> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/bemnifosbuvir-sulfate-c698e97e-2daf-46cb-8abb-2c12e4bb6288
> Record changed: 2026-11-04

# Bemnifosbuvir sulfate

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095037)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095037)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095037)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095037)

**Drug name**

Bemnifosbuvir sulfate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095037)

**Molecular weight**

1,261.16

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095037)

**Structure (SMILES)**

CNc1nc(N)nc2c1ncn2\[C@@H\]1O\[C@H\](COP(=O)(N\[C@@H\](C)C(=O)OC(C)C)Oc2ccccc2)\[C@@H\](O)\[C@@\]1(C)F.CNc1nc(N)nc2c1ncn2\[C@@H\]1O\[C@H\](COP(=O)(N\[C@@H\](C)C(=O)OC(C)C)Oc2ccccc2)\[C@@H\](O)\[C@@\]1(C)F.O=S(=O)(O)O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095037)

### Other names (22)

- at 511 hemisulfate salt
- at 527
- At 527
- at 527 550 mg cyclosporine
- at 527 digoxin
- at 527 fed
- at 527 r07496998
- AT-511-hemisulfate salt
- At-527
- AT-527
- AT-527 (R07496998)
- AT-527 fed
- at527
- AT527
- bemnifosbuvir hemisulfate
- Bemnifosbuvir hemisulfate
- bemnifosbuvir sulfate
- Bemnifosbuvir sulfate
- BEMNIFOSBUVIR SULFATE \[USAN\]
- bemnifosbuvir sulfate usan
- ro7496998
- RO7496998

## Identifiers

**CAS registry numbers**

- 2241337-84-6

**ChEMBL ID**

CHEMBL5095037

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095037)

**InChIKey**

QIGYBLSWYRTXCA-ZTVMIBNESA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095037)

**FDA ingredient codes (UNII)**

- DAI4WL7JQ6

### PubChem compound IDs (2)

- 155926085
- 163192104

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-fos-; -vir

### Investigated indications (5)

- **Condition**  
Hepatitis C

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003047

**Subject identifier**  
D006526
- **Condition**  
Kidney Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003086

**Subject identifier**  
D007674
- **Condition**  
Hepatitis C, Chronic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004220

**Subject identifier**  
D019698
- **Condition**  
COVID-19

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D000086382
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0003086

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005231

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
3

### Trial references (8)

- NCT03219957  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03219957)
- NCT04019717  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04019717)
- NCT04309734  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04309734)
- NCT04396106  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04396106)
- NCT04709835  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04709835)
- NCT04889040  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04889040)
- NCT05126576  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05126576)
- NCT05618314  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05618314)

## Chemical properties

**Hydrogen bond acceptors**

13

**Hydrogen bond donors**

4

**Polar surface area**

184.97

**Calculated partition coefficient (ALogP)**

2.57

**Prodrug**

Yes

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

11

**Heavy atoms**

85

**Molecular formula**

C48H68F2N14O18P2S

**Monoisotopic mass**

1260.40000287

**Natural product**

No

## Related records

### Trials (17)

- Bronchopulmonary PK of AT-527 (R07496998)
- Drug-drug Interaction Study of Digoxin and AT-527 (R07496998)
- Drug-drug Interaction Study of Midazolam and AT-527 (R07496998)
- Drug-drug Interaction Study of Rosuvastatin and AT-527 (R07496998)
- Effect of Carbamazepine on the Pharmacokinetics (PK) of AT-527
- Effect of Cyclosporine on the Pharmacokinetics (PK) of AT-527 (R07496998)
- Mass Balance Study of AT-527 in Healthy Adult Male Subjects (R07496998)
- Pharmacokinetics of Fixed-Dose Combination Tablet of Bemnifosbuvir and Ruzasvir
- Safety and Efficacy of AT-527 in Subjects With Moderate Coronavirus Disease (COVID-19) in a Hospital Setting
- Study of AT-527 in Combination With Daclatasvir in Subjects With Hepatitis C Virus (HCV) Infection
- Study of AT-527 in Healthy and HCV-Infected Subjects
- Study of AT-527 in Healthy Subjects (R07496998)
- [Study of AT-527 in Healthy Subjects Under Fasting Conditions or With a Meal](https://trialight.com/data/trial/study-of-at-527-in-healthy-subjects-under-fasting-conditions-0a04063a-0696-46bf-9560-5549fce23c20.md)
- Study of AT-527 in Subjects With Normal and Impaired Renal Function
- Study of AT-777 in Healthy Subjects and AT-777 in Combination With AT-527 in HCV-Infected Subjects
- Study to Evaluate the Effects of AT-527 in Non-Hospitalized Adult Patients With Mild or Moderate COVID-19
- Study to Evaluate the Effects of RO7496998 (AT-527) in Non-Hospitalized Adult and Adolescent Participants With Mild or Moderate COVID-19

### In development for (4)

- [Chronic hepatitis C virus infection](https://trialight.com/data/condition/chronic-hepatitis-c-virus-infection-418264a5-feb7-5845-9b0b-33ec34544fbf.md) Phase 2
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3
- [Hepatitis C virus infection](https://trialight.com/data/condition/hepatitis-c-virus-infection-b3fd810d-71d3-57f9-8a11-71138c904f4d.md) Phase 1
- [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1

---

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