII)**

- B25CF42QKP

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

benmelstobart

**Type**

Antibody

**Drug name stem**

\-bart

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action

- **Action**  
Binding

**Action type**  
Binding

**Target**  
programmed cell death 1 ligand 1

**Gene symbol**  
programmed cell death 1 ligand 1

**Primary target**  
Yes

### Investigated indications (18)

- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000096

**Subject identifier**  
D008224
- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000181

**Subject identifier**  
D002294
- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Esophageal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002916

**Subject identifier**  
D004938
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Cholangiocarcinoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005221

**Subject identifier**  
D018281
- **Condition**  
Esophageal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005922

**Subject identifier**  
D004938
- **Condition**  
Kidney Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0002367

**Subject identifier**  
D007680
- **Condition**  
Uterine Cervical Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0002974

**Subject identifier**  
D002583
- **Condition**  
Biliary Tract Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0003060

**Subject identifier**  
D001661
- **Condition**  
Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0008170

**Subject identifier**  
D010051
- **Condition**  
Lung Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0008903

**Subject identifier**  
D008175
- **Condition**  
Endometrial Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0011962

**Subject identifier**  
D016889
- **Condition**  
Nasopharyngeal Carcinoma

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0015459

**Subject identifier**  
D000077274

### Open Targets indications (50)

- **Condition identifier**  
EFO\_0000096

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000181

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000182

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000702

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0002916

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003891

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005221
- **Condition identifier**  
EFO\_0005922

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000448

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002108

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003219

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003960

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004958

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004992
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005005

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005036

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005086

**Highest recorded phase**  
3

And 25 more, listed on the interactive page.

### Trial references (34)

- NCT03460457  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03460457)
- NCT03897283  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03897283)
- NCT05645315  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05645315)
- NCT06116240  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06116240)
- NCT03855358  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03855358)
- NCT03855384  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03855384)
- NCT03910127  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03910127)
- NCT04306926  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04306926)
- NCT04325763  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04325763)
- NCT04964479  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04964479)
- NCT05346952  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05346952)
- NCT05718167  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05718167)
- NCT05913089  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05913089)
- NCT05922345  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05922345)
- NCT06141226  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06141226)
- NCT03983928  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03983928)
- NCT03996408  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03996408)
- NCT04002622  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04002622)
- NCT04234607  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04234607)
- NCT04539977  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04539977)
- NCT04236362  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04236362)
- NCT04809142  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04809142)
- NCT04523272  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04523272)
- NCT04574284  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04574284)
- NCT06475599  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06475599)

And 9 more, listed on the interactive page.

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (4)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QITLKESGPTLVKPTQTLTLTCTVSGFSLSTYGVHWIRQPPGKALEWLGVIWRGVTTDYNAAFMSRLTITKDNSKNQVVLTMNNMDPVDTATYYCARLGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Disulfide bridges

**Sequence**  
22-95 $ 22''-95'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 143-199 $ 143''-199'' $ 219-214' $ 219''-214''' $ 225-225'' $ 228-228'' $ 260-320 $ 260''-320'' $ 366-424 $ 366''-424''
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIQMTQSPSSLSASVGDRVTITCKASQSVSNDVAWYQQKPGKAPKLLIYYAANRYTGVPDRFSGSGYGTDFTFTISSLQPEDIATYFCQQDYTSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Glycosylation sites (N)

