> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/azenosertib-944931bf-2ff3-48e7-8c82-2d2dde814b6e
> Record changed: 2026-10-13

# Azenosertib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095036)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095036)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095036)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095036)

**Drug name**

Azenosertib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095036)

**Molecular weight**

526.65

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095036)

**Structure (SMILES)**

C=CCn1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1ccc2c(n1)\[C@@\](O)(CC)CC2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095036)

### Other names (10)

- azenosertib
- Azenosertib
- Azenosertib \[INN\]
- Azenosertib \[WHO-DD\]
- azenosertib inn
- azenosertib who dd
- zn c3
- Zn-c3
- ZN-c3
- ZN-C3

## Identifiers

**CAS registry numbers**

- 2376146-48-2

**ChEMBL ID**

CHEMBL5095036

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095036)

**InChIKey**

OXTSYWDBUVRXFF-GDLZYMKVSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095036)

**PubChem compound IDs**

- 139467635

**FDA ingredient codes (UNII)**

- 9J13XU96Z1

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

azenosertib

**Type**

Synthetic organic

**Drug name stem**

\-sertib

### Mechanisms of action (2)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
WEE1 G2 checkpoint kinase

**Gene symbol**  
WEE1

**Protein identifier**  
P30291

**Median affinity**

8.41

**Affinity units**  
pIC50
- **Mechanism**  
Serine/threonine-protein kinase WEE1 inhibitor

**Action type**  
Inhibitor

**Target**  
Wee1-like protein kinase

**Protein identifier**  
P30291

### Open Targets mechanisms

- **Mechanism**  
Serine/threonine-protein kinase WEE1 inhibitor

**Action type**  
Inhibitor

**Target**  
Wee1-like protein kinase

### Investigated indications (5)

- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Osteosarcoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000637

**Subject identifier**  
D012516
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Leukemia, Myeloid

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004643

**Subject identifier**  
D007951
- **Condition**  
Carcinoma, Pancreatic Ductal

**Highest recorded phase**

0.5

**Condition identifier**  
MONDO:0005184

**Subject identifier**  
D021441

### Open Targets indications (19)

- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1000238

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002087

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004643
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005140

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005184

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005494

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0006047

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006196

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0009807

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0015686

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018874

**Highest recorded phase**  
1

### Trial references (5)

- NCT04005690  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04005690)
- NCT04158336  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04158336)
- NCT04972422  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04972422)
- NCT04833582  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04833582)
- NCT05682170  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05682170)

## Chemical properties

**Hydrogen bond acceptors**

10

**Hydrogen bond donors**

2

**Polar surface area**

104.34

**Calculated partition coefficient (ALogP)**

3.2

**Calculated partition coefficient (XLogP)**

3.7

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

7

**Heavy atoms**

39

**Molecular formula**

C29H34N8O2

**Monoisotopic mass**

526.28047236

**Natural product**

No

## Evidence counts

**Recorded assays**

136

**Active assays**

80

### Active assay types

- Confirmatory

## Related records

### Trials (16)

- A Phase 1b Study of ZN-c3 in Chinese Subjects
- A Study of Azenosertib (ZN-c3) and Niraparib in Subjects With Platinum-Resistant Ovarian Cancer
- A Study of Azenosertib (ZN-c3) in Combination With Gemcitabine in Subjects With Osteosarcoma
- A Study of Azenosertib (ZN-c3) in Participants With Solid Tumors
- A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer
- [A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer](https://trialight.com/data/trial/a-study-of-azenosertib-zn-c3-in-subjects-with-platinum-35a0b920-5423-4580-8bb9-86ecfa32b8d4.md)
- A Study of Azenosertib (ZN-c3) in Women With Recurrent or Persistent Uterine Serous Carcinoma
- A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression
- Azenosertib in Uterine Serous Carcinoma: Biomarker Study
- Phase I Study of ZN-c3 and Bevacizumab ± Pembrolizumab in Metastatic CCNE1 Amplified and TP53 Mutant Solid Tumors
- Study of the ZN-d5 and ZN-c3 in Subjects With Acute Myeloid Leukemia (AML)
- Targeted Pathway Inhibition in Patients With Pancreatic Cancer
- Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors
- ZAP-IT: ZN-c3 + Carboplatin + Pembrolizumab in mTNBC
- ZN-c3 for the Treatment of Metastatic Triple-Negative Breast Cancer and Advanced Ovarian Cancer
- ZN-c3 in Adult Participants With Metastatic Colorectal Cancer

### In development for (6)

- [Endometrial serous adenocarcinoma](https://trialight.com/data/condition/endometrial-serous-adenocarcinoma-f5a5a317-3bef-59e5-ab47-e093f671ce56.md) Phase 2
- Exocrine pancreatic carcinoma Early phase 1
- [Myeloid leukemia](https://trialight.com/data/condition/myeloid-leukemia-6cc43f22-3c0b-566a-b15d-32a90ad528e5.md) Phase 1
- Neoplasm Phase 2
- [Osteosarcoma](https://trialight.com/data/condition/osteosarcoma-d6ad580f-c521-585b-9a22-26006b6bff2b.md) Phase 1
- [Pancreatic ductal adenocarcinoma](https://trialight.com/data/condition/pancreatic-ductal-adenocarcinoma-77c1c5a8-638b-51d0-b18e-2c881b8902e5.md) Early phase 1

### Targets (1)

- [WEE1](https://trialight.com/data/target/wee1-8c0285e9-fac0-5703-a814-cf22335badee.md) Serine/threonine-protein kinase WEE1 inhibitor

---

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