> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/baxdrostat-a2e43871-8326-4540-9aa3-5a6511c12d97
> Record changed: 2026-10-13

# Baxdrostat

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4113975)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4113975)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4113975)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4113975)

**Drug name**

Baxdrostat

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4113975)

**Molecular weight**

363.46

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4113975)

**Structure (SMILES)**

CCC(=O)N\[C@@H\]1CCCc2c(-c3ccc4c(c3)CCC(=O)N4C)cncc21

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4113975)

### Other names (20)

- baxdrostat
- Baxdrostat
- baxdrostat (formerly CIN-107) oral solution
- baxdrostat \[INN\]
- BAXDROSTAT \[USAN\]
- Baxdrostat \[WHO-DD\]
- baxdrostat 2mg
- baxdrostat inn
- baxdrostat usan
- baxdrostat who dd
- baxfendy
- BAXFENDY
- cin 107
- Cin-107
- CIN-107
- ro 6836191
- RO-6836191
- ro6836191
- Ro6836191
- RO6836191

## Identifiers

**ATC classification codes**

- C02KN02

Sources for recorded values

Source: [mor.nlm.nih.gov](https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2743398)

**CAS registry numbers**

- 1428652-17-8

**ChEMBL ID**

CHEMBL4113975

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4113975)

**InChIKey**

VDEUDSRUMNAXJG-LJQANCHMSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4113975)

**PubChem compound IDs**

- 71535962

**RxNorm IDs (RxCUI)**

- 2743398

**FDA ingredient codes (UNII)**

- NF3P9Z8J5Y

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

baxdrostat

**Type**

Synthetic organic

**Drug name stem**

\-stat

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
CYP11B2

**Gene symbol**  
CYP11B2

**Protein identifier**  
P19099

**Median affinity**

7.89

**Affinity units**  
pKi

### Investigated indications (2)

- **Condition**  
Hypertension

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000537

**Subject identifier**  
D006973
- **Condition**  
Atherosclerosis

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003914

**Subject identifier**  
D050197

### Open Targets indications (11)

- **Condition identifier**  
EFO\_0000537

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003144

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003914

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0004285

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1002006

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000822

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0011736

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0430034

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0001422

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005044

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005300

**Highest recorded phase**  
3

### Trial references (11)

- NCT01995383  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01995383)
- NCT04519658  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04519658)
- NCT05137002  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05137002)
- NCT05459688  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05459688)
- NCT05470725  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05470725)
- NCT05500820  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05500820)
- NCT05526690  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05526690)
- NCT05961384  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05961384)
- NCT05961397  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05961397)
- NCT05966324  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05966324)
- NCT06336356  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06336356)

## Chemical properties

**Hydrogen bond acceptors**

3

**Hydrogen bond donors**

1

**Polar surface area**

62.3

**Calculated partition coefficient (ALogP)**

3.56

**Calculated partition coefficient (XLogP)**

2.2

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

27

**Molecular formula**

C22H25N3O2

**Monoisotopic mass**

363.19467705

**Natural product**

No

## National Drug Codes

- 0310-6001
- 0310-6002

## Evidence counts

**Recorded assays**

2

**Active assays**

2

### Active assay types

- Confirmatory

## Related records

### Trials (27)

- A Phase IIb Study to Evaluate the Effect of Dapagliflozin in Combination With Baxdrostat Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure.
- [A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure](https://trialight.com/data/trial/a-phase-iii-renal-outcomes-and-cardiovascular-mortality-c5f29ecd-a0cc-4264-97cc-549e6ce6e4bb.md)
- [A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.](https://trialight.com/data/trial/a-phase-iii-study-to-investigate-the-efficacy-and-safety-of-21bfd3d8-102d-4cae-a956-0db6f03bd0ac.md)
- A Phase IIIb Study to Investigate the Effect of Baxdrostat in Chinese Participants With Uncontrolled Hypertension.
- A Single Ascending Dose Study Investigating the Safety, Pharmacokinetics and Pharmacodynamics of RO6836191 in Healthy Male Volunteers.
- A Study of CIN-107 in Adults With Primary Aldosteronism
- A Study of CIN-107 in Adults With Treatment-Resistant Hypertension (rHTN)
- A Study of CIN-107 in Patients With Uncontrolled Hypertension
- A Study to Assess Efficacy and Safety of Baxdrostat in Participants With Primary Aldosteronism
- A Study to Evaluate CIN-107 for the Treatment of Patients With Uncontrolled Hypertension and Chronic Kidney Disease
- A Study to Evaluate Cortisol Reserve in Response to Adrenocorticotropic Hormone (ACTH) Stimulation Test Following Baxdrostat Treatment Compared to Placebo in Participants With Uncontrolled Hypertension
- A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension
- A Study to Investigate the Effect on QTcF of Baxdrostat Compared With Placebo, Using Moxifloxacin as a Positive Control, in Healthy Participants
- A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension
- A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension
- A Study to Investigate the Pharmacokinetics of Baxdrostat When Given Alone and in Combination With Itraconazole in Healthy Participants
- A Study to Investigate the Pharmacokinetics of Ethinyl Estradiol and Levonorgestrel When Given Alone and in Combination With Baxdrostat in Healthy Females of Non-childbearing Potential
- Baxdrostat and Ventricular Remodeling
- Baxdrostat Bioavailability and Bioequivalence Study
- Baxdrostat Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in a Japanese Population

### In development for (3)

- [Atherosclerosis](https://trialight.com/data/condition/atherosclerosis-5dab64e9-1fd4-5dd2-90c2-ce84935652d1.md) Phase 1
- [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 3
- [Hypertensive disorder](https://trialight.com/data/condition/hypertensive-disorder-6d786557-b9e8-5afc-80f3-89a1995f9da5.md) Phase 2

---

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