> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/becotatug-vedotin-19bfe668-c8f3-4830-b42f-20786967f11c
> Record changed: 2026-10-13

# Becotatug vedotin

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068210)

Drug type

Antibody drug conjugate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068210)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068210)

## Names and chemistry

**Drug type**

Antibody drug conjugate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068210)

**Drug name**

Becotatug vedotin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068210)

### Other names (35)

- adc
- ADC
- anti egfr adc mrg003
- anti egfr antibody drug conjugate mrg003
- Anti-egfr adc mrg003
- Anti-EGFR Antibody-drug Conjugate MRG003
- antibody drug conjugate (ADC) composed of a recombinant humanized anti-human Epidermal growth factor receptor (EGFR) monoclonal antibody JMT101 conjugated with the cytotoxic small molecule MMAE
- antibody drug conjugate adc composed of a recombinant humanized anti human epidermal growth factor receptor egfr monoclonal antibody jmt101 conjugated with the cytotoxic small molecule mmae
- Antibody-drug conjugate (ADC)
- Antibody-drug conjugate (ADC) combination therapy
- becotatug vedotin
- Becotatug vedotin
- Becotatug Vedotin
- Becotatug Vedotin (MRG003)
- becotatug vedotin \[INN\]
- Becotatug Vedotin for Injection
- becotatug vedotin inn
- becotatug vedotina
- Becotatug vedotina
- becotatug vedotine
- Becotatug vedotine
- h gamma1 heavy chain humanized 1 449 vh homo sapiens ighv4 4 08 79 4 ighd ighj4 01 92 9 cdr imgt 8 7 13 26 33 51 57 96 108 1 119 homo sapiens ighg1 03 100 g1m3 ng1m1 ch1 r120 216 120 217 hinge 1 15 218 232 ch2 233 342 ch3 e12 358 m14 360 343 447 chs 448 449 120 449 222 214 disulfide with l kappa light chain humanized 1 214 v kappa homo sapiens igkv6 21 02 89 5 igkj2 03 100 cdrimgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 v101 ckappa a45 1 153 v101 191 108 214 dimer 228 228 231 231 bisdisulfide produced in chinese hamster ovary cho cells cell line chos glycoform alfa substituted at the sulfur atoms of four l cysteinyl residues on an average among 222 228 231 214 222 228 231 and 214 with a group consisting of 3rs 1 6 2s 1 2s 5 carbamoylamino 1 4 2s 1 2s 1 3r 4s 5s 1 2s 2 1r 2r 3 1s 2r 1 hydroxy 1 phenylpropan 2 yl amino 1 methoxy 2 methyl 3 oxopropyl pyrrolidin 1 yl 3 methoxy 5 methyl 1 oxoheptan 4 yl methyl amino 3 methyl 1 oxobutan 2 yl amino 3 methyl 1 oxobutan 2 yl methyl carbamoyl oxy methyl anilino 1 oxopentan 2 yl amino 3 methyl 1 oxobutan 2 yl amino 6 oxohexyl 2 5 dioxopyrrolidin 3 yl vedotin
- H-gamma1 heavy chain humanized (1-449) \[VH (Homo sapiens IGHV4-4\*08 (79.4%) -(IGHD) -IGHJ4\*01 (92.9%), CDR-IMGT \[8.7.13\] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1\*03 (100%) G1m3, nG1m1 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)\], (222-214')-disulfide with L-kappa light chain humanized (1'-214') \[V-KAPPA (Homo sapiens IGKV6-21\*02 (89.5%) -IGKJ2\*03 (100%), CDRIMGT \[6.3.9\] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC\*01 (100%) Km3 A45.1, V101 (CKAPPA A45.1 (153'), V101 (191')) (108'-214')\]; dimer (228-228'': 231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHOS, glycoform alfa; substituted at the sulfur atoms of four L-cysteinyl residues on an average among 222, 228, 231, 214', 222'', 228'', 231'' and 214''' with a group consisting of (3RS)-1-(6-{\[(2S)-1-{\[(2S)-5-(carbamoylamino)-1-{4-\[({\[(2S)-1-{\[(2S)-1-{\[(3R,4S,5S)-1-{(2S)-2-\[(1R,2R)-3-{\[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl\]amino}-1-methoxy-2-methyl-3-oxopropyl\]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl\](methyl)amino}-3-methyl-1-oxobutan-2-yl\]amino}-3-methyl-1-oxobutan-2-yl\](methyl)carbamoyl}oxy)methyl\]anilino}-1-oxopentan-2-yl\]amino}-3-methyl-1-oxobutan-2-yl\]amino}-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl (vedotin)
- immunoglobulin g1 kappa anti homo sapiens egfr epidermal growth factor receptor receptor tyrosine protein kinase erbb 1 erbb1 her1 her 1 erbb humanized monoclonal antibody conjugated on an average of four cysteinyl residues to vedotin comprising a cleavable linker and monomethylauristatin e mmae
- Immunoglobulin G1-kappa, anti-\[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)\], humanized monoclonal antibody, conjugated on an average of four cysteinyl residues to vedotin, comprising a cleavable linker and monomethylauristatin E (MMAE)

