> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/balcinrenone-039aff61-faf5-4267-bfc5-f89dce767007
> Record changed: 2026-10-13

# Balcinrenone

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916929)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916929)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916929)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916929)

**Drug name**

Balcinrenone

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916929)

**Molecular weight**

399.38

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916929)

**Structure (SMILES)**

CNC(=O)C\[C@H\]1COc2cc(F)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916929)

### Other names (27)

- azd 9977
- Azd 9977
- AZD 9977 \[WHO-DD\]
- azd 9977 who dd
- Azd-9977
- AZD-9977
- azd9977
- Azd9977
- AZD9977
- AZD9977 capsule
- AZD9977 capsule 50 mg
- AZD9977 ER capsule (fastvrate)
- AZD9977 ER capsule (Int. rate)
- AZD9977 immediate release (IR) oral suspension
- AZD9977 oral suspension
- AZD9977 Oral suspension (reference)
- AZD9977, oral suspension
- balcinrenona
- Balcinrenona
- balcinrenone
- Balcinrenone
- balcinrenone \[INN\]
- BALCINRENONE \[USAN\]
- Balcinrenone 100mg Capsule
- Balcinrenone 50mg Capsule

And 2 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 1850385-64-6

**ChEMBL ID**

CHEMBL3916929

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916929)

**InChIKey**

MBKYLPOPYYLTNW-ZDUSSCGKSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3916929)

**PubChem compound IDs**

- 118599727

**FDA ingredient codes (UNII)**

- 6C9UKZ0CYE

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

balcinrenone

**Type**

Synthetic organic

**Drug name stem**

\-renone

### Mechanisms of action (2)

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
Mineralocorticoid receptor

**Gene symbol**  
NR3C2

**Protein identifier**  
P08235

**Median affinity**

6.4

**Affinity units**  
pIC50
- **Mechanism**  
Mineralocorticoid receptor modulator

**Action type**  
MODULATOR

**Target**  
Mineralocorticoid receptor

**Protein identifier**  
P08235

### Open Targets mechanisms

- **Mechanism**  
Mineralocorticoid receptor modulator

**Action type**  
MODULATOR

**Target**  
Mineralocorticoid receptor

### Investigated indications (6)

- **Condition**  
Cardiovascular Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000319

**Subject identifier**  
D002318
- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Kidney Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003086

**Subject identifier**  
D007674
- **Condition**  
Heart Failure

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003144

**Subject identifier**  
D006333
- **Condition**  
Renal Insufficiency, Chronic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003884

**Subject identifier**  
D051436
- **Condition**  
Kidney Failure, Chronic

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0024327

**Subject identifier**  
D007676

### Open Targets indications (8)

- **Condition identifier**  
EFO\_0000319

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003086

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003144

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003884

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004285

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005252

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005300

**Highest recorded phase**  
2

### Trial references (10)

- NCT03682497  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03682497)
- NCT03801967  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03801967)
- NCT03804645  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03804645)
- NCT03843060  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03843060)
- NCT04798222  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04798222)
- NCT04469907  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04469907)
- NCT04686591  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04686591)
- NCT05884866  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05884866)
- NCT06350123  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06350123)
- NCT06388616  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06388616)

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

2

**Polar surface area**

96.97

**Calculated partition coefficient (ALogP)**

1.7

**Calculated partition coefficient (XLogP)**

1.1

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

29

**Molecular formula**

C20H18FN3O5

**Monoisotopic mass**

399.12304885

**Natural product**

No

## Evidence counts

**Recorded assays**

25

**Active assays**

8

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (165)

- A Bioequivalence Study Between Fluticasone Propionate 250 mcg and Salmeterol Xinafoate 50 mcg Inhalation Powder/Respirent Pharmaceuticals vs. ADVAIR DISKUS® 250/50 Inhalation Powder/GSK in Healthy Volunteers
- A Bioequivalence Study Comparing A Fixed Dose Combination Formulation, Rin 150 And Individual Reference Drugs In Healthy Volunteers
- A Bioequivalence Study of Pegylated Interferon Alfa-2a (PEG-IFN Alfa-2a) Benzyl Alcohol (BA)-Free Formulation Versus PEG-IFN Alfa-2a (Pegasys) Following Subcutaneous Administration
- A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching
- A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries
- A Comparative Study of New Formulation and Approved Formulation for Levothyroxine in Healthy Volunteers
- A Comparing Study Between SJ04 and Ovidrel® in Healthy Subjects
- A Cross-over Study Examining the Bioequivalence of 3 Test Formulations to a Reference Formulation of Alectinib (RO5424802) in Healthy Volunteers
- A Crossover Study to Evaluate the Relative Bioavailability of Two Formulations of Deuterated Remdesivir Hydrobromide for Oral Suspension in Healthy Chinese Adults
- A Pharmacokinetic (PK) Study Of PF-00299804 And Dextromethorphan In Healthy Volunteers
- A Phase 1 Relative Bioavailability Study of Ambrisentan and Tadalfil Fixed Dose Combination Tablets in Healthy Subjects
- A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers
- A Phase 1, Open-Label, Parallel Group Study to Evaluate the Pharmacokinetics and Safety of DARE-HRT1 in Healthy PostMenopausal Women
- A Phase I PK Study of Balcinrenone/Dapagliflozin in Healthy Chinese Participants
- A Phase I/II Clinical Study of SK&F-105517-D in Japanese Patients With Chronic Heart Failure
- [A Phase III Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With CKD Stage 3b and 4 (BalanceD-CKD)](https://trialight.com/data/trial/a-phase-iii-study-to-evaluate-the-effect-of-balcinrenone-3367ad0e-7c58-4477-8bb9-35f740540b3a.md)
- A Single Oral Dose Study to Evaluate Four Different Formulations of AZD9977 and the Effect of Food in Healthy Male Subjects
- A Single-center, Open, Randomized, Single-dose, Cross-over Bioequivalence Study to Evaluate the Effects of the Test Formulation Abalparatide Injection and the Reference Formulation Abalparatide Injection (Tymlos®) in Healthy Adult Subjects
- A Six-week Study Comparing the Efficacy and Safety of Tiotropium Plus Formoterol to Salmeterol Plus Fluticasone in Chronic Obstructive Pulmonary Disease (COPD)
- A Study Assessing the Effects of an Experimental Dentifrice in Maintaining Tooth Color Following Tooth Bleaching

### In development for (6)

- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 1
- [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) Phase 2
- [Chronic renal failure syndrome](https://trialight.com/data/condition/chronic-renal-failure-syndrome-5b98a1aa-2089-59e6-af27-bff008ad07ac.md) Phase 2
- [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 1
- [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1

### Targets (1)

- [NR3C2](https://trialight.com/data/target/nr3c2-ddf600eb-ddcf-5af5-b7a0-935d2b5ed817.md) Mineralocorticoid receptor modulator

---

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