> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/belrestotug-8b42a452-65fb-46e5-9c7c-f2106bd60d56 > Record changed: 2026-10-29 # Belrestotug Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802205) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802205) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802205) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802205) **Drug name** Belrestotug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802205) ### Other names (33) - belrestotug - Belrestotug - belrestotug \[INN\] - BELRESTOTUG \[USAN\] - Belrestotug \[WHO-DD\] - belrestotug inn - belrestotug usan - belrestotug who dd - Belrestotug. - clone 31282 - Clone 31282 - eos 448 - eos 884448 - EOS-448 - Eos-884448 - EOS-884448 - eos884448 - Eos884448 - EOS884448 - gsk 4428859a - GSK-4428859A - gsk4428859a - GSK4428859A - immunoglobulin g1 anti human receptor tigit human monoclonal eos884448 gamma 1 chain disulfide with human monoclonal eos884448 kappa chain dimer - IMMUNOGLOBULIN G1, ANTI-(HUMAN RECEPTOR TIGIT) (HUMAN MONOCLONAL EOS884448 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL EOS884448 .KAPPA.-CHAIN, DIMER And 8 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 2574438-65-4 **ChEMBL ID** CHEMBL4802205 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802205) **FDA ingredient codes (UNII)** - 59HAW3EQ4C ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (5) - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Multiple Myeloma **Highest recorded phase** 1 **Condition identifier** EFO:0001378 **Subject identifier** D009101 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 3 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Head and Neck Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0005950 **Subject identifier** D006258 - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0004992 **Subject identifier** D009369 ### Open Targets indications (6) - **Condition identifier** EFO\_0000616 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0009693 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0010150 **Highest recorded phase** 2 ### Trial references (8) - NCT03739710 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03739710) - NCT04446351 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04446351) - NCT05277051 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05277051) - NCT04335253 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04335253) - NCT05289492 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05289492) - NCT05565378 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05565378) - NCT06472076 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06472076) - NCT06062420 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06062420) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (5) - **Component** Heavy chain **Type** Protein **Sequence** QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGVIGPSGASTSYAQKFQGRVTLTRDTSTSTVYMELSSLRSEDTAVYYCARDHSDYWSGIMEVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** EIVLTQSPGTLSLSPGERATLSCRASQSVRSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYFSPPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-89' $ 23'''-89''' $ 135'-195' $ 135'''-195''' $ 148-204 $ 148''-204'' $ 215'-224 $ 215'''-224'' $ 230-230'' $ 233-233'' $ 265-325 $ 265''-325'' $ 371-429 $ 371''-429'' - **Component** Glycosylation sites (N) **Sequence** 301 $ 301'''' - **Component** Glycosylation sites (N) **Sequence** 301 $ 301'' ## Related records ### Trials (10) - [A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202](https://trialight.com/data/trial/a-platform-study-of-novel-immunotherapy-combinations-as-f887453f-7656-4251-ba87-8be3fcd752b0.md) - [A Platform Study of Novel Immunotherapy Combinations in Participants With Previously Untreated, Advanced/Metastatic Non-Small-Cell Lung Cancer](https://trialight.com/data/trial/a-platform-study-of-novel-immunotherapy-combinations-in-29430999-4540-4481-8d22-236d21ffd249.md) - A Study of Belrestotug Plus Dostarlimab Compared With Placebo Plus Pembrolizumab in Previously Untreated Participants With Programmed Death Ligand 1 (PD-L1) High Non-small-cell Lung Cancer (NSCLC) - First-In-Human Study of EOS884448 in Participants with Advanced Cancers. - [First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/first-time-in-human-study-of-gsk4381562-in-participants-with-2b234294-67e5-437c-b4a4-a51fc28f3e3b.md) - Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Participants With Non-small Cell Lung Cancer (NSCLC) - Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Participants With Non-small Cell Lung Cancer (NSCLC) - Sub-study 3 - Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors - Study of Novel Regimens in Relapsed or Refractory Multiple Myeloma - Study of the Safety and Effectiveness of GSK6097608 in Participants With Advanced Solid Tumors ### In development for (5) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2 - [Head and neck neoplasm](https://trialight.com/data/condition/head-and-neck-neoplasm-6436d68c-825f-5a7a-bb29-99e9ae9e009a.md) Phase 2 - Neoplasm Phase 2 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 3 - [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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