And 10 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2770851-80-2

**ChEMBL ID**

CHEMBL6068210

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068210)

**FDA ingredient codes (UNII)**

- VHA6L8H5FM

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

becotatug vedotin

**Type**

Antibody

**Drug name stem**

\-dotin

**Approval recorded by Guide to Pharmacology**

Yes

### Investigated indications (5)

- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000181

**Subject identifier**  
D002294
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Nasopharyngeal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004252

**Subject identifier**  
D009303
- **Condition**  
Biliary Tract Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0003060

**Subject identifier**  
D001661

### Open Targets indications (27)

- **Condition identifier**  
EFO\_0000181

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001927

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000521

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001325

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001402

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001528

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004669

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004958

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004971

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005096

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005580

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006382

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006468

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007256

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0010150

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0015459

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018352

**Highest recorded phase**  
2

And 2 more, listed on the interactive page.

### Trial references (7)

- NCT04838548  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04838548)
- NCT04838964  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04838964)
- NCT04868162  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04868162)
- NCT05751512  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05751512)
- NCT04868344  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04868344)
- NCT05688605  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05688605)
- NCT05126719  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05126719)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (4)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QVQLQESGPGLVKPSETLSLTCTVSGFSLSNYDVHWVRQAPGKGLEWLGVIWSGGNTDYNTPFTSRLTISVDTSKNQFSLKLSSVTAADTAVYYCARALDYYDYEFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLEPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Disulfide bridges

**Sequence**  
22-95 $ 22''-95 $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 146-202 $ 146''-202'' $ 222-214' $ 222''-214''' $ 228-228'' $ 231-231'' $ 263-323 $ 263''-323'' $ 369-427 $ 369''-427''
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
EIVLTQSPDFQSVTPKEKVTITCRASQSIGTNIHWYQQKPDQSPKLLIKYASESISGIPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQNNEWPTSFEGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Glycosylation sites (N)

**Sequence**  
299 $ 299''

## Related records

### Trials (427)

- 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome
- ²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma
- 40.2Gy Versus 49.2Gy Radiotherapy in Low-Risk Target Volume for Chemosensitive Stage II Nasopharyngeal Carcinoma
- A Clinical Study of Omalizumab in the Treatment of Allergic Asthma(ESSENCE)
- A Clinical Trial on Autologous NK Cells Combined With GD2 Monoclonal Antibody in the Treatment of Children With Newly Diagnosed High-risk or Relapsed/Refractory Neuroblastoma
- A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
- A First-in-Human Study of EOS301984 as Monotherapy or Combination Therapy in Adult Participants With Advanced Solid Tumors
- A Maintenance Extension of Phase I Pilot Study of Chimeric Anti-CD4 Antibody M-T412 in Patients With Multiple Sclerosis
- A Phase 1b/2 Study of the Safety and Efficacy of the Monoclonal Antibody OM-RCA-01 in Patients With Metastatic Tumors Expressing Fibroblast Growth Factor Receptor 1
- A Phase 3 Study of IN10018 in Combination With D-1553 Versus Standard Therapy for First Line Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation
- A Phase I Clinical Study for Evaluating the Safety and Efficacy of MASCT-I in Patients With Advanced Solid Tumors
- A Phase I Clinical Study for Evaluating the Safety of MASCT-I in Advanced Soild Tumor
- A Phase I Trial Of The Humanized Anti-GD2 Antibody In Children And Adolescents With Neuroblastoma, Osteosarcoma, Ewing Sarcoma and Melanoma
- A Phase II Clinical Trial of Anti-EGFR Antibody-drug Conjugate (ADC) Combined With or Without Immune Checkpoint Inhibitors in the Neoadjuvant Treatment of Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma
- A Phase II Study of Anti-EGFR Antibody-drug Conjugate (ADC) Combine With CDK4/6 Inhibitors Posterior Line in the Treatment of Recurrent/Metastatic CDKN2A Gene Variant Head and Neck Squamous Cell Carcinoma
- A Phase II Study of MRG003 Injection Combined With Pucotenlimab Injection ± Cisplatin Injection in the Neoadjuvant Treatment Locally Advanced EGFR-positive Head and Neck Squamous Cell Carcinoma
- A Phase II Study of PD-1/IL-2α-bias Bispecific Antibody Fusion Protein Monotherapy in Advanced Esophageal Squamous Cell Carcinoma After Failure of Prior ICI Plus Platinum-Based Chemotherapy
- A Phase II Study of SSGJ-612 Plus a HER2-Targeted ADC in HR-Positive, HER2-Low or HER2-Ultralow Expression Metastatic Breast Cancer
- A Phase II Trial Comparing Immunotherapy Versus Capecitabine Maintenance After Chemo-chemoradiotherapy for High-risk Nasopharyngeal Carcinoma
- A Phase II Trial of Camrelizumab in Combination With Apatinib for Neoadjuvant Treatment of Early-stage TNBC With a High Proportion of TILs

### In development for (5)

- [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 2
- [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 3
- [Nasopharyngeal neoplasm](https://trialight.com/data/condition/nasopharyngeal-neoplasm-48691b20-fad8-5218-b6aa-4dd6c49469e4.md) Phase 2
- Neoplasm Phase 2
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2

---

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