> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/azirkitug-4abb572a-80a6-453e-816e-6de029b59181 > Record changed: 2026-10-13 # Azirkitug Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068092) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068092) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068092) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068092) **Drug name** Azirkitug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068092) ### Other names (16) - azirkitug - Azirkitug - azirkitug \[INN\] - AZIRKITUG \[USAN\] - azirkitug inn - azirkitug usan - h gamma1 heavy chain humanized 1 450 vh homo sapiens ighv3 73 01 84 8 ighd ighj4 01 92 9 cdr imgt 8 10 11 26 33 51 60 99 109 1 120 homo sapiens ighg1 03v g1m3 g1m17 ng1m1 ch1 k120 ch3 e12 m14 ch1 r120 k 217 121 218 hinge 1 15 219 233 ch2 234 343 ch3 e12 359 m14 361 344 448 chs 449 450 121 450 223 214 disulfide with l kappa light chain humanized 1 214 v kappa homo sapiens igkv3 11 01 78 9 igkj2 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 229 229 232 232 bisdisulfide produced in a chinese hamster ovary cho cell line derived from the cell line cho dux b11 lacking the enzyme dihydrofolate reductase dhfr and co expressing the rmd enzyme gdp 6 deoxy dlyxo 4 hexulose reductase glycoform alfa - H-gamma1 heavy chain humanized (1-450) \[VH (Homo sapiens IGHV3-73\*01 (84.8%) -(IGHD) -IGHJ4\*01 (92.9%), CDR-IMGT\[8.10.11\] (26-33.51-60.99-109)) (1-120) -Homo sapiens IGHG1\*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)\], (223-214')-disulfide with L-kappa light chain humanized (1'-214') \[V-KAPPA (Homo sapiens IGKV3-11\*01 (78.9%) -IGKJ2\*01 (100%), CDR-IMGT \[6.3.9\] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')\]; dimer (229-229'':232-232'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line, derived from the cell line CHO-DUX-B11, lacking the enzyme dihydrofolate reductase (DHFR), and co-expressing the RMD enzyme (GDP-6-deoxy-Dlyxo-4-hexulose reductase), glycoform alfa - immunoglobulin g1 anti human cc chemokine receptor ccr8 human rattus norvegicus monoclonal pr 1925514 γ1 chain disulfide with human rattus norvegicus monoclonal pr 1925514 κ chain dimer - immunoglobulin g1 kappa anti homo sapiens ccr8 c c motif chemokine receptor 8 ckr l1 cdw198 humanized monoclonal antibody - immunoglobulin G1-kappa, anti-\[Homo sapiens CCR8 (C-C motif chemokine receptor 8, CKR-L1, CDw198)\], humanized monoclonal antibody - Immunoglobulin G1, anti-(human CC chemokine receptor CCR8) (human-Rattus norvegicus monoclonal PR-1925514 γ1-chain), disulfide with human-Rattus norvegicus monoclonal PR-1925514 κ-chain, dimer - pr 1925514 - PR-1925514 - pr1925514 - PR1925514 ## Identifiers **CAS registry numbers** - 2837169-12-5 **ChEMBL ID** CHEMBL6068092 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068092) **FDA ingredient codes (UNII)** - R6HJ7X69JZ ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (4) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0010150 **Highest recorded phase** 1 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLVESGGGLVQPGGSLKLSCAASGFIFSNAVMYWVRQASGKGLEWVARIKTKFNNYATYYADAVKGRFTISRDDSKNMVYLQMNSLKTEDTAVYYCTAGDRNKPFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-98 $ 22''-98'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 147-203 $ 147''-203'' $ 223-214' $ 223''-214''' $ 229-229'' $ 232-232'' $ 264-324 $ 264''-324'' $ 370-428 $ 370''-428'' - **Component** Light chain **Type** Protein **Sequence** ETVVTQSPATLSLSPGERATLSCRASTSVITLLHWFQQKPGQAPRLLIHGASNLESRVPARFSGSGSGTDFTLTISSLEPEDFATYFCQQSWNDPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 300 $ 300'' ## Related records ### Trials (1) - [Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan](https://trialight.com/data/trial/study-to-assess-adverse-events-and-pharmacokinetics-in-adult-75ac0852-abf8-4cb9-b25e-7ac41ffa0876.md) ### In development for (1) - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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