**Sequence**  
296 $ 296''

## Related records

### Trials (96)

- A Clinical Study of TQB2450 Combined With Anlotinib in Limited-Stage Small Cell Lung Cancer Patients
- A Clinical Study of TQB2450 Injection Combined With Anlotinib Hydrochloride Capsules Versus K Drug in the Treatment of First-line Non-small Cell Lung Cancer(NSCLC)
- A Clinical Study of TQB2450 Injection Combined With Anlotinib Hydrochloride Capsules Versus Paclitaxel as Weekly Treatment of Relapsed Platinum-resistant Ovarian Cancer
- A Clinical Study of TQB2450 Injection Combined With Chemotherapy or Anlotinib Hydrochloride Capsule in the Treatment of Non Small Cell Lung Cancer
- A Clinical Trial Evaluating TQB2102 for Injection in Combination With Behmosubaisumab/Payamprolizumab With or Without Chemotherapy in Unresectable Locally Advanced, Recurrent, or Metastatic Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastroesophageal Adenocarcinoma
- A Clinical Trial of TQB2450 Injection Combined With AL2846 Capsules in Patients With Advanced Solid Tumors
- A Phase Ib Study of TQB2450 Combined With Anlotinib in Patients With Limited Stage Small Cell Lung Cancer After First-line Radiotherapy and Chemotherapy
- A Phase II Study of Benmelstobart + Anlotinib + Chemotherapy as First-Line Treatment for LCNEC and EP-NEC
- A Phase II Study to Evaluate the Safety and Efficacy of TQB2450 Injection in Relapsed or Refractory Classical Hodgkin's Lymphoma
- A Phase Ⅱ/Ⅲ Study of HRS-2129 for Postsurgical Pain Management in Abdominal Surgery
- A Single-arm, Exploratory Clinical Study Evaluating the Efficacy and Safety of Bevacizumab in Combination With Anlotinib and Etoposide as First-line Therapy for Elderly Patients With Small-cell Lung Cancer or Those Who Are Intolerant to Intensive Chemotherapy
- A Single-arm, Multicenter Exploratory Clinical Trial of Anlotinib Combined With TQB2450 and the SOX Regimen as First-line Treatment for Advanced Gastric Cancer With Low PD-L1 Expression
- A Study of Benmelstobart, Anlotinib, Chemotherapy and Thoracic Radiotherapy for People With Extensive-stage Small Cell Lung Cancer
- A Study of TQB2450 Combined With Anlotinib in Subjects With Gynecological Cancer
- A Study of TQB2450 in Combination With Intensity-modulated Radiotherapy in Patients With Inoperable Locally Recurrent Nasopharyngeal Carcinoma
- A Study of TQB2450 in Subjects With Stage III Non-Small Cell Lung Cancer(NSCLC)
- A Study of TQB2450 Injection and Anlotinib Hydrochloride Capsules to Treat Triple Negative Breast Cancer (TNBC)
- A Study of TQB2450 Injection Combined With Anlotinib Hydrochloride Capsule as Second-line Treatment in Subjects With Advanced Biliary Cancer
- A Study of TQB2450 Injection Combined With Anlotinib Hydrochloride Capsule in Subjects With Advanced Endometrial Cancer
- A Study of TQB2450 Injection Combined With Anlotinib Hydrochloride Capsule Versus Paclitaxel for Injection (Albumin Bound) in Subjects With Triple Negative Breast Cancer (TNBC)

### In development for (21)

- [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 2
- [Biliary tract neoplasm](https://trialight.com/data/condition/biliary-tract-neoplasm-5b757066-5940-52f7-aa7d-e5aafdc5b54e.md) Phase 2
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 1
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 3
- Carcinoma of esophagus Phase 2
- [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 2
- [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 1
- [Endometrial cancer](https://trialight.com/data/condition/endometrial-cancer-4da2a0bc-7943-502b-a698-cc2beccbed8c.md) Phase 3
- [Esophageal squamous cell carcinoma](https://trialight.com/data/condition/esophageal-squamous-cell-carcinoma-c10bd9c9-02f9-5805-8008-b021f4604e7a.md) Phase 2
- [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 3
- [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) Phase 3
- Kidney cancer Phase 3
- [Lung cancer](https://trialight.com/data/condition/lung-cancer-c4ca1fe0-9b3d-5957-a668-2d6cf26bd16a.md) Phase 1
- [Nasopharyngeal carcinoma](https://trialight.com/data/condition/nasopharyngeal-carcinoma-9ead4a97-f794-5dda-b62e-20f8ca202f89.md) Phase 2
- Neoplasm Phase 3
- Neoplasm of mature B-cells Phase 2
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 3
- [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md) Phase 3
- Pheochromocytoma Phase 2
- [Small cell lung carcinoma](https://trialight.com/data/condition/small-cell-lung-carcinoma-505ad14d-ce79-5398-b171-f724c32e1b4e.md) Phase 3

---

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