> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/balinatunfib-9c492aaf-b4ae-4189-a4a9-33efe9adea40
> Record changed: 2026-10-13

# Balinatunfib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068043)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068043)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068043)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068043)

**Drug name**

Balinatunfib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068043)

**Molecular weight**

502.53

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068043)

**Structure (SMILES)**

CN1C(=O)c2cccc(OC(F)F)c2\[C@H\]2C\[C@@H\]1c1nc3ccc(-c4cnc(C5(N)CCC5)nc4)cc3n12

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068043)

### Other names (12)

- balinatunfib
- Balinatunfib
- balinatunfib \[INN\]
- BALINATUNFIB \[USAN\]
- Balinatunfib \[WHO-DD\]
- balinatunfib inn
- balinatunfib usan
- balinatunfib who dd
- sar 441566
- SAR-441566
- sar441566
- SAR441566

## Identifiers

**CAS registry numbers**

- 2248726-53-4

**ChEMBL ID**

CHEMBL6068043

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068043)

**InChIKey**

UROFXMLQPAUCGV-WOJBJXKFSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068043)

**PubChem compound IDs**

- 132042903

**FDA ingredient codes (UNII)**

- PLY98MAN4C

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

balinatunfib

**Type**

Synthetic organic

### Mechanisms of action

- **Action**  
Binding

**Action type**  
Binding

**Target**  
tumour necrosis factor shed form

**Gene symbol**  
tumour necrosis factor shed form

**Median affinity**

7.82

**Affinity units**  
pKd

### Open Targets indications (2)

- **Condition identifier**  
MONDO\_0005011

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005101

**Highest recorded phase**  
2

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

1

**Polar surface area**

99.16

**Calculated partition coefficient (ALogP)**

4.55

**Calculated partition coefficient (XLogP)**

2.7

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

4

**Heavy atoms**

37

**Molecular formula**

C27H24F2N6O2

**Monoisotopic mass**

502.19288035

**Natural product**

No

## Related records

### Trials (9)

- A Randomized Placebo- and Active Comparator-controlled Study to Evaluate the Photosafety of SAR441566
- A Single Ascending Dose Study to Characterize the Pharmacokinetics, Safety, and Tolerability of SAR441566 in Healthy Adult Japanese Male Participants.
- A Study to Evaluate Efficacy and Safety of SAR441566 in Adults With Plaque Psoriasis
- A Study to Evaluate SAR441566 Efficacy and Safety in Adults With Rheumatoid Arthritis
- A Study to Evaluate the Effect of Single Oral Dose of Balinatunfib on Cardiac Repolarization in Healthy Adult Participants.
- A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Crohn's Disease.
- A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Ulcerative Colitis
- A Study to Investigate Safety, Tolerability and Clinical Response With SAR441566 Compared With Placebo in Participants With Mild to Moderate Psoriasis
- [A Study to Investigate the Long-term Safety, Tolerability and Efficacy of Balinatunfib in Participants With Crohn's Disease or Ulcerative Colitis (SPECIFI-IBD-LTS)](https://trialight.com/data/trial/a-study-to-investigate-the-long-term-safety-tolerability-and-3cc3cabc-61f3-4dec-818e-a3a6aea0e52b.md)